{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:36:38Z","timestamp":1763037398399,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.toxrep.2020.01.006","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T11:36:59Z","timestamp":1579347419000},"page":"183-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Cytotoxic and antimicrobial potential of different leaves extracts of R. fruticosus used traditionally to treat diabetes"],"prefix":"10.1016","volume":"7","author":[{"given":"Afaf M.","family":"Weli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanady S.","family":"Al-Saadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rouqaya S.","family":"Al-Fudhaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amzad","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zabida Binti","family":"Putit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood K.","family":"Jasim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2020.01.006_bib0005","first-page":"7757","article-title":"Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models mole","volume":"17","author":"Seremet","year":"2018","journal-title":"Med. Rep."},{"issue":"3","key":"10.1016\/j.toxrep.2020.01.006_bib0010","first-page":"1017","article-title":"Oral toxicity study of certain plant extracts containing pyrrolizidine alkaloids Romanian","volume":"57","author":"\u015eeremet OC","year":"2016","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0015","first-page":"661","article-title":"Antibacterial evaluation and phytochemical analysis of Betula utilis","volume":"4","author":"Kumaraswamy","year":"2008","journal-title":"World J. Agri. Sci."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0020","first-page":"49","article-title":"Phytochemical and antimicrobial evaluations of some medicinal plants of Nepal Kathmandu Uni","volume":"1","author":"Chhetri","year":"2008","journal-title":"J. Sci. Eng. Techno."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0025","series-title":"Aqaiq AL-juman fee AL-Tadawi be Nabatat Oman Diwan Royal Court.","first-page":"172","author":"Al-Whaibi","year":"1987"},{"issue":"16","key":"10.1016\/j.toxrep.2020.01.006_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/0973-7847.134239","article-title":"Rubus fruticosus (blackberry) use as an herbal medicine","volume":"8","author":"Verma","year":"2014","journal-title":"Pharmacogn. Rev."},{"issue":"24","key":"10.1016\/j.toxrep.2020.01.006_bib0035","first-page":"5920","article-title":"Antimicrobial screening of fruit, leaves, root and stem of Rubus fruticosus","volume":"5","author":"Riaz","year":"2011","journal-title":"J. Med. Plants Res."},{"issue":"34","key":"10.1016\/j.toxrep.2020.01.006_bib0040","first-page":"5550","article-title":"Biological spectrum with some other ecological attributes of the flora and vegetation of the Asir Mountain of South West, Saudi Arabia","volume":"9","author":"Al-Yemeni","year":"2017","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0045","first-page":"355","article-title":"Phytoplasma and phytoplasma diseases: a review of recent research","volume":"48","author":"Bertaccini","year":"2009","journal-title":"Phytopathol. Mediterr."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0050","series-title":"An Andean Ecosystem under Human Influence","first-page":"85","author":"Balslev","year":"1992"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.12702\/1984-7033.v07n03a03","article-title":"Genetic diversity of wild and cultivated Rubus species in Colombia using AFLP and SSR markers","volume":"7","author":"Marulanda","year":"2007","journal-title":"Crop Breed. App. Biotech."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0060","first-page":"384","volume":"1","author":"Schweingruber","year":"2013"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.17660\/ActaHortic.2007.759.6","article-title":"Rubus iconography: antiquity to the renaissance","volume":"759","author":"Hummer","year":"2007","journal-title":"Acta Hortic."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0070","first-page":"138","article-title":"Acute toxicity, brine shrimp cytotoxicity, anthelmintic and relaxant potentials of fruits of Rubus fruticosus Agg BMC Complement","volume":"13","author":"Niaz","year":"2013","journal-title":"Altern. Med."},{"issue":"4","key":"10.1016\/j.toxrep.2020.01.006_bib0075","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.foodchem.2011.08.022","article-title":"Rubus fruit phenolic research: the good, the bad, and the confusing","volume":"130","author":"Lee","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0080","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1021\/jf8026149","article-title":"Antioxidant status in humans after consumption of blackberry (Rubus fruticosusL.) juices with and without defatted milk","volume":"56","author":"Hassimotto","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0085","doi-asserted-by":"crossref","first-page":"10998","DOI":"10.3390\/molecules190810998","article-title":"L., constituents, biological activities and health related uses","volume":"19","author":"Zia-Ul-Haq","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0090","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2174\/0929867043365143","article-title":"Therapeutic constituents and actions of Rubus species","volume":"11","author":"Patel","year":"2004","journal-title":"Curr. Med. Chem."