{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:23:16Z","timestamp":1781083396699,"version":"3.54.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF2019R1I1A3A01060447"],"award-info":[{"award-number":["NRF2019R1I1A3A01060447"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF-2020R1A6A1A03043026"],"award-info":[{"award-number":["NRF-2020R1A6A1A03043026"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience & Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003702","name":"Korea Institute of Energy Research","doi-asserted-by":"publisher","award":["20018494"],"award-info":[{"award-number":["20018494"]}],"id":[{"id":"10.13039\/501100003702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003702","name":"Korea Institute of Energy Research","doi-asserted-by":"publisher","award":["P0020622"],"award-info":[{"award-number":["P0020622"]}],"id":[{"id":"10.13039\/501100003702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003661","name":"Korea Institute for Advancement of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tranon.2025.102546","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:17:08Z","timestamp":1759547828000},"page":"102546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A scheme to navigate \u201cbiomolecule X\u201d from Platycladi Folium against hepatocellular carcinoma via phytoinformatics"],"prefix":"10.1016","volume":"62","author":[{"given":"Ki-Kwang","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seol Hee","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ha","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki-Tae","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2025.102546_bib0001","article-title":"Hepatocellular carcinoma in 2021: an exhaustive update","volume":"13","author":"Philips","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.tranon.2025.102546_bib0002","first-page":"1","article-title":"Hepatocellular carcinoma (HCC): epidemiology, etiology and molecular classification","volume":"149","author":"Chidambaranathan-Reghupaty","year":"2021","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911363","article-title":"Challenges and future trends of Hepatocellular Carcinoma immunotherapy","volume":"23","author":"Rizzo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102546_bib0004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-981-10-5765-6_2","article-title":"Hepatitis B Virus-associated hepatocellular carcinoma","volume":"1018","author":"Xie","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.tranon.2025.102546_bib0005","first-page":"1","article-title":"Correlation analysis of metabolic characteristics and the risk of metabolic-associated fatty liver disease - related hepatocellular carcinoma","author":"Xie","year":"2022","journal-title":"Sci. Reports"},{"key":"10.1016\/j.tranon.2025.102546_bib0006","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221145549","article-title":"MAFLD: a multisystem disease","volume":"14","author":"Pipitone","year":"2023","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.tranon.2025.102546_bib0007","first-page":"352","article-title":"Associations between \u201ccancer risk\u201d, \u201cinflammation\u201d and \u201cmetabolic syndrome\u201d: a scoping review","volume":"13","author":"Vitale","year":"2024","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.tranon.2025.102546_bib0008","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.tranon.2025.102546_bib0009","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ng.3252","article-title":"Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets","volume":"47","author":"Schulze","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tranon.2025.102546_bib0010","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102546_bib0011","doi-asserted-by":"crossref","first-page":"69267","DOI":"10.18632\/oncotarget.12121","article-title":"Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2025.102546_bib0012","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ygeno.2013.04.001","article-title":"Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections","volume":"102","author":"Tornesello","year":"2013","journal-title":"Genomics"},{"key":"10.1016\/j.tranon.2025.102546_bib0013","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.clnesp.2025.03.023","article-title":"Prognostic significance of the cachexia index (CXI) in patients with cancer: a systematic review and meta-analysis","volume":"68","author":"Bas","year":"2025","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.tranon.2025.102546_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71746-z","article-title":"Sex differences in adverse events among cancer patients receiving immune checkpoint inhibitors: the MOUSEION-07 systematic review and meta-analysis","volume":"14","author":"Vitale","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2025.102546_bib0015","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3390\/jpm12111788","article-title":"Trans-arterial chemoembolization plus systemic treatments for hepatocellular carcinoma: an update","volume":"12","author":"Rizzo","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.tranon.2025.102546_bib0016","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1200\/JCO.2012.45.8372","article-title":"Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial","volume":"31","author":"Cheng","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102546_bib0017","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1200\/JCO.2012.47.3009","article-title":"Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study","volume":"31","author":"Llovet","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102546_bib0018","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1200\/JCO.2013.54.3298","article-title":"Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial","volume":"33","author":"Cainap","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102546_bib0019","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1200\/JCO.2013.53.7746","article-title":"SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma","volume":"33","author":"Zhu","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102546_bib0020","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.28600","article-title":"Randomized, open-label phase 2 study comparing frontline dovitinib versus sorafenib in patients with advanced hepatocellular carcinoma","volume":"64","author":"Cheng","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.tranon.2025.102546_bib0021","article-title":"An overview on natural product drug formulations from conventional medicines to nanomedicines: past, present and future","volume":"63","author":"Elkordy","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.tranon.2025.102546_bib0022","first-page":"420","article-title":"Natural products as reservoirs of novel therapeutic agents","volume":"17","author":"Mushtaq","year":"2018","journal-title":"EXCLI J."