{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T22:00:06Z","timestamp":1779400806095,"version":"3.53.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Shanghai Pujiang Program","award":["16PJ1406200"],"award-info":[{"award-number":["16PJ1406200"]}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"crossref","award":["15ZZ060"],"award-info":[{"award-number":["15ZZ060"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.tranon.2018.06.009","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T13:42:49Z","timestamp":1531143769000},"page":"1065-1073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular Imaging of Pancreatic Duct Adenocarcinoma Using a Type 2 Cannabinoid Receptor-Targeted Near-Infrared Fluorescent Probe"],"prefix":"10.1016","volume":"11","author":[{"given":"Xiaoxia","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-1955","authenticated-orcid":false,"given":"Xiaoxi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2018.06.009_bb0005","first-page":"7","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.tranon.2018.06.009_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0140-6736(16)00141-0","article-title":"Pancreatic cancer","volume":"388","author":"Kamisawa","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.tranon.2018.06.009_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000267","article-title":"Preoperative\/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages","volume":"7","author":"Gillen","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.tranon.2018.06.009_bb0020","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/SLA.0b013e318263da2f","article-title":"Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a \"true\" R0 resection?","volume":"257","author":"Konstantinidis","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.tranon.2018.06.009_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2217\/fon.12.175","article-title":"Is there a 'margin' for error in pancreatic cancer surgery?","volume":"9","author":"Frampton","year":"2013","journal-title":"Future Oncol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.2012.569","article-title":"Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer","volume":"108","author":"Provenzano","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.tranon.2018.06.009_bb0035","first-page":"318","article-title":"Recent progress in pancreatic cancer","volume":"63","author":"Wolfgang","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.tranon.2018.06.009_bb0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2017.09.016","article-title":"Speeding towards individualized treatment for pancreatic cancer by taking an alternative road","volume":"410","author":"Iovanna","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.tranon.2018.06.009_bb0045","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/gutjnl-2012-302577","article-title":"Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions","volume":"62","author":"Neesse","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.tranon.2018.06.009_bb0050","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2967\/jnumed.113.129619","article-title":"Multimodal molecular imaging of integrin alphavbeta3 for in vivo detection of pancreatic cancer","volume":"55","author":"Trajkovic-Arsic","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.tranon.2018.06.009_bb0055","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/acs.molpharmaceut.6b01123","article-title":"ImmunoPET and near-infrared fluorescence imaging of pancreatic cancer with a dual-labeled bispecific antibody fragment","volume":"14","author":"Luo","year":"2017","journal-title":"Mol Pharm"},{"key":"10.1016\/j.tranon.2018.06.009_bb0060","article-title":"Dendron-grafted polylysine-based dual-modal nanoprobe for ultra-early diagnosis of pancreatic precancerosis via targeting a urokinase-type plasminogen activator receptor","volume":"7","author":"Li","year":"2017","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.tranon.2018.06.009_bb0065","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1245\/s10434-018-6344-6","article-title":"Tumor-specific labeling of pancreatic cancer using a humanized anti-CEA antibody conjugated to a near-infrared fluorophore","volume":"25","author":"Lwin","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0070","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1158\/0008-5472.CAN-14-1656","article-title":"Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography","volume":"74","author":"Hudson","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.tranon.2018.06.009_bb0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.drudis.2016.08.005","article-title":"Targeting the endocannabinoid system: future therapeutic strategies","volume":"22","author":"Aizpurua-Olaizola","year":"2017","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.tranon.2018.06.009_bb0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2018.06.009_bb0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2018.06.009_bb0090","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMra1402309","article-title":"Adverse health effects of marijuana use","volume":"370","author":"Volkow","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tranon.2018.06.009_bb0095","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.biopsych.2014.04.009","article-title":"Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal","volume":"77","author":"Deng","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.tranon.2018.06.009_bb0100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"Galiegue","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0105","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1158\/0008-5472.CAN-06-0169","article-title":"Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes","volume":"66","author":"Carracedo","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.tranon.2018.06.009_bb0110","doi-asserted-by":"crossref","first-page":"e664","DOI":"10.1038\/cddis.2013.151","article-title":"Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells","volume":"4","author":"Dando","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.tranon.2018.06.009_bb0115","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/cdd.2011.32","article-title":"Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy","volume":"18","author":"Vara","year":"2011","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.tranon.2018.06.009_bb0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI200316116","article-title":"Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors","volume":"111","author":"Casanova","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tranon.2018.06.009_bb0125","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1021\/acs.jmedchem.5b00078","article-title":"Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer","volume":"58","author":"Morales","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0130","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2174\/156802610793176819","article-title":"Non-invasive imaging of the type 2 cannabinoid receptor, focus on positron emission tomography","volume":"10","author":"Evens","year":"2010","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0135","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1021\/acs.molpharmaceut.7b00746","article-title":"From structure-activity relationships on thiazole derivatives to the in vivo evaluation of a new radiotracer for cannabinoid subtype 2 PET imaging","volume":"14","author":"Caille","year":"2017","journal-title":"Mol Pharm"},{"key":"10.1016\/j.tranon.2018.06.009_bb0140","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1016\/j.bmc.2011.06.033","article-title":"Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging","volume":"19","author":"Evens","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0145","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.cbpa.2003.08.007","article-title":"In vivo near-infrared fluorescence imaging","volume":"7","author":"Frangioni","year":"2003","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0150","article-title":"Molecular imaging of human tumor cells that naturally overexpress type 2 cannabinoid receptors using a quinolone-based near-infrared fluorescent probe","volume":"19","author":"Wu","year":"2014","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.tranon.2018.06.009_bb0155","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/bc400328m","article-title":"In vivo type 2 cannabinoid receptor-targeted tumor optical imaging using a near infrared fluorescent probe","volume":"24","author":"Zhang","year":"2013","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0160","article-title":"Targeted zwitterionic near infrared fluorescent probe for improved imaging of type 2 cannabinoid receptors","volume":"19","author":"Wu","year":"2014","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.tranon.2018.06.009_bb0165","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biomaterials.2015.04.018","article-title":"A novel near-infrared fluorescence imaging probe that preferentially binds to cannabinoid receptors CB2R over CB1R","volume":"57","author":"Ling","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.tranon.2018.06.009_bb0170","doi-asserted-by":"crossref","DOI":"10.1177\/1536012115624917","article-title":"Immunotargeting of integrin alpha6beta4 for single-photon emission computed tomography and near-infrared fluorescence imaging in a pancreatic cancer model","volume":"15","author":"Aung","year":"2016","journal-title":"Mol Imaging"},{"key":"10.1016\/j.tranon.2018.06.009_bb0175","doi-asserted-by":"crossref","first-page":"9751","DOI":"10.1021\/jm301002f","article-title":"Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy","volume":"55","author":"Huynh","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.tranon.2018.06.009_bb0180","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/cgt.2013.9","article-title":"Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy","volume":"20","author":"Camp","year":"2013","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.tranon.2018.06.009_bb0185","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nnano.2012.237","article-title":"Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface","volume":"8","author":"Salvati","year":"2013","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057522","article-title":"Inhibiting the growth of pancreatic adenocarcinoma in vitro and in vivo through targeted treatment with designer gold nanotherapeutics","volume":"8","author":"Kudgus","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.tranon.2018.06.009_bb0195","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4161\/cbt.13.4.18692","article-title":"RGD-conjugated albumin nanoparticles as a novel delivery vehicle in pancreatic cancer therapy","volume":"13","author":"Ji","year":"2012","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.tranon.2018.06.009_bb0200","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/ijc.23114","article-title":"Cannabinoids in pancreatic cancer: correlation with survival and pain","volume":"122","author":"Michalski","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.tranon.2018.06.009_bb0205","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.chembiol.2014.01.009","article-title":"Target-selective phototherapy using a ligand-based photosensitizer for type 2 cannabinoid receptor","volume":"21","author":"Zhang","year":"2014","journal-title":"Chem Biol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11481-012-9430-8","article-title":"Differential expression of intracellular and extracellular CB(2) cannabinoid receptor protein by human peripheral blood leukocytes","volume":"8","author":"Castaneda","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0215","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1124\/mol.111.074013","article-title":"Functional selectivity in CB2 cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB2 ligands","volume":"81","author":"Atwood","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0220","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.mce.2010.07.010","article-title":"Regulation of GPCR signal networks via membrane trafficking","volume":"331","author":"Jean-Alphonse","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.tranon.2018.06.009_bb0225","first-page":"246","article-title":"In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe","volume":"5","author":"Zhang","year":"2015","journal-title":"Am J Nucl Med Mol Imaging"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523318301827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523318301827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:33:16Z","timestamp":1761834796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523318301827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1936523318301827"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2018.06.009","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Imaging of Pancreatic Duct Adenocarcinoma Using a Type 2 Cannabinoid Receptor-Targeted Near-Infrared Fluorescent Probe","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2018.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.","name":"copyright","label":"Copyright"}]}}