{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:00:55Z","timestamp":1785186055436,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.toxrep.2020.12.003","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T13:28:00Z","timestamp":1607002080000},"page":"1629-1633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-0931","authenticated-orcid":false,"given":"R.S.D.","family":"van der Pas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.J.","family":"Gresnigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-9488","authenticated-orcid":false,"given":"L.","family":"Wansink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.F.","family":"Franssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Riezebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxrep.2020.12.003_bib0005","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.annemergmed.2017.07.482","article-title":"Fatalities, cerebral hemorrhage, and severe cardiovascular toxicity after exposure to the new psychoactive substance 4-Fluoroamphetamine: a prospective cohort study","volume":"71","author":"Hondebrink","year":"2018","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0010","series-title":"Flash Eurobarometer 401: Young People and Drugs","author":"European Commission","year":"2016"},{"issue":"Pt 1","key":"10.1016\/j.toxrep.2020.12.003_bib0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tiv.2017.05.010","article-title":"Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay","volume":"45","author":"Zwartsen","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxrep.2020.12.003_bib0020","series-title":"Nationale Drug Monitor","author":"van Laar","year":"2019"},{"issue":"3","key":"10.1016\/j.toxrep.2020.12.003_bib0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.euroneuro.2014.12.012","article-title":"Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones","volume":"25","author":"Rickli","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuropharm.2013.11.008","article-title":"Monoamine transporter and receptor interaction profiles of a new series of designer cathinones","volume":"79","author":"Simmler","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxrep.2020.12.003_bib0035","series-title":"Factsheet 4-FA","author":"Croes","year":"2017"},{"issue":"12","key":"10.1016\/j.toxrep.2020.12.003_bib0040","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1007\/s00216-013-6798-0","article-title":"Liquid chromatography\/time-of-flight mass spectrometry analysis of postmortem blood samples for targeted toxicological screening","volume":"405","author":"Roman","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"October","key":"10.1016\/j.toxrep.2020.12.003_bib0045","first-page":"8","article-title":"Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration: Can (R)\/(S) Concentration Ratios Help in Interpreting Forensic Cases?","author":"Losacker","year":"2020","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.113008","article-title":"Excretion of 4-fluoroamphetamine and three metabolites in urine after controlled oral ingestion","volume":"179","author":"Toennes","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"April","key":"10.1016\/j.toxrep.2020.12.003_bib0055","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.toxrep.2020.04.007","article-title":"Toxicological screening in the Amsterdam acute setting becomes more relevant if the standard panel of the drugs-of-abuse point-of-care test is expanded with GHB and ketamine","volume":"7","author":"van der Schaar","year":"2020","journal-title":"Toxicol. Rep."},{"issue":"9","key":"10.1016\/j.toxrep.2020.12.003_bib0060","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3390\/jcm8091295","article-title":"A mechanistic and pathophysiological approach for stroke associated with drugs of abuse","volume":"8","author":"Tsatsakis","year":"2019","journal-title":"J. Clin. Med."},{"issue":"7311","key":"10.1016\/j.toxrep.2020.12.003_bib0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/bmj.323.7311.464","article-title":"Cardiovascular complications of recreational drugs","volume":"323","author":"Ghuran","year":"2001","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.toxrep.2020.12.003_bib0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/2589977511666190716111303","article-title":"Transient left ventricular acute failure after cocaine use","volume":"11","author":"Cardinale","year":"2019","journal-title":"Curr. Drug. Res. Rev."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0075","first-page":"1","article-title":"Slow on the uptake, progression to heartbreak","volume":"8","author":"Binder","year":"2020","journal-title":"J. Investig. Med. High Impact. Case Reports"},{"issue":"6","key":"10.1016\/j.toxrep.2020.12.003_bib0080","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4065\/81.6.829","article-title":"Transient left ventricular apical ballooning after cocaine use: Is catecholamine cardiotoxicity the pathologic link?","volume":"81","author":"Arora","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0085","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.12659\/AJCR.918918","article-title":"A case of status epilepticus and transient stress cardiomyopathy associated with smoking the synthetic psychoactive cannabinoid, UR-144","volume":"20","author":"Al Fawaz","year":"2019","journal-title":"Am. J. Case Rep."