{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:13:53Z","timestamp":1787847233223,"version":"build-2784847793"},"reference-count":180,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015871","name":"Groupe Lipides et Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008954","name":"Soci\u00e9t\u00e9 Francophone Nutrition Clinique et M\u00e9tabolisme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011045","name":"Minist\u00e8re de l&apos;Enseignement sup\u00e9rieur de la Recherche et de l&apos;Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004562","name":"Minist\u00e8re de l&apos;Enseignement sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.tranon.2025.102596","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T14:12:32Z","timestamp":1762870352000},"page":"102596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nutritional strategies against skeletal muscle wasting in cancer-associated cachexia: the role of \u03b2-hydroxybutyrate and polyunsaturated fatty acids"],"prefix":"10.1016","volume":"63","author":[{"given":"Benjamin","family":"Hay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fougerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-6354","authenticated-orcid":false,"given":"Vera","family":"Mazurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-973X","authenticated-orcid":false,"given":"