{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:10:32Z","timestamp":1792203032957,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["KGM5252221"],"award-info":[{"award-number":["KGM5252221"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["IGM0402111"],"award-info":[{"award-number":["IGM0402111"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["IGM0372011"],"award-info":[{"award-number":["IGM0372011"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.tranon.2022.101398","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T04:17:50Z","timestamp":1648181870000},"page":"101398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice"],"prefix":"10.1016","volume":"20","author":[{"given":"Guen Tae","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hyun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyowon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-7749","authenticated-orcid":false,"given":"Kaapjoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Young","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-5501","authenticated-orcid":false,"given":"Sun Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-2731","authenticated-orcid":false,"given":"Jae Wha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2022.101398_bib0001","article-title":"Small molecules in targeted cancer therapy: advances, challenges, and future perspectives","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal Transd. Targeted Therapy"},{"key":"10.1016\/j.tranon.2022.101398_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102054","article-title":"Testicular cancer: determinants of cisplatin sensitivity and novel therapeutic opportunities","volume":"88","author":"De Vries","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.tranon.2022.101398_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-2081-4","article-title":"Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells","volume":"10","author":"Kleih","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.tranon.2022.101398_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184360","article-title":"Incidence and severity of self-reported chemotherapy side effects in routine care: a prospective cohort study","volume":"12","author":"Pearce","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tranon.2022.101398_bib0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/jamaoncol.2015.4720","article-title":"Self-evaluation of Adjuvant Chemotherapy-Related Adverse Effects by Patients With Breast Cancer","volume":"2","author":"Montemurro","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0006","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1200\/JCO.2014.57.9334","article-title":"Symptomatic Toxicities Experienced During Anticancer Treatment: agreement Between Patient and Physician Reporting in Three Randomized Trials","volume":"33","author":"Di Maio","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0007","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/bcp.14159","article-title":"Serious adverse effects occurring after chemotherapy: a general cancer registry-based incidence survey","volume":"86","author":"Ingrand","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.tranon.2022.101398_bib0008","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/ijms21041242","article-title":"Cisplatin-Induced Skeletal Muscle Dysfunction: mechanisms and Counteracting Therapeutic Strategies","volume":"21","author":"Conte","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2022.101398_bib0009","doi-asserted-by":"crossref","unstructured":"S. Sheth, D. Mukherjea, L.P. Rybak, V. Ramkumar, Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection, 11 (2017).","DOI":"10.3389\/fncel.2017.00338"},{"key":"10.1016\/j.tranon.2022.101398_bib0010","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.3390\/ijms20205238","article-title":"The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity","volume":"20","author":"Tanase","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2022.101398_bib0011","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0518-9","article-title":"Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity","volume":"26","author":"Volarevic","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tranon.2022.101398_bib0012","volume":"11","author":"Yu","year":"2020","journal-title":"Current Strategies to Combat Cisplatin-Induced Ototoxicity"},{"key":"10.1016\/j.tranon.2022.101398_bib0013","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.21873\/anticanres.14210","article-title":"Skeletal Muscle Mass Change During Chemotherapy: a Systematic Review and Meta-analysis","volume":"40","author":"Jang","year":"2020","journal-title":"Anticancer Res."},{"key":"10.1016\/j.tranon.2022.101398_bib0014","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.3390\/cancers13143615","article-title":"Chemotherapy-Induced Myopathy: the Dark Side of the Cachexia Sphere","volume":"13","author":"Campelj","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tranon.2022.101398_bib0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1001\/jamaoncol.2018.6771","article-title":"Chemotherapy-Induced Peripheral Neuropathy","volume":"5","author":"Brown","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0016","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0017","article-title":"Mechanisms of chemotherapy-induced muscle wasting in mice with cancer cachexia","author":"Murphy","year":"2021","journal-title":"JCSM Rapid Commun."},{"key":"10.1016\/j.tranon.2022.101398_bib0018","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jcsm.12360","article-title":"Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism","volume":"10","author":"Pin","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2022.101398_bib0019","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01635581.2014.894103","article-title":"Sarcopenia Is Linked to Treatment Toxicity in Patients With Metastatic Colorectal Cancer","volume":"66","author":"Barret","year":"2014","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tranon.2022.101398_bib0020","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1007\/s10147-019-01460-8","article-title":"Skeletal muscle loss during systemic chemotherapy for colorectal cancer indicates treatment response: a pooled analysis of a multicenter clinical trial (KSCC 1605-A)","volume":"24","author":"Sasaki","year":"2019","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0021","first-page":"382","article-title":"Cancer-Mediated Muscle Cachexia: etiology and Clinical Management, Trends in endocrinology and metabolism","volume":"32","author":"Siff","year":"2021","journal-title":"TEM"},{"key":"10.1016\/j.tranon.2022.101398_bib0022","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-021-08300-x","article-title":"Clinical significance of the cachexia index in patients with small cell lung cancer","volume":"21","author":"Go","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tranon.2022.101398_bib0023","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.clnu.2016.12.003","article-title":"Association between cachexia, chemotherapy and outcomes in older cancer patients: a systematic review","volume":"36","author":"Caillet","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tranon.2022.101398_bib0024","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000444393","article-title":"The Therapeutic Effect of PLAG against Oral Mucositis in Hamster and Mouse Model","volume":"6","author":"Lee","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tranon.2022.101398_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/odi.13224","article-title":"1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates chemoradiation-induced oral mucositis","volume":"26","author":"Choi","year":"2020","journal-title":"Oral Dis."