{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:20:23Z","timestamp":1791944423925,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012829"],"award-info":[{"award-number":["2024A1515012829"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370836"],"award-info":[{"award-number":["32370836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2022168"],"award-info":[{"award-number":["B2022168"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tranon.2024.102242","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T20:00:02Z","timestamp":1734206402000},"page":"102242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study"],"prefix":"10.1016","volume":"52","author":[{"given":"Zhihui","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4315-3039","authenticated-orcid":false,"given":"Huolun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tranon.2024.102242_bib0001","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"10251","key":"10.1016\/j.tranon.2024.102242_bib0002","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"The Lancet"},{"issue":"5","key":"10.1016\/j.tranon.2024.102242_bib0003","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41571-023-00747-0","article-title":"Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention","volume":"20","author":"Thrift","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.tranon.2024.102242_bib0004","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/j.gastro.2023.01.018","article-title":"Controlling gastric cancer in a world of heterogeneous risk","volume":"164","author":"Huang","year":"2023","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"issue":"6465","key":"10.1016\/j.tranon.2024.102242_bib0006","doi-asserted-by":"crossref","first-page":"eaan4673","DOI":"10.1126\/science.aan4673","article-title":"Clonal hematopoiesis in human aging and disease","volume":"366","author":"Jaiswal","year":"2019","journal-title":"Science)"},{"key":"10.1016\/j.tranon.2024.102242_bib0007","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.trsl.2022.11.009","article-title":"Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations","volume":"255","author":"Jakubek","year":"2023","journal-title":"Transl. Res."},{"issue":"12","key":"10.1016\/j.tranon.2024.102242_bib0008","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"issue":"26","key":"10.1016\/j.tranon.2024.102242_bib0009","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.tranon.2024.102242_bib0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.tranon.2024.102242_bib0011","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCULATIONAHA.120.051775","article-title":"Premature menopause, clonal hematopoiesis, and coronary artery disease in postmenopausal women","volume":"143","author":"Honigberg","year":"2021","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.tranon.2024.102242_bib0012","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/STROKEAHA.121.037388","article-title":"Clonal hematopoiesis is associated with higher risk of stroke","volume":"53","author":"Bhattacharya","year":"2022","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.tranon.2024.102242_bib0013","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1\u03b2\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.tranon.2024.102242_bib0014","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/eurheartj\/ehad670","article-title":"Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias","volume":"45","author":"Schuermans","year":"2024","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.tranon.2024.102242_bib0015","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41375-018-0047-7","article-title":"Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis","volume":"32","author":"Arends","year":"2018","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.tranon.2024.102242_bib0016","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tcb.2022.12.001","article-title":"Clonal hematopoiesis and inflammation \u2013 the perpetual cycle","volume":"33","author":"Avagyan","year":"2023","journal-title":"Trends Cell Biol."},{"issue":"8","key":"10.1016\/j.tranon.2024.102242_bib0017","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/1078-0432.CCR-22-2598","article-title":"CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors","volume":"29","author":"Reed","year":"2023","journal-title":"Offic. J. Am. Assoc.r Cancer Res."},{"issue":"22","key":"10.1016\/j.tranon.2024.102242_bib0018","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1158\/0008-5472.CAN-22-0985","article-title":"Clonal hematopoiesis of indeterminate potential in patients with solid tumor malignancies","volume":"82","author":"Marshall","year":"2022","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.tranon.2024.102242_bib0019","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1200\/JCO.22.00857","article-title":"Clonal hematopoiesis and risk of incident lung cancer","volume":"41","author":"Tian","year":"2023","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.tranon.2024.102242_bib0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1158\/0008-5472.CAN-21-1903","article-title":"Clonal hematopoiesis mutations in patients with lung cancer are associated with lung cancer risk factors","volume":"82","author":"Hong","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2024.102242_bib0021","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.23.01071","article-title":"Prevalence, dynamics, and prognostic role of clonal hematopoiesis of indeterminate potential in patients with breast cancer","author":"Morganti","year":"2024","journal-title":"Offic. J. Am. Soc. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.tranon.2024.102242_bib0022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/diseases10030035","article-title":"Inflammation and Gastric Cancer","volume":"10","author":"Jaroenlapnopparat","year":"2022","journal-title":"Diseases."