{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:44:21Z","timestamp":1789080261341,"version":"build-2803163510"},"reference-count":155,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.tranon.2021.101058","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T10:58:54Z","timestamp":1615114734000},"page":"101058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-4468","authenticated-orcid":false,"given":"Yenddy N.","family":"Carrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana E.","family":"Callejas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas A.","family":"Mosquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2021.101058_bib0001","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/182073","article-title":"Challenges and opportunities to im-prove cervical cancer screening rates in US Heath centers through patient-centered medical home transformation","volume":"2015","author":"Moshkovich","year":"2015","journal-title":"Adv. Prev. Med."},{"key":"10.1016\/j.tranon.2021.101058_bib0002","first-page":"1004","article-title":"Vital signs: cervical cancer incidence, mortality, and screening \u2013 United States, 2007- 2012","volume":"63","author":"Benard","year":"2014","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.tranon.2021.101058_bib0003","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.tranon.2021.101058_bib0004","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2021.101058_bib0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0006","first-page":"184","article-title":"Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism","volume":"60","author":"Jaiswal","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.tranon.2021.101058_bib0007","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.ajpath.2012.08.044","article-title":"Matrix metalloproteinases: changing roles in tumor progression and metastasis","volume":"181","author":"Shuman-Moss","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tranon.2021.101058_bib0008","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1111\/j.1440-1746.2010.06428.x","article-title":"Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta- analysis","volume":"25","author":"Xue","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0009","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jlb.67.1.53","article-title":"The tumorigenic and angiogenic effects of MGSA\/GRO proteins in melanoma","volume":"67","author":"Haghnegahdar","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tranon.2021.101058_bib0010","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc1388","article-title":"Cancer and the chemokine network","volume":"4","author":"Balkwill","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0011","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2021.101058_bib0012","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nri3191","article-title":"Adoptive immunotherapy for cancer: harnessing the T cell response","volume":"12","author":"Restifo","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0013","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1053\/j.gastro.2009.10.057","article-title":"Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer","volume":"138","author":"Mlecnik","year":"2010","journal-title":"Gastroenterology"},{"issue":"20","key":"10.1016\/j.tranon.2021.101058_bib0014","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1158\/0008-5472.CAN-11-0952","article-title":"Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer","volume":"71","author":"de Chaisemartin","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.tranon.2021.101058_bib0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrc1586","article-title":"Immunosuppressive networks in the tumour environment and their therapeutic relevance","volume":"5","author":"Zou","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.tranon.2021.101058_bib0016","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tranon.2021.101058_bib0017","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.immunol.26.021607.090331","article-title":"PD-1 and its ligands in tolerance and immunity","volume":"26","author":"Keir","year":"2008","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.tranon.2021.101058_bib0018","first-page":"1021","article-title":"An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papilloma virus (HPV)","volume":"10","author":"Castle","year":"2001","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.tranon.2021.101058_bib0019","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1172\/JCI59889","article-title":"The molecular pathogenesis of head and neck squamous cell carcinoma","volume":"122","author":"Rothenberg","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2021.101058_bib0020","first-page":"80","article-title":"Review of HPV-related diseases and cancers","volume":"40","author":"Brianti","year":"2017","journal-title":"New. Microbiol."