{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:08:00Z","timestamp":1781266080040,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004457","name":"The World Academy of Sciences","doi-asserted-by":"publisher","award":["3240293151"],"award-info":[{"award-number":["3240293151"]}],"id":[{"id":"10.13039\/100004457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005863","name":"National Brain Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.toxrep.2021.01.015","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T10:20:09Z","timestamp":1611656409000},"page":"264-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Reduction of anoxia-induced bioenergetic disturbance in astrocytes by methanol fruit extract of Tetrapleura tetraptera and in silico evaluation of the effect of its antioxidative constituents on excitotoxicity"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-5992","authenticated-orcid":false,"given":"Ibrahim Olabayode","family":"Saliu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubukola Benedicta","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afolabi C.","family":"Akinmoladun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Tolulope","family":"Olaleye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velayudhan","family":"Rema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.toxrep.2021.01.015_bib0005","first-page":"828","article-title":"Potential applications of antioxidants \u2013 a review","volume":"7","author":"Sindhi","year":"2013","journal-title":"J. Pharm. Res."},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antiox3030472","article-title":"Oxidative stress and the use of antioxidants in stroke","volume":"3","author":"Shirley","year":"2014","journal-title":"Antioxidants"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","article-title":"Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight","volume":"74","author":"Bhat","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: a review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.toxrep.2021.01.015_bib0025","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders \u2014 A step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000484517","article-title":"Improvement of 2-Vessel occlusion cerebral ischaemia\/reperfusion-induced corticostriatal electrolyte and redox imbalance, lactic acidosis and modified acetylcholinesterase activity by kolaviron correlates with reduction in neurobehavioural deficits","volume":"25","author":"Akinmoladun","year":"2018","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0035","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.biopha.2018.12.144","article-title":"Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia\/reperfusion injury","volume":"111","author":"Ojo","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"issue":"01","key":"10.1016\/j.toxrep.2021.01.015_bib0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1995.sp020786","article-title":"Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition","volume":"486","author":"Di Lisa","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0055","series-title":"Oxidative Stress and Free Radical Damage in Neurology","first-page":"137","article-title":"Stroke and oxidative stress","author":"Vignini","year":"2011"},{"issue":"2","key":"10.1016\/j.toxrep.2021.01.015_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","article-title":"Ischemic stroke: experimental models and reality","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090864","article-title":"Relaxin protects astrocytes from hypoxia in vitro","volume":"9","author":"Willcox","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.toxrep.2021.01.015_bib0070","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1007\/s11064-015-1667-1","article-title":"Critical evaluation of the changes in glutamine synthetase activity in models of cerebral stroke","volume":"40","author":"Jeitner","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0080","first-page":"35","article-title":"Distribution of immunoreactive glutamine synthetase in the adult human and mouse brain. Qualitative and quantitative observations with special emphasis on extra-astrogial protein localization","volume":"61\u201362C","author":"Bernstein","year":"2014","journal-title":"J. Chem. Neuroanat."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0085","first-page":"S8","article-title":"Astrocytes and ischemic injury","volume":"40","author":"Takano","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0090","series-title":"Functional Neuroscience","author":"Steward","year":"2012"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0095","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/01.WCB.0000044631.80210.3C","article-title":"Astrocyes and brain injury","volume":"23","author":"Chen","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0100","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ana.24347","article-title":"Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain","volume":"77","author":"Baik","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0105","article-title":"Current advances in ischemic stroke research and therapies","author":"Barthels","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0110","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jksus.2015.02.003","article-title":"Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam","volume":"27","author":"Iqbal","year":"2015","journal-title":"J. King Saud Univ. - Sci."