{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:05:03Z","timestamp":1780419903669,"version":"3.54.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Universal-432458\/2018-2"],"award-info":[{"award-number":["Universal-432458\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007382","name":"Universidade Federal do Par\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.toxrep.2021.07.015","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T11:41:31Z","timestamp":1627731691000},"page":"1480-1487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Toxicity evaluation of Eleutherine plicata Herb. extracts and possible cell death mechanism"],"prefix":"10.1016","volume":"8","author":[{"given":"Antonio Rafael","family":"Quadros Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-1478","authenticated-orcid":false,"given":"Natasha Costa","family":"da Rocha Galucio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Cristina Oliveira","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heliton Patrick Cordovil","family":"Br\u00edgido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-3791","authenticated-orcid":false,"given":"Everton Luiz Pompeu","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura Gadelha","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-4875","authenticated-orcid":false,"given":"Valdicley Vieira","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Oliveira","family":"Bahia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-234X","authenticated-orcid":false,"given":"Rommel Mario","family":"Rodriguez Burbano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6923","authenticated-orcid":false,"given":"F\u00e1bio Alberto","family":"de Molfeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane Almeida","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-0361","authenticated-orcid":false,"given":"Sandro","family":"Percario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-5804","authenticated-orcid":false,"given":"Maria F\u00e2ni","family":"Dolabela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2021.07.015_bib0005","first-page":"286","article-title":"Eleutherine bulbous (Mill.) Urb.: a review study","volume":"10","author":"Couto","year":"2016","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0010","first-page":"57","article-title":"Uso e diversidade de plantas medicinais em uma comunidade quilombola na Amaz\u00f4nia Oriental, Abaetetuba, Par\u00e1","volume":"7","author":"Pereira","year":"2017","journal-title":"Biota Amaz."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0015","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1590\/1983-084X\/15_170","article-title":"Etnobot\u00e2nica de esp\u00e9cies vegetais medicinais no tratamento de transtornos do sistema gastrointestinal","volume":"18","author":"Gois","year":"2016","journal-title":"Rev. Bras. Plantas Med."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0020","first-page":"43","article-title":"Levantamento das plantas utilizadas como medicinais na cidade de Caxias-MA: uma perspectiva etnofarmacol\u00f3gica","volume":"9","author":"Oliveira","year":"2016","journal-title":"Rev. Interdisc."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-4269-6-21","article-title":"Ash\u00e1ninka medicinal plants: a case study from the native community of Bajo Quimiriki, Jun\u00edn, Peru","volume":"6","author":"Luziatelli","year":"2010","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1590\/1809-4392201400423","article-title":"Etnobot\u00e2nica de plantas medicinais em comunidades ribeirinhas do munic\u00edpio de Manacapuru, Amazonas, Brasil","volume":"44","author":"V\u00e1squez","year":"2014","journal-title":"Acta Amaz\u00f4n."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0035","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10708-017-9835-2","article-title":"A review of the plant-based traditions of the Cocoa Panyols of Trinidad","volume":"83","author":"Lans","year":"2018","journal-title":"GeoJournal"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/6087509","article-title":"The use of medicinal plants in the Riverside Community of the Mazag\u00e3o River in the Brazilian Amazon, Amap\u00e1, Brazil: Ethnobotanical and ethnopharmacological studies","volume":"2019","author":"Sarquis","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jep.2012.12.014","article-title":"Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon)","volume":"146","author":"Odonne","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0050","series-title":"Phytochemicals \u2013 Isolation, Characterization and Role in Human Health","first-page":"323","article-title":"Eleutherine plicata \u2013 quinones and antioxidant activity","author":"Malheiros","year":"2015"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0055","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1248\/cpb.45.1714","article-title":"Elecanacin, a novel new naphthoquinone from the bulb of Eleutherine americana","volume":"45","author":"Hara","year":"1997","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0060","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1248\/cpb.34.2743","article-title":"Hongconin, a new naphthalene derivative from Hong-Cong, the rizome of Eleutherine americana Merr. et Heyne (Iridaceae)","volume":"37","author":"Zhengxiong","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0378-8741(82)90072-1","article-title":"Plants of Haiti used as antifertility agents","volume":"6","author":"Weniger","year":"1982","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0070","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jpba.2008.04.005","article-title":"Analysis of naphthoquinone derivatives in the Asian medicinal plant Eleutherine americana by RP-HPLC and