{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:21:38Z","timestamp":1785295298430,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2311-B-182A-001-MY3"],"award-info":[{"award-number":["110-2311-B-182A-001-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2311-B-182A-001"],"award-info":[{"award-number":["NSTC 113-2311-B-182A-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 110\\u20132311-B-182A-001-MY3"],"award-info":[{"award-number":["NSTC 110\\u20132311-B-182A-001-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Linkou Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["NRRPG3P0011"],"award-info":[{"award-number":["NRRPG3P0011"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["NRRPG3L6011-13"],"award-info":[{"award-number":["NRRPG3L6011-13"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3M1271"],"award-info":[{"award-number":["CMRPG3M1271"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CRRPG3N0041"],"award-info":[{"award-number":["CRRPG3N0041"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3M2181-2182"],"award-info":[{"award-number":["CMRPG3M2181-2182"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3M2181\\u20132183"],"award-info":[{"award-number":["CMRPG3M2181\\u20132183"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tranon.2024.102250","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:42:38Z","timestamp":1734669758000},"page":"102250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-6062","authenticated-orcid":false,"given":"Yang-Hsiang","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Cheng","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau-Ting","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.tranon.2024.102250_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061687","article-title":"Causes of death among patients with hepatocellular carcinoma according to chronic liver disease etiology","volume":"15","author":"Yen","year":"2023","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.tranon.2024.102250_bib0002","article-title":"Biology of childhood hepatoblastoma and the search for novel treatments","author":"Pihlajoki","year":"2023","journal-title":"Adv. Biol. Regul."},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030731","article-title":"Tyrosine kinase inhibitors in cancer: breakthrough and challenges of targeted therapy","volume":"12","author":"Pottier","year":"2020","journal-title":"Cancers. (Basel)"},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0004","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41420-022-01251-7","article-title":"Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer?","volume":"8","author":"Seidel","year":"2022","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.tranon.2024.102250_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.891652","article-title":"Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches","volume":"12","author":"Emran","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0007","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jcp.30534","article-title":"Emerging roles of angiopoietin-like proteins in inflammation: mechanisms and potential as pharmacological targets","volume":"237","author":"Yang","year":"2022","journal-title":"J. Cell Physiol."},{"issue":"14","key":"10.1016\/j.tranon.2024.102250_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147310","article-title":"Angiopoietin-like protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tranon.2024.102250_bib0009","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/MOL.0000000000000789","article-title":"ANGPTL3 as therapeutic target","volume":"32","author":"Kersten","year":"2021","journal-title":"Curr. Opin. Lipidol."},{"issue":"2","key":"10.1016\/j.tranon.2024.102250_bib0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12020-015-0838-9","article-title":"The role of ANGPTL3 in controlling lipoprotein metabolism","volume":"52","author":"Tikka","year":"2016","journal-title":"Endocrine"},{"issue":"48","key":"10.1016\/j.tranon.2024.102250_bib0011","doi-asserted-by":"crossref","first-page":"19751","DOI":"10.1073\/pnas.1217552109","article-title":"Atypical angiopoietin-like protein that regulates ANGPTL3","volume":"109","author":"Quagliarini","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"10.1016\/j.tranon.2024.102250_bib0012","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tcm.2023.01.008","article-title":"ANGPTL3 inhibition, dyslipidemia, and cardiovascular diseases","volume":"34","author":"Luo","year":"2024","journal-title":"Trends. Cardiovasc. Med."},{"issue":"7","key":"10.1016\/j.tranon.2024.102250_bib0013","article-title":"ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins","volume":"1865","author":"Ruhanen","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.tranon.2024.102250_bib0014","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/cam4.418","article-title":"ANGPTL3 is a novel biomarker as it activates ERK\/MAPK pathway in oral cancer","volume":"4","author":"Koyama","year":"2015","journal-title":"Cancer Med."},{"issue":"2","key":"10.1016\/j.tranon.2024.102250_bib0015","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1080\/21655979.2021.2024951","article-title":"Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3","volume":"13","author":"Zhong","year":"2022","journal-title":"Bioengineered."},{"key":"10.1016\/j.tranon.2024.102250_bib0016","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cyto.2017.03.006","article-title":"Angiopoietin-like protein 3 and 4 expression 4 and their serum levels in hepatocellular carcinoma","volume":"96","author":"El-Shal","year":"2017","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0017","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbrc.2019.06.120","article-title":"ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation","volume":"516","author":"Zhao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"13","key":"10.1016\/j.tranon.2024.102250_bib0018","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1002\/cam4.3100","article-title":"Mining the role of angiopoietin-like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis","volume":"9","author":"Tang","year":"2020","journal-title":"Cancer Med."},{"issue":"10","key":"10.1016\/j.tranon.2024.102250_bib0019","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.humpath.2009.07.003","article-title":"Hep G2 is a hepatoblastoma-derived cell line","volume":"40","author":"Lopez-Terrada","year":"2009","journal-title":"Hum. Pathol."},{"issue":"23","key":"10.1016\/j.tranon.2024.102250_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313135","article-title":"The curious case of the HepG2 Cell Line: 40 years of expertise","volume":"22","author":"Arzumanian","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0021","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/ejso.2001.1237","article-title":"Telomerase activity in human hepatocellular carcinoma: parallel correlation with human telomerase reverse transcriptase (hTERT) mRNA isoform expression but not with cell cycle modulators or c-Myc expression","volume":"28","author":"Chen","year":"2002","journal-title":"Eur. J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0022","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12935-023-02879-w","article-title":"Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma","volume":"23","author":"Tsai","year":"2023","journal-title":"Cancer Cell Int."