},{"key":"10.1016\/j.tranon.2022.101398_bib0026","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jcb.26299","article-title":"1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) reduces hepatic injury in concanavalin A-treated mice","volume":"119","author":"Ko","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.tranon.2022.101398_bib0027","article-title":"1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates arthritic joints through reducing neutrophil infiltration mediated by IL-6\/STAT3 and MIP-2 activation","volume":"5","author":"Kim","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2022.101398_bib0028","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3389\/fimmu.2019.02177","article-title":"1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Rapidly Resolves LPS-Induced Acute Lung Injury Through the Effective Control of Neutrophil Recruitment","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2022.101398_bib0029","article-title":"Prevention of LPS-induced lung inflammation by PLAG administration via blocking of IL-6-STAT3-MIP-2 pathway","volume":"196","author":"Lee","year":"2016","journal-title":"J. Immnunol."},{"key":"10.1016\/j.tranon.2022.101398_bib0030","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fimmu.2020.00710","article-title":"1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol (PLAG) Mitigates Monosodium Urate (MSU)-Induced Acute Gouty Inflammation in BALB\/c Mice","volume":"11","author":"Shin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2022.101398_bib0031","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.trecan.2018.10.001","article-title":"Cancer Cachexia: more Than Skeletal Muscle Wasting","volume":"4","author":"Schmidt","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.tranon.2022.101398_bib0032","doi-asserted-by":"crossref","unstructured":"T.W. Mattox, Cancer Cachexia: cause, Diagnosis, and Treatment, Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition, 32 (2017) 599\u2013606.","DOI":"10.1177\/0884533617722986"},{"key":"10.1016\/j.tranon.2022.101398_bib0033","first-page":"363","article-title":"Cancer treatment and survivorship statistics","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tranon.2022.101398_bib0034","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2147\/CMAR.S187317","article-title":"Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades","volume":"11","author":"Lu","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.tranon.2022.101398_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21037\/apm.2018.08.04","article-title":"Health-related quality of life across cancer cachexia stages","volume":"8","author":"Kasvis","year":"2019","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.tranon.2022.101398_bib0036","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jcsm.12267","article-title":"Loss of skeletal muscle during systemic chemotherapy is prognostic of poor survival in patients with foregut cancer","volume":"9","author":"Daly","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2022.101398_bib0037","first-page":"67","article-title":"Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival","author":"Ryan","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.tranon.2022.101398_bib0038","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41568-020-0251-4","article-title":"Understanding cachexia in the context of metastatic progression","volume":"20","author":"Biswas","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tranon.2022.101398_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2022.101398_bib0040","article-title":"The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention","volume":"3","author":"Cole","year":"2018","journal-title":"JCSM Clin. Rep."},{"key":"10.1016\/j.tranon.2022.101398_bib0041","first-page":"1","article-title":"Role of Inflammation in Muscle Homeostasis and Myogenesis","author":"Costamagna","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.tranon.2022.101398_bib0042","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.lungcan.2011.09.012","article-title":"Pre-cachexia in patients with stages I\u2013III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system","volume":"76","author":"Op Den Kamp","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.tranon.2022.101398_bib0043","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.lfs.2016.11.033","article-title":"TNF-\u03b1 and cancer cachexia: molecular insights and clinical implications","volume":"170","author":"Patel","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.tranon.2022.101398_bib0044","volume":"11","author":"Webster","year":"2020","journal-title":"Inflammation and Skeletal Muscle Wasting During Cachexia"},{"key":"10.1016\/j.tranon.2022.101398_bib0045","doi-asserted-by":"crossref","first-page":"e47258","DOI":"10.15252\/embr.201847258","article-title":"Energy metabolism in cachexia","volume":"20","author":"Rohm","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tranon.2022.101398_bib0046","volume":"7","author":"Rudrappa","year":"2016","journal-title":"Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance\u2014A Qualitative Review"},{"key":"10.1016\/j.tranon.2022.101398_bib0047","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Mediators, Signaling, and Metabolic Pathways","volume":"16","author":"Kenneth","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2022.101398_bib0048","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.3390\/ijms21072321","article-title":"Cancer Cachexia and Related Metabolic Dysfunction","volume":"21","author":"Fonseca","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2022.101398_bib0049","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5694223","article-title":"Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK\/FoxO and JNK\/FoxO Pathways","author":"Chi","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tranon.2022.101398_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143615","article-title":"Chemotherapy-Induced Myopathy: the Dark Side of the Cachexia Sphere","volume":"13","author":"Campelj","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tranon.2022.101398_bib0051","article-title":"Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1\/Akt\/FoxO Pathway","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523322000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523322000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:28:35Z","timestamp":1778833715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523322000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":51,"alternative-id":["S1936523322000602"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2022.101398","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2022.101398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101398"}}