{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:41:21Z","timestamp":1793349681787,"version":"4.5.0"},"reference-count":151,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2012-ADG_20120314"],"award-info":[{"award-number":["ERC-2012-ADG_20120314"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R223-2016-85"],"award-info":[{"award-number":["R223-2016-85"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF 16OC0021616"],"award-info":[{"award-number":["NNF 16OC0021616"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF 0054563"],"award-info":[{"award-number":["NNF 0054563"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Plant Science"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.tplants.2020.05.005","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:10:22Z","timestamp":1593994222000},"page":"985-1004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":398,"title":["Phytocannabinoids: Origins and Biosynthesis"],"prefix":"10.1016","volume":"25","author":[{"given":"Thies","family":"G\u00fclck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger Lindberg","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tplants.2020.05.005_bb0005","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1039\/C6NP00074F","article-title":"Phytocannabinoids: a unified critical inventory","volume":"33","author":"Hanu\u0161","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.tplants.2020.05.005_bb0010","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.plefa.2018.11.016","article-title":"The endocannabinoid system: overview of an emerging multi-faceted therapeutic target","volume":"140","author":"Chanda","year":"2019","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.tplants.2020.05.005_bb0015","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/cbdv.200790144","article-title":"History of cannabis and its preparations in saga, science, and sobriquet","volume":"4","author":"Russo","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.tplants.2020.05.005_bb0020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.lfs.2005.09.011","article-title":"Chemical constituents of marijuana: the complex mixture of natural cannabinoids","volume":"78","author":"ElSohly","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0025","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1055\/s-0042-108058","article-title":"Monitoring metabolite profiles of Cannabis sativa L. trichomes during flowering period using 1H NMR-based metabolomics and real-time PCR","volume":"82","author":"Happyana","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.tplants.2020.05.005_bb0030","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/pcp\/pci166","article-title":"Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes","volume":"46","author":"Sirikantaramas","year":"2005","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0035","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s11101-008-9094-4","article-title":"Secondary metabolism in cannabis","volume":"7","author":"Flores-Sanchez","year":"2008","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.tplants.2020.05.005_bb0040","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.fitote.2018.03.017","article-title":"New chromane and chromene meroterpenoids from flowers of Rhododendron rubiginosum Franch. var. rubiginosum","volume":"127","author":"Yang","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.tplants.2020.05.005_bb0045","doi-asserted-by":"crossref","DOI":"10.1080\/15592324.2017.1422463","article-title":"Daurichromenic acid and grifolic acid: phytotoxic meroterpenoids that induce cell death in cell culture of their producer Rhododendron dauricum","volume":"13","author":"Taura","year":"2018","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.tplants.2020.05.005_bb0050","first-page":"185","article-title":"Some prenylated phenols of Rhododendron adamsii: isolation, modification and pharmacological tests","volume":"17","author":"Rogachev","year":"2009","journal-title":"Chem. Sustain. Dev."},{"key":"10.1016\/j.tplants.2020.05.005_bb0055","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/np900543r","article-title":"Tetracyclic chromane derivatives from Rhododendron anthopogonoides","volume":"73","author":"Iwata","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0060","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1248\/cpb.59.1409","article-title":"New cannabinoid-like chromane and chromene derivatives from Rhododendron anthopogonoides","volume":"59","author":"Iwata","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.tplants.2020.05.005_bb0065","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1021\/np500747y","article-title":"Amorfrutins are natural PPAR\u03b3 agonists with potent anti-inflammatory properties","volume":"78","author":"Fuhr","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.fitote.2017.09.010","article-title":"Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum","volume":"123","author":"Pollastro","year":"2017","journal-title":"Fitoterapia"},{"key":"10.1016\/j.tplants.2020.05.005_bb0075","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3390\/molecules23061353","article-title":"Chemotypes and biomarkers of seven species of new caledonian liverworts from the bazzanioideae subfamily","volume":"23","author":"M\u00e9toyer","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.tplants.2020.05.005_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat2166","article-title":"Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high","volume":"4","author":"Chicca","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tplants.2020.05.005_bb0085","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/chin.200314179","article-title":"New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata","volume":"34","author":"Toyota","year":"2003","journal-title":"ChemInform"},{"key":"10.1016\/j.tplants.2020.05.005_bb0090","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0031-9422(00)90371-6","article-title":"Bibenzyl cannabinoid and bisbibenzyl derivative from the liverwort Radula perrottetii","volume":"37","author":"Toyota","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0095","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s11101-019-09638-8","article-title":"Demystifying