{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:40:39Z","timestamp":1786534839415,"version":"build-2736575974"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007676","name":"Asahi Group Holdings Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007676","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.toxrep.2026.102222","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:50:53Z","timestamp":1771001453000},"page":"102222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of the safety of high-dose Lactobacillus gasseri CP2305 supplementation in healthy adults: A randomized, double-blind, placebo-controlled study"],"prefix":"10.1016","volume":"16","author":[{"given":"Hajime","family":"Fuchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2026.102222_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.toxrep.2026.102222_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet-microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.toxrep.2026.102222_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000533131","article-title":"Psychological stress and gut microbiota composition: a systematic review of human studies","volume":"82","author":"Ma","year":"2023","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.toxrep.2026.102222_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.toxrep.2026.102222_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fnins.2017.00490","article-title":"Cross talk: the microbiota and neurodevelopmental disorders","volume":"11","author":"Kelly","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.toxrep.2026.102222_bib6","first-page":"30259","article-title":"Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function","volume":"27","author":"Sugawara","year":"2016","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.toxrep.2026.102222_bib7","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/jam.13594","article-title":"Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality","volume":"123","author":"Nishida","year":"2017","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.toxrep.2026.102222_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu11081859","article-title":"Health benefits of Lactobacillus gasseri CP2305 tablets in young adults exposed to chronic stress: a randomized, double-blind, placebo-controlled study","volume":"11","author":"Nishida","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.toxrep.2026.102222_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/jam.13329","article-title":"The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome","volume":"122","author":"Nobutani","year":"2017","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.toxrep.2026.102222_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091695","article-title":"Effects of Lactobacillus gasseri CP2305 on mild menopausal symptoms in middle-aged women","volume":"14","author":"Sawada","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.toxrep.2026.102222_bib11","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.clnu.2023.06.019","article-title":"Daily consumption of Lactobacillus gasseri CP2305 improves quality of sleep in adults -a systematic literature review and meta-analysis","volume":"42","author":"Chu","year":"2023","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.toxrep.2026.102222_bib12","first-page":"1711","article-title":"The safety evaluation of long-term or excessive intake of the beverage containing Lactococcus lactis subsp. lactis JCM 5805 and resistant maltodextrin\u2015a randomized, double-blind, placebo-controlled, parallel-group trial\u2015","volume":"43","author":"Tanaka","year":"2015","journal-title":"Jpn Pharm. Ther."},{"key":"10.1016\/j.toxrep.2026.102222_bib13","first-page":"89","article-title":"Antihypertensive effect and safety of a drink containing tomato vinegar in case of long-term intake for subjects with high-normal blood pressure or mild hypertension","volume":"35","author":"Sado","year":"2007","journal-title":"Jpn Pharm. Ther."},{"key":"10.1016\/j.toxrep.2026.102222_bib14","first-page":"389","article-title":"Safety evaluation of excessive intake of tea containing quercetin glucosides in healthy adults including obese subjects \uff0da randomized, double-blind, placebo-controlled, parallel-group study\uff0d","volume":"43","author":"Yasutake","year":"2015","journal-title":"Jpn Pharm. Ther."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750026000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750026000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:17:15Z","timestamp":1786533435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750026000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":14,"alternative-id":["S2214750026000247"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2026.102222","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the safety of high-dose Lactobacillus gasseri CP2305 supplementation in healthy adults: A randomized, double-blind, placebo-controlled study","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2026.102222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102222"}}