},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI30111","article-title":"Inflammation, atrophy, and gastric cancer","volume":"117","author":"Fox","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.tranon.2024.102242_bib0024","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.tranon.2024.102242_bib0025","article-title":"Inflammatory microenvironment in gastric premalignant lesions: implication and application","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0026","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1515\/cclm-2023-0261","article-title":"Clinical relevance of clonal hematopoiesis and its interference in cell-free DNA profiling of patients with gastric cancer","volume":"62","author":"Lee","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"issue":"7886","key":"10.1016\/j.tranon.2024.102242_bib0027","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-021-04103-z","article-title":"Exome sequencing and analysis of 454,787 UK Biobank participants","volume":"599","author":"Backman","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.tranon.2024.102242_bib0028","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/s41588-022-01121-z","article-title":"Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis","volume":"54","author":"Kar","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tranon.2024.102242_bib0029","article-title":"Genomics in the cloud: using docker, GATK, and WDL in Terra","year":"2020","journal-title":"O'Reilly Media"},{"issue":"7571","key":"10.1016\/j.tranon.2024.102242_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"issue":"7809","key":"10.1016\/j.tranon.2024.102242_bib0031","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0032","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"issue":"D1","key":"10.1016\/j.tranon.2024.102242_bib0033","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0034","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.tranon.2024.102242_bib0035","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/S1470-2045(20)30460-5","article-title":"Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study","volume":"21","author":"Jin","year":"2020","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2024.102242_bib0036","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41568-021-00348-y","article-title":"Sex disparities matter in cancer development and therapy","volume":"21","author":"Haupt","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"26","key":"10.1016\/j.tranon.2024.102242_bib0037","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"New England J. Med."},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0038","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1038\/s41598-022-09604-z","article-title":"Genetics of smoking and risk of clonal hematopoiesis","volume":"12","author":"Levin","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2024.102242_bib0039","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1182\/blood-2023-190008","article-title":"Chronic alcohol exposure causes myeloid-biased hematopoiesis via double-strand RNA sensors and type 1 interferon response","volume":"142","author":"Bea","year":"2023","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.tranon.2024.102242_bib0040","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163968","article-title":"Obesity-induced inflammation exacerbates clonal hematopoiesis","volume":"133","author":"Pasupuleti","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.tranon.2024.102242_bib0041","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1182\/bloodadvances.2023011445","article-title":"Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation","volume":"8","author":"Heimlich","year":"2024","journal-title":"Blood Adv."},{"issue":"10105","key":"10.1016\/j.tranon.2024.102242_bib0042","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1\u03b2 inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"The Lancet"},{"issue":"8","key":"10.1016\/j.tranon.2024.102242_bib0043","doi-asserted-by":"crossref","first-page":"E1490","DOI":"10.1073\/pnas.1616420114","article-title":"Dnmt3a restrains mast cell inflammatory responses","volume":"114","author":"Leoni","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7958","key":"10.1016\/j.tranon.2024.102242_bib0044","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","article-title":"Clonal haematopoiesis and risk of chronic liver disease","volume":"616","author":"Wong","year":"2023","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.tranon.2024.102242_bib0045","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ccell.2023.04.006","article-title":"Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population","volume":"41","author":"van Zeventer","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0046","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacc.2021.04.085","article-title":"Supplemental association of clonal hematopoiesis with incident heart failure","volume":"78","author":"Yu","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.tranon.2024.102242_bib0047","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.1038\/s41467-022-33093-3","article-title":"Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease","volume":"13","author":"Uddin","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.tranon.2024.102242_bib0048","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s44161-022-00206-6","article-title":"TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease","volume":"2","author":"Zekavat","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"issue":"13","key":"10.1016\/j.tranon.2024.102242_bib0049","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146076","article-title":"TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response","volume":"6","author":"Sano","year":"2021","journal-title":"JCI. Insight."},{"issue":"3","key":"10.1016\/j.tranon.2024.102242_bib0050","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41591-024-02854-6","article-title":"Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury","volume":"30","author":"Vlasschaert","year":"2024","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.tranon.2024.102242_bib0051","first-page":"591","article-title":"Risk factors for gastric cancer: a systematic review","volume":"19","author":"Yusefi","year":"2018","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"10.1016\/j.tranon.2024.102242_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.101980","article-title":"Challenges in the treatment of gastric cancer in the older patient","volume":"85","author":"Joharatnam-Hogan","year":"2020","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"10.1016\/j.tranon.2024.102242_bib0053","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S2468-1253(18)30237-1","article-title":"Resolving gastric cancer aetiology: an update in genetic predisposition","volume":"3","author":"Lott","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523324003681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523324003681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T08:49:08Z","timestamp":1737622148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523324003681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":53,"alternative-id":["S1936523324003681"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2024.102242","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clonal hematopoiesis of indeterminate potential is a risk factor of gastric cancer: A Prospective Cohort in UK Biobank study","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2024.102242","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102242"}}