{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:41:10Z","timestamp":1785922870276,"version":"3.56.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.toxrep.2021.10.009","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T16:50:56Z","timestamp":1634143856000},"page":"1792-1802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inorganic substances and their uses in Nikolaos Myrepsos\u2019 Dynameron. Recent applications in modern therapy"],"prefix":"10.1016","volume":"8","author":[{"given":"E.","family":"Valiakos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marselos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Skaltsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2021.10.009_bib0005","series-title":"A Short History of Medicine","first-page":"60","author":"Ackerknecht","year":"1982"},{"issue":"3","key":"10.1016\/j.toxrep.2021.10.009_bib0010","first-page":"44","article-title":"A review of arsenic trioxide and acute promyelocytic leukemia int","volume":"8","author":"Alimoghaddam","year":"2014","journal-title":"J. Hematol. Oncol. Stem Cell Res."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0015","series-title":"The Cambridge Encyclopedia of Human Paleopathology","first-page":"128","author":"Aufderheide","year":"1998"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1039\/c1mt00062d","article-title":"Gold compounds, as therapeutic agents for human diseases","volume":"9","author":"Berners-Price","year":"2011","journal-title":"Metallomics"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0025","series-title":"Theophrastus on Stones","author":"Caley","year":"1956"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0030","first-page":"24","article-title":"The evolution of medical perceptions in Byzantium during the 9th century, Athens","volume":"12","author":"Chrone","year":"2012","journal-title":"Archaiologia"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0035","series-title":"History of Pharmacy","author":"Emmanuel","year":"1948"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0040","series-title":"Nicolai Myrepsi Alexandrini. De Compositione Medicamentorum","author":"Fuchs","year":"1549"},{"issue":"2006","key":"10.1016\/j.toxrep.2021.10.009_bib0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1746-4269-2-4","article-title":"Ethno-diversity within current ethno-pharmacology as part of Israeli traditional medicine \u2013 a review","volume":"2","author":"Lev","year":"2006","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF02904770","article-title":"Nicander. On stones and inorganic materials","volume":"17","author":"Mottana","year":"2006","journal-title":"Rend. Lincey Sci. Fis. Acc."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0055","series-title":"Chapter 13. Greco-Egyptian and Byzantine Alchemy","author":"Martelli","year":"2016"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0060","unstructured":"NIST database. https:\/\/webbook.nist.gov\/chemistry."},{"issue":"1","key":"10.1016\/j.toxrep.2021.10.009_bib0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40268-015-0083-y","article-title":"Auranofin: repurposing an old drug for a golden new age","volume":"15","author":"Roder","year":"2015","journal-title":"Drugs R. D."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0070","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00775-014-1135-4","article-title":"Historical and biochemical aspects of a 17th century gold-based aurum vitae recipe","volume":"19","author":"Rubbiani","year":"2014","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0075","series-title":"Drug Discovery: A History","author":"Sneader","year":"2005"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0080","series-title":"The Theophrastus Mineralogy. Athens, A","author":"Stephanides","year":"1896"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0085","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.toxrep.2018.10.001","article-title":"The dose response principle from philosophy to modern toxicology: the impact of ancient philosophy and medicine in modern toxicology science","volume":"5","author":"Tsatsakis","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jep.2015.01.005","article-title":"Ethnopharmacological approach to the herbal medicines of the \u201cAntidotes\u201d in Nikolaos Myrepsos\u2019 Dynameron","volume":"163","author":"Valiakos","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0095","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jep.2017.04.021","article-title":"Ethnopharmacological approach to the herbal medicines of the \u201cElements Alpha to Delta\u201d in Nikolaos Myrepsos\u05f3 Dynameron. Part II","volume":"205","author":"Valiakos","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0100","series-title":"Das Dynameron des Nikolaos Myrepsos","author":"Valiakos","year":"2019"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0105","series-title":"Nikolaos Myrepsos\u2019 Dynameron","author":"Valiakos","year":"2020"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114191","article-title":"Remedies of animal origin and their indications in Nikolaos Myrepsos\u05f3 Dynameron","volume":"276","author":"Valiakos","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2021.10.009_bib0115","volume":"Vol. 5","author":"Wellmann","year":"1958"},{"issue":"5","key":"10.1016\/j.toxrep.2021.10.009_bib0120","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1182\/blood-2007-07-102798","article-title":"Acute promyelocytic leukemia: from highly fatal to highly curable","volume":"111","author":"Wang","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.toxrep.2021.10.009_bib0125","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.toxrep.2020.04.011","article-title":"Cadmium sulfide-induced toxicity in the cortex and cerebellum: in vitro and in vivo studies","volume":"7","author":"Varmazyari","year":"2020","journal-title":"Toxicol. Rep."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021001815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750021001815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:55:16Z","timestamp":1780415716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750021001815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":25,"alternative-id":["S2214750021001815"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.10.009","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inorganic substances and their uses in Nikolaos Myrepsos\u2019 Dynameron. Recent applications in modern therapy","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2021.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}