{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:14:52Z","timestamp":1783692892429,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008231","name":"Periyar University","doi-asserted-by":"publisher","award":["PU\/AD-3\/URF Order\/ 008170\/24F94493\/2024"],"award-info":[{"award-number":["PU\/AD-3\/URF Order\/ 008170\/24F94493\/2024"]}],"id":[{"id":"10.13039\/501100008231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.toxrep.2024.101758","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T19:47:21Z","timestamp":1728503241000},"page":"101758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Bioefficacy of Zinc oxide nanoparticle synthesis and their Biological, Environmental applications from Eranthemum roseum"],"prefix":"10.1016","volume":"13","author":[{"given":"Ramachandran","family":"Adhavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppusamy","family":"Selvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanisamy","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peraman","family":"Manimegalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmalingam","family":"Kirubakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthugounder Subramanian","family":"Shivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.toxrep.2024.101758_bib1","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.3390\/molecules28186624","article-title":"Emerging applications of nanotechnology in healthcare and medicine","volume":"28","author":"Malik","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.toxrep.2024.101758_bib2","series-title":"In Multifunctional Hybrid Semiconductor Photocatalyst Nanomaterials: Application on Health, Energy and Environment","first-page":"31","article-title":"Synthesis of Multifunctional Hybrid Semiconductor Nanomaterials","author":"Samriti","year":"2023"},{"key":"10.1016\/j.toxrep.2024.101758_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116040","article-title":"Nanoparticles: Mechanism of biosynthesis using plant extracts, bacteria, fungi, and their applications","volume":"334","author":"Qamar","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.toxrep.2024.101758_bib4","doi-asserted-by":"crossref","first-page":"1158198","DOI":"10.3389\/fchem.2023.1158198","article-title":"Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases","volume":"11","author":"Chaudhary","year":"2023","journal-title":"Front. Chem."},{"issue":"4","key":"10.1016\/j.toxrep.2024.101758_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3390\/antiox11040791","article-title":"The antioxidant effect of the metal and metal-oxide nanoparticles","volume":"11","author":"Ge","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.dsx.2018.10.008","article-title":"Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention","volume":"13","author":"Tan","year":"2019","journal-title":"Diabetes Metab. Syndr.: Clin. Res. Rev."},{"issue":"9","key":"10.1016\/j.toxrep.2024.101758_bib7","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.3390\/ijms23094596","article-title":"Inflammation: A new look at an old problem","volume":"23","author":"Gusev","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxrep.2024.101758_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103423","article-title":"A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach","volume":"94","author":"Agarwal","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"10","key":"10.1016\/j.toxrep.2024.101758_bib9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3390\/biom12101337","article-title":"Implication of nanoparticles to combat chronic liver and kidney diseases: progress and perspectives","volume":"12","author":"Hashim","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.toxrep.2024.101758_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.dsx.2020.04.026","article-title":"Trace element nanoparticles improved diabetes mellitus; a brief report","volume":"14","author":"Ashrafizadeh","year":"2020","journal-title":"Diabetes Metab. Syndr.: Clin. Res. Rev."},{"key":"10.1016\/j.toxrep.2024.101758_bib11","first-page":"467","article-title":"An updated taxonomic checklist of angiosperms in Jammu and Kashmir state","author":"Dar","year":"2020","journal-title":"Biodivers. Himalaya: Jammu Kashmir State"},{"issue":"11","key":"10.1016\/j.toxrep.2024.101758_bib12","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2174\/1570180819666220816115506","article-title":"Survey on medicinal plants and herbs in traditional Iranian medicine with anti-oxidant, anti-viral, anti-microbial, and anti-inflammation properties","volume":"20","author":"Shahrajabian","year":"2023","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.toxrep.2024.101758_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116567","article-title":"Green synthesis of ZnO nanoparticles from Syzygium cumini leaves extract with robust photocatalysis applications","volume":"335","author":"Sadiq","year":"2021","journal-title":"J. Mol. Liq."},{"issue":"4","key":"10.1016\/j.toxrep.2024.101758_bib14","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1007\/s12668-023-01222-x","article-title":"Eco-friendly Synthesis of Zinc Oxide Nanoparticles by Clerodendrum heterophyllum Leaf Extract and Their Biological Applications","volume":"13","author":"Kirubakaran","year":"2023","journal-title":"BioNanoScience"},{"key":"10.1016\/j.toxrep.2024.101758_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117078","article-title":"Isolation, purification, structure and antioxidant activity of polysaccharide from pinecones of Pinus koraiensis","volume":"251","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.toxrep.2024.101758_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2021.100178","article-title":"Proficient synthesis of zinc oxide nanoparticles from Tabernaemontana heyneana Wall. via green combustion method: Antioxidant, anti-inflammatory, antidiabetic, anticancer and photocatalytic activities","volume":"3","author":"Manasa","year":"2021","journal-title":"Results Chem."