{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:30:04Z","timestamp":1793651404589,"version":"4.5.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.toxrep.2026.102308","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:25:45Z","timestamp":1783178745000},"page":"102308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis"],"prefix":"10.1016","volume":"17","author":[{"given":"XingLai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2026.102308_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pharmtox-030220-013418","article-title":"Arsenic: a global environmental challenge","volume":"61","author":"Chen","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6493","key":"10.1016\/j.toxrep.2026.102308_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.aba1510","article-title":"Global threat of arsenic in groundwater","volume":"368","author":"Podgorski","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.toxrep.2026.102308_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12011-020-02047-5","article-title":"Effects of essential trace elements and oxidative stress on endemic arsenicosis caused by coal burning in PR China","volume":"198","author":"Hu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.toxrep.2026.102308_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117940","article-title":"Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management","volume":"289","author":"Rahaman","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxrep.2026.102308_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2019.104539","article-title":"Arsenic exposure: A public health problem leading to several cancers","volume":"110","author":"Palma-Lara","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"8","key":"10.1016\/j.toxrep.2026.102308_bib6","doi-asserted-by":"crossref","DOI":"10.1289\/EHP577","article-title":"The association of arsenic metabolism with cancer, cardiovascular disease, and diabetes: a systematic review of the epidemiological evidence","volume":"125","author":"Kuo","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.toxrep.2026.102308_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/toxsci\/kfr184","article-title":"Arsenic exposure and toxicology: a historical perspective","volume":"123","author":"Hughes","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.toxrep.2026.102308_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jat.1649","article-title":"Arsenic: toxicity, oxidative stress and human disease","volume":"31","author":"Jomova","year":"2011","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.toxrep.2026.102308_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","article-title":"Arsenic-induced oxidative stress and its reversibility","volume":"51","author":"Flora","year":"2011","journal-title":"Free. Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.toxrep.2026.102308_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/biom10020235","article-title":"Arsenic toxicity: molecular targets and therapeutic agents","volume":"10","author":"Nurchi","year":"2020","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.toxrep.2026.102308_bib11","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1039\/c3mt00186e","article-title":"Analysis of the biological response of mouse liver exposed to As\u2082O\u2083 based on integrated -omics approaches","volume":"5","author":"Garcia-Sevillano","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.toxrep.2026.102308_bib12","doi-asserted-by":"crossref","first-page":"32518","DOI":"10.1038\/srep32518","article-title":"Integrated proteomics and metabolomics analysis of rat testis: mechanism of arsenic-induced male reproductive toxicity","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxrep.2026.102308_bib13","doi-asserted-by":"crossref","first-page":"37925","DOI":"10.1038\/s41598-025-23396-y","article-title":"A novel spatial framework to validate arsenic exposure gene expression profiling in bladder cancer using multiplex FISH and AI-powered digital pathology","volume":"15","author":"Singhal","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxrep.2026.102308_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140485","article-title":"Identifying biomarkers for arsenic exposure-induced nonalcoholic fatty liver disease: an integrated proteomics, metabolomics, and machine learning approach","volume":"500","author":"Sun","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"12_suppl","key":"10.1016\/j.toxrep.2026.102308_bib15","doi-asserted-by":"crossref","first-page":"S826","DOI":"10.1177\/09603271211045955","article-title":"Arsenic exposure and non-carcinogenic health effects","volume":"40","author":"Martinez-Castillo","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"issue":"12","key":"10.1016\/j.toxrep.2026.102308_bib16","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/acschemneuro.3c00009","article-title":"Proteomic study on the mechanism of arsenic neurotoxicity in the rat cerebral cortex","volume":"14","author":"Zhang","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.toxrep.2026.102308_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118038","article-title":"Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach","volume":"293","author":"Ma","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7783","key":"10.1016\/j.toxrep.2026.102308_bib18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.toxrep.2026.102308_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2025.1636431","article-title":"Arsenic toxicity in the Drosophila brain at single cell resolution","volume":"7","author":"Chaturvedi","year":"2025","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.toxrep.2026.102308_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116913","article-title":"Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen","volume":"284","author":"Ran","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.toxrep.2026.102308_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrg.2018.4","article-title":"Integrative omics for health and disease","volume":"19","author":"Karczewski","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.toxrep.2026.102308_bib22","unstructured":"Suthahar S.S.A., Allard P. Integrative analysis of epigenetic, transcriptomic, and metabolomic responses to arsenic exposure using coupled matrix factorization. bioRxiv. 2025."