{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:32:10Z","timestamp":1793251930905,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.toxrep.2022.04.017","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T21:52:38Z","timestamp":1650577958000},"page":"961-969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells"],"prefix":"10.1016","volume":"9","author":[{"given":"Sushweta","family":"Mahalanobish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joydeep","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.toxrep.2022.04.017_bib1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4314\/tjpr.v14i5.4","article-title":"Protective effects of tetrahydrocurcumin and curcumin against doxorubicin and cadmium-induced cytotoxicity in Chang liver cells","volume":"14","author":"Sompar","year":"2015","journal-title":"Trop. J. Pharm. Res."},{"issue":"6","key":"10.1016\/j.toxrep.2022.04.017_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/biof.1301","article-title":"Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses","volume":"42","author":"Chowdhury","year":"2016","journal-title":"Biofactors"},{"key":"10.1016\/j.toxrep.2022.04.017_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fct.2019.02.022","article-title":"Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis","volume":"126","author":"Mahalanobish","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.toxrep.2022.04.017_bib4","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.febslet.2006.02.020","article-title":"Mechanisms and strategies to overcome multiple drug resistance in cancer","volume":"580","author":"Ozben","year":"2006","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.toxrep.2022.04.017_bib5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/sj.onc.1210631","article-title":"Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice","volume":"27","author":"Howard","year":"2008","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.toxrep.2022.04.017_bib6","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1124\/dmd.108.022491","article-title":"Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)","volume":"36","author":"Grant","year":"2008","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.toxrep.2022.04.017_bib7","first-page":"22","article-title":"The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells","volume":"8","author":"Kim","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.toxrep.2022.04.017_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111588","article-title":"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice","volume":"144","author":"Mahalanobish","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.toxrep.2022.04.017_bib9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mnfr.200700326","article-title":"Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways","volume":"52","author":"Ramos","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.toxrep.2022.04.017_bib10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","article-title":"Nanoparticle and targeted systems for cancer therapy","volume":"56","author":"Brannon-Peppas","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.toxrep.2022.04.017_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejmech.2017.07.034","article-title":"Recent discoveries of anticancer flavonoids","volume":"142","author":"Raffa","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.toxrep.2022.04.017_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.fct.2019.04.012","article-title":"Natural products: an upcoming therapeutic approach to cancer","volume":"128","author":"Dutta","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.toxrep.2022.04.017_bib13","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1124\/dmd.120.000085","article-title":"Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes and on OATP, P-gp, BCRP, and MRP2 transporters, drug metabolism and disposition: the biological fate of chemicals","volume":"48","author":"Mohos","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.toxrep.2022.04.017_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.toxrep.2022.04.017_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2125.2001.01317.x","article-title":"Disposition and metabolism of the flavonoid chrysin in normal volunteers","volume":"51","author":"Walle","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxrep.2022.04.017_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2011.08.004","article-title":"Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione","volume":"258","author":"Brechbuhl","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxrep.2022.04.017_bib17","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.2147\/IJN.S165699","article-title":"Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1\/Parkin-mediated mitophagy","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.toxrep.2022.04.017_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.msec.2017.05.065","article-title":"Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment","volume":"79","author":"Ghaffari","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"7","key":"10.1016\/j.toxrep.2022.04.017_bib19","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/acsami.6b13776","article-title":"pH-responsive ZnO nanocluster for lung cancer chemotherapy","volume":"9","author":"Cai","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.toxrep.2022.04.017_bib20","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/jat.3415","article-title":"Cytotoxicity, oxidative stress and inflammation induced by ZnO nanoparticles in endothelial cells: interaction with palmitate or lipopolysaccharide","volume":"37","author":"Gong","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.toxrep.2022.04.017_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","article-title":"Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.toxrep.2022.04.017_bib22","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"issue":"38","key":"10.1016\/j.toxrep.2022.04.017_bib23","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/27\/38\/385101","article-title":"Phenylboronic acid-decorated gelatin nanoparticles for enhanced tumor targeting and penetration","volume":"27","author":"Wang","year":"2016","journal-title":"Nanotechnology"},{"issue":"4","key":"10.1016\/j.toxrep.2022.04.017_bib24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/ange.201207131","article-title":"MRI visualization of melanoma cells by targeting overexpressed sialic acid with a GdIII\u2010dota\u2010en\u2010pba imaging reporter","volume":"125","author":"Geninatti Crich","year":"2013","journal-title":"Angew. Chem."},{"issue":"3","key":"10.1016\/j.toxrep.2022.04.017_bib25","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1021\/ac1028853","article-title":"Quantum dots with phenylboronic acid tags for specific labeling of sialic acids on living cells","volume":"83","author":"Liu","year":"2011","journal-title":"Anal. Chem."