LC-MS","volume":"47","author":"Paramapojn","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-8741(00)00294-4","article-title":"Antimicrobial activity of extracts of eastern North American hardwood trees and relation to traditional medicine","volume":"73","author":"Omar","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0080","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejphar.2010.06.072","article-title":"Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondrial dependent pathway","volume":"645","author":"Xu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0085","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.fct.2012.01.002","article-title":"Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism","volume":"50","author":"Xu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","article-title":"Cellular response to oxidative stress: signaling for suicide and survival","volume":"192","author":"Martindale","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrc1046","article-title":"Radical causes of cancer","volume":"3","author":"Hussain","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0100","doi-asserted-by":"crossref","first-page":"27088","DOI":"10.1074\/jbc.M314015200","article-title":"Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc776","article-title":"Death and anti-death: tumor resistance to apoptosis","volume":"2","author":"Igney","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0110","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1158\/0008-5472.CAN-15-0257","article-title":"miR-634 activates the mitochondrial apoptosis pathway and enhances chemotherapy-induced cytotoxicity","volume":"75","author":"Fujiwara","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0115","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1084\/jem.20071632","article-title":"Stimulation of Toll-like receptor 3 and 4 induces interleukin 1 beta maturation by caspase-8","volume":"205","author":"Maelfait","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0120","doi-asserted-by":"crossref","first-page":"e1636","DOI":"10.1038\/cddis.2015.16","article-title":"Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death","volume":"6","author":"Moriwaki","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0125","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00044-019-02498-z","article-title":"Naphthoquinones isolated from Eleutherine plicata herb: in vitro antimalarial activity and molecular modeling to investigate their binding modes","volume":"29","author":"Vale","year":"2020","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0130","doi-asserted-by":"crossref","DOI":"10.33448\/rsd-v9i11.9992","article-title":"Botanical studies, antimicrobial activity and cytotoxity of Eleutherine bulbosa (Mill.) Urb","volume":"9","author":"Borges","year":"2020","journal-title":"Res. Soc. Dev."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0135","first-page":"44673","article-title":"Antitumoral activity of Eleutherine plicata Herb. and its compounds","volume":"11","author":"Castro","year":"2021","journal-title":"Int. J. Dev. Res."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103084","article-title":"Evaluation of the genotoxicity and mutagenicity of isoeleutherin and eleutherin isolated fromEleutherine plicata Herb. using bioassays and in silico approaches","volume":"14","author":"Castro","year":"2021","journal-title":"Arab. J. Chem."},{"issue":"11","key":"10.1016\/j.toxrep.2021.07.015_bib0145","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2307\/3558433","article-title":"Molecular systematics of Iridaceae: evidence from four plastid DNA regions","volume":"88","author":"Reeves","year":"2001","journal-title":"Am. J. Bot."},{"issue":"3","key":"10.1016\/j.toxrep.2021.07.015_bib0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1600\/036364408785679806","article-title":"Iridaceae \u201cout of Australasia\u201d? Phylogeny, biogeography, and divergence time based on plastid DNA sequences","volume":"33","author":"Goldblatt","year":"2008","journal-title":"Syst. Bot."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0160","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2306\/scienceasia1513-1874.2010.36.112","article-title":"Protective effect of makrut lime leaf (Citrus hystrix) in HepG2 cells: implications for oxidative stress","volume":"36","author":"Laohavechvanich","year":"2010","journal-title":"Science Asia"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"Lebensm. Wiss. Technol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1590\/S0103-64402012000100004","article-title":"Antioxidant activity by DPPH assay of potential solutions to be applied on bleached teeth","volume":"23","author":"Garcia","year":"2012","journal-title":"Braz. Dent. J."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0180","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/em.20659","article-title":"In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes","volume":"52","author":"Mota","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0185","series-title":"OECD Guideline for Testing of Chemicals","article-title":"Acute oral toxicity \u2013 fixed dose procedure","author":"OECD- Organization for Economic Co-Operation and Development","year":"2001"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0190","first-page":"122","article-title":"Manual de ensaios toxicol\u00f3gicos in vivo","volume":"1","author":"Brito","year":"1994","journal-title":"Univ. Camp."