{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:04:59Z","timestamp":1788743099550,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"publisher","award":["A2024140"],"award-info":[{"award-number":["A2024140"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["20251218"],"award-info":[{"award-number":["20251218"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017712","name":"Ganzhou City Bureau of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204449"],"award-info":[{"award-number":["82204449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["GZ2024YLJ067"],"award-info":[{"award-number":["GZ2024YLJ067"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.tranon.2025.102534","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:44:26Z","timestamp":1758069866000},"page":"102534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dioscin initiates dual roles in bladder cancer progression via miR-195\u20135p\/FASN\/SLC3A2 axis-mediated cell death mechanisms"],"prefix":"10.1016","volume":"61","author":[{"given":"Yongchang","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zechao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2025.102534_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071418","article-title":"Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogramming beyond the Warburg effect","volume":"16","author":"Afonso","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.tranon.2025.102534_bib0002","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10495-017-1366-2","article-title":"Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis","volume":"22","author":"Al-Bahlani","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.tranon.2025.102534_bib0003","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.tranon.2025.102534_bib0004","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1080\/01635581.2020.1856895","article-title":"Targeting major signaling pathways of bladder cancer with phytochemicals: a review","volume":"73","author":"Chestnut","year":"2021","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tranon.2025.102534_bib0005","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cmet.2021.05.016","article-title":"Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects","volume":"33","author":"Dierge","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102534_bib0006","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jcp.29197","article-title":"Dioscin inhibits the growth of human osteosarcoma by inducing G2\/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo","volume":"235","author":"Ding","year":"2020","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.tranon.2025.102534_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1136590","article-title":"Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study","volume":"10","author":"Feng","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tranon.2025.102534_bib0008","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-019-1102-6","article-title":"Long non-coding RNA ZEB1-AS1 regulates miR-200b\/FSCN1 signaling and enhances migration and invasion induced by TGF-beta1 in bladder cancer cells","volume":"38","author":"Gao","year":"2019","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.tranon.2025.102534_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106475","article-title":"Crosstalk of miRNAs with signaling networks in bladder cancer progression: therapeutic, diagnostic and prognostic functions","volume":"185","author":"Hashemi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tranon.2025.102534_bib0010","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3389\/fphar.2020.01099","article-title":"Dioscin promotes prostate cancer cell apoptosis and inhibits cell invasion by increasing SHP1 phosphorylation and suppressing the subsequent MAPK signaling pathway","volume":"11","author":"He","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tranon.2025.102534_bib0011","article-title":"Dioscin alleviates cisplatin-induced mucositis in rats by modulating gut microbiota, enhancing intestinal barrier function and attenuating TLR4\/NF-kappaB signaling cascade","volume":"23","author":"Jin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102534_bib0012","first-page":"2196","article-title":"Targeting metabolic reprogramming to overcome drug resistance in advanced bladder cancer: insights from gemcitabine- and cisplatin-resistant models","volume":"18","author":"Kawahara","year":"2024","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.tranon.2025.102534_bib0013","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3892\/or.2012.1962","article-title":"Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and bcl-2","volume":"28","author":"Kim","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.tranon.2025.102534_bib0014","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/ijc.30872","article-title":"Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization","volume":"141","author":"Kou","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tranon.2025.102534_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154559","article-title":"Dioscin induces M1 macrophage polarization through connexin-43 channels in Tumor-associated-macrophages-mediated melanoma metastasis","volume":"109","author":"Kou","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.tranon.2025.102534_bib0016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13046-019-1149-4","article-title":"LINC00612 enhances the proliferation and invasion ability of bladder cancer cells as ceRNA by sponging miR-590 to elevate expression of PHF14","volume":"38","author":"Miao","year":"2019","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.tranon.2025.102534_bib0017","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/ijc.31392","article-title":"The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model","volume":"143","author":"Papaevangelou","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tranon.2025.102534_bib0018","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.toxlet.2017.11.031","article-title":"Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation","volume":"284","author":"Qiao","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tranon.2025.102534_bib0019","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/j.wneu.2019.12.182","article-title":"MicroRNA-195 functions as a tumor suppressor by directly targeting fatty acid synthase in malignant meningioma","volume":"136","author":"Song","year":"2020","journal-title":"World Neurosurg."