the liverwort Radula marginata, a critical review on its taxonomy, genetics, cannabinoid phytochemistry and pharmacology","volume":"18","author":"Hussain","year":"2019","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.tplants.2020.05.005_bb0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ardp.200390008","article-title":"Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin","volume":"336","author":"Hellwig","year":"2003","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.tplants.2020.05.005_bb0105","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.3987\/COM-05-10501","article-title":"Isolation, synthesis and biological activity of grifolic acid dervivatives from the inedible mushroom Albatrellus dispansus","volume":"65","author":"Hashimoto","year":"2005","journal-title":"Heterocycles"},{"key":"10.1016\/j.tplants.2020.05.005_bb0110","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0031-9422(94)85016-X","article-title":"Cannabiorci- and 8-chlorocannabiorcichromenic acid as fungal antagonists from Cylindrocarpon olidum","volume":"37","author":"Quaghebeur","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phytochem.2012.11.001","article-title":"Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR","volume":"87","author":"Happyana","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0120","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000495582","article-title":"Chemical and biological studies of Cannabis sativa roots. Med","volume":"1","author":"Elhendawy","year":"2018","journal-title":"Cannabis Cannabinoids"},{"key":"10.1016\/j.tplants.2020.05.005_bb0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/tpj.14516","article-title":"Cannabis glandular trichomes alter morphology and metabolite content","volume":"101","author":"Livingston","year":"2020","journal-title":"Plant J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0130","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/j.1537-2197.1977.tb11948.x","article-title":"Morphogenesis of capitate glandular hairs of Cannabis sativa (Cannabaceae)","volume":"64","author":"Hammond","year":"1977","journal-title":"Am. J. Bot."},{"key":"10.1016\/j.tplants.2020.05.005_bb0135","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/j.1537-2197.1991.tb14518.x","article-title":"Cuticle development on glandular trichomes of Cannabis sativa (Cannabaceae)","volume":"78","author":"Mahlberg","year":"2017","journal-title":"Am. J. Bot."},{"key":"10.1016\/j.tplants.2020.05.005_bb0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1300\/J237v09n01_04","article-title":"Accumulation of cannabinoids in glandular trichomes of Cannabis (Cannabaceae)","volume":"9","author":"Mahlberg","year":"2004","journal-title":"J. Ind. Hemp"},{"key":"10.1016\/j.tplants.2020.05.005_bb0145","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/jps.2600630705","article-title":"Physicochemical properties, solubility, and protein binding of \u03949-tetrahydrocannabinol","volume":"63","author":"Garrett","year":"1974","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0150","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/aob\/mcl133","article-title":"Structure\u2013function relationships in highly modified shoots of cactaceae","volume":"98","author":"Mauseth","year":"2006","journal-title":"Ann. Bot."},{"key":"10.1016\/j.tplants.2020.05.005_bb0155","first-page":"195","article-title":"Influence of environmental conditions on tetrahydrocannabinol (\u03949-TCH) in different cultivars of Cannabis sativa L","volume":"5","author":"Murari","year":"1983","journal-title":"Electron. J. Environ. Agric. Food Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0305-1978(75)90036-8","article-title":"Photosynthesis and cannabinoid content of temperate and tropical populations of Cannabis sativa","volume":"3","author":"Bazzaz","year":"1975","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0165","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3389\/fpls.2019.00736","article-title":"Impact of N, P, K, and humic acid supplementation on the chemical profile of medical cannabis (Cannabis sativa L)","volume":"10","author":"Bernstein","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0170","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2134\/agronj1975.00021962006700040010x","article-title":"Cannabinoid profile and elemental uptake of Cannabis sativa L. as influenced by soil characteristics","volume":"67","author":"Coffman","year":"1975","journal-title":"Agron. J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0175","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fpls.2019.00296","article-title":"An update on plant photobiology and implications for cannabis production","volume":"10","author":"Eichhorn Bilodeau","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0180","article-title":"The rhododendron leaf scale","volume":"37","author":"Desch","year":"1983","journal-title":"J. Am. Rhododendron Soc."},{"key":"10.1016\/j.tplants.2020.05.005_bb0185","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/BF00987361","article-title":"Role of glandular scales of lepidote rhododendrons in insect resistance","volume":"10","author":"Doss","year":"1984","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0190","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1104\/pp.17.00586","article-title":"Identification and characterization of daurichromenic acid synthase active in anti-HIV biosynthesis","volume":"174","author":"Iijima","year":"2017","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0195","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1021\/acs.jnatprod.6b01046","article-title":"Chemical constituents of bryophytes: structures and biological activity","volume":"81","author":"Asakawa","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0200","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/07352689.2013.765765","article-title":"The oil bodies of liverworts: unique and important organelles in land plants","volume":"32","author":"He","year":"2013","journal-title":"CRC. Crit. Rev. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0205","series-title":"Chemical Constituents of the Hepaticae (Progress in the Chemistry of Organic Natural Products Vol. 42)","author":"Asakawa","year":"1982"},{"key":"10.1016\/j.tplants.2020.05.005_bb0210","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.jnatprod.5b01128","article-title":"Identification of PTP1B and \u03b1-glucosidase inhibitory serrulatanes from Eremophila spp. by combined use of dual high-resolution PTP1B and \u03b1-glucosidase inhibition profiling and HPLC\u2013HRMS\u2013SPE\u2013NMR","volume":"79","author":"Wubshet","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.fitote.2016.02.008","volume":"110","author":"Tahtah","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.tplants.2020.05.005_bb0220","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12870-020-2293-x","article-title":"Biosynthesis of diterpenoids in Eremophila","volume":"20","author":"Gericke","year":"2020","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119302","article-title":"Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum","volume":"10","author":"Matsuba","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tplants.2020.05.005_bb0230","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1086\/595285","article-title":"Effects of de- and rehydration in desiccation-tolerant liverworts: a cytological and physiological study","volume":"170","author":"Pressel","year":"2009","journal-title":"Int. J. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0235","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/BF00390214","article-title":"Lunularic acid, a common endogenous growth inhibitor of liverworts","volume":"97","author":"Pryce","year":"1971","journal-title":"Planta"},{"key":"10.1016\/j.tplants.2020.05.005_bb0240","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0031-9422(00)00454-4","article-title":"Recent advances in phytochemistry of bryophytes-acetogenins, terpenoids and bis(bibenzyl)s from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts","volume":"56","author":"Asakawa","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0245","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1476-5381.2011.01238.x","article-title":"Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects","volume":"163","author":"Russo","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0250","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00515685","article-title":"Microbial transformation of cannabinoids","volume":"5","author":"Binder","year":"1978","journal-title":"Eur. J. Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0255","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00436900","article-title":"Pathogenicity of Phomopsis ganjae on Cannabis sativa and the fungistatic effect of cannabinoids produced by the host","volume":"87","author":"McPartland","year":"1984","journal-title":"Mycopathologia"},{"key":"10.1016\/j.tplants.2020.05.005_bb0260","article-title":"Legal cannabis industry poised for big growth, in North America and around the world","author":"Pellechia","year":"2018","journal-title":"Forbes"},{"key":"10.1016\/j.tplants.2020.05.005_bb0265","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4236\/cm.2012.31010","article-title":"Antimicrobial activity of Cannabis sativa L","volume":"3","author":"Ali","year":"2012","journal-title":"J. Chinese Med."},{"key":"10.1016\/j.tplants.2020.05.005_bb0270","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1021\/np8002673","article-title":"Antibacterial cannabinoids from Cannabis sativa: a structure\u2013activity study","volume":"71","author":"Appendino","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0275","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00399444","article-title":"Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol","volume":"42","author":"Van Klingeren","year":"1976","journal-title":"Antonie Van Leeuwenhoek"},{"key":"10.1016\/j.tplants.2020.05.005_bb0280","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1111\/bph.13250","article-title":"Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor","volume":"172","author":"Laprairie","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0285","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2165\/00003088-200342040-00003","article-title":"Pharmacokinetics and pharmacodynamics of cannabinoids","volume":"42","author":"Grotenhermen","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.tplants.2020.05.005_bb0290","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1476-5381.2010.01166.x","article-title":"Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes","volume":"163","author":"De Petrocellis","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0295","first-page":"294","article-title":"Cannabinoid receptors in the central nervous system: their signaling and roles in disease","volume":"10","author":"Kendall","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0300","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.plantsci.2019.03.022","article-title":"Terpenes in Cannabis sativa \u2013 from plant genome to humans","volume":"284","author":"Booth","year":"2019","journal-title":"Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0305","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0310","doi-asserted-by":"crossref","first-page":"24845","DOI":"10.1074\/jbc.M114.557025","article-title":"Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons","volume":"289","author":"Laprairie","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0315","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/cpt1976196782","article-title":"Effeets of marijuana extract and tetrahydrocannabinol on electroencephalographic sleep patterns","volume":"19","author":"Feinberg","year":"1976","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.tplants.2020.05.005_bb0320","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1208\/s12249-011-9639-5","article-title":"Enhanced solubility, stability, and transcorneal permeability of \u03b4-8-tetrahydrocannabinol in the presence of cyclodextrins","volume":"12","author":"Hippalgaonkar","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.tplants.2020.05.005_bb0325","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/cbdv.200790147","article-title":"Cannabidiol \u2013 recent advances","volume":"4","author":"Mechoulam","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.tplants.2020.05.005_bb0330","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11481-014-9575-8","article-title":"Neuroprotection in experimental autoimmune encephalomyelitis and progressive multiple sclerosis by cannabis-based cannabinoids","volume":"10","author":"Pryce","year":"2015","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0335","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yebeh.2018.05.013","article-title":"Open-label use of highly purified CBD (Epidiolex\u00ae) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes","volume":"86","author":"Devinsky","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.tplants.2020.05.005_bb0340","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1002\/j.1552-4604.2002.tb05998.x","article-title":"Cannabidiol: an overview of some pharmacological aspects","volume":"42","author":"Mechoulam","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0345","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2174\/1570159X17666190603171901","article-title":"Cannabidiol adverse effects and toxicity","volume":"17","author":"Huestis","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0350","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0269881112460109","article-title":"Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment","volume":"27","author":"Englund","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0355","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1021\/np200500p","article-title":"Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa)","volume":"74","author":"Pollastro","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0360","series-title":"Photocannabinoids (Progress in the Chemistry of Organic Natural Products Vol. 103)","first-page":"61","article-title":"Molecular pharmacology of phytocannabinoids","author":"Turner","year":"2017"},{"key":"10.1016\/j.tplants.2020.05.005_bb0365","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tips.2009.07.006","article-title":"Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb","volume":"30","author":"Izzo","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0370","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/j.1476-5381.2012.01879.x","article-title":"Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice","volume":"166","author":"Izzo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0375","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.drugalcdep.2010.05.019","article-title":"Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by \u03949-tetrahydrocannabinol","volume":"112","author":"DeLong","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.tplants.2020.05.005_bb0380","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2013.9","article-title":"The cannabinoid \u03949-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity","volume":"3","author":"Wargent","year":"2013","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.tplants.2020.05.005_bb0385","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jhep.2015.01.001","article-title":"Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis","volume":"62","author":"Silvestri","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0390","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/sj.bjp.0707124","article-title":"The psychoactive plant cannabinoid, \u03949-tetrahydrocannabinol, is antagonized by \u03948- and \u03949-tetrahydrocannabivarin in mice in vivo","volume":"150","author":"Pertwee","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0395","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41467-019-08448-y","article-title":"A cell-free platform for the prenylation of natural products and application to cannabinoid production","volume":"10","author":"Valliere","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tplants.2020.05.005_bb0400","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dc16-0650","article-title":"Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study","volume":"39","author":"Jadoon","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tplants.2020.05.005_bb0405","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1089\/can.2016.0008","article-title":"Can you pass the acid test? Critical review and novel therapeutic perspectives of \u03949-tetrahydrocannabinolic acid A","volume":"1","author":"Moreno-Sanz","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.tplants.2020.05.005_bb0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/can.2016.0032","article-title":"Affinity and efficacy studies of tetrahydrocannabinolic acid A at cannabinoid receptor types one and two","volume":"2","author":"McPartland","year":"2017","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.tplants.2020.05.005_bb0415","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1111\/bph.14019","article-title":"Tetrahydrocannabinolic acid is a potent PPAR\u03b3 agonist with neuroprotective activity","volume":"174","author":"Nadal","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0420","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.intimp.2005.10.002","article-title":"Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways","volume":"6","author":"Verhoeckx","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0425","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1007\/s00213-018-5034-1","article-title":"Effect of cannabidiolic acid and \u22069-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain","volume":"235","author":"Rock","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.tplants.2020.05.005_bb0430","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s12272-011-0913-6","article-title":"The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus","volume":"34","author":"Cluny","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.tplants.2020.05.005_bb0440","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00125-013-2920-2","article-title":"Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPAR\u03b3) agonist with potent glucose-lowering