},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40203-023-00163-3","article-title":"In-vitro antibacterial, antioxidant and anti-inflammatory and In-silico ADMET, molecular docking study on Hardwickia binata phytocompunds with potential inhibitor of skin cancer protein","volume":"11","author":"Manimegalai","year":"2023","journal-title":"Silico Pharmacol."},{"issue":"2","key":"10.1016\/j.toxrep.2024.101758_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40097-021-00460-3","article-title":"Comparative evaluation of chemically and green synthesized zinc oxide nanoparticles: Their in vitro antioxidant, antimicrobial, cytotoxic and anticancer potential towards HepG2 cell line","volume":"13","author":"Ashraf","year":"2023","journal-title":"J. Nanostructure Chem."},{"key":"10.1016\/j.toxrep.2024.101758_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.procbio.2022.02.022","article-title":"In vitro anticancer activity of silver nanoparticles phyto-fabricated by Hylocereus undatus peel extracts on human liver carcinoma (HepG2) cell lines","volume":"116","author":"Shyamalagowri","year":"2022","journal-title":"Process Biochem."},{"issue":"11","key":"10.1016\/j.toxrep.2024.101758_bib20","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3390\/insects13111030","article-title":"Larvicidal and antifeedant effects of copper nano-pesticides against Spodoptera frugiperda (JE Smith) and its immunological response","volume":"13","author":"Rahman","year":"2022","journal-title":"Insects"},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/cryst12010022","article-title":"Photocatalytic degradation of methylene blue and metanil yellow dyes using green synthesized zinc oxide (ZnO) nanocrystals","volume":"12","author":"Priyadharshini","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.toxrep.2024.101758_bib22","unstructured":"Bhagat, T.S., Lokhande, R.S., Khadke-Lokhande, L. and Chandorkar, J.G., 2023. Green synthesis, characterization, application and study of antimicrobial properties of zinc oxide nano particles using Cyathocline purpurea phytoextract."},{"issue":"7","key":"10.1016\/j.toxrep.2024.101758_bib23","doi-asserted-by":"crossref","first-page":"19313","DOI":"10.1007\/s11356-022-23518-3","article-title":"The photocatalytic, cytotoxicity, and antibacterial properties of zinc oxide nanoparticles synthesized using Trigonella foenum-graecum L extract","volume":"30","author":"Kermani","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.toxrep.2024.101758_bib24","first-page":"1","article-title":"Optimization and characterization of eco-friendly formulated ZnO NPs in various parameters: assessment of its antidiabetic, antioxidant and antibacterial properties","author":"Karthick","year":"2023","journal-title":"Biomass-.-. Convers. Biorefinery"},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/17518253.2018.1547925","article-title":"Green synthesis of zinc oxide nanoparticles: a comparison","volume":"12","author":"Fakhari","year":"2019","journal-title":"Green. Chem. Lett. Rev."},{"key":"10.1016\/j.toxrep.2024.101758_bib26","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s10904-020-01490-0","article-title":"Structural, morphological and biological features of ZnO nanoparticles using Hyphaene thebaica (L.) Mart. fruits","volume":"30","author":"Mohamed","year":"2020","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"issue":"51","key":"10.1016\/j.toxrep.2024.101758_bib27","doi-asserted-by":"crossref","first-page":"29541","DOI":"10.1039\/C9RA04424H","article-title":"Optical, morphological and biological analysis of zinc oxide nanoparticles (ZnO NPs) using Papaver somniferum L","volume":"9","author":"Muhammad","year":"2019","journal-title":"RSC Adv."},{"issue":"29","key":"10.1016\/j.toxrep.2024.101758_bib28","doi-asserted-by":"crossref","first-page":"73870","DOI":"10.1007\/s11356-023-27483-3","article-title":"\"Antiplatelet, cytotoxic activities and characterization of green-synthesized zinc oxide nanoparticles using aqueous extract of Nephrolepis exaltata","volume":"30","author":"Aboul-Soud","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.toxrep.2024.101758_bib29","first-page":"1","article-title":"Green synthesis of zinc oxide (ZnO) nanoparticles using aqueous leaf extract of Hardwickia binata: their characterizations and biological applications","author":"Manimegalai","year":"2023","journal-title":"Biomass-.-. Convers. Biorefinery"},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib30","doi-asserted-by":"crossref","first-page":"15921","DOI":"10.1038\/s41598-023-42702-0","article-title":"Green synthesis, characterization, anti-SARS-CoV-2 entry, and replication of lactoferrin-coated zinc nanoparticles with halting lung fibrosis induced in adult male albino rats","volume":"13","author":"El-Fakharany","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib31","first-page":"7","article-title":"Green Synthesis of ZnO-NPs by Juglans regia Green Husk Aqueous Extract","volume":"14","author":"Dehghani","year":"2023","journal-title":"Mater. Proc."},{"key":"10.1016\/j.toxrep.2024.101758_bib32","first-page":"1","article-title":"Biogenic synthesis of zinc oxide nanoparticles using Drynaria Quercifolia tuber extract for antioxidant, antibiofilm, larvicidal, and photocatalytic applications","author":"Kalaimurgan","year":"2023","journal-title":"Biomass-.