},{"key":"10.1016\/j.tranon.2021.101058_bib0021","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tim.2017.07.007","article-title":"The HPV E6\/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets","volume":"26","author":"Hoppe-Seyler","year":"2018","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.tranon.2021.101058_bib0022","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13669-015-0134-y","article-title":"Immunology of HPV Infection","volume":"4","author":"Stanley","year":"2015","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"10.1016\/j.tranon.2021.101058_bib0023","first-page":"243","article-title":"Cancer Immunology and HPV. Recent Results","volume":"206","author":"Wollenberg","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.tranon.2021.101058_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/540850","article-title":"HPV infection: immunological aspects and their utility in future therapy","volume":"2013","author":"Deligeoroglou","year":"2013","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"10.1016\/j.tranon.2021.101058_bib0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1034\/j.1600-065X.2002.18816.x","article-title":"Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes","volume":"188","author":"Melief","year":"2002","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tranon.2021.101058_bib0026","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1128\/JVI.77.9.5464-5474.2003","article-title":"Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein","volume":"77","author":"Nilges","year":"2003","journal-title":"J, Virol"},{"key":"10.1016\/j.tranon.2021.101058_bib0027","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1158\/1078-0432.CCR-16-0423","article-title":"Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells","volume":"22","author":"Choi","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tranon.2021.101058_bib0028","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/1066896909343435","article-title":"Abnormal immunoexpression of cell adhesion molecules (CAMs) in cervical cancer","volume":"19","author":"de M\u00e9ndez","year":"2011","journal-title":"Int. J. Surg. Pathol."},{"key":"10.1016\/j.tranon.2021.101058_bib0029","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/GCO.0b013e32831a9890","article-title":"Host immune responses to cervical cancer","volume":"21","author":"Patel","year":"2009","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.tranon.2021.101058_bib0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/mi.2008.33","article-title":"Evolving immunosuppressive microenvironment during human cervical carcinog\u00e9nesis","volume":"1","author":"Kobayashi","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.tranon.2021.101058_bib0031","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1128\/JVI.77.15.8378-8385.2003","article-title":"Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin","volume":"77","author":"Matthews","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.tranon.2021.101058_bib0032","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1586\/14737159.2015.1012068","article-title":"Natural history of high-grade cervical intraepithelial neoplasia: a review of prognostic biomarkers","volume":"15","author":"Koeneman","year":"2015","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.tranon.2021.101058_bib0033","article-title":"Molecular landscape of recurrent cervical cancer","volume":"157","author":"Adiga","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.tranon.2021.101058_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.102985","article-title":"Radiomics in cervical cancer: Current applications and future potential","volume":"152","author":"Ai","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0035","first-page":"746","article-title":"DNA methylation markers as triage test for the early identification of cervical lesions in a Chinese population","volume":"144","author":"Li","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"18","key":"10.1016\/j.tranon.2021.101058_bib0036","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2217\/epi-2019-0331","article-title":"Evaluation of six methylation markers derived from genome-wide screens for detection of cervical precancer and cancer","volume":"12","author":"Dick","year":"2020","journal-title":"Epigenomics"},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0037","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/cyt.12943","article-title":"DNA ploidy measurement and human papillomavirus in abnormal cervical cytology","volume":"32","author":"Costa","year":"2021","journal-title":"Cytopathology"},{"key":"10.1016\/j.tranon.2021.101058_bib0038","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.3390\/jcm9113668","article-title":"MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer","volume":"9","author":"Pisarska","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tranon.2021.101058_bib0039","article-title":"Long noncoding RNAs (lncRNAs) in cervical carcinogenesis: New molecular targets, current prospects","volume":"156","author":"de Carvalho Galv\u00e3o","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.tranon.2021.101058_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103192","article-title":"Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles","volume":"157","author":"Razavi","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.tranon.2021.101058_bib0041","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.2147\/CMAR.S273079","article-title":"Evaluating the Performance of p16 INK4a Immunocytochemistry in Cervical Cancer Screening","volume":"12","author":"Song","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.tranon.2021.101058_bib0042","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","article-title":"Cervical Cancer","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0043","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","article-title":"Cytokines and CNS