{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:32:11Z","timestamp":1793251931754,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":150,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.toxrep.2022.05.021","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T21:42:55Z","timestamp":1654206175000},"page":"1291-1296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Lack of skin sensitization hazard potential for alpha-glycosyl isoquercitrin (AGIQ) utilizing the Local Lymph Node Assay"],"prefix":"10.1016","volume":"9","author":[{"given":"Puneet","family":"Vij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith P.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shim-mo","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Maronpot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.toxrep.2022.05.021_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3358\/shokueishi.41.54","article-title":"Constituents of enzymatically modified isoquercitrin and enzymatically modified rutin (extract)","volume":"41","author":"Akiyama","year":"2000","journal-title":"Food Hyg. Saf. Sci. (Shokuhin Eiseigaku Zasshi)"},{"issue":"5","key":"10.1016\/j.toxrep.2022.05.021_bib2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/ACI.0b013e32833e08ae","article-title":"Keratinocytes in allergic skin diseases","volume":"10","author":"Albanesi","year":"2010","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.toxrep.2022.05.021_bib3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/CAD.0b013e32832d1149","article-title":"Isoquercitrin isolated from hyptis fasciculata reduces glioblastoma cell proliferation and changes \u03b2-catenin cellular localization","volume":"20","author":"Amado","year":"2009","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.toxrep.2022.05.021_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/424203","article-title":"The LLNA: a brief review of recent advances and limitations","volume":"2011","author":"Anderson","year":"2011","journal-title":"J. Allergy"},{"issue":"10","key":"10.1016\/j.toxrep.2022.05.021_bib5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0278-6915(96)00059-2","article-title":"The local lymph node assay: a viable alternative to currently accepted skin sensitization tests","volume":"34","author":"Basketter","year":"1996","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.toxrep.2022.05.021_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yrtph.2012.06.003","article-title":"Optimised testing strategies for skin sensitization\u2013the LLNA and beyond","volume":"64","author":"Basketter","year":"2012","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.toxrep.2022.05.021_bib7","unstructured":"FDA, Agency response letter GRAS notice no. GRN00220 [alpha-glycosyl isoquercitrin], 2007."},{"key":"10.1016\/j.toxrep.2022.05.021_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fct.2017.12.059","article-title":"Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential","volume":"113","author":"Hobbs","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2022.05.021_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vascn.2015.01.001","article-title":"Application of BALB\/c mouse in the local lymph node assay: BrdU-ELISA for the prediction of the skin sensitizing potential of chemicals","volume":"72","author":"Hou","year":"2015","journal-title":"J. Pharm. Toxicol. Methods"},{"key":"10.1016\/j.toxrep.2022.05.021_bib10","unstructured":"ICCVAM, The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Test Method Evaluation Report. The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication Number 09-6439), National Institute of Environmental Health Sciences, Research Triangle Park, NC, 2009. [\u3008https:\/\/ntp.niehs.nih.gov\/whatwestudy\/niceatm\/index.html\u3009]."},{"issue":"2","key":"10.1016\/j.toxrep.2022.05.021_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","article-title":"Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme","volume":"134","author":"Junior","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.toxrep.2022.05.021_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2010.08.016","article-title":"Inhibition of influenza virus replication by plant-derived isoquercetin","volume":"88","author":"Kim","year":"2010","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.toxrep.2022.05.021_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0041-008X(92)90230-P","article-title":"Dendritic cells and cutaneous immune responses to chemical allergens","volume":"117","author":"Kimber","year":"1992","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxrep.2022.05.021_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yrtph.2016.10.021","article-title":"Comparison of BALB\/c and CBA\/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry (LLNA: BrdU-FCM)","volume":"83","author":"Lee","year":"2017","journal-title":"Regul. Toxicol. Pharm.: Regul. Toxicol. Pharm."},{"key":"10.1016\/j.toxrep.2022.05.021_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4939-8549-4_8","article-title":"Use of the LLNA: BrdU-ELISA for skin sensitization hazard assessment","volume":"1803","author":"Lehmann","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.toxrep.2022.05.021_bib16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-011-0613-2","article-title":"In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney","volume":"383","author":"Li","year":"2011","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharm."},{"key":"10.1016\/j.toxrep.2022.05.021_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2019.104409","article-title":"Proposal of GHS sub-categorization criteria for LLNA: BrdU-ELISA (OECD TG442B)","volume":"107","author":"Maeda","year":"2019","journal-title":"Regul. Toxicol. Pharm.: RTP"},{"key":"10.1016\/j.toxrep.2022.05.021_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112103","article-title":"alpha-Glycosyl Isoquercitrin (AGIQ) and its lack of carcinogenicity in rasH2 mice","volume":"151","author":"Mahapatra","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.toxrep.2022.05.021_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s13530-017-0328-y","article-title":"Investigation of cytotoxicity and skin-sensitizing potential of asarum radix oil using LLNA: BrdU-ELISA","volume":"9","author":"Moon","year":"2017","journal-title":"Toxicol. Environ. Health Sci."},{"key":"10.1016\/j.toxrep.2022.05.021_bib20","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fct.2016.09.030","article-title":"Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rats","volume":"97","author":"Nyska","year":"2016","journal-title":"Food Chem. Toxicol"},{"key":"10.1016\/j.toxrep.2022.05.021_bib21","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test no. 429: skin sensitisation: local lymph node assay","author":"OECD","year":"2010"},{"key":"10.1016\/j.toxrep.2022.05.021_bib22","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test no. 442B: skin sensitization: local lymph node assay: BrdU-ELISA or -FCM","author":"OECD","year":"2018"},{"issue":"2","key":"10.1016\/j.toxrep.2022.05.021_bib23","first-page":"147","article-title":"A histological and autoradiographic study of lymph nodes during the development of contact sensitivity in the guinea-pig","volume":"46","author":"Oort","year":"1965","journal-title":"Brit. J. Exp. Pathol."},{"issue":"8","key":"10.1016\/j.toxrep.2022.05.021_bib24","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.fct.2004.11.012","article-title":"Criteria for the safety evaluation of flavoring substances: the expert panel of the flavor and extract manufacturers association","volume":"43","author":"Smith","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2022.05.021_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fct.2014.03.018","article-title":"Isoquercitrin: pharmacology, toxicology, and metabolism","volume":"68","author":"Valentov\u00e1","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxrep.2022.05.021_bib26","first-page":"86","article-title":"An effective biphase system accelerates hesperidinase-catalyzed conversion of rutin to isoquercitrin","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:44:45Z","timestamp":1793249085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750022001366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":26,"alternative-id":["S2214750022001366"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.05.021","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lack of skin sensitization hazard potential for alpha-glycosyl isoquercitrin (AGIQ) utilizing the Local Lymph Node Assay","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}