{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:26:11Z","timestamp":1783783571465,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["JSDW202203"],"award-info":[{"award-number":["JSDW202203"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.tranon.2025.102390","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T02:49:50Z","timestamp":1744426190000},"page":"102390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["circHIPK2 promotes malignant progression of laryngeal squamous cell carcinoma through the miR-889-3p\/MCTS1\/IL-6 axis"],"prefix":"10.1016","volume":"56","author":[{"given":"Yang-Guang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-6758","authenticated-orcid":false,"given":"Zhen-Kun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-3382","authenticated-orcid":false,"given":"Si-Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2505-1482","authenticated-orcid":false,"given":"Wan-Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6541-7702","authenticated-orcid":false,"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2025.102390_bib0001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.tranon.2025.102390_bib0002","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s13577-022-00799-x","article-title":"Potentials of lncRNA-miRNA-mRNA networks as biomarkers for laryngeal squamous cell carcinoma","volume":"36","author":"Lv","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.tranon.2025.102390_bib0003","first-page":"59","article-title":"The Prognostic Utilities of Various Risk Factors for Laryngeal Squamous Cell Carcinoma: a Systematic Review and Meta-Analysis","author":"Kim","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.tranon.2025.102390_bib0004","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1080\/01635581.2021.1952446","article-title":"Impact of Nutritional Status on Survival in Head and Neck Cancer Patients After Total Laryngectomy","volume":"74","author":"Santos","year":"2022","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.oraloncology.2018.09.012","article-title":"Treatment of early-stage laryngeal cancer: a comparison of treatment options","volume":"87","author":"Baird","year":"2018","journal-title":"Oral Oncol."},{"key":"10.1016\/j.tranon.2025.102390_bib0006","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12943-022-01582-0","article-title":"The functional roles of the circRNA\/Wnt axis in cancer","volume":"21","author":"Xue","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0007","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.7150\/thno.42174","article-title":"Circular RNA-protein interactions: functions, mechanisms, and identification","volume":"10","author":"Huang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.tranon.2025.102390_bib0008","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.7150\/thno.45302","article-title":"Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.tranon.2025.102390_bib0009","doi-asserted-by":"crossref","first-page":"10149","DOI":"10.2147\/OTT.S274574","article-title":"The novel circular RNA Circ-PGAP3 promotes the proliferation and invasion of triple negative breast cancer by regulating the miR-330-3p\/Myc axis","volume":"13","author":"He","year":"2020","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.tranon.2025.102390_bib0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ebiom.2019.06.030","article-title":"The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production","volume":"45","author":"Dong","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tranon.2025.102390_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2020.152861","article-title":"Circular RNAs: the crucial regulatory molecules in colorectal cancer","volume":"216","author":"Zeng","year":"2020","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.tranon.2025.102390_bib0012","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1002\/cam4.3006","article-title":"Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients","volume":"9","author":"Shen","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.tranon.2025.102390_bib0013","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fgene.2020.00193","article-title":"circGNB1 facilitates triple-negative breast cancer progression by regulating miR-141-5p-IGF1R","volume":"11","author":"Liu","year":"2020","journal-title":"Axis. Front. Genet."},{"key":"10.1016\/j.tranon.2025.102390_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20163926","article-title":"Circular RNAs: biogenesis, mechanism, and function in human cancers","volume":"20","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102390_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109874","article-title":"Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p\/RAP2C axis","volume":"125","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.tranon.2025.102390_bib0016","first-page":"951","article-title":"CircDOCK1 suppresses cell apoptosis via inhibition of miR\u2011196a\u20115p by targeting BIRC3 in OSCC","volume":"39","author":"Wang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.tranon.2025.102390_bib0017","first-page":"39","article-title":"Circular RNA MYLK serves as an oncogene to promote cancer progression via microRNA-195\/cyclin D1 axis in laryngeal squamous cell carcinoma","author":"Duan","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.tranon.2025.102390_bib0018","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.anl.2022.02.004","article-title":"Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma","volume":"49","author":"He","year":"2022","journal-title":"Auris Nasus. Larynx"},{"key":"10.1016\/j.tranon.2025.102390_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003376","article-title":"circFAT1 promotes cancer stemness and immune evasion by promoting STAT3 activation","volume":"8","author":"Jia","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.tranon.2025.102390_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/1878-0261.13821","article-title":"CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR-15b-5p and miR-7-1-3p processing in nasopharyngeal carcinoma","author":"Fan","year":"2025","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.tranon.2025.102390_bib0021","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1097\/CAD.0000000000001197","article-title":"Circular RNA circ_0008450 regulates the proliferation, migration, invasion, apoptosis and chemosensitivity of CDDP-resistant nasopharyngeal carcinoma cells by the miR-338-3p\/SMAD5 axis","volume":"33","author":"Liu","year":"2022","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.tranon.2025.102390_bib0022","doi-asserted-by":"crossref","first-page":"8609","DOI":"10.1038\/s41467-024-52981-4","article-title":"Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma","volume":"15","author":"Ge","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2025.102390_bib0023","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.21037\/tcr-22-1645","article-title":"CircHIPK2 promotes proliferation of nasopharyngeal carcinoma by down-regulating HIPK2","volume":"11","author":"Zhang","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.tranon.2025.102390_bib0024","first-page":"4233","article-title":"A novel candidate oncogene, MCT-1, is involved in cell cycle progression","volume":"58","author":"Prosniak","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2025.102390_bib0025","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.12659\/MSM.919690","article-title":"Multiple copies in T-cell malignancy 1 (MCT-1) promotes the Stemness of non-small cell lung cancer cells via activating interleukin-6 (IL-6) signaling through suppressing MiR-34a