},{"key":"10.1016\/j.tranon.2025.102534_bib0020","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/j.wneu.2019.12.182","article-title":"MicroRNA-195 functions as a tumor suppressor by directly targeting fatty acid synthase in malignant meningioma","volume":"136","author":"Song","year":"2020","journal-title":"World Neurosurg."},{"key":"10.1016\/j.tranon.2025.102534_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3170950","article-title":"In Silico establishment and validation of novel lipid metabolism-related gene signature in bladder cancer","volume":"2022","author":"Sun","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tranon.2025.102534_bib0022","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.18632\/aging.103374","article-title":"Long non-coding RNA DLX6-AS1 facilitates bladder cancer progression through modulating miR-195-5p\/VEGFA signaling pathway","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.tranon.2025.102534_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102396","article-title":"Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer","volume":"56","author":"Wang","year":"2025","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.tranon.2025.102534_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102396","article-title":"Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer","volume":"56","author":"Wang","year":"2025","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.tranon.2025.102534_bib0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbrc.2021.04.024","article-title":"Dioscin induces ferroptosis and synergistic cytotoxicity with chemotherapeutics in melanoma cells","volume":"557","author":"Xie","year":"2021","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.tranon.2025.102534_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.836939","article-title":"Fatty acid synthase is the key regulator of Fatty acid metabolism and is related to immunotherapy in bladder cancer","volume":"13","author":"Xiong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2025.102534_bib0027","first-page":"843","article-title":"Expression of miR-195 and MEK1 in patients with bladder cancer and their relationship to prognosis","volume":"12","author":"Yang","year":"2019","journal-title":"Int. J. Clin. Exp. Patho."},{"key":"10.1016\/j.tranon.2025.102534_bib0028","doi-asserted-by":"crossref","first-page":"97260","DOI":"10.18632\/oncotarget.21919","article-title":"Expression of miR-195 is associated with chemotherapy sensitivity of cisplatin and clinical prognosis in gastric cancer","volume":"8","author":"Ye","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2025.102534_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111399","article-title":"LncRNA HOXA11-AS intercepts the POU2F2-mediated downregulation of SLC3A2 in osteoarthritis to suppress ferroptosis","volume":"124","author":"Yu","year":"2024","journal-title":"Cell Signal."},{"key":"10.1016\/j.tranon.2025.102534_bib0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41585-024-00857-z","article-title":"Targeting histone modifiers in bladder cancer therapy - preclinical and clinical evidence","volume":"21","author":"Zhang","year":"2024","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.tranon.2025.102534_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112973","article-title":"Dioscin potentiates the antitumor effect of suicide gene therapy in melanoma by gap junction intercellular communication-mediated antigen cross-presentation","volume":"150","author":"Zhang","year":"2022","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.tranon.2025.102534_bib0032","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/bph.13862","article-title":"Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a\/sirtuin 1 signalling pathway","volume":"174","author":"Zhang","year":"2017","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.tranon.2025.102534_bib0033","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3892\/etm.2015.2633","article-title":"microRNA-195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog\/signal transducer and activator of transcription-3 signaling","volume":"10","author":"Zhao","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.tranon.2025.102534_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.919829","article-title":"Analysis and identification of the necroptosis landscape on therapy and prognosis in bladder cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.tranon.2025.102534_bib0035","first-page":"101","article-title":"Dioscin induces demethylation of DAPK-1 and RASSF-1alpha genes via the antioxidant capacity, resulting in apoptosis of bladder cancer T24 cells","volume":"16","author":"Zhou","year":"2017","journal-title":"EXCLI. J."},{"key":"10.1016\/j.tranon.2025.102534_bib0036","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325002657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325002657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:54:59Z","timestamp":1773118499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523325002657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"alternative-id":["S1936523325002657"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102534","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dioscin initiates dual roles in bladder cancer progression via miR-195\u20135p\/FASN\/SLC3A2 axis-mediated cell death mechanisms","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. CCBYLICENSE","name":"copyright","label":"Copyright"}],"article-number":"102534"}}