},{"issue":"12","key":"10.1016\/j.toxrep.2022.04.017_bib26","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1021\/ja021303r","article-title":"Anomalous binding profile of phenylboronic acid with N-acetylneuraminic acid (Neu5Ac) in aqueous solution with varying pH","volume":"125","author":"Otsuka","year":"2003","journal-title":"J. Am. Chem. Soc."},{"issue":"23","key":"10.1016\/j.toxrep.2022.04.017_bib27","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1021\/ja200328s","article-title":"pH-Triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids","volume":"133","author":"Muhammad","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"34","key":"10.1016\/j.toxrep.2022.04.017_bib28","doi-asserted-by":"crossref","first-page":"22442","DOI":"10.1021\/acsami.6b04933","article-title":"pH-sensitive ZnO quantum dots-doxorubicin nanoparticles for lung cancer targeted drug delivery","volume":"8","author":"Cai","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.toxrep.2022.04.017_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2019.02.036","article-title":"pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy","volume":"18","author":"Kundu","year":"2019","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.toxrep.2022.04.017_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111239","article-title":"Tumor targeted delivery of umbelliferone via a smart mesoporous silica nanoparticles controlled-release drug delivery system for increased anticancer efficiency, Materials science & engineering","volume":"116","author":"Kundu","year":"2020","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"key":"10.1016\/j.toxrep.2022.04.017_bib31","series-title":"Cell Migration: Developmental Methods and Protocols","first-page":"23","article-title":"Wound-healing assay","author":"Rodriguez","year":"2005"},{"issue":"1","key":"10.1016\/j.toxrep.2022.04.017_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/0471141755.ph1208s56","article-title":"Measurement of cell death in mammalian cells","volume":"56","author":"Cummings","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.toxrep.2022.04.017_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.msec.2019.02.096","article-title":"Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy","volume":"100","author":"Sadhukhan","year":"2019","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"24","key":"10.1016\/j.toxrep.2022.04.017_bib34","doi-asserted-by":"crossref","first-page":"22183","DOI":"10.1021\/am505848p","article-title":"Dextran-gated, multifunctional mesoporous nanoparticle for glucose-responsive and targeted drug delivery","volume":"6","author":"Sinha","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.toxrep.2022.04.017_bib35","article-title":"Raman spectroscopy in graphene-based systems: prototypes for nanoscience and nanometrology","volume":"2012","author":"Jorio","year":"2012","journal-title":"Int. Sch. Res. Not."},{"issue":"3","key":"10.1016\/j.toxrep.2022.04.017_bib36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/smll.201001314","article-title":"Effective gene silencing by multilayered siRNA\u2010coated gold nanoparticles","volume":"7","author":"Lee","year":"2011","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.toxrep.2022.04.017_bib37","first-page":"1365","article-title":"Differential expression of the \u03b12, 3-sialic acid residues in breast cancer is associated with metastatic potential","volume":"25","author":"Cui","year":"2011","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.toxrep.2022.04.017_bib38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ygyno.2004.10.010","article-title":"Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids","volume":"96","author":"Hsu","year":"2005","journal-title":"Gynecol. Oncol."},{"issue":"41","key":"10.1016\/j.toxrep.2022.04.017_bib39","doi-asserted-by":"crossref","first-page":"15501","DOI":"10.1021\/ja406406h","article-title":"Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors","volume":"135","author":"Deshayes","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"16","key":"10.1016\/j.toxrep.2022.04.017_bib40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/0973-7847.134247","article-title":"Cytotoxicity of dietary flavonoids on different human cancer types","volume":"8","author":"Sak","year":"2014","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.toxrep.2022.04.017_bib41","first-page":"313","article-title":"Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways","volume":"5","author":"Saha","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"issue":"5","key":"10.1016\/j.toxrep.2022.04.017_bib42","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1039\/C3PY01202F","article-title":"Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery","volume":"5","author":"Ma","year":"2014","journal-title":"Polym. Chem."},{"issue":"10","key":"10.1016\/j.toxrep.2022.04.017_bib43","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003236","article-title":"Oncogenes and tumor suppressor genes","volume":"2","author":"Lee","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"6","key":"10.1016\/j.toxrep.2022.04.017_bib44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4161\/rna.20481","article-title":"The hallmarks of cancer: a long non-coding RNA point of view","volume":"9","author":"Gutschner","year":"2012","journal-title":"RNA Biol."},{"issue":"2","key":"10.1016\/j.toxrep.2022.04.017_bib45","article-title":"Mitochondrial death functions of p53","volume":"1","author":"Marchenko","year":"2014","journal-title":"Mol. Cell. Oncol."},{"issue":"8","key":"10.1016\/j.toxrep.2022.04.017_bib46","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbadis.2013.12.015","article-title":"p53 and mitochondrial function in neurons","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"56","key":"10.1016\/j.toxrep.2022.04.017_bib47","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1038\/sj.onc.1207116","article-title":"Control of apoptosis by p53","volume":"22","author":"Fridman","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.toxrep.2022.04.017_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104591","article-title":"Matrix metalloproteinase: an upcoming therapeutic approach for idiopathic pulmonary fibrosis","volume":"152","author":"Mahalanobish","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.toxrep.2022.04.017_bib49","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3892\/ol.2013.1555","article-title":"A new perspective of vasculogenic mimicry: EMT and cancer stem cells","volume":"6","author":"Fan","year":"2013","journal-title":"Oncol. Lett."},{"issue":"9","key":"10.1016\/j.toxrep.2022.04.017_bib50","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/jcmm.12851","article-title":"The relationship between vasculogenic mimicry and epithelial\u2010mesenchymal transitions","volume":"20","author":"Liu","year":"2016","journal-title":"J. Cell. Mol. Med."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:45:40Z","timestamp":1793249140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750022001007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":50,"alternative-id":["S2214750022001007"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.04.017","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}