{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:59:39Z","timestamp":1781326779205,"version":"3.54.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["88\/2562\/2"],"award-info":[{"award-number":["88\/2562\/2"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007288","name":"Mahasarakham University","doi-asserted-by":"publisher","award":["6105031\/1\/2561"],"award-info":[{"award-number":["6105031\/1\/2561"]}],"id":[{"id":"10.13039\/501100007288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.toxrep.2022.09.013","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T06:41:23Z","timestamp":1664606483000},"page":"1831-1845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Assessment of 28-day oral exposure to Pueraria candollei var. mirifica (Fabaceae) roots on pituitary-ovarian axis function and selected metabolic parameters in ovary-intact rats"],"prefix":"10.1016","volume":"9","author":[{"given":"Mallika","family":"Srasri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prayook","family":"Srivilai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panida","family":"Loutchanwoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2022.09.013_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11684-012-0184-8","article-title":"Medical applications of phytoestrogens from the Thai herb Pueraria mirifica","volume":"6","author":"Malaivijitnond","year":"2012","journal-title":"Front. Med."},{"key":"10.1016\/j.toxrep.2022.09.013_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-2000-8603","article-title":"Isoflavonoids from Pueraria mirifica and their estrogenic activity","volume":"66","author":"Chansakaow","year":"2000","journal-title":"Planta Med."},{"key":"10.1016\/j.toxrep.2022.09.013_bib3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1254\/jphs.FPJ04029X","article-title":"Different effects of Pueraria mirifica, a herb containing phytoestrogens, on LH and FSH secretion in gonadectomized female and male rats","volume":"96","author":"Malaivijitnond","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jep.2004.03.041","article-title":"The differential anti-proliferation effect of white (Pueraria mirifica), red (Butea superba), and black (Mucuna collettii) Kwao Krua plants on the growth of MCF-7 cells","volume":"93","author":"Cherdshewasart","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib5","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.tjog.2017.10.011","article-title":"Pueraria mirifica inhibits 17beta-estradiol-induced cell proliferation of human endometrial mesenchymal stem cells","volume":"56","author":"Lin","year":"2017","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1262\/jrd.18065","article-title":"Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay","volume":"53","author":"Cherdshewasart","year":"2007","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.toxrep.2022.09.013_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8110275","article-title":"Pueraria mirifica exerts estrogenic effects in the mammary gland and uterus and promotes mammary carcinogenesis in Donryu rats","volume":"8","author":"Kakehashi","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.toxrep.2022.09.013_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1055\/s-2006-923888","article-title":"Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid-axis","volume":"114","author":"B\u00f6ttner","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.toxrep.2022.09.013_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1677\/JOE-08-0127","article-title":"Effects of long-term treatment with 8-prenylnaringenin and oral estradiol on the GH-IGF-1 axis and lipid metabolism in rats","volume":"198","author":"B\u00f6ttner","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2015.02.002","article-title":"The influence of equol on the hypothalamic-pituitary-thyroid axis and hepatic lipid metabolic parameters in adult male rats","volume":"128","author":"Loutchanwoot","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.maturitas.2007.08.001","article-title":"Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERalpha and ERbeta","volume":"58","author":"Cherdshewasart","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.toxrep.2022.09.013_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2020.02.235","article-title":"Effects of peanut shell and skin extracts on the antioxidant ability, physical and structure properties of starch-chitosan active packaging films","volume":"152","author":"Meng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib13","series-title":"Szycher\u2019s Handbook of Polyurethanes (Online)","author":"Szycher","year":"2013"},{"key":"10.1016\/j.toxrep.2022.09.013_bib14","series-title":"Functionalized Graphene Nanocomposites and Their Derivatives: Synthesis, Processing and Applications","first-page":"265","article-title":"A corelation between the graphene surface area, functional groups, defects, and porosity on the performance of the nanocomposites","author":"Prusty","year":"2019"},{"key":"10.1016\/j.toxrep.2022.09.013_bib15","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s10853-014-8714-1","article-title":"Effect of molecular weight on conformational changes of PEO: an infrared spectroscopic analysis","volume":"50","author":"Yang","year":"2015","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00210-012-0804-5","article-title":"HP-\u03b2-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats","volume":"386","author":"Tao","year":"2013","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.toxrep.2022.09.013_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02669","article-title":"Daidzein cocrystals: an opportunity to improve its biopharmaceutical parameters","volume":"5","author":"Bhalla","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.toxrep.2022.09.013_bib18","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jpba.2009.11.025","article-title":"Physico-chemical characterization of an amphiphilic cyclodextrin\/genistein complex","volume":"51","author":"Cannav\u00e0","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.toxrep.2022.09.013_bib19","series-title":"Part 3: FEMALE REPRODUCTIVE SYSTEM, Series on Testing and Assessment","article-title":"Guidance document for histologic evaluation of endocrine and reproductive tests in rodents","author":"Organisation for Economic Co-operation and Development (OECD)","year":"2009"},{"key":"10.1016\/j.toxrep.2022.09.013_bib20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2014.04.010","article-title":"Chronic administration of fluoxetine or clozapine induces oxidative stress in rat liver: a histopathological