{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:42:47Z","timestamp":1789522967994,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA023108"],"award-info":[{"award-number":["P30CA023108"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.tranon.2021.101217","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T02:45:52Z","timestamp":1631587552000},"page":"101217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer"],"prefix":"10.1016","volume":"14","author":[{"given":"Daniel","family":"Hopkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Berwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Wilkinson-Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2021.101217_bib0001","series-title":"Cancer Facts & Figures 2020","year":"2020"},{"issue":"51","key":"10.1016\/j.tranon.2021.101217_bib0002","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1073\/pnas.0509182102","article-title":"Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer","volume":"102","author":"Sato","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.tranon.2021.101217_bib0003","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm1093","article-title":"Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival","volume":"10","author":"Curiel","year":"2004","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.tranon.2021.101217_bib0004","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa020177","article-title":"Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer","volume":"348","author":"Zhang","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"34","key":"10.1016\/j.tranon.2021.101217_bib0005","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1200\/JCO.2015.62.3397","article-title":"Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in patients with platinum-resistant Ovarian Cancer","volume":"33","author":"Hamanishi","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.tranon.2021.101217_bib0006","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2217\/imt.14.90","article-title":"Past, present and future targets for immunotherapy in ovarian cancer","volume":"6","author":"Schwab","year":"2014","journal-title":"Immunotherapy"},{"issue":"3","key":"10.1016\/j.tranon.2021.101217_bib0007","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1600-0897.2011.01068.x","article-title":"Distinct subpopulations of epithelial ovarian cancer cells can differentially induce macrophages and T regulatory cells toward a pro-tumor phenotype","volume":"67","author":"Alvero","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.tranon.2021.101217_bib0008","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/ijc.27759","article-title":"Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells","volume":"132","author":"Fialova","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"8","key":"10.1016\/j.tranon.2021.101217_bib0009","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.4049\/jimmunol.176.8.5023","article-title":"Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype","volume":"176","author":"Hagemann","year":"2006","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.tranon.2021.101217_bib0010","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s12094-017-1686-2","article-title":"Influence of ovarian cancer type I and type II microenvironment on the phenotype and function of monocyte-derived dendritic cells","volume":"19","author":"Sur\u00f3wka","year":"2017","journal-title":"Clin. Transl. Oncol."},{"issue":"7","key":"10.1016\/j.tranon.2021.101217_bib0011","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.20050463","article-title":"Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation","volume":"202","author":"Ghiringhelli","year":"2005","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.tranon.2021.101217_bib0012","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1182\/blood-2007-02-072587","article-title":"Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells","volume":"110","author":"Duluc","year":"2007","journal-title":"Blood"},{"issue":"18","key":"10.1016\/j.tranon.2021.101217_bib0013","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1158\/0008-5472.CAN-07-1866","article-title":"Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma","volume":"67","author":"Kryczek","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.tranon.2021.101217_bib0014","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1593\/neo.09228","article-title":"Phenotypic and functional delineation of murine CX(3)CR1 monocyte-derived cells in ovarian cancer","volume":"11","author":"Hart","year":"2009","journal-title":"Neoplasia"},{"key":"10.1016\/j.tranon.2021.101217_bib0015","unstructured":"National Comprehensive Cancer Network. Ovarian Cancer (Version 2.2020. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/ovarian_blocks.pdf. Accessed March 10.2021."},{"issue":"12","key":"10.1016\/j.tranon.2021.101217_bib0016","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1158\/1078-0432.CCR-15-2657","article-title":"Neo-adjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma","volume":"22","author":"B\u00f6hm","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.tranon.2021.101217_bib0017","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1158\/1078-0432.CCR-16-1433","article-title":"Neo-adjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy","volume":"23","author":"Lo","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.tranon.2021.101217_bib0018","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1158\/0008-5472.CAN-12-2225","article-title":"Dose-dense chemotherapy improves mechanisms of antitumor immune response","volume":"73","author":"Chang","year":"2013","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.tranon.2021.101217_bib0019","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/annonc\/mdw625","article-title":"Neo-adjuvant chemotherapy (NACT) increases immune infiltration and programmed death-ligand 1 (PD-L1) expression in epithelial ovarian cancer (EOC)","volume":"28","author":"Mesnage","year":"2017","journal-title":"Ann. Oncol."},{"issue":"4","key":"10.1016\/j.tranon.2021.101217_bib0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/carcin\/21.4.585","article-title":"Development of a syngeneic mouse model for events related to ovarian cancer","volume":"21","author":"Roby","year":"2000","journal-title":"Carcinogenesis"},{"issue":"18","key":"10.1016\/j.tranon.2021.101217_bib0021","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.1158\/0008-5472.CAN-08-1167","article-title":"Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity","volume":"68","author":"Huarte","year":"2008","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.tranon.2021.101217_bib0022","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.4049\/jimmunol.178.10.6140","article-title":"Sentman Cl. NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model","volume":"178","author":"Barber","year":"2007","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.tranon.2021.101217_bib0023","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.tranon.2021.101217_bib0024","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1593\/neo.09228","article-title":"Phenotypic and functional delineation of murine CX(3)CR1 monocyte-derived cells in ovarian cancer","volume":"11","author":"Hart","year":"2009","journal-title":"Neoplasia"},{"issue":"42","key":"10.1016\/j.tranon.2021.101217_bib0025","doi-asserted-by":"crossref","first-page":"68489","DOI":"10.18632\/oncotarget.12095","article-title":"RPN13\/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells","volume":"7","author":"Soong","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.tranon.2021.101217_bib0026","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ijc.26094","article-title":"VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor Type 2","volume":"130","author":"Ziogas","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.tranon.2021.101217_bib0027","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.yexcr.2007.02.011","article-title":"Scavenger receptor-a functions in phagocytosis of E. coli by bone marrow dendritic cells","volume":"313","author":"Amiel","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"23","key":"10.1016\/j.tranon.2021.101217_bib0028","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1158\/0008-5472.CAN-14-3098","article-title":"Chemotherapy induces programmed cell death-Ligand 1 overexpression via the Nuclear Factor-\u03baB to foster an immunosuppressive tumor microenvironment in Ovarian Cancer","volume":"75","author":"Peng","year":"2015","journal-title":"Cancer Res."},{"issue":"6062","key":"10.1016\/j.tranon.2021.101217_bib0029","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1208347","article-title":"Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice","volume":"334","author":"Michaud","year":"2011","journal-title":"Science"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523321002096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523321002096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:18:28Z","timestamp":1761844708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523321002096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1936523321002096"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2021.101217","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2021.101217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101217"}}