},{"issue":"4","key":"10.1016\/j.toxrep.2021.01.015_bib0115","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and prooxidant properties of flavonoids","volume":"82","author":"Proch\u00e1zkov\u00e1","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00204-011-0774-2","article-title":"Antioxidant activity of food constituents: an overview I \u02d9 lhami G\u00fc l\u00e7in","volume":"86","author":"G\u00fcl\u00e7in","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.toxrep.2021.01.015_bib0125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.foodres.2015.04.018","article-title":"Antioxidants: characterization, natural sources, extraction and analysis","volume":"74","author":"Oroian","year":"2015","journal-title":"Food Res. Int."},{"issue":"113284","key":"10.1016\/j.toxrep.2021.01.015_bib0135","first-page":"1","article-title":"Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia\/reperfusion injury by Tetrapleura tetraptera fruit extract","volume":"264","author":"Saliu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.toxrep.2021.01.015_bib0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/14728028.2018.1498027","article-title":"Tetrapleura tetraptera in Ghana, Nigeria and Uganda: households uses and local market","volume":"27","author":"Kemigisha","year":"2018","journal-title":"For. Trees Livelihoods"},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/BJPR\/2016\/26554","article-title":"Tetrapleura tetraptera Taub-ethnopharmacology, chemistry, medicinal and nutritional values - a review","volume":"12","author":"Adesina","year":"2016","journal-title":"Br. J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0150","first-page":"143","article-title":"The potentials of Ocimum gratissimum, Penrgularia extensa and Tetrapleura tetraptera as spice and flavouring agents","volume":"34","author":"Okwu","year":"2004","journal-title":"Nigeria Agric. J."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0155","series-title":"Tetrapleura Tetraptera (Schum. & Thonn.) Taubert. Agroforestree Database:a Tree Reference and Selection Guide Version 4.0","author":"Orwa","year":"2009"},{"issue":"6","key":"10.1016\/j.toxrep.2021.01.015_bib0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jtusci.2017.03.007","article-title":"Ethanol extract of Tetrapleura tetraptera fruit peels: chemical characterization, and antioxidant potentials against free radicals and lipid peroxidation in hepatic tissues","volume":"11","author":"Erukainure","year":"2017","journal-title":"J. Taibah Univ. Sci."},{"issue":"12","key":"10.1016\/j.toxrep.2021.01.015_bib0165","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/ptr.1779","article-title":"Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice","volume":"19","author":"Ojewole","year":"2005","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.toxrep.2021.01.015_bib0170","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3923\/jbs.2007.1520.1524","article-title":"Anticonvulsant, analgesic and hypothermic effects of aridanin isolated from Tetrapleura tetrapetra fruit in mice","volume":"7","author":"Aderibigbe","year":"2007","journal-title":"J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0175","first-page":"23","article-title":"Effects of tetrapleura tetraptera (Taub) fruit extract on some isolated tissues: possible mechanism(s) of antihypertensive action","volume":"28","author":"Woode","year":"2008","journal-title":"J. Sci. Technol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0180","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2018.01.043","article-title":"Aqueous extracts of two tropical ethnobotanicals (Tetrapleura tetraptera and Quassia undulata) improved spatial and non-spatial working memories in scopolamine-induced amnesic rats: Influence of neuronal cholinergic and antioxidant systems","volume":"99","author":"Odubanjo","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"Suppl. 1","key":"10.1016\/j.toxrep.2021.01.015_bib0185","doi-asserted-by":"crossref","first-page":"S359","DOI":"10.12980\/APJTB.4.2014C1030","article-title":"Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. For in vitro antioxidant activities","volume":"4","author":"Senguttuvan","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0190","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cotox.2018.10.001","article-title":"A battery of translational biomarkers for the assessment of the in vitro and in vivo antioxidant action of plant polyphenolic compounds: the biomarker issue","volume":"13","author":"Veskoukis","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"issue":"9\u201310","key":"10.1016\/j.toxrep.2021.01.015_bib0195","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0200","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.toxrep.2015.04.005","article-title":"Antioxidant and free radical sacvenging activity of iron chelators","volume":"2","author":"Adjimani","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0205","doi-asserted-by":"crossref","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201c\u2018Antioxidant power\u2019\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.toxrep.2021.01.015_bib0210","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00604-007-0777-0","article-title":"Mechanism of antioxidant capacity assays and the CUPRAC (cupric ion reducing antioxidant capacity) assay","volume":"160","author":"Apak","year":"2008","journal-title":"Microchim. Acta"},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0215","first-page":"146","article-title":"In\u00advitro antioxidant and anti\u00adinflammatory activity of methanol extract of oxalis corniculata linn","volume":"2","author":"Sakat","year":"2010","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.toxrep.2021.01.015_bib0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0225","first-page":"300","article-title":"Minireview Methods for estimating lipid peroxidation: an analysis of merits and demerits","volume":"40","author":"Devasagayam","year":"2003","journal-title":"Indian J. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.toxrep.2021.01.015_bib0230","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/glia.23089","article-title":"Novel insight into role of miR-320a-VDAC1 axis in astrocyte-mediated neuronal damage in neuroAIDS","volume":"65","author":"Fatima","year":"2017","journal-title":"GLIA"},{"issue":"10","key":"10.1016\/j.toxrep.2021.01.015_bib0235","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41418-018-0163-y","article-title":"Zika virus E protein alters properties of human fetal neural stem cells by modulating microRNA circuitry","volume":"25","author":"Bhagat","year":"2018","journal-title":"Cell Death Diff."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0240","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0245","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1387-2656(05)11004-7","article-title":"Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction","volume":"11","author":"Berridge","year":"2005","journal-title":"Biotechnol. Ann. Rev."},{"issue":"2","key":"10.1016\/j.toxrep.2021.01.015_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0090697","article-title":"Astrocytic mitochondrial membrane hyperpolarization following extended oxygen and glucose deprivation","volume":"9","author":"Korenic","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.toxrep.2021.01.015_bib0255","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1747-4949.2012.00839.x","article-title":"Pathophysiologic cascades in ischemic stroke","volume":"7","author":"Xing","year":"2012","journal-title":"Int. J. Stroke"},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0260","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/neup.12182","article-title":"Activated microglia in ischemic stroke penumbra upregulate MCP-1 and CCR2 expression in response to lysophosphatidylcholine derived from adjacent neurons and astrocytes","volume":"35","author":"Inose","year":"2015","journal-title":"Neuropathology"},{"issue":"6","key":"10.1016\/j.toxrep.2021.01.015_bib0265","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1515\/revneuro-2017-0076","article-title":"Experimental models of focal and multifocal cerebral ischemia: A review","volume":"29","author":"Meadows","year":"2018","journal-title":"Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.toxrep.2021.01.015_bib0270","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.toxrep.2021.01.015_bib0275","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/jcbfm.1995.52","article-title":"Acidosis causes failure of astrocyte glutamate uptake during hypoxia","volume":"15","author":"Swanson","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0280","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Progress Neurobiol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0285","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jmb.2007.10.029","article-title":"Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design","volume":"375","author":"Krajewski","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"W1","key":"10.1016\/j.toxrep.2021.01.015_bib0290","doi-asserted-by":"crossref","first-page":"W443","DOI":"10.1093\/nar\/gkv315","article-title":"PLIP: fully automated protein-ligand interation profiler","volume":"43","author":"Salentine","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0295","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cca.2014.06.004","article-title":"Antioxidants and human diseases","volume":"436","author":"Rajendran","year":"2014","journal-title":"Clin. Chim. Acta"},{"issue":"2\u20133","key":"10.1016\/j.toxrep.2021.01.015_bib0300","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2004.06.026","article-title":"Anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) [fabaceae] fruit aqueous extract in rats","volume":"95","author":"Ojewole","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/423689","article-title":"In vitro ion chelating, antioxidative mechanism of extracts from fruits and barks of tetrapleura tetraptera and their protective effects against fenton mediated toxicity of metal ions on liver homogenates","volume":"2015","author":"Moukette","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"issue":"6","key":"10.1016\/j.toxrep.2021.01.015_bib0310","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1142\/S0192415X08006570","article-title":"Ferulic acid reduces cerebral infarct through its antioxidative and anti-inflammatory effects following transient focal cerebral ischemia in rats","volume":"36","author":"Chen","year":"2008","journal-title":"Am. J. Chin. Med."