},{"issue":"1","key":"10.1016\/j.toxrep.2020.12.003_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12012-016-9385-8","article-title":"Exposure to amphetamines leads to development of amphetamine type stimulants associated cardiomyopathy (ATSAC)","volume":"17","author":"Jafari Giv","year":"2017","journal-title":"Cardiovasc. Toxicol."},{"issue":"10","key":"10.1016\/j.toxrep.2020.12.003_bib0095","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3109\/15563650.2014.974262","article-title":"Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels","volume":"52","author":"Al-Abri","year":"2014","journal-title":"Clin. Toxicol."},{"issue":"24","key":"10.1016\/j.toxrep.2020.12.003_bib0100","first-page":"1","article-title":"Takotsubo cardiomyopathy as a consequence of 4-fluoroamphetamine Mono-intoxication documented by toxicological analyses","author":"Aly","year":"2020","journal-title":"Clin. Toxicol."},{"issue":"6","key":"10.1016\/j.toxrep.2020.12.003_bib0105","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1016\/j.ijcard.2013.08.067","article-title":"Basal stress cardiomyopathy induced by exogenous catecholamines in younger adults","volume":"168","author":"Fulcher","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"6","key":"10.1016\/j.toxrep.2020.12.003_bib0110","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/imj.13050","article-title":"Methamphetamine-associated cardiomyopathy: patterns and predictors of recovery","volume":"46","author":"Voskoboinik","year":"2016","journal-title":"Intern. Med. J."},{"issue":"2","key":"10.1016\/j.toxrep.2020.12.003_bib0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.15420\/ecr.2015.10.2.83","article-title":"Takotsubo syndrome - Stress-induced heart failure syndrome","volume":"10","author":"Sheppard","year":"2015","journal-title":"Eur. Cardiol. Rev"},{"issue":"3","key":"10.1016\/j.toxrep.2020.12.003_bib0120","first-page":"24","article-title":"Takotsubo cardiomyopathy: review of broken heart syndrome","volume":"33","author":"Boyd","year":"2020","journal-title":"J. Am. Acad. Physician Assist."},{"issue":"February","key":"10.1016\/j.toxrep.2020.12.003_bib0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pharmthera.2017.10.022","article-title":"Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?","volume":"182","author":"Hondebrink","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.toxrep.2020.12.003_bib0130","doi-asserted-by":"crossref","first-page":"921","DOI":"10.21873\/invivo.11330","article-title":"Acute heart failure in the emergency department: respiratory rate as a risk predictor","volume":"32","author":"Siniorakis","year":"2018","journal-title":"In Vivo (Brooklyn)"},{"issue":"7","key":"10.1016\/j.toxrep.2020.12.003_bib0135","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ejhf.872","article-title":"Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"19","author":"Harjola","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"16","key":"10.1016\/j.toxrep.2020.12.003_bib0140","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.jacc.2018.07.072","article-title":"Stress cardiomyopathy diagnosis and treatment: JACC state-of-the-Art review","volume":"72","author":"Medina de Chazal","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"January","key":"10.1016\/j.toxrep.2020.12.003_bib0145","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijcard.2016.10.042","article-title":"The heart failure pandemic: the clinical and economic burden in Greece","volume":"227","author":"Stafylas","year":"2017","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"10.1016\/j.toxrep.2020.12.003_bib0150","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.hrtlng.2016.06.007","article-title":"Successful treatment of inverted Takotsubo cardiomyopathy after severe traumatic brain injury with milrinone after dobutamine failure","volume":"45","author":"Mrozek","year":"2016","journal-title":"Hear Lung J Acute Crit Care"},{"issue":"24","key":"10.1016\/j.toxrep.2020.12.003_bib0155","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/j.jacc.2014.09.017","article-title":"2014 AHA\/acc guideline for the management of patients with Non-ST-Elevation acute coronary syndromes: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"64","author":"Amsterdam","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.toxrep.2020.12.003_bib0160","article-title":"Haemorrhagic stroke related to the use of 4-fluoroamphetamine","author":"Visser","year":"2018","journal-title":"J. Neurol."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750020304455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750020304455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:52:25Z","timestamp":1762012345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750020304455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":32,"alternative-id":["S2214750020304455"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2020.12.003","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute onset heart failure due to reverse type Takotsubo cardiomyopathy caused by a single dose of 4-Fluoroamphetamine in a healthy young individual","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2020.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}