},{"key":"10.1016\/j.toxrep.2026.102308_bib23","series-title":"Statistical Learning with Sparsity: The Lasso and Generalizations","author":"Hastie","year":"2015"},{"issue":"R1","key":"10.1016\/j.toxrep.2026.102308_bib24","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.toxrep.2026.102308_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119195","article-title":"Multi-omic insight into the causal networks of arsenic-related genes in the pathogenesis of type 2 diabetes mellitus","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxrep.2026.102308_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.aca.2018.08.002","article-title":"statTarget: A streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data","volume":"1036","author":"Luan","year":"2018","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.toxrep.2026.102308_bib27","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.toxrep.2026.102308_bib28","first-page":"4125","article-title":"Oral exposure of arsenic-contaminated soils triggers hepatic ferroptosis via iron dysregulation and glutathione metabolism disruption: From bioavailability to mechanisms","volume":"59","author":"Wang","year":"2025","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.toxrep.2026.102308_bib29","first-page":"112","article-title":"Arsenic-Cadmium co-exposure rewires lipid-iron homeostasis to drive ferroptosis in human proximal tubular cells","volume":"36","author":"Liu","year":"2026","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.toxrep.2026.102308_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139049","article-title":"A translational in vitro to in vivo study on chronic arsenic exposure induced pulmonary ferroptosis and multi-omics analysis of gut-lung axis correlation","volume":"495","author":"Sajid","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.toxrep.2026.102308_bib31","article-title":"Methylseleninic acid elevating the Nrf2-GPX4 axis relieves endothelial dysfunction and ferroptosis induced by arsenic exposure","author":"Cai","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxrep.2026.102308_bib32","article-title":"Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression","volume":"522","author":"Li","year":"2026","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.toxrep.2026.102308_bib33","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3390\/molecules27051495","article-title":"Investigating the neurotoxic impacts of arsenic and the neuroprotective effects of Dictyophora polysaccharide using SWATH-MS-based proteomics","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.toxrep.2026.102308_bib34","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1007\/s12011-022-03466-2","article-title":"Study on the mechanism of arsenic-induced lung injury based on SWATH proteomics technology","volume":"201","author":"Wang","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"6","key":"10.1016\/j.toxrep.2026.102308_bib35","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1007\/s12035-024-04635-1","article-title":"Neurotoxicity of realgar: Crosstalk between UBXD8-DRP1-regulated mitochondrial fission and PINK1-Parkin-mediated mitophagy","volume":"62","author":"Chen","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.toxrep.2026.102308_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109686","article-title":"Mitochondrial metabolism reprogramming-mediated cardiomyocyte senescence involved in arsenic stress-evoked heart failure","volume":"202","author":"Wang","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxrep.2026.102308_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2024.127390","article-title":"Study on the mechanism of arsenic-induced renal injury based on SWATH proteomics technology","volume":"83","author":"Chen","year":"2024","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.toxrep.2026.102308_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.144046","article-title":"A comprehensive review of arsenic-induced neurotoxicity: Exploring the role of glial cell pathways and mechanisms","volume":"372","author":"Garg","year":"2025","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxrep.2026.102308_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s42003-025-09216-z","article-title":"Arsenic promotes ROS-mediated malignant transformation of bronchial epithelial cells by specifically downregulating TXNL1 expression","volume":"8","author":"Zhao","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.toxrep.2026.102308_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.154033","article-title":"Myocardial deposition of aluminum, arsenic, cadmium, and lead accelerates heart failure and alters UPRmt in humans","volume":"511","author":"Svagusa","year":"2025","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.toxrep.2026.102308_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10653-025-02622-6","article-title":"Acute arsenic exposure induces CD4\u207a T cell subpopulations differentiation in spleen and thymus with the involvement of DAMPs-TLR4\/NF-\u03baB signaling pathway","volume":"47","author":"Qi","year":"2025","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.toxrep.2026.102308_bib42","article-title":"Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies","author":"Li","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.toxrep.2026.102308_bib43","article-title":"SILAC-based quantitative proteomic analysis reveals widespread molecular alterations in human skin keratinocytes upon chronic arsenic exposure","author":"Advani","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.toxrep.2026.102308_bib44","article-title":"iTRAQ-based quantitative proteomic analysis reveals important metabolic pathways for arsenic-induced liver fibrosis in rats","author":"Wu","year":"2018","journal-title":"Sci. Rep."},{"issue":"6213","key":"10.1016\/j.toxrep.2026.102308_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258096","article-title":"The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"issue":"7553","key":"10.1016\/j.toxrep.2026.102308_bib46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.toxrep.2026.102308_bib47","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/aoc.590080304","article-title":"Species differences in the metabolism of arsenic compounds","volume":"8","author":"Vahter","year":"1994","journal-title":"Appl. Organomet. Chem."},{"issue":"9822","key":"10.1016\/j.toxrep.2026.102308_bib48","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.toxrep.2026.102308_bib49","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1079\/BJN2000280","article-title":"Selenium in global food systems","volume":"85","author":"Combs","year":"2001","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.toxrep.2026.102308_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.toxrep.2026.102308_bib51","first-page":"630","article-title":"Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial","volume":"11","author":"Duffield-Lillico","year":"2002","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"10","key":"10.1016\/j.toxrep.2026.102308_bib52","first-page":"3846","article-title":"Scientific opinion on dietary reference values for selenium","volume":"12","author":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)","year":"2014","journal-title":"EFSA J."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750026001101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750026001101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:58:48Z","timestamp":1793649528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750026001101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":52,"alternative-id":["S2214750026001101"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2026.102308","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2026.102308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102308"}}