{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:43:13Z","timestamp":1775072593015,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Clinique et Biologique"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.tracli.2020.12.002","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T12:35:47Z","timestamp":1607430947000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of red blood cell transfusion on peripheral tissue oxygen delivery and consumption in septic patients"],"prefix":"10.1016","volume":"28","author":[{"given":"L.C.","family":"Nicolescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Nicolescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Mihu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Balta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tracli.2020.12.002_bib0220","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.3390\/s17081798","article-title":"Current status of HbA1c biosensors","volume":"17","author":"Lin","year":"2017","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.tracli.2020.12.002_bib0225","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.1537-2995.2011.03099.x","article-title":"Microparticles in stored red blood cells as potential mediators of transfusion complications","volume":"51","author":"Jy","year":"2011","journal-title":"Transfusion"},{"key":"10.1016\/j.tracli.2020.12.002_bib0230","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1182\/asheducation-2011.1.475","article-title":"Vascular effects of the red blood cell storage lesion","volume":"2011","author":"Roback","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.tracli.2020.12.002_bib0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ccc.2003.12.002","article-title":"Efficacy of red blood cell transfusion in the critically ill","volume":"20","author":"Napolitano","year":"2004","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcb.10060","article-title":"Molecular recognition: identifying compounds and their targets","volume":"Suppl 37","author":"Fernandes","year":"2001","journal-title":"J Cell Biochem Suppl"},{"key":"10.1016\/j.tracli.2020.12.002_bib0245","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1016\/j.biomaterials.2005.05.063","article-title":"Fibrinogen surface distribution correlates to platelet adhesion pattern on fluorinated surface-modified polyetherurethane","volume":"26","author":"Massa","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.tracli.2020.12.002_bib0250","doi-asserted-by":"crossref","first-page":"S542","DOI":"10.1097\/01.CCM.0000145906.63859.1A","article-title":"Use of blood products in sepsis: an evidence-based review","volume":"32","author":"Zimmerman","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0255","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0885066612452838","article-title":"Red cell distribution width and outcome in patients with septic shock","volume":"28","author":"Sadaka","year":"2013","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0260","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1557\/mrs2010.571","article-title":"Shape and biomechanical characteristics of human red blood cells in health and disease","volume":"35","author":"Diez-Silva","year":"2010","journal-title":"MRS Bull"},{"key":"10.1016\/j.tracli.2020.12.002_bib0265","first-page":"91","article-title":"Evaluating hypoxemia in critically ill","volume":"20","author":"Duarte","year":"2005","journal-title":"Crit Illness"},{"key":"10.1016\/j.tracli.2020.12.002_bib0270","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1378\/chest.129.1.210","article-title":"Permissive hypoxemia. Is it time to change our approach?","volume":"129","author":"Abdelsalam","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.tracli.2020.12.002_bib0275","doi-asserted-by":"crossref","first-page":"S678","DOI":"10.1097\/01.CCM.0000100124.50579.D9","article-title":"Risks of blood transfusion","volume":"31","author":"Goodnough","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0280","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ccc.2009.12.001","article-title":"Detection of hypoxia at cellular level","volume":"26","author":"Loiacono","year":"2010","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0285","first-page":"219","article-title":"Mitochondrial dysfunction and resuscitation in sepsis","volume":"17","author":"Rugierri","year":"2010","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0290","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/00000542-200610000-00029","article-title":"Clinical implications of mitochondrial dysfunction","volume":"105","author":"Muravchick","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tracli.2020.12.002_bib0295","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/01.CCM.0000282072.56245.91","article-title":"Mechanisms of sepsis-induced organ dysfunction","volume":"35","author":"Abraham","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0300","first-page":"29","article-title":"Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically ill trauma patients","volume":"67","author":"Kiraly","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.tracli.2020.12.002_bib0305","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jemermed.2012.01.038","article-title":"Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock","volume":"43","author":"Fuller","year":"2012","journal-title":"J Emerg Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0310","series-title":"epoc System Manual","author":"Epocal","year":"2006"},{"key":"10.1016\/j.tracli.2020.12.002_bib0315","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1309\/AJCP7QB3QQIBZPEK","article-title":"Analytical and clinical performance of the epoc blood analysis system: experience at a Large TertiaryAcademic Medical Center","volume":"140","author":"Stotler","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.tracli.2020.12.002_bib0320","doi-asserted-by":"crossref","first-page":"e0122655","DOI":"10.1371\/journal.pone.0122655","article-title":"Plasma free hemoglobin and microcirculatory response to fresh and old blood transfusion in sepsis","volume":"10","author":"Damiani","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tracli.2020.12.002_bib0325","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1001\/jama.1993.03500230106037","article-title":"Effect of stored-blood transfusion on oxygen delivery in patients with sepsis","volume":"269","author":"Marick","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.tracli.2020.12.002_bib0330","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00000542-200508000-00007","article-title":"Trends