},{"issue":"8","key":"10.1016\/j.toxrep.2021.01.015_bib0315","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s11064-014-1326-y","article-title":"Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-kB, MMP-9 and up-regulated claudin-5 expression","volume":"39","author":"Bai","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/963248","article-title":"Review on natural Coumarin lead compounds for their pharmacological activity","author":"Venugopala","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0325","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fct.2016.12.026","article-title":"UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia\/reperfusion","volume":"100","author":"Connell","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0330","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fnagi.2018.00348","article-title":"Phytochemical and pahrmacological role of Liquiritigenin and Isoliquiritigenin from Radix glycyrrhizae in human health and disease models","volume":"10","author":"Ramalingam","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.toxrep.2021.01.015_bib0335","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00580-019-03004-y","article-title":"Ameliorative property of Kigelia africana crude and flavonoid leaf extracts on aluminum-induced hepatotoxicity in albino rats","volume":"28","author":"Falode","year":"2019","journal-title":"Comp. Clin. Pathol."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0340","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tiv.2019.04.013","article-title":"Glyphaea brevis \u2013 in vitro antioxidant and in silico biological activity of major constituents and molecular docking analyses","volume":"59","author":"Olugbodi","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0345","first-page":"2438","article-title":"Antioxidant activity and total phenolic content of medicinal plants associated with prevention and treatment of cardiovascular and cerebrovascular diseases","volume":"4","author":"Gan","year":"2010","journal-title":"J. Med. Plant Res."},{"issue":"5","key":"10.1016\/j.toxrep.2021.01.015_bib0350","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5897\/AJBR2014.0769","article-title":"Antidenaturation and antioxidative properties of phytochemical components from Spondias mombin","volume":"8","author":"Akinmoladun","year":"2014","journal-title":"Afr. J. Biochem. Res."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0355","doi-asserted-by":"crossref","DOI":"10.1186\/s40816-018-0068-9","article-title":"Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase","volume":"4","author":"Obade","year":"2018","journal-title":"Clin. Phytosci."},{"issue":"7","key":"10.1016\/j.toxrep.2021.01.015_bib0360","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/glia.20655","article-title":"Hyperoxia promotes astrocyte cell death after oxygen and glucose deprivation","volume":"56","author":"Danilov","year":"2008","journal-title":"GLIA"},{"key":"10.1016\/j.toxrep.2021.01.015_bib0365","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00769538","article-title":"Voltage activation of heart inner mitochondrial membrane channels","volume":"24","author":"Zorov","year":"1992","journal-title":"J. Bioenerget. Biomembr."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0370","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.toxrep.2020.08.032","article-title":"Amyloid-\u03b2 peptides inhibit the expression of AQP4 and glutamate transporter EAAC1 in insulin-treated C6 glioma cells","volume":"7","author":"Park","year":"2020","journal-title":"Toxicol. Rep."},{"issue":"4","key":"10.1016\/j.toxrep.2021.01.015_bib0375","doi-asserted-by":"crossref","first-page":"708","DOI":"10.31925\/farmacia.2018.4.22","article-title":"Synthesis, antimicrobial and \u03b1-glucosidase inhibitory potential of mannich bases of mercapto oxadiazoles and their molecular docking studies","volume":"66","author":"Ahmad","year":"2018","journal-title":"Farmacia"},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-019-2482-z","article-title":"In vitro evaluation of the \u03b1-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants","volume":"19","author":"Bhatia","year":"2019","journal-title":"BMC Complem. Altern. Med."},{"issue":"1","key":"10.1016\/j.toxrep.2021.01.015_bib0385","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1874199100903010034","article-title":"Hydrogen bonds and hydrophobic interactions of porphyrins in porphyrin-containing proteins","volume":"3","author":"Stojanovic","year":"2009","journal-title":"Open Struct. Biol. J."},{"key":"10.1016\/j.toxrep.2021.01.015_bib0390","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1747-0285.2008.00659.x","article-title":"Novel method for probing the specificity binding profile of ligands: applications to HIV protease","volume":"71","author":"Sherman","year":"2008","journal-title":"Chem. Biol. Drug Des."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021000159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021000159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:56:58Z","timestamp":1780415818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750021000159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":78,"alternative-id":["S2214750021000159"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.01.015","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction of anoxia-induced bioenergetic disturbance in astrocytes by methanol fruit extract of Tetrapleura tetraptera and in silico evaluation of the effect of its antioxidative constituents on excitotoxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}