-. Convers. Biorefinery"},{"key":"10.1016\/j.toxrep.2024.101758_bib33","first-page":"1","article-title":"Novel Green Synthesis of UV-Sunscreen ZnO Nanoparticles Using Solanum lycopersicum Fruit Extract and Evaluation of Their Antibacterial and Anticancer Activity","author":"Elbrolesy","year":"2023","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"10.1016\/j.toxrep.2024.101758_bib34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s12257-021-0211-1","article-title":"Antioxidant and antibacterial profiling of pomegranate-pericarp extract functionalized-zinc oxide nanocomposite","volume":"26","author":"Singh","year":"2021","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"10.1016\/j.toxrep.2024.101758_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/3155962","article-title":"Phytoantioxidant functionalized nanoparticles: A green approach to combat nanoparticle-induced oxidative stress","volume":"2021","author":"Balkrishna","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.toxrep.2024.101758_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.micpath.2018.03.048","article-title":"Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method","volume":"119","author":"Soren","year":"2018","journal-title":"Microb. Pathog."},{"issue":"24","key":"10.1016\/j.toxrep.2024.101758_bib37","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.1021\/cr500310b","article-title":"Environmental implications of hydroxyl radicals (\u2022 OH)","volume":"115","author":"Gligorovski","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.toxrep.2024.101758_bib38","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.foodchem.2016.05.049","article-title":"Immobilization of diastase \u03b1-amylase on nano zinc oxide","volume":"211","author":"Antony","year":"2016","journal-title":"Food Chem."},{"issue":"14","key":"10.1016\/j.toxrep.2024.101758_bib39","doi-asserted-by":"crossref","first-page":"9709","DOI":"10.1021\/acsomega.1c00310","article-title":"Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications","volume":"6","author":"Faisal","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.toxrep.2024.101758_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4786227","article-title":"Plant-Based Synthesis of Zinc Oxide Nanoparticles (ZnO-NPs) Using Aqueous Leaf Extract of Aquilegia pubiflora: Their Antiproliferative Activity against HepG2 Cells Inducing Reactive Oxygen Species and Other In Vitro Properties","volume":"2021","author":"Jan","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"issue":"2","key":"10.1016\/j.toxrep.2024.101758_bib41","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3390\/ijms24021474","article-title":"Antibacterial and Anti-Inflammatory Properties of ZnO Nanoparticles Synthesized by a Green Method Using Sargassum Extracts","volume":"24","author":"Lopez-Miranda","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxrep.2024.101758_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/7459042","article-title":"Synthesis of zinc oxide nanoparticles using leaf extract of lippia adoensis (koseret) and evaluation of its antibacterial activity","volume":"2020","author":"Demissie","year":"2020","journal-title":"J. Chem."},{"issue":"9","key":"10.1016\/j.toxrep.2024.101758_bib43","article-title":"Green Synthesis of Zinc Oxide Nanoparticles Using Chamomile and Green Tea Extracts and Evaluation of Their Anti-inflammatory and Antioxidant Activity: An In Vitro Study","volume":"15","author":"Chatterjee","year":"2023","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib44","article-title":"Comparative anti-inflammatory activity of silver and zinc oxide nanoparticles synthesized using Ocimum tenuiflorum and Ocimum gratissimum herbal formulations","volume":"16","author":"Varghese","year":"2024","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.toxrep.2024.101758_bib45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/biom12060855","article-title":"Bio-Assisted Synthesis and Characterization of Zinc Oxide Nanoparticles from Lepidium sativum and Their Potent Antioxidant, Antibacterial and Anticancer Activities","volume":"12","author":"Meer","year":"2022","journal-title":"Biomolecules"},{"issue":"27","key":"10.1016\/j.toxrep.2024.101758_bib46","doi-asserted-by":"crossref","first-page":"15357","DOI":"10.1039\/C9RA01659G","article-title":"Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities","volume":"9","author":"Hussain","year":"2019","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.toxrep.2024.101758_bib47","first-page":"166","article-title":"Synthesis and characterization of silver nanoparticles and their application as an antibacterial agent","volume":"5","author":"Gamboa","year":"2019","journal-title":"Int J. Biosen Bioelectron."},{"issue":"1","key":"10.1016\/j.toxrep.2024.101758_bib48","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/13880209.2021.1946090","article-title":"Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa","volume":"59","author":"Alam","year":"2021","journal-title":"Pharm. Biol."},{"issue":"10","key":"10.1016\/j.toxrep.2024.101758_bib49","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.3390\/app10103620","article-title":"Preparation and characterization of zinc oxide nanoparticles using leaf extract of Sambucus ebulus","volume":"10","author":"Alamdari","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.toxrep.2024.101758_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2022.100637","article-title":"Methylene blue dye degradation potential of zinc oxide nanoparticles bioreduced using Solanum trilobatum leaf extract","volume":"4","author":"Venkatesan","year":"2022","journal-title":"Results Chem."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750024001410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750024001410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T12:06:49Z","timestamp":1735301209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750024001410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":50,"alternative-id":["S2214750024001410"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2024.101758","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioefficacy of Zinc oxide nanoparticle synthesis and their Biological, Environmental applications from Eranthemum roseum","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2024.101758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101758"}}