},{"issue":"16","key":"10.1016\/j.toxrep.2020.01.006_bib0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/0973-7847.134239","article-title":"Rubus fruticosus (blackberry) use as an herbal medicine","volume":"8","author":"Verma","year":"2014","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0100","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2337\/diacare.12.8.553","article-title":"Traditional plant medicines as treatments for diabetes","volume":"12","author":"Bailey","year":"1989","journal-title":"Diabetes Care Educ. Newsl."},{"issue":"7\u20138","key":"10.1016\/j.toxrep.2020.01.006_bib0105","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0367-326X(02)00222-8","article-title":"Hyaluronidase inhibitory activity from the polyphenols in the fruit of blackberry (Rubus fruticosus B.)","volume":"73","author":"Marquina","year":"2002","journal-title":"Fitoterap"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0110","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1021\/jf203318p","article-title":"The blackberry fruit: a review on its composition and chemistry, metabolism and bioavailability, and health benefits","volume":"60","author":"Kaume","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0115","series-title":"Practical Pharmacognosy","first-page":"106","author":"Kokate","year":"1997"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0120","first-page":"282","article-title":"Blood pressure lowering effect of Adenanthera pavonina seed extract on normotensive rats","volume":"3","author":"Aduragbenro","year":"2009","journal-title":"Rec. Nat. Prod"},{"issue":"12","key":"10.1016\/j.toxrep.2020.01.006_bib0125","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1021\/jf011405l","article-title":"Antioxidant activity and phenolic content of Oregon cranberries","volume":"50","author":"Wada","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0130","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1021\/jf011097r","article-title":"Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries","volume":"50","author":"Sellappan","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/202534","article-title":"Formation of short-chain fatty acids, excretion of anthocyanins, and microbial diversity in rats fed blackcurrants, blackberries, and raspberries","author":"Jakobsdottir","year":"2013","journal-title":"J. Nutr. Metab."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0140","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1515\/znc-2002-3-412","article-title":"Cytotoxic, hypoglycemic activity and phytochemical analysis of Rubus imperialis (Rosaceae)","volume":"57","author":"Kanegusuku","year":"2002","journal-title":"Z. Naturforsch."},{"issue":"5","key":"10.1016\/j.toxrep.2020.01.006_bib0145","first-page":"339","article-title":"Phytochemical, cytotoxic and immunomodulatory analysis of an Indian blackberry Rubus fruticosus","volume":"5","author":"Bahgat","year":"2015","journal-title":"J. Biol. Prod. Nat."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0150","first-page":"2318","article-title":"Antimicrobial activity of the ethanol extracts of some plants natural growing in Aydin, Turkey","volume":"4","author":"\u00c7oban","year":"2010","journal-title":"Afr. J. Microbiol. Res."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jtusci.2014.01.004","article-title":"Cytotoxic properties of some plants in Oman","volume":"8","author":"Said","year":"2014","journal-title":"J. Taibah Univ. Sci."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0160","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/ol.2015.3453","article-title":"Anticancer potential of selected Fallopia adans species","volume":"10","author":"Olaru","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0165","series-title":"Thomsen Manual of Bioassay Techniques for Natural Product Research","first-page":"82","author":"Rehman","year":"1991"},{"year":"1971","series-title":"Probit analysis.","author":"Finney","key":"10.1016\/j.toxrep.2020.01.006_bib0170"},{"key":"10.1016\/j.toxrep.2020.01.006_bib0175","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1128\/am.21.6.1011-1016.1971","article-title":"Scott PM Brine shrimp (Artemia salina L.) larvae as a screening system for fungal toxins","volume":"21","author":"Harwig","year":"1971","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0180","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.toxrep.2019.10.003","article-title":"Cytotoxic and antimicrobial potential of different varieties of ripe banana used traditionally to treat ulcers","volume":"4","author":"Mqbali","year":"2019","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.toxrep.2020.01.006_bib0185","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.toxrep.2018.08.008","article-title":"Acute toxicity studies of the South African medicinal plant Galenia africana","volume":"5","author":"Ng\u2019uni","year":"2018","journal-title":"Toxicol. Rep."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750019305724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750019305724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:47:37Z","timestamp":1762012057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750019305724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":37,"alternative-id":["S2214750019305724"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2020.01.006","relation":{},"ISSN":["2214-7500"],"issn-type":[{"type":"print","value":"2214-7500"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxic and antimicrobial potential of different leaves extracts of R. fruticosus used traditionally to treat diabetes","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2020.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}