Development","volume":"64","author":"Deverman","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.tranon.2021.101058_bib0044","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1476-5381.2009.00206.x","article-title":"Current status and challenges of cytokine pharmacology","volume":"157","author":"Z\u00eddek","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.tranon.2021.101058_bib0045","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI36130","article-title":"The cytokine network in asthma and chronic obstructive pulmonary disease","volume":"118v","author":"Barnes","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2021.101058_bib0046","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cyto.2008.07.014","article-title":"Cytokines as a key component of cancer-related inflammation","volume":"43","author":"Germano","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.tranon.2021.101058_bib0047","doi-asserted-by":"crossref","first-page":"ftz048","DOI":"10.1093\/femspd\/ftz048","article-title":"Association of Human Papillomavirus Infection and Inflammation in Cervical Cancer","volume":"77","author":"Hemmat","year":"2019","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.tranon.2021.101058_bib0048","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000445161","article-title":"Cytokines of cervical mucosa and human papilloma virus infection of the cervix: A descriptive study","volume":"60","author":"Daniilidis","year":"2016","journal-title":"Acta Cytol"},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0049","doi-asserted-by":"crossref","first-page":"753","DOI":"10.5306\/wjco.v5.i4.753","article-title":"Role of IL-10 and TGF-\u03b21 in local immunosuppression in HPV-associated cervical neoplasia","volume":"5","author":"Torres-Poveda","year":"2014","journal-title":"World J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0050","first-page":"5","article-title":"[Gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and interleukins 2, 4 and 6 (IL-2, IL-4, IL-6) in cervical-uterine cells of intraepithelial neoplasia: a preliminary report]","volume":"46","author":"Pardo-Govea","year":"2005","journal-title":"Invest. Clin."},{"key":"10.1016\/j.tranon.2021.101058_bib0051","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/cyto.2001.0909","article-title":"Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia","volume":"14","author":"Tjiong","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.tranon.2021.101058_bib0052","first-page":"3604","article-title":"Imbalance of Th1\/Th2 and Th17\/Treg during the development of uterine cervical cancer","volume":"12","author":"Lin","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.tranon.2021.101058_bib0053","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.eimc.2014.05.014","article-title":"[Expression of gamma interferon during HPV and chlamydia trachomatis infection in cervical samples]","volume":"33","author":"Col\u00edn-Ferreyra","year":"2015","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.tranon.2021.101058_bib0054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13000-015-0254-8","article-title":"Accumulation of invariant NKT cells with increased IFN-\u03b3 production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia","volume":"10","author":"Hu","year":"2015","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.tranon.2021.101058_bib0055","first-page":"294","article-title":"Dynamics of cervical langerhans cell counts in the course of HPV-positive CIN treatment with the use of human recombinant interferon gamma","volume":"26","author":"Sikorski","year":"2005","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0056","first-page":"147","article-title":"Recombinant human interferon gamma in the treatment of cervical intraepithelial neoplasia (CIN) associated with human papillomavirus (HPV) infection","volume":"24","author":"Sikorski","year":"2003","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0057","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/imr.12614","article-title":"IL-1 and IL-1 regulatory pathways in cancer progression and therapy","volume":"281","author":"Mantovani","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.tranon.2021.101058_bib0058","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2021.101058_bib0059","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/OLQ.0b013e318255aeef","article-title":"Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation","volume":"39","author":"Mhatre","year":"2012","journal-title":"Sex Transm. Dis."},{"issue":"11","key":"10.1016\/j.tranon.2021.101058_bib0060","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.neo.2014.09.003","article-title":"Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through interleukin-1\u03b1 induces cancer progression","volume":"16","author":"Bae","year":"2014","journal-title":"Neoplasia"},{"key":"10.1016\/j.tranon.2021.101058_bib0061","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/IGC.0000000000000165","article-title":"Interleukin 1b and interleukin 1 receptor antagonist gene polymorphisms and cervical cancer: a meta-analysis","volume":"24","author":"Wu","year":"2014","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0062","first-page":"2715","article-title":"Reduced expression of IL-1\u03b2 and IL-18 proinflammatory interleukins increases the risk of developing cervical cancer. Asian Pac","volume":"20","author":"Matamoros","year":"2019","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.tranon.2021.101058_bib0063","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.immunol.26.021607.090357","article-title":"The biology of interleukin-2","volume":"26","author":"Malek","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tranon.2021.101058_bib0064","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/14740338.2017.1382472","article-title":"High-dose interleukin-2 (IL-2) for the treatment of melanoma: safety considerations and future directions","volume":"16","author":"Marabondo","year":"2017","journal-title":"Expert. Opin. Drug Saf."