properties","volume":"56","author":"Weidner","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.tplants.2020.05.005_bb0445","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1248\/cpb.50.1390","article-title":"New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata","volume":"50","author":"Toyota","year":"2002","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.tplants.2020.05.005_bb0450","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/znc-1999-3-401","article-title":"Prenylated bibenzyls from the liverwort Radula laxiramea","volume":"54","author":"Cullmann","year":"1999","journal-title":"Z. Naturforsch. C"},{"key":"10.1016\/j.tplants.2020.05.005_bb0455","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3389\/fpls.2016.01452","article-title":"A novel class of plant type III polyketide synthase involved in orsellinic acid biosynthesis from Rhododendron dauricum","volume":"7","author":"Taura","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0460","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1021\/np0303916","article-title":"Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum","volume":"67","author":"Iwata","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0465","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ejmech.2016.07.057","article-title":"Biological importance of structurally diversified chromenes","volume":"123","author":"Costa","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0470","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1021\/np900821e","article-title":"Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach","volume":"73","author":"Lee","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.tplants.2020.05.005_bb0475","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1039\/b508577b","article-title":"A short synthetic route to biologically active (\u00b1)-daurichromenic acid as highly potent anti-HIV agent","volume":"3","author":"Yong Rok Lee","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0480","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41586-019-0978-9","article-title":"Complete biosynthesis of cannabinoids and their unnatural analogues in yeast","volume":"567","author":"Luo","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tplants.2020.05.005_bb0490","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1046\/j.1432-1327.2001.02030.x","article-title":"Biosynthesis of cannabinoids. Incorporation experiments with 13C-labeled glucoses","volume":"268","author":"Fellermeier","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0495","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.plantsci.2019.04.008","article-title":"Cannabinoid synthases and osmoprotective metabolites accumulate in the exudates of Cannabis sativa L. glandular trichomes","volume":"284","author":"Rodziewicz","year":"2019","journal-title":"Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0500","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s10529-018-2545-0","article-title":"Subcellular localization defines modification and production of \u03949-tetrahydrocannabinolic acid synthase in transiently transformed Nicotiana benthamiana","volume":"40","author":"Geissler","year":"2018","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0505","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-313X.2012.04949.x","article-title":"The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes","volume":"71","author":"Stout","year":"2012","journal-title":"Plant J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0510","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.febslet.2009.05.024","article-title":"Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway","volume":"583","author":"Taura","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0515","doi-asserted-by":"crossref","first-page":"12811","DOI":"10.1073\/pnas.1200330109","article-title":"Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides","volume":"109","author":"Gagne","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tplants.2020.05.005_bb0520","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0014-5793(98)00450-5","article-title":"Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol","volume":"427","author":"Fellermeier","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0525","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.febslet.2007.05.043","article-title":"Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa","volume":"581","author":"Taura","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0530","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0031-9422(98)00278-7","article-title":"Purification and characterization of cannabichromenic acid synthase from Cannabis sativa","volume":"49","author":"Morimoto","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0535","doi-asserted-by":"crossref","first-page":"9766","DOI":"10.1021\/ja00143a024","article-title":"First direct evidence for the mechanism of \u03941-tetrahydrocannabinolie acid biosynthesis","volume":"117","author":"Taura","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.tplants.2020.05.005_bb0540","doi-asserted-by":"crossref","first-page":"17411","DOI":"10.1074\/jbc.271.29.17411","article-title":"Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L","volume":"271","author":"Taura","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0545","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1101\/gr.242594.118","article-title":"A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC\/CBD acid synthase locus","volume":"29","author":"Laverty","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.tplants.2020.05.005_bb0555","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.lfs.2005.09.014","article-title":"Natural cannabinoids: templates for drug discovery","volume":"78","author":"Thakur","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0560","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1104\/pp.18.00655","article-title":"An aromatic farnesyltransferase functions in biosynthesis of the anti-HIV meroterpenoid daurichromenic acid","volume":"178","author":"Saeki","year":"2018","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0565","first-page":"1329","article-title":"Daurichromenic acid-producing oxidocyclase in the young leaves of Rhododendron dauricum","volume":"9","author":"Taura","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.tplants.2020.05.005_bb0575","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10600-010-9649-7","article-title":"Phenolic compounds from Rhododendron dauricum from the Baikal region","volume":"46","author":"Olennikov","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.tplants.2020.05.005_bb0580","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1021\/acs.orglett.7b01288","article-title":"Combinatorial biosynthesis of (+)-daurichromenic acid and its halogenated analogue","volume":"19","author":"Okada","year":"2017","journal-title":"Org. Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0585","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3389\/fpls.2018.00537","article-title":"Identification of putative precursor genes for the biosynthesis of cannabinoid-like compound in Radula marginata","volume":"9","author":"Hussain","year":"2018","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0590","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1046\/j.1432-1327.1999.00562.x","article-title":"p-Coumaroyltriacetic acid synthase, a new homologue of chalcone synthase, from Hydrangea macrophylla var. thunbergii","volume":"263","author":"Akiyama","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0595","series-title":"Bryophytes, Their Chemistry and Chemical Taxonomy","author":"Zinsmeister","year":"1990"},{"key":"10.1016\/j.tplants.2020.05.005_bb0600","first-page":"848","article-title":"New stilbene carboxylic acid from Convolvulus hystrix","volume":"55","author":"Dawidar","year":"2000","journal-title":"Pharmazie"},{"key":"10.1016\/j.tplants.2020.05.005_bb0605","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1104\/pp.79.3.751","article-title":"Intracellular localization of lunularic acid and prelunularic acid in suspension cultured cells of Marchantia polymorpha","volume":"79","author":"Imoto","year":"1985","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0610","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1039\/b100917f","article-title":"The chalcone synthase superfamily of type III polyketide synthases","volume":"20","author":"Austin","year":"2003","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.tplants.2020.05.005_bb0615","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/febs.13654","article-title":"Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa","volume":"283","author":"Yang","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0620","series-title":"Cannabis sativa L. \u2013 Botany and Biotechnology","first-page":"285","article-title":"Micropropagation of Cannabis sativa L. \u2013 an update","author":"Lata","year":"2017"},{"key":"10.1016\/j.tplants.2020.05.005_bb0625","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-0043-125087","article-title":"Current perspectives on biotechnological cannabinoid production in plants","volume":"84","author":"Schachtsiek","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.tplants.2020.05.005_bb0630","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11240-019-01635-1","article-title":"Back to the roots: protocol for the photoautotrophic micropropagation of medicinal Cannabis","volume":"138","author":"Kodym","year":"2019","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"10.1016\/j.tplants.2020.05.005_bb0635","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.copbio.2017.07.004","article-title":"Plastid transformation and its application in metabolic engineering","volume":"49","author":"Fuentes","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0640","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1104\/pp.18.00998","article-title":"Reconfigured cyanogenic glucoside biosynthesis in Eucalyptus cladocalyx involves a cytochrome P450 CYP706C55","volume":"178","author":"Hansen","year":"2018","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0645","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1104\/pp.18.00922","article-title":"Elucidation of the amygdalin pathway reveals the metabolic basis of bitter and sweet almonds (Prunus dulcis)","volume":"178","author":"Thodberg","year":"2018","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0650","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/tpj.13247","article-title":"Biosynthesis of the leucine derived \u03b1-, \u03b2- and \u03b3-hydroxynitrile glucosides in barley (Hordeum vulgare L.)","volume":"88","author":"Knoch","year":"2016","journal-title":"Plant J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0655","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10529-017-2492-1","article-title":"The application of plant in vitro cultures in cannabinoid production","volume":"40","author":"Wr\u00f3bel","year":"2018","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0660","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.4236\/ajps.2015.611188","article-title":"Cannabinoids production by hairy root cultures of Cannabis sativa L","volume":"06","author":"Farag","year":"2015","journal-title":"Am. J. Plant Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0665","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.06.022","article-title":"\u03949-Tetrahydrocannabinolic acid synthase: the application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis","volume":"233","author":"Lange","year":"2016","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0670","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1038\/s41467-017-02031-z","article-title":"Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa","volume":"8","author":"Kannangara","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tplants.2020.05.005_bb0675","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nchembio.2263","article-title":"Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase","volume":"13","author":"Chen","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0680","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2191-2858-2-9","article-title":"Four butyrolactones and diverse bioactive secondary metabolites from terrestrial Aspergillus flavipes MM2: isolation and structure determination","volume":"2","author":"Nagia","year":"2012","journal-title":"Org. Med. Chem. Lett."