},{"key":"10.1016\/j.tranon.2025.102546_bib0023","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-derived natural products: a source for drug discovery and development","volume":"3","author":"Sezer","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"10.1016\/j.tranon.2025.102546_bib0024","article-title":"Effects of platycodins folium on depression in mice based on a UPLC-Q\/TOF-MS serum assay and hippocampus metabolomics","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.tranon.2025.102546_bib0025","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1080\/14786419.2018.1530234","article-title":"Abd El-Azim, new cytotoxic flavonoids from aerial parts of Platycladus orientalis L","volume":"34","author":"Selim","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0026","article-title":"A review on applications of computational methods in drug screening and design","volume":"25","author":"Lin","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.tranon.2025.102546_bib0027","first-page":"1","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","author":"Daina","year":"2017","journal-title":"Sci. Reports"},{"key":"10.1016\/j.tranon.2025.102546_bib0028","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tranon.2025.102546_bib0029","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0030","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0031","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0032","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbaa357","article-title":"Topological network measures for drug repositioning","volume":"22","author":"Badkas","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.tranon.2025.102546_bib0034","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10822-020-00370-6","article-title":"Testing automatic methods to predict free binding energy of host\u2013guest complexes in SAMPL7 challenge","volume":"35","author":"Serillon","year":"2021","journal-title":"J. Comput. Aided. Mol. Des."},{"key":"10.1016\/j.tranon.2025.102546_bib0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev-biophys-070816-033654","article-title":"Predicting binding free energies: frontiers and benchmarks","volume":"46","author":"Mobley","year":"2017","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.tranon.2025.102546_bib0036","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein\u2013ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0037","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.soc.2022.03.013","article-title":"The cancer genome atlas: impact and future directions in Sarcoma","volume":"31","author":"Burns","year":"2022","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"10.1016\/j.tranon.2025.102546_bib0038","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tranon.2025.102546_bib0039","doi-asserted-by":"crossref","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2021.05.028","article-title":"In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: a systematic review","volume":"335","author":"Fedi","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.tranon.2025.102546_bib0041","first-page":"81","article-title":"Drug absorption and bioavailability, Introd. To basics pharmacol. Toxicol","volume":"Vol. 1","author":"Paul","year":"2019","journal-title":"Gen. Mol. Pharmacol. Princ. Drug Action"},{"key":"10.1016\/j.tranon.2025.102546_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13321-015-0054-x","article-title":"Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients","volume":"7","author":"Freitas","year":"2015","journal-title":"J. Cheminform."},{"key":"10.1016\/j.tranon.2025.102546_bib0043","first-page":"1","author":"Price","year":"2023","journal-title":"Drug Bioavailability, XPharm Compr. Pharmacol. Ref."},{"key":"10.1016\/j.tranon.2025.102546_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109995","article-title":"ESR1 and p53 interactome alteration defines mechanisms of tamoxifen response in luminal breast cancer","volume":"27","author":"Oturkar","year":"2024","journal-title":"IScience"},{"key":"10.1016\/j.tranon.2025.102546_bib0045","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.3390\/ijms19082354","article-title":"Retinoid X receptor antagonists","volume":"19","author":"Watanabe","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102546_bib0046","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.3390\/ijms21093126","article-title":"Hedgehog signal inhibitor GANT61 inhibits the malignant behavior of undifferentiated hepatocellular carcinoma cells by targeting non-canonical GLI signaling","volume":"21","author":"Harada","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102546_bib0047","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1039\/D3CP02256K","article-title":"Data-driven tailoring of molecular dipole polarizability and frontier orbital energies in chemical compound space","volume":"25","author":"G\u00f3ger","year":"2023","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.tranon.2025.102546_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-024-05059-0","article-title":"A strategy to pioneer key agent(s) in cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology","volume":"22","author":"Oh","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tranon.2025.102546_bib0049","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.1080\/21655979.2021.1985328","article-title":"Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings","volume":"12","author":"Zhao","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.tranon.2025.102546_bib0050","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1751-1097.2008.00531.x","article-title":"Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of Human keratinocytes","volume":"85","author":"Han","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.tranon.2025.102546_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/ehp.10403","article-title":"PI-3K\/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced Human keratinocyte transformation","volume":"116","author":"Ouyang","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tranon.2025.102546_bib0052","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/biom15060835","article-title":"\u03b19 Nicotinic acetylcholine receptor promotes tumor proliferation and suppresses ferroptosis in triple-negative breast cancer","volume":"15","author":"Feng","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.tranon.2025.102546_bib0053","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/bcp.13021","article-title":"AKT in cancer: new molecular insights and advances in drug development","volume":"82","author":"Mundi","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.tranon.2025.102546_bib0054","doi-asserted-by":"crossref","DOI":"10.1111\/cts.13778","article-title":"New insight of chemical constituents in Persea americana fruit against obesity via integrated pharmacology","volume":"17","author":"Cha","year":"2024","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.tranon.2025.102546_bib0055","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1038\/emm.2015.115","article-title":"Estrogen-related receptor \u03b3 is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tranon.2025.102546_bib0056","first-page":"1","article-title":"FGF\/FGFR signaling in hepatocellular carcinoma: from carcinogenesis to recent therapeutic intervention","volume":"13","author":"Wang","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tranon.2025.102546_bib0057","article-title":"Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha","volume":"7","author":"Lu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.tranon.2025.102546_bib0058","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-23-3941","article-title":"Cell-free human papillomavirus (HPV) DNA is a sensitive biomarker for prognosis and for early detection of relapse in locally advanced cervical cancer","author":"Sivars","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0059","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.amjsurg.2015.03.001","article-title":"Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma","volume":"210","author":"Jeng","year":"2015","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.tranon.2025.102546_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106858","article-title":"Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth","volume":"195","author":"Maresca","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tranon.2025.102546_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10040253","article-title":"Pharmacokinetic profile of kaurenoic acid after oral administration of Araliae Continentalis Radix extract powder to humans","volume":"10","author":"Choi","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.tranon.2025.102546_bib0062","first-page":"1","article-title":"Anti-inflammatory effects of \u03b1-humulene on the release of pro-inflammatory cytokines in lipopolysaccharide-induced THP-1 cells","author":"Becker","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.tranon.2025.102546_bib0063","first-page":"147","article-title":"Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer","volume":"12","author":"Jones","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.tranon.2025.102546_bib0064","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1573406411006040184","article-title":"Phytosterols in physiological concentrations target multidrug resistant cancer cells","volume":"6","author":"Rubis","year":"2010","journal-title":"Med. Chem."},{"key":"10.1016\/j.tranon.2025.102546_bib0065","first-page":"7965","volume":"7","author":"Gylling","year":"2015","journal-title":"Phytosterols, Phytostanols, and Lipoprotein Metabolism"},{"key":"10.1016\/j.tranon.2025.102546_bib0066","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/cmdc.201600161","article-title":"Multitarget drug discovery and polypharmacology","volume":"11","author":"Bolognesi","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.tranon.2025.102546_bib0067","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/cmdc.201500521","article-title":"A. Cavalli, development and application of a virtual screening protocol for the identification of multitarget fragments","volume":"11","author":"Bottegoni","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.tranon.2025.102546_bib0068","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11010-014-2071-x","article-title":"Down-regulation of Gli-1 inhibits hepatocellular carcinoma cell migration and invasion","volume":"393","author":"Chen","year":"2014","journal-title":"Mol. Cell. Biochem."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325002773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325002773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:12:10Z","timestamp":1773159130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523325002773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":68,"alternative-id":["S1936523325002773"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102546","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A scheme to navigate \u201cbiomolecule X\u201d from Platycladi Folium against hepatocellular carcinoma via phytoinformatics","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102546","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102546"}}