},{"key":"10.1016\/j.tranon.2021.101058_bib0065","first-page":"533","article-title":"Increased IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of uterine cervix","volume":"49","author":"Mindioli","year":"2008","journal-title":"Invest. Clin."},{"key":"10.1016\/j.tranon.2021.101058_bib0066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12905-019-0806-2","article-title":"Difference in vaginal microecology, local immunity and HPV infection among childbearing-age women with different degrees of cervical lesions in Inner Mongolia","volume":"19","author":"Zheng","year":"2019","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.tranon.2021.101058_bib0067","first-page":"5543","article-title":"Association between interleukin-2, interleukin-10, secretory immunoglobulin A and immunoglobulin G expression in vaginal fluid and human papilloma virus outcome in patients with cervical lesions","volume":"18","author":"Meng","year":"2019","journal-title":"Oncol. Letters"},{"key":"10.1016\/j.tranon.2021.101058_bib0068","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2849523","article-title":"Pleiotropic effects of IL-2 on cancer: Its role in cervical cancer","volume":"2016","author":"Valle-Mendiola","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.tranon.2021.101058_bib0069","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0006-291X(02)02715-8","article-title":"Interleukin-2 inhibits proliferation of HPV-associated tumor cells and halts tumor growth in vivo","volume":"299","author":"Casana","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tranon.2021.101058_bib0070","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.tranon.2021.101058_bib0071","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/gyno.2001.6235","article-title":"Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor","volume":"82","author":"Wei","year":"2001","journal-title":"Gynecol. Oncol."},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0072","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4049\/jimmunol.165.4.1939","article-title":"Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine il-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production","volume":"165","author":"Hess","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.tranon.2021.101058_bib0073","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13027-019-0231-z","article-title":"The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix","volume":"14","author":"Li","year":"2019","journal-title":"Infect. Agent Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0074","first-page":"989","article-title":"Serum IL-6 and micrometry of pap smears in women with cervical low-grade intraepithelial lesions. Asian Pac","volume":"11","author":"Paradkar","year":"2010","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.tranon.2021.101058_bib0075","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ctrv.2017.08.004","article-title":"Interleukin-8 in cancer pathogenesis, treatment and follow-up","volume":"60","author":"Alfaro","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tranon.2021.101058_bib0076","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0077","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10147-014-0680-8","article-title":"Cytokine profile in cervical mucosa of Japanese patients with cervical intraepithelial neoplasia","volume":"20","author":"Iwata","year":"2015","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0078","first-page":"2632","article-title":"Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers","volume":"60","author":"Fujimoto","year":"2000","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0079","first-page":"1350","article-title":"IL-8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells","volume":"15","author":"Jia","year":"2018","journal-title":"Oncol. Letters"},{"key":"10.1016\/j.tranon.2021.101058_bib0080","first-page":"69","article-title":"Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis","volume":"375","author":"Wu","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tranon.2021.101058_bib0081","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","article-title":"Interleukin-10 and related cytokines and receptors","volume":"22","author":"Pestka","year":"2004","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0082","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000334089","article-title":"Altered HLA class I and HLA-G expression is associated with IL-10 expression in patients with cervical cancer","volume":"79","author":"Rodr\u00edguez","year":"2012","journal-title":"Pathobiology"},{"key":"10.1016\/j.tranon.2021.101058_bib0083","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/1547691X.2011.642419","article-title":"Concentration levels of IL-10 and TNF\u03b1 cytokines in patients with human papilloma virus (HPV) DNA\u207a and DNA\u207b cervical