},{"key":"10.1016\/j.tplants.2020.05.005_bb0685","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nature03668","article-title":"Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products","volume":"435","author":"Kuzuyama","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.tplants.2020.05.005_bb0690","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.phytochem.2009.08.023","article-title":"Prenylation of aromatic compounds, a key diversification of plant secondary metabolites","volume":"70","author":"Yazaki","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0695","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/anie.201510650","article-title":"Expanding the landscape of diterpene structural diversity through stereochemically controlled combinatorial biosynthesis","volume":"55","author":"Andersen-Ranberg","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tplants.2020.05.005_bb0700","first-page":"E5223","article-title":"Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis","volume":"114","author":"Ban","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.tplants.2020.05.005_bb0705","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.phytochem.2009.01.013","article-title":"Substrate specificities of family 1 UGTs gained by domain swapping","volume":"70","author":"Hansen","year":"2009","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0710","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.3390\/md13074044","article-title":"Biological activity of recently discovered halogenated marine natural products","volume":"13","author":"Gribble","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.tplants.2020.05.005_bb0715","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1104\/pp.111.178426","article-title":"Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology?","volume":"156","author":"Choi","year":"2011","journal-title":"Plant Physiol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0720","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2015.03.123","article-title":"Tailoring properties of natural deep eutectic solvents with water to facilitate their applications","volume":"187","author":"Dai","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.tplants.2020.05.005_bb0725","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1002\/anie.201702486","article-title":"The effect of water upon deep eutectic solvent nanostructure: an unusual transition from ionic mixture to aqueous solution","volume":"56","author":"Hammond","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.tplants.2020.05.005_bb0730","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1039\/C8NP00037A","article-title":"Dynamic metabolic solutions to the sessile life style of plants","volume":"35","author":"Knudsen","year":"2018","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.tplants.2020.05.005_bb0735","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1021\/ar200294y","article-title":"Aqueous phase separation as a possible route to compartmentalization of biological molecules","volume":"45","author":"Keating","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.tplants.2020.05.005_bb0740","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cis.2016.06.011","article-title":"Experimental models for dynamic compartmentalization of biomolecules in liquid organelles: reversible formation and partitioning in aqueous biphasic systems","volume":"239","author":"Aumiller","year":"2017","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.tplants.2020.05.005_bb0745","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tplants.2020.05.005_bb0750","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.15252\/embj.201593517","article-title":"Droplet organelles?","volume":"35","author":"Courchaine","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0755","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aca.2012.12.019","article-title":"Natural deep eutectic solvents as new potential media for green technology","volume":"766","author":"Dai","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.tplants.2020.05.005_bb0760","doi-asserted-by":"crossref","first-page":"112214","DOI":"10.1016\/j.phytochem.2019.112214","article-title":"Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent","volume":"170","author":"Knudsen","year":"2020","journal-title":"Phytochemistry"},{"key":"10.1016\/j.tplants.2020.05.005_bb0765","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/medicines6010003","article-title":"Medicinal cannabis \u2013 potential drug interactions","volume":"6","author":"Alsherbiny","year":"2018","journal-title":"Medicines"},{"key":"10.1016\/j.tplants.2020.05.005_bb0770","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-313X.2004.02275.x","article-title":"Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana","volume":"41","author":"Richman","year":"2005","journal-title":"Plant J."},{"key":"10.1016\/j.tplants.2020.05.005_bb0775","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1126\/science.1081288","article-title":"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice: the rice full-length cDNA consortium","volume":"301","author":"Kikuchi","year":"2003","journal-title":"Science"}],"container-title":["Trends in Plant Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1360138520301874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1360138520301874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:31:16Z","timestamp":1778603476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1360138520301874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":151,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1360138520301874"],"URL":"https:\/\/doi.org\/10.1016\/j.tplants.2020.05.005","relation":{},"ISSN":["1360-1385"],"issn-type":[{"value":"1360-1385","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytocannabinoids: Origins and Biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Trends in Plant Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tplants.2020.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}