expression","volume":"25","author":"Li","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.tranon.2025.102390_bib0026","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/1440-1681.13640","article-title":"MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability","volume":"49","author":"Yang","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tranon.2025.102390_bib0027","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12943-019-0988-0","article-title":"MCT-1\/miR-34a\/IL-6\/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer","volume":"18","author":"Weng","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0028","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.tranon.2025.102390_bib0029","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fcell.2019.00052","article-title":"Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy","volume":"7","author":"Canning","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tranon.2025.102390_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12943-019-0983-5","article-title":"Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review","volume":"18","author":"Peltanova","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0031","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hed.20561","article-title":"Clinical significance of MMP-2 and MMP-9 in patients with oral cancer","volume":"29","author":"Patel","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.tranon.2025.102390_bib0032","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hed.20322","article-title":"Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer","volume":"28","author":"Luukkaa","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.tranon.2025.102390_bib0033","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12943-019-0994-2","article-title":"Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance","volume":"18","author":"Fiori","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0034","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102390_bib0035","first-page":"1588","article-title":"Proliferation-associated 2G4 P48 is stabilized by malignant T-cell amplified sequence 1 and promotes the proliferation of head and neck squamous cell carcinoma","volume":"18","author":"Sun","year":"2023","journal-title":"JDS"},{"key":"10.1016\/j.tranon.2025.102390_bib0036","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.7150\/ijbs.47203","article-title":"miRNA-based biomarkers, therapies, and resistance in Cancer","volume":"16","author":"He","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.tranon.2025.102390_bib0037","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2014.08.039","article-title":"Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells","volume":"147","author":"Wan","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tranon.2025.102390_bib0038","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.tranon.2025.102390_bib0039","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41571-021-00585-y","article-title":"The emerging roles of circRNAs in cancer and oncology","volume":"19","author":"Kristensen","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102390_bib0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12943-020-1135-7","article-title":"Translation and functional roles of circular RNAs in human cancer","volume":"19","author":"Lei","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102660","article-title":"Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke","volume":"52","author":"Wang","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tranon.2025.102390_bib0042","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s40168-019-0733-3","article-title":"Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2","volume":"7","author":"Zhang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.tranon.2025.102390_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117694","article-title":"Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder","volume":"552","author":"Yu","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tranon.2025.102390_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109907","article-title":"Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1","volume":"117","author":"Huang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tranon.2025.102390_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113276","article-title":"The malignant property of circHIPK2 for angiogenesis and chemoresistance in non-small cell lung cancer","volume":"419","author":"Ren","year":"2022","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.tranon.2025.102390_bib0046","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/CritRevEukaryotGeneExpr.2022042925","article-title":"circHIPK2 has a potentially important clinical significance in colorectal cancer progression via HSP90 ubiquitination by miR485-5p","volume":"32","author":"Tong","year":"2022","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.tranon.2025.102390_bib0047","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2025.102390_bib0048","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12943-022-01560-6","article-title":"The N(6)-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p\/PGF signalling pathway","volume":"21","author":"Lin","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0049","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12943-022-01598-6","article-title":"The circSPON2\/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression","volume":"21","author":"Yao","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.tranon.2025.102390_bib0050","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1158\/1078-0432.CCR-22-3836","article-title":"A Tumor-suppressive molecular axis EP300\/circRERE\/miR-6837-3p\/MAVS Activates type I IFN pathway and antitumor immunity to suppress colorectal cancer","volume":"29","author":"Ding","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tranon.2025.102390_bib0051","doi-asserted-by":"crossref","first-page":"10945","DOI":"10.1080\/21655979.2021.2000283","article-title":"MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1","volume":"12","author":"Zhu","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.tranon.2025.102390_bib0052","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00631-20","article-title":"Silencing of hsa_circ_0009035 suppresses cervical cancer progression and enhances radiosensitivity through MicroRNA 889-3p-dependent regulation of HOXB7","volume":"41","author":"Zhao","year":"2021","journal-title":"MCB"},{"key":"10.1016\/j.tranon.2025.102390_bib0053","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbrc.2023.08.036","article-title":"MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination","volume":"678","author":"Ma","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tranon.2025.102390_bib0054","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nm.4128","article-title":"Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity","volume":"22","author":"Eichner","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.tranon.2025.102390_bib0055","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat. Rev. Immunol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325001214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325001214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:30:10Z","timestamp":1762597810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523325001214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S1936523325001214"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102390","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"circHIPK2 promotes malignant progression of laryngeal squamous cell carcinoma through the miR-889-3p\/MCTS1\/IL-6 axis","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. CCBYLICENSE","name":"copyright","label":"Copyright"}],"article-number":"102390"}}