},{"issue":"28","key":"10.1016\/j.tranon.2024.102250_bib0023","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1038\/s41388-021-01905-3","article-title":"LINC01348 suppresses hepatocellular carcinoma metastasis through inhibition of SF3B3-mediated EZH2 pre-mRNA splicing","volume":"40","author":"Lin","year":"2021","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.tranon.2024.102250_bib0024","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1158\/0008-5472.CAN-10-2607","article-title":"A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients","volume":"70","author":"Roessler","year":"2010","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.tranon.2024.102250_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12102730","article-title":"Transcriptomics-based drug repurposing approach identifies novel drugs against sorafenib-resistant hepatocellular carcinoma","volume":"12","author":"Regan-Fendt","year":"2020","journal-title":"Cancers. (Basel)"},{"issue":"8","key":"10.1016\/j.tranon.2024.102250_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081528","article-title":"Conditioned medium from malignant breast cancer cells induces an EMT-like phenotype and an altered n-glycan profile in normal epithelial MCF10A Cells","volume":"18","author":"Guo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.tranon.2024.102250_bib0027","doi-asserted-by":"crossref","first-page":"e00160","DOI":"10.1042\/BSR20140115","article-title":"Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation","volume":"34","author":"Tikka","year":"2014","journal-title":"Biosci. Rep."},{"issue":"21","key":"10.1016\/j.tranon.2024.102250_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25215144","article-title":"Targeting lipid peroxidation for cancer treatment","volume":"25","author":"Clemente","year":"2020","journal-title":"Molecules."},{"key":"10.1016\/j.tranon.2024.102250_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"2","key":"10.1016\/j.tranon.2024.102250_bib0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10585-021-10144-5","article-title":"Current challenges in metastasis research and future innovation for clinical translation","volume":"39","author":"Parker","year":"2022","journal-title":"Clin. Exp. Metastasis"},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0031","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.devcel.2019.04.010","article-title":"Epithelial-mesenchymal plasticity in cancer progression and metastasis","volume":"49","author":"Lu","year":"2019","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0032","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41389-022-00420-8","article-title":"Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance","volume":"11","author":"Vasseur","year":"2022","journal-title":"Oncogenesis."},{"key":"10.1016\/j.tranon.2024.102250_bib0033","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.875318","article-title":"Novel insights on lipid metabolism alterations in drug resistance in cancer","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tranon.2024.102250_bib0034","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3389\/fonc.2020.01122","article-title":"Intrinsic and extrinsic modulators of the epithelial to mesenchymal transition: driving the fate of tumor microenvironment","volume":"10","author":"D'Angelo","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41392-020-0134-x","article-title":"Molecular principles of metastasis: a hallmark of cancer revisited","volume":"5","author":"Fares","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.tranon.2024.102250_bib0036","article-title":"Lipid metabolism and cancer","volume":"12","author":"Cheng","year":"2022","journal-title":"Life (Basel)."},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0037","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/mco2.27","article-title":"Lipid metabolism in cancer progression and therapeutic strategies","volume":"2","author":"Fu","year":"2021","journal-title":"MedComm. (2020)"},{"issue":"2","key":"10.1016\/j.tranon.2024.102250_bib0038","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqz046","article-title":"CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential","volume":"161","author":"Schlaepfer","year":"2020","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.tranon.2024.102250_bib0039","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41420-021-00504-1","article-title":"Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis","volume":"7","author":"Ren","year":"2021","journal-title":"Cell Death. Discov."},{"issue":"6","key":"10.1016\/j.tranon.2024.102250_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2023.100127","article-title":"CPT1A mediates chemoresistance in human hypopharyngeal squamous cell carcinoma via ATG16L1-dependent cellular autophagy","volume":"2","author":"Sun","year":"2023","journal-title":"Cell Insight"},{"issue":"4","key":"10.1016\/j.tranon.2024.102250_bib0041","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41416-018-0189-4","article-title":"Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response","volume":"119","author":"Bao","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tranon.2024.102250_bib0042","article-title":"ANGPTL3 overexpression suppresses the development of oncogenic properties in renal cell carcinoma via the wnt\/beta-catenin signaling pathway and predicts good prognosis","volume":"2021","author":"Zhang","year":"2021","journal-title":"Dis. Markers"},{"key":"10.1016\/j.tranon.2024.102250_bib0043","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1844352","article-title":"The role of ANGPTL gene family members in hepatocellular carcinoma","volume":"2022","author":"Bai","year":"2022","journal-title":"Dis. Markers"},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0044","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12272-021-01321-x","article-title":"The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance","volume":"44","author":"Seo","year":"2021","journal-title":"Arch. Pharm. Res."},{"issue":"3","key":"10.1016\/j.tranon.2024.102250_bib0045","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1172\/JCI64044","article-title":"Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility","volume":"123","author":"Kuo","year":"2013","journal-title":"J. Clin. Invest."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523324003760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523324003760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:30:26Z","timestamp":1778833826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523324003760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":45,"alternative-id":["S1936523324003760"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2024.102250","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2024.102250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102250"}}