{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:31:56Z","timestamp":1793395916271,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["107104"],"award-info":[{"award-number":["107104"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015777","name":"South African Medical Research Council Division of Research Capacity Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015777","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.toxrep.2022.10.006","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:36:47Z","timestamp":1665977807000},"page":"1920-1928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["In vitro and in vivo hepatotoxicity study of Afriplex\u2122 GRT through an inflammatory response"],"prefix":"10.1016","volume":"9","author":[{"given":"Kwazikwakhe B.","family":"Gabuza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntandoyenkosi","family":"Buthelezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abidemi Paul","family":"Kappo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thendo I.","family":"Mabuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebamang","family":"Mosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Louw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christo J.F.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2022.10.006_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-0029-1240002","article-title":"Epidemiology of idiosyncratic drug-induced liver injury","volume":"29","author":"Bell","year":"2009","journal-title":"Semin Liver Dis."},{"key":"10.1016\/j.toxrep.2022.10.006_bib2","article-title":"Possible effects of natural antioxidants on experimentally induced hepatotoxicity in rats","volume":"0","author":"El-Sayed","year":"2016","journal-title":"CU Theses"},{"key":"10.1016\/j.toxrep.2022.10.006_bib3","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity","volume":"354","author":"Navarro","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxrep.2022.10.006_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mayocp.2013.09.016","article-title":"Drug-induced liver injury","volume":"89","author":"Leise","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.toxrep.2022.10.006_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00204-015-1456-2","article-title":"Drug-induced liver injury: an overview over the most critical compounds","volume":"89","author":"Bj\u00f6rnsson","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib6","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/gast.2002.33573","article-title":"Nonalcoholic fatty liver disease","volume":"122","author":"Clark","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.toxrep.2022.10.006_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fphys.2015.00363","article-title":"Drug-induced liver toxicity and prevention by herbal antioxidants: an overview","volume":"6","author":"Singh","year":"2016","journal-title":"Front Physiol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/mp060011k","article-title":"Methods to evaluate biliary excretion of drugs in humans: an updated review","volume":"3","author":"Ghibellini","year":"2006","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.toxrep.2022.10.006_bib9","series-title":"Handbook of Drug-Nutrient Interactions","first-page":"341","article-title":"Interaction of Natural Products with Medication and Nutrients","author":"Chan","year":"2009"},{"key":"10.1016\/j.toxrep.2022.10.006_bib10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug-induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","author":"Kullak-Ublick","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.toxrep.2022.10.006_bib11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1568026013394831","article-title":"& Nukhet Aykin-Burns, B. S. P. Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage","volume":"1","author":"Nuran Ercal","year":"2001","journal-title":"Curr. Top. Med Chem."},{"key":"10.1016\/j.toxrep.2022.10.006_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"issue":"390","key":"10.1016\/j.toxrep.2022.10.006_bib13","article-title":"Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice","volume":"10","author":"Villanueva-Paz","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.toxrep.2022.10.006_bib14","first-page":"1076","article-title":"[Oxidative stress and human disease. Current knowledge and perspectives for prevention]","volume":"30","author":"Lehucher-Michel","year":"2001","journal-title":"Presse Med."},{"key":"10.1016\/j.toxrep.2022.10.006_bib15","unstructured":"NF-&kappa;B in oxidative stress | Elsevier Enhanced Reader. \u3008https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S2468202017301195?token=696049F2C0D092EFB5081945EE71386D4CA7A3B58E9122BBAE8DAD72DF759ADC912357CAEBA1B9FFE5F30B5545464141&originRegion=eu-west-1&originCreation=20220719140227\u3009."},{"key":"10.1016\/j.toxrep.2022.10.006_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.livres.2020.10.003","article-title":"Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function","volume":"5","author":"Ommati","year":"2021","journal-title":"Liver Res"},{"key":"10.1016\/j.toxrep.2022.10.006_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.phrs.2017.11.030","article-title":"Phytochemicals as inhibitors of NF-\u03baB for treatment of Alzheimer\u2019s disease","volume":"129","author":"Seo","year":"2018","journal-title":"Pharm. Res"},{"key":"10.1016\/j.toxrep.2022.10.006_bib18","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.3390\/ijms23052764","article-title":"Natural compounds for counteracting nonalcoholic fatty liver disease (NAFLD): advantages and limitations of the suggested candidates","volume":"23","author":"Salvoza","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxrep.2022.10.006_bib19","unstructured":"World Health Organization (WHO). WHO Global Report on Traditional and Alternate Medicine. (2019)."