but not individual values of central venous oxygen saturation agree with mixed venous saturation during varying hemodynamic conditions","volume":"103","author":"Dueck","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tracli.2020.12.002_bib0335","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM199902113400601","article-title":"Amulticenter,randomized, controlled clinical trial of transfusion requirement in critical care","volume":"6","author":"Herbert","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0340","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.annemergmed.2009.08.014","article-title":"Multicenter study of central venous oxygen saturation (Scvo2) as a predictor of mortality in patients with sepsis","volume":"55","author":"Pope","year":"2010","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0345","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ccc.2009.12.006","article-title":"Optimizing hemodynamic support in septic shock using central venous and mixed venous oxygen saturation","volume":"26","author":"Maddirala","year":"2010","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0350","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00003246-200107000-00008","article-title":"Tissue oxygenation and perfusion in patients with systemic sepsis","volume":"29","author":"Sair","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0355","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s002689910104","article-title":"Sequential metabolic changes following induction of systemic inflammatory response with severe sepsis or major blunt trauma","volume":"24","author":"Plank","year":"2000","journal-title":"World J Surg"},{"key":"10.1016\/j.tracli.2020.12.002_bib0360","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/cc8854","article-title":"Venous oxygen saturation as a physiologic trigger transfusion","volume":"14","author":"Vallet","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.tracli.2020.12.002_bib0365","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0268-960X(03)00018-3","article-title":"Anaemia and red cell transfusion in the critically ill patient","volume":"17","author":"McLellan","year":"2003","journal-title":"Blood Rev"},{"key":"10.1016\/j.tracli.2020.12.002_bib0370","first-page":"381","article-title":"Oxygen extraction and perfusion markers in severe sepsis and septic shock: diagnostic, therapeutic and outcome implications","volume":"21","author":"Rivers","year":"2015","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.tracli.2020.12.002_bib0375","first-page":"261","volume":"49","author":"Park","year":"2015","journal-title":"Initial low oxygen extraction ratio is related to severe organ dysfunction and high in-hospital mortality in severe sepsis and septic shock patients"},{"key":"10.1016\/j.tracli.2020.12.002_bib0380","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ccc.2010.12.013","article-title":"Lactate: biomarker and potential therapeutic agent","volume":"27","author":"Okorie","year":"2011","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0385","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00005373-199310000-00014","article-title":"Lactate clearance and survival following injury","volume":"35","author":"Abramson","year":"1993","journal-title":"J Trauma"},{"key":"10.1016\/j.tracli.2020.12.002_bib0390","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1378\/chest.15-1703","article-title":"Lactic acidosis in sepsis: it's not all anaerobic: implications for diagnosis and management","volume":"149","author":"Suetrong","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.tracli.2020.12.002_bib0395","first-page":"2924","article-title":"Lactate production under fully aerobic conditions: the lactate shuttle during rest and execise","volume":"45","author":"Brooks","year":"1986","journal-title":"Fed Proc"},{"key":"10.1016\/j.tracli.2020.12.002_bib0400","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism:a new paradigm for third millennium","volume":"558","author":"Gladden","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.tracli.2020.12.002_bib0405","series-title":"Bioenergetics","first-page":"16","author":"Lehninger","year":"1965"},{"key":"10.1016\/j.tracli.2020.12.002_bib0410","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0749-0704(05)70161-5","article-title":"Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contribuiting to organ dysfunction in sepsis","volume":"17","author":"Fink","year":"2001","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0415","first-page":"628","article-title":"Potential dysregulation of the pyruvate dehidrogenase complex by bacterial toxins and insulin","volume":"67","author":"Thomas","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.tracli.2020.12.002_bib0420","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ccc.2003.12.006","article-title":"Clinical consequences of anemia and red cell transfusion in the critically ill","volume":"20","author":"Hebert","year":"2004","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.tracli.2020.12.002_bib0425","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.tracli.2020.12.002_bib0430","doi-asserted-by":"crossref","first-page":"ii11","DOI":"10.1093\/jac\/dkq515","article-title":"Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective)","volume":"66","author":"Daniels","year":"2011","journal-title":"J Antimicrob Chemother"}],"container-title":["Transfusion Clinique et Biologique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1246782020301658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1246782020301658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:39:12Z","timestamp":1761129552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1246782020301658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1246782020301658"],"URL":"https:\/\/doi.org\/10.1016\/j.tracli.2020.12.002","relation":{},"ISSN":["1246-7820"],"issn-type":[{"value":"1246-7820","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of red blood cell transfusion on peripheral tissue oxygen delivery and consumption in septic patients","name":"articletitle","label":"Article Title"},{"value":"Transfusion Clinique et Biologique","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tracli.2020.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Soci\u00e9t\u00e9 fran\u00e7aise de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}