{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:48:21Z","timestamp":1765374501040,"version":"3.46.0"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.toxrep.2025.102098","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T06:12:00Z","timestamp":1753683120000},"page":"102098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["First case reports of intentional Imepitoin overdose in humans: A case of two patients"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6970-7724","authenticated-orcid":false,"given":"Gerard","family":"Ronda-Roca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-2085","authenticated-orcid":false,"given":"Antonio F.","family":"Caballero-Bermejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cantillana-Barrenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-9077","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Ruiz-Antor\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"journal-title":"Ficha t\u00e9cnica Pexion [Internet]","year":"2022","author":"Agencia Europea del Medicamento","key":"10.1016\/j.toxrep.2025.102098_bib1"},{"issue":"9","key":"10.1016\/j.toxrep.2025.102098_bib2","article-title":"Evaluation of Pexion\u00ae (imepitoin) for treatment of storm anxiety in dogs: a randomised, double-blind, placebo-controlled trial","volume":"188","author":"Perdew","year":"2021","journal-title":"Vet. Rec. [Internet]"},{"issue":"2","key":"10.1016\/j.toxrep.2025.102098_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/jvp.12151","article-title":"Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs","volume":"38","author":"Tipold","year":"2015","journal-title":"J. Vet. Pharm. Ther. [Internet]"},{"issue":"1","key":"10.1016\/j.toxrep.2025.102098_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40263-013-0129-z","article-title":"The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy","volume":"28","author":"Rundfeldt","year":"2014","journal-title":"CNS Drugs [Internet]"},{"key":"10.1016\/j.toxrep.2025.102098_bib5","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J. Clin. Epidemiol. [Internet]"},{"issue":"3","key":"10.1016\/j.toxrep.2025.102098_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1358\/dof.1998.023.03.450427","article-title":"AWD-131-138","volume":"23","author":"Rostock","year":"1998","journal-title":"Anxiolytic Antico Drugs Future"},{"issue":"2","key":"10.1016\/j.toxrep.2025.102098_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3940(98)00186-4","article-title":"The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzoadiazephine binding site","volume":"245","author":"Sigel","year":"1998","journal-title":"Neurosci. Lett. [Internet]"},{"key":"10.1016\/j.toxrep.2025.102098_bib8","article-title":"Benzodiazepine toxicity","author":"Kang","year":"2023","journal-title":"StatPearls [Internet]"},{"issue":"1","key":"10.1016\/j.toxrep.2025.102098_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/bcpt.12434","article-title":"Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication\u2013a systematic review with meta-analyses of randomised trials","volume":"118","author":"Penninga","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol. [Internet]"},{"issue":"16","key":"10.1016\/j.toxrep.2025.102098_bib10","first-page":"E149","volume":"148","author":"Lavonas","year":"2023","journal-title":"Circulation [Internet]"}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750025002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750025002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:50:19Z","timestamp":1765371019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750025002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":10,"alternative-id":["S2214750025002161"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2025.102098","relation":{},"ISSN":["2214-7500"],"issn-type":[{"type":"print","value":"2214-7500"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First case reports of intentional Imepitoin overdose in humans: A case of two patients","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2025.102098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102098"}}