},{"key":"10.1016\/j.toxrep.2022.10.006_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0034-1375958","article-title":"Hepatotoxicity induced by herbal and dietary supplements","volume":"34","author":"Navarro","year":"2014","journal-title":"Semin Liver Dis."},{"key":"10.1016\/j.toxrep.2022.10.006_bib21","doi-asserted-by":"crossref","unstructured":"Astrid von Gadow,\u2020 , Elizabeth Joubert,*,\u2021 and & Hansmann\u2021, C.F. Comparison of the Antioxidant Activity of Aspalathin with That of Other Plant Phenols of Rooibos Tea (Aspalathus linearis), \u03b1-Tocopherol, BHT, and BHA. (1997) doi:10.1021\/JF960281N.","DOI":"10.1021\/jf960281n"},{"key":"10.1016\/j.toxrep.2022.10.006_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.1992","article-title":"A review of the bioactivity of South African herbal teas: Rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia)","volume":"vol. 21","author":"McKay","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxrep.2022.10.006_bib23","first-page":"1","article-title":"Aspalathin a unique phytochemical from the South African rooibos plant (Aspalathus linearis): a mini Review","volume":"5","author":"Erlwanger","year":"2017","journal-title":"J. Afr. Ass. Physiol. Sci. J. Afr. Assoc. Physiol. Sci. Off. Publ. Afr. Assoc. Physiol. Sci."},{"key":"10.1016\/j.toxrep.2022.10.006_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.phymed.2008.11.009","article-title":"Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db\/db mice","volume":"16","author":"Kawano","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.toxrep.2022.10.006_bib25","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1021\/jf0344643","article-title":"Modulation of hepatic drug metabolizing enzymes and oxidative status by rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), green and black (Camellia Sinensis) teas in rats","volume":"51","author":"Marnewick","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2022.10.006_bib26","doi-asserted-by":"crossref","unstructured":"Lauren Standley, \u2020 et al. Influence of Processing Stages on Antimutagenic and Antioxidant Potentials of Rooibos Tea. (2000) doi:10.1021\/JF000802D.","DOI":"10.1021\/jf000802d"},{"key":"10.1016\/j.toxrep.2022.10.006_bib27","first-page":"277","article-title":"Rooibos and Honeybush: recent advances in chemistry","author":"Marnewick","year":"2010","journal-title":"Biol. Act. Pharmacogn."},{"key":"10.1016\/j.toxrep.2022.10.006_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/07315724.2006.10719518","article-title":"Beneficial effects of green tea\u2014a review","volume":"25","author":"Cabrera","year":"2006","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.toxrep.2022.10.006_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2013.10.029","article-title":"The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats","volume":"21","author":"Dludla","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.toxrep.2022.10.006_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.14309\/crj.2013.20","article-title":"Tea not tincture: hepatotoxicity associated with Rooibos herbal tea","volume":"1","author":"Engels","year":"2013","journal-title":"ACG Case Rep. J."},{"key":"10.1016\/j.toxrep.2022.10.006_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00228-009-0776-7","article-title":"Possible hepatotoxic effect of rooibos tea: A case report","volume":"vol. 66","author":"Sinisalo","year":"2010","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21111515","article-title":"Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(??-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs","volume":"21","author":"Patel","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.toxrep.2022.10.006_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.toxrep.2022.10.006_bib34","unstructured":"Hinton, D. M. US FDA \"Redbook II\" Immunotoxicity Testing Guidelines and Research in Immunotoxicity Evaluations of Food Chemicals and New Food Proteins."},{"key":"10.1016\/j.toxrep.2022.10.006_bib35","doi-asserted-by":"crossref","first-page":"22674","DOI":"10.3390\/molecules201219868","article-title":"Short-Term and Sub-Chronic Dietary Exposure to Aspalathin-Enriched Green Rooibos (Aspalathus linearis) Extract Affects Rat Liver Function and Antioxidant Status","volume":"20","author":"van der Merwe","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.toxrep.2022.10.006_bib36","unstructured":"Vitamin K.: A vital micronutrient with the cardioprotective potential against diabetes-associated complications | Elsevier Enhanced Reader. \u3008https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S0024320521010559?token=F008E9A8480EE87F13DED34357115F1C466A9AA5F4FBDC5DC0D2483455B8F5331E69436C179A3A1DF002D05CBF5613C4&originRegion=eu-west-1&originCreation=20211027081155\u3009."},{"key":"10.1016\/j.toxrep.2022.10.006_bib37","unstructured":"Redbook 2000: IV.B.1. General Guidelines for Designing and Conducting Toxicity Studies | FDA. \u3008https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/redbook-2000-ivb1-general-guidelines-designing-and-conducting-toxicity-studies\u3009."