lesions","volume":"9","author":"Ali","year":"2012","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.tranon.2021.101058_bib0084","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00428-009-0850-7","article-title":"Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort","volume":"455","author":"Syrj\u00e4nen","year":"2009","journal-title":"Virchows Arch"},{"key":"10.1016\/j.tranon.2021.101058_bib0085","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.4049\/jimmunol.1400216","article-title":"IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia","volume":"193","author":"Gosmann","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.tranon.2021.101058_bib0086","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cam4.1279","article-title":"Effects of Th17 cells and IL-17 in the progression of cervical carcinogenesis with high-risk human papillomavirus infection","volume":"7","author":"Xue","year":"2018","journal-title":"Cancer Med"},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0087","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1590\/1516-3180.2013.7170009","article-title":"Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 (IL-17) in cervical intraepithelial neoplasia: analytical cross-sectional study","volume":"133","author":"Miranda","year":"2015","journal-title":"Sao Paulo Med. J."},{"key":"10.1016\/j.tranon.2021.101058_bib0088","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fonc.2019.00546","article-title":"Interleukin-17 promotes migration and invasion of human cancer cells through upregulation of mta1 expression","volume":"9","author":"Guo","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0089","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cyto.2019.05.011","article-title":"Cytokine expression profiles in cervical mucus from patients with cervical cancer and its precursor lesions","volume":"120","author":"Otani","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.tranon.2021.101058_bib0090","first-page":"839","article-title":"Interleukin-21 increases direct cytotoxicity and IFN-\u03b3 production of ex vivo expanded NK cells towards breast cancer cells","volume":"32","author":"Park","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tranon.2021.101058_bib0091","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000070921","article-title":"Molecular mechanisms of dendritic cell sublineage development from human hematopoietic progenitor\/stem cells","volume":"131","author":"Strobl","year":"2003","journal-title":"Int, Arch, Allergy Immunol"},{"key":"10.1016\/j.tranon.2021.101058_bib0092","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nature Rev. Immunol."},{"key":"10.1016\/j.tranon.2021.101058_bib0093","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/cncr.22428","article-title":"Role of tumor-derived proinflammatory cytokines GM-CSF, TNF-alpha, and IL-12 in the migration and differentiation of antigen-presenting cells in cervical carcinoma","volume":"109","author":"Zijlmans","year":"2007","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.tranon.2021.101058_bib0094","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1097\/IGC.0b013e3182358955","article-title":"IL-21 and IL-12 inhibit differentiation of Treg and TH17 cells and enhance cytotoxicity of peripheral blood mononuclear cells in patients with cervical cancer","volume":"21","author":"Tian","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0095","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.ygyno.2003.12.022","article-title":"Eastern Cooperative Oncology Group, A phase ii trial of interleukin-12 in patients with advanced cervical cancer: Clinical and immunologic correlates. Eastern Cooperative Oncology Group Study E1E96","volume":"92","author":"Wadler","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0096","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5483\/BMBRep.2019.52.3.019","article-title":"Interleukin-32: Frenemy in Cancer?","volume":"52","author":"Han","year":"2019","journal-title":"BMB Rep"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0097","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2567.2010.03377.x","article-title":"Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene","volume":"132","author":"Lee","year":"2011","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0098","first-page":"41","article-title":"Role of interleukin-32 in cancer biology","volume":"16","author":"Yan","year":"2018","journal-title":"Oncol. Letters"},{"key":"10.1016\/j.tranon.2021.101058_bib0099","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nature Rev. Immunol."},{"key":"10.1016\/j.tranon.2021.101058_bib0100","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nature Med"},{"issue":"5","key":"10.1016\/j.tranon.2021.101058_bib0101","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.tranon.2021.101058_bib0102","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1080\/09513590.2019.1590699","article-title":"Could interleukin-33 and its suppressor of tumorigenicity 2 (st2) receptor have a role in cervical human papillomavirus (HPV) infections?","volume":"35","author":"Kulhan","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.tranon.2021.101058_bib0103","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12032-014-0143-0","article-title":"Examining IL-33 expression in the cervix of HPV-infected patients: a preliminary study comparing IL-33 levels in different stages of disease and analyzing its potential association with IFN-\u03b3","volume":"31","author":"Wang","year":"2014","journal-title":"Med. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0104","first-page":"4711","article-title":"Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy","volume":"15","author":"Wang","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.tranon.2021.101058_bib0105","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.2147\/OTT.S201664","article-title":"IL-37 promotes cell apoptosis in cervical cancer involving bim upregulation","volume":"12","author":"Ouyang","year":"2019","journal-title":"Onco. Targets Ther."},{"issue":"10","key":"10.1016\/j.tranon.2021.101058_bib0106","doi-asserted-by":"crossref","first-page":"962","DOI":"10.7150\/jca.12266","article-title":"Interleukin 37 expression inhibits stat3 to suppress the proliferation and invasion of human cervical cancer cells","volume":"6","author":"Wang","year":"2015","journal-title":"J. Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0107","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1007\/s13277-016-5028-8","article-title":"Transforming growth factor-\u03b21 in carcinogenesis, progression, and therapy in cervical cancer","volume":"37","author":"Zhu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.tranon.2021.101058_bib0108","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1053\/hupa.2002.130109","article-title":"Transforming growth factor-beta1 induces tumor stroma and reduces tumor infiltrate in cervical cancer","volume":"33","author":"Hazelbag","year":"2002","journal-title":"Human Pathol"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0109","first-page":"113","article-title":"TGF-beta signaling pathway factors in HPV-induced cervical lesions roum","volume":"69","author":"Iancu","year":"2010","journal-title":"Arch. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ygyno.2005.09.051","article-title":"Effects of human papillomavirus type 16 E7 protein on the growth of cervical carcinoma cells and immuno-escape through the TGF-beta1 signaling pathway","volume":"101","author":"Xu","year":"2006","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0111","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01635580903305326","article-title":"Intakes of vitamin A, C, and E, and beta-carotene are associated with risk of cervical cancer: a case control study in Korea","volume":"62","author":"Kim","year":"2010","journal-title":"Nutr. Cancer"},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0112","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.prp.2015.01.002","article-title":"In situ increased chemokine expression in human cervical intraepithelial neoplasia and cervical cancer","volume":"211","author":"Carrero","year":"2015","journal-title":"Pathol. Res. Pract."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0113","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.canlet.2015.04.029","article-title":"The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell","volume":"364","author":"Xie","year":"2015","journal-title":"Cancer Lett"},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0114","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/gyno.2001.6378","article-title":"Cytokine profile of cervical cancer cells","volume":"83","author":"Hazelbag","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0115","doi-asserted-by":"crossref","first-page":"148","DOI":"10.11604\/pamj.2019.32.148.16314","article-title":"Evaluation of interleukin 8 and interleukin 10 cytokines in liquid based cervical cytology samples","volume":"32","author":"Osiagwu","year":"2019","journal-title":"Pan. Afr. Med. J."},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0116","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/03014460.2014.1001436","article-title":"Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to HPV infection in patients with and without cervical intraepithelial lesion","volume":"43","author":"Tavares","year":"2016","journal-title":"Ann. Hum. Biol."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0117","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3727\/096504009789745656","article-title":"Role of tgf-beta1 (-509c>t) promoter polymorphism in susceptibility to cervical cancer","volume":"18","author":"Singh","year":"2009","journal-title":"Oncol. Res."},{"issue":"7","key":"10.1016\/j.tranon.2021.101058_bib0118","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1007\/s11033-012-1597-9","article-title":"IFN-gamma and IL-12B polymorphisms in women with cervical intraepithellial neoplasia caused by human papillomavirus","volume":"39","author":"do Carmo Vasconcelos de Carvalho","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.tranon.2021.101058_bib0119","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1136\/ijgc-00009577-200511001-00016","article-title":"Interleukin-10 and Fas polymorphisms and susceptibility for (pre)neoplastic cervical disease","volume":"3","author":"Zoodsma","year":"2005","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"11","key":"10.1016\/j.tranon.2021.101058_bib0120","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/jjco\/hyq094","article-title":"Interleukin-10 -1082 gene polymorphism and susceptibility to cervical cancer among Japanese women","volume":"40","author":"Matsumoto","year":"2010","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0121","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejmhg.2015.10.005","article-title":"Cytokine gene polymorphisms and their association with cervical cancer: A North Indian study","volume":"17","author":"Gupta","year":"2016","journal-title":"Egyptian J. Med. Hum. Genet."