study","volume":"59","author":"Zlatkovic","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ygcen.2015.01.006","article-title":"Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels","volume":"212","author":"Marcondes","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1743-7075-7-40","article-title":"Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol \u2013 pituitary tumor induction in Fischer 344 rats","volume":"7","author":"Jeng","year":"2010","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.toxrep.2022.09.013_bib24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.fertnstert.2012.07.1060","article-title":"Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats","volume":"98","author":"Cruz","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.toxrep.2022.09.013_bib25","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1293\/tox.27.1S","article-title":"Nonproliferative and proliferative lesions of the rat and mouse female reproductive system","volume":"27","author":"Dixon","year":"2014","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib26","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1177\/0192623311402220","article-title":"Histologic and cytologic detection of endocrine and reproductive tract effects of exemestane in female rats treated for up to twenty-eight days","volume":"39","author":"Mirsky","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib27","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1289\/ehp.9367","article-title":"Effects of chronic genistein treatment in mammary gland, uterus, and vagina","volume":"115\u00a0Suppl.","author":"Rimoldi","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxrep.2022.09.013_bib28","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/13697130701624757","article-title":"Uterotropic effects of dietary equol administration in ovariectomized Sprague-Dawley rats","volume":"10","author":"Racho\u0144","year":"2007","journal-title":"Climacteric"},{"key":"10.1016\/j.toxrep.2022.09.013_bib29","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1177\/0192623312454242","article-title":"Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal\u2019s, preputial, and clitoral glands","volume":"40","author":"Rudmann","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib30","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1177\/0192623310386499","article-title":"Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system","volume":"38","author":"Thoolen","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.steroids.2018.05.003","article-title":"Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats","volume":"135","author":"Loutchanwoot","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.toxrep.2022.09.013_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.steroids.2010.03.009","article-title":"Effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female Wistar rats","volume":"75","author":"Pantaleao","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.toxrep.2022.09.013_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/faat.1996.0156","article-title":"An in vivo battery for identifying endocrine modulators that are estrogenic or dopamine regulators","volume":"33","author":"O\u2019connor","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib34","series-title":"Toxicologic Pathology for Non-Pathologists","author":"Steinbach","year":"2019"},{"key":"10.1016\/j.toxrep.2022.09.013_bib35","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s12020-015-0691-x","article-title":"Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats","volume":"50","author":"Medigovic","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.toxrep.2022.09.013_bib36","first-page":"383","article-title":"The estrous cycle and associated phenomena in a strain of rats characterized by a high incidence of mammary tumors together with observations on the effects of advancing age on these phenomena","volume":"38","author":"Wolfe","year":"1940","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.toxrep.2022.09.013_bib37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.anireprosci.2009.05.002","article-title":"Influence of the length of proestrus on fertility and endocrine function in female cattle","volume":"117","author":"Bridges","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1477-7827-7-47","article-title":"The estrogen-injected female mouse: new insight into the etiology of PCOS","volume":"7","author":"Chapman","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib39","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1210\/jc.2009-2108","article-title":"Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women","volume":"95","author":"Shaw","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.toxrep.2022.09.013_bib40","first-page":"116","article-title":"90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17\u03b2-estradiol","volume":"44","author":"Biegel","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxrep.2022.09.013_bib41","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1172\/JCI108015","article-title":"The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue","volume":"55","author":"Hamosh","year":"1975","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.toxrep.2022.09.013_bib42","first-page":"2410","article-title":"Relation of estrogen and its receptor to rat liver growth and regeneration","volume":"44","author":"Fisher","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxrep.2022.09.013_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0102-86502009000100002","article-title":"The influence of estrogen on liver regeneration: an experimental study in rats","volume":"24","author":"Biondo-Simoes Mde","year":"2009","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.toxrep.2022.09.013_bib44","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib45","series-title":"R.C.B.T.-B.","first-page":"241","article-title":"Chapter 13 \u2013 hepatic toxicity biomarkers","author":"Yang","year":"2014"},{"key":"10.1016\/j.toxrep.2022.09.013_bib46","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxrep.2022.09.013_bib47","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/toxsci\/69.1.92","article-title":"Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens","volume":"69","author":"O\u2019Connor","year":"2002","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022001962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T07:56:08Z","timestamp":1718524568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750022001962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":47,"alternative-id":["S2214750022001962"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.09.013","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of 28-day oral exposure to Pueraria candollei var. mirifica (Fabaceae) roots on pituitary-ovarian axis function and selected metabolic parameters in ovary-intact rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}