},{"key":"10.1016\/j.toxrep.2022.10.006_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.toxrep.2022.10.006_bib39","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.acthis.2019.05.008","article-title":"A histomorphometric study on the hepatoprotective effects of a green rooibos extract in a diet-induced obese rat model","volume":"121","author":"Layman","year":"2019","journal-title":"Acta Histochem"},{"key":"10.1016\/j.toxrep.2022.10.006_bib40","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib41","doi-asserted-by":"crossref","DOI":"10.4254\/wjh.v9.i16.715","article-title":"Non-alcoholic fatty liver disease: an expanded review","author":"Benedict","year":"2017","journal-title":"World J. Hepatol. Vol. 9 715\u2013732 Prepr."},{"key":"10.1016\/j.toxrep.2022.10.006_bib42","article-title":"Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.toxrep.2022.10.006_bib43","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/tx3001708","article-title":"Particle-induced artifacts in the MTT and LDH viability assays","volume":"25","author":"Holder","year":"2012","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0300-483X(98)00095-X","article-title":"Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague\u2013Dawley rats","volume":"130","author":"Moghaddam","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.toxrep.2022.10.006_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jep.2003.09.037","article-title":"Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats","volume":"90","author":"Achliya","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/569037","article-title":"Attenuation of CCl4-induced oxidative stress and hepatonephrotoxicity by saudi sidr honey in rats","volume":"2013","author":"Al-Yahya","year":"2013","journal-title":"Evid. Based Complement Altern. Med"},{"key":"10.1016\/j.toxrep.2022.10.006_bib47","doi-asserted-by":"crossref","unstructured":"Ku, S.-K.K., Kwak, S., Kim, Y. & Bae, J.-S.S. Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) Inhibits High Glucose-Induced Inflammation In Vitro and In Vivo. Inflammation 38, 445\u2013455.","DOI":"10.1007\/s10753-014-0049-1"},{"key":"10.1016\/j.toxrep.2022.10.006_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10495-007-0155-8","article-title":"Recombinant human erythropoietin attenuates hepatic injury induced by ischemia\/reperfusion in an isolated mouse liver model","volume":"13","author":"Hochhauser","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxrep.2022.10.006_bib49","first-page":"1","article-title":"Hepatic insulin resistance and nonalcoholic fatty liver disease","author":"Aguila","year":"2009","journal-title":"Insul. Resist.: Symptoms, Causes Treat."},{"key":"10.1016\/j.toxrep.2022.10.006_bib50","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.nutres.2008.08.002","article-title":"Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside","volume":"28","author":"Kreuz","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.toxrep.2022.10.006_bib51","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.3748\/wjg.v22.i30.6890","article-title":"Herbal medicines and nonalcoholic fatty liver disease","volume":"22","author":"Yao","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib52","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006080","article-title":"Cell death signaling","volume":"7","author":"Green","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib53","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1083\/jcb.140.6.1485","article-title":"The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling","volume":"140","author":"Mancini","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxrep.2022.10.006_bib54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2004.07.013","article-title":"Role of chemopreventive agents in cancer therapy","volume":"215","author":"Dorai","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxrep.2022.10.006_bib55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/B978-0-12-405927-6.00013-8","article-title":"Tannins and related compounds from medicinal plants of Africa","author":"Shahat","year":"2013","journal-title":"Med. Plant Res. Afr."},{"key":"10.1016\/j.toxrep.2022.10.006_bib56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.canlet.2004.11.014","article-title":"Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas","volume":"224","author":"Marnewick","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxrep.2022.10.006_bib57","unstructured":"Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulat | JIR. \u3008https:\/\/www.dovepress.com\/mechanisms-of-nf-kappab-p65-and-strategies-for-therapeutic-manipulatio-peer-reviewed-fulltext-article-JIR\u3009."},{"key":"10.1016\/j.toxrep.2022.10.006_bib58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxlet.2021.05.012","article-title":"The inhibition of NF\u043aB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity","volume":"349","author":"Ahmadi","year":"2021","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022002025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750022002025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:59:23Z","timestamp":1793393963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750022002025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":58,"alternative-id":["S2214750022002025"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.10.006","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro and in vivo hepatotoxicity study of Afriplex\u2122 GRT through an inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2022.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}