},{"issue":"1-2","key":"10.1016\/j.tranon.2021.101058_bib0122","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-011-0782-9","article-title":"Association between circulating interleukin-1 beta (il-1\u03b2) levels and il-1\u03b2 c-511t polymorphism with cervical cancer risk in egyptian women","volume":"353","author":"Al-Tahhan","year":"2011","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0123","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3346\/jkms.2007.22.1.110","article-title":"Interleukin-1 beta-511 polymorphism and risk of cervical cancer","volume":"22","author":"Kang","year":"2007","journal-title":"J. Korean Med. Sci."},{"issue":"18","key":"10.1016\/j.tranon.2021.101058_bib0124","doi-asserted-by":"crossref","first-page":"29795","DOI":"10.18632\/oncotarget.16080","article-title":"Role of interleukin-12 gene polymorphisms in the onset risk of cancer: A meta-analysis","volume":"8","author":"Zheng","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0125","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/ijgc-00009577-200707000-00019","article-title":"Cytokine profile in Indian women with cervical intraepithelial neoplasia and cancer cervix","volume":"17","author":"Sharma","year":"2007","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.tranon.2021.101058_bib0126","first-page":"35","article-title":"[The prognostic significance of estimation of levels of peripheral blood cytokines in patients with cervical neoplasms]","volume":"3","author":"Abramovskikh","year":"2012","journal-title":"Klin. Lab. Diagn."},{"issue":"9","key":"10.1016\/j.tranon.2021.101058_bib0127","first-page":"3851","article-title":"Role of cytokines in genesis, progression and prognosis of cervical cancer. Asian Pac","volume":"15","author":"Paradkar","year":"2014","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.tranon.2021.101058_bib0128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s41182-017-0059-4","article-title":"Tumor infiltrating leukocyte density is independent of tumor grade and molecular subtype in aggressive breast cancer of Western Kenya","volume":"45","author":"Sawe","year":"2017","journal-title":"Trop. Med. Health"},{"issue":"11","key":"10.1016\/j.tranon.2021.101058_bib0129","first-page":"642","article-title":"Chemokines and tumors","volume":"93","author":"Pellegrino","year":"2002","journal-title":"Recent Prog. Med."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2008.03.018","article-title":"The inflammatory chemokines CCL2 and CCL5 in breast cancer","volume":"267","author":"Soria","year":"2008","journal-title":"Cancer Lett"},{"issue":"16","key":"10.1016\/j.tranon.2021.101058_bib0131","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1002\/cncr.24411","article-title":"Increased vascular endothelial growth factor expression, CD3 positive cell infiltration and oxidative stress in premalignant lesions of the cervix","volume":"115","author":"Carrero","year":"2009","journal-title":"Cancer"},{"issue":"24","key":"10.1016\/j.tranon.2021.101058_bib0132","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1158\/0008-5472.CAN-15-0732","article-title":"Stromal Fibroblasts Induce CCL20 through IL6\/C\/EBP\u03b2 to Support the Recruitment of Th17 Cells during Cervical Cancer Progression","volume":"75","author":"Walch-R\u00fcckheim","year":"2015","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0133","doi-asserted-by":"crossref","first-page":"10473","DOI":"10.4238\/2015.September.8.8","article-title":"Correlation of E6 and E7 Levels in High-Risk HPV16 Type Cervical Lesions with CCL20 and Langerhans Cells","volume":"14","author":"Jiang","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"14","key":"10.1016\/j.tranon.2021.101058_bib0134","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1158\/1078-0432.CCR-19-3826","article-title":"Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of CDC1 and CD8\u202f+\u202fT Cells and Elevated \u03b2-Catenin Activation Compared with Squamous Cell Carcinoma","volume":"26","author":"Rotman","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tranon.2021.101058_bib0135","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.2147\/OTT.S68286","article-title":"Angiogenesis and antiangiogenic agents in cervical cancer","volume":"7","author":"Tomao","year":"2014","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.tranon.2021.101058_bib0136","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12935-018-0647-3","article-title":"Prognostic value of microvessel density in cervical cancer","volume":"18","author":"Hu","year":"2018","journal-title":"Cancer Cell. Int."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0137","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajme.2011.12.001","article-title":"VEGF expression and microvascular density in relation to high-risk-HPV infection in cervical carcinoma \u2013 An immunohistochemical study","volume":"48","author":"El Sabaa","year":"2012","journal-title":"Alexandria J. Med."