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0195","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12936-015-0643-1","article-title":"Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon","volume":"14","author":"Vale","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0200","series-title":"Guideline 407: Repeated Dose 28-Day Oral Toxicity Study in Rodent","author":"OECD- Organization for Economic Cooperation and Development","year":"1995"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2174\/138920307781369382","article-title":"Structure-based drug design: docking and scoring","volume":"8","author":"Kroemer","year":"2007","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0210","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Comput. Drug Des."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0215","first-page":"1","article-title":"Structure based docking studies towards exploring potential antiandrogen activity of selected phytochemicals against prostate cancer","volume":"7","author":"Singh","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0220","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","article-title":"Development and validation of a genetic algorithm for flexible docking","volume":"267","author":"Jones","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0225","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/ml100164p","article-title":"Drawing the PDB: protein-ligand complexes in two dimensions","volume":"1","author":"Stierand","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0230","first-page":"48","article-title":"Pharmacogenetics of drug receptors","volume":"19","author":"Marc","year":"2008","journal-title":"EJIFCC"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0235","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1590\/S0074-02762003000500021","article-title":"Eleutherinone, a Novel Fungitoxic Naphthoquinone from Eleutherine bulbosa (Iridaceae)","volume":"98","author":"Alves","year":"2003","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0240","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0100-40422003000300019","article-title":"Um panorama atual da qu\u00edmica e da farmacologia de naftoquinonas com \u00eanfase na \u03b2-lapachona e derivados","volume":"25","author":"Silva","year":"2003","journal-title":"Quim. Nova"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0245","doi-asserted-by":"crossref","first-page":"14625","DOI":"10.1021\/ja1063857","article-title":"Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents","volume":"132","author":"Verga","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0250","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3109\/13880209.2015.1091847","article-title":"Antiproliferative effect of extracts and pyranonaphthoquinones obtained from Cipura paludosa bulbs","volume":"54","author":"Campos","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0255","doi-asserted-by":"crossref","first-page":"12251","DOI":"10.1021\/jacs.7b05899","article-title":"Late-stage C-H alkylation of heterocycles and 1,4-quinones via oxidative homolysis of 1,4-dihydropyridines","volume":"139","author":"Guti\u00e9rrez-Bonet","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0260","series-title":"Estudos fitoqu\u00edmicos, citotoxicidade e genotoxicidade de Eleutherine plicata Herb. 90f","author":"Galucio","year":"2014"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0265","first-page":"55","article-title":"Testes Citogen\u00e9ticos na Avalia\u00e7\u00e3o da Genotoxicidade de Produtos Naturais Provindos de Plantas Medicinais","volume":"30","author":"Verri","year":"2017","journal-title":"Revista UNING\u00c1 Review"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0270","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/1120009X.2019.1610832","article-title":"2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK and STAT3 signaling pathway in human gastric cancer cells","volume":"31","author":"Wang","year":"2019","journal-title":"J. Chemother."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0275","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1590\/s1679-45082010rb1685","article-title":"Apoptose e modelos in vivo para estudo das mol\u00e9culas relacionadas a este fen\u00f4meno","volume":"8","author":"Luchs","year":"2010","journal-title":"Einstein"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0280","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0163-7258(01)00159-0","article-title":"The machinery of programmed cell death","volume":"92","author":"Zimmermann","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0285","first-page":"486","article-title":"Fontes, forma\u00e7\u00e3o, reatividade e determina\u00e7\u00e3o de quinonas na atmosfera","volume":"39","author":"Sousa","year":"2016","journal-title":"Qu\u00edmica Nova"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0290","series-title":"A Comprehensive Guide To Toxicology In Preclinical Drug Development","article-title":"Introduction","author":"Faqi","year":"2013"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0295","series-title":"Guideline on Repeated Dose Toxicity","author":"EMA, European Medicines Agency","year":"2010"},{"key":"10.1016\/j.toxrep.2021.07.015_bib0300","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0278-6915(01)00115-6","article-title":"Hazard characterization of chemicals in food and diet: dose response, mechanism and extrapolation issue","volume":"40","author":"Dybing","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2021.07.015_bib0305","author":"Araujo","year":"2012"}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:08:50Z","timestamp":1780416530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750021001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":61,"alternative-id":["S2214750021001426"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.07.015","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicity evaluation of Eleutherine plicata Herb. extracts and possible cell death mechanism","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}