},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0138","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3892\/ol.2017.5595","article-title":"Monocyte-derived dendritic cells from patients with cervical intraepithelial lesions","volume":"13","author":"Lopes","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.tranon.2021.101058_bib0139","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-0-387-72005-0_16","article-title":"Immunological Role of Dendritic Cells in Cervical Cancer","volume":"601","author":"Manickam","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0140","first-page":"20","article-title":"An evaluation of immune system cell infiltrate in the cervical stroma of patients with grade III cervical intraepithelial neoplasia after treatment with intralesional alpha-2B interferon","volume":"35","author":"Machado","year":"2014","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.tranon.2021.101058_bib0141","first-page":"1","article-title":"Synergistic antitumor effect on cervical cancer by rational combination of PD1 blockade and CRISPR-Cas9-mediated HPV knockout","volume":"27","author":"Zhen","year":"2019","journal-title":"Cancer Gene Ther"},{"issue":"4","key":"10.1016\/j.tranon.2021.101058_bib0142","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/imm.12101","article-title":"Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia","volume":"139","author":"Yang","year":"2013","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.tranon.2021.101058_bib0143","doi-asserted-by":"crossref","first-page":"e19433","DOI":"10.1097\/MD.0000000000019433","article-title":"CTLA-4 rs5742909 polymorphism and cervical cancer risk: a meta-analysis","volume":"99","author":"Hu","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0144","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2019.152782","article-title":"The immune checkpoints CTLA-4 and PD-L1 in carcinomas of the uterine cervix","volume":"216","author":"Karpathiou","year":"2020","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40425-019-0526-z","article-title":"Efficacy of PD-1 blockade in cervical cancer is related to a CD8(+)FoxP3(+)CD25(+) T-cell subset with operational effector functions despite high immune checkpoint levels","volume":"7","author":"Heeren","year":"2019","journal-title":"J. Immunothe.r Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2021.101058_bib0146","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s40425-019-0728-4","article-title":"Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD- 1 immunotherapy in preclinical model of HPV(+) oral cancer","volume":"7","author":"Dorta-Estremera","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0147","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jcyt.2017.11.010","article-title":"Human papilloma virus-specific T cells can be generated from naive T cells for use as an immunotherapeutic strategy for immunocompromised patients","volume":"20","author":"McCormack","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.tranon.2021.101058_bib0148","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103115","article-title":"Killing cervical cancer cells by specific chimeric antigen receptor-modified T cells","volume":"139","author":"He","year":"2020","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.tranon.2021.101058_bib0149","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s12253-018-0541-2","article-title":"Combined treatment with autologous CIK cells, radiotherapy and chemotherapy in advanced cervical cancer","volume":"25","author":"Li","year":"2019","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.tranon.2021.101058_bib0150","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7475295","article-title":"IL-2 induces transient arrest in the G1 phase to protect cervical cancer cells from entering apoptosis","volume":"2019","author":"Lagunas-Cruz","year":"2019","journal-title":"J. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2021.101058_bib0151","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007835","article-title":"Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NF\u03baB-IL-6 signalling axis","volume":"15","author":"Morgan","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.tranon.2021.101058_bib0152","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.intimp.2018.11.015","article-title":"Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are associated with an increased risk of cervical cancer","volume":"66","author":"Du","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.tranon.2021.101058_bib0153","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2019.1629259","article-title":"HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory","volume":"8","author":"Grunwitz","year":"2019","journal-title":"Oncoimmunology"},{"issue":"3","key":"10.1016\/j.tranon.2021.101058_bib0154","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00705-017-3647-z","article-title":"Enhancement of therapeutic DNA vaccine potency by melatonin through inhibiting VEGF expression and induction of antitumor immunity mediated by CD8+ T cells","volume":"163","author":"Rahimi","year":"2018","journal-title":"Arch. Virol."},{"issue":"10","key":"10.1016\/j.tranon.2021.101058_bib0155","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1080\/14760584.2016.1176533","article-title":"Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies","volume":"15","author":"Vici","year":"2016","journal-title":"Expert. Rev. Vaccines"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523321000504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523321000504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:39:47Z","timestamp":1761835187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523321000504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":155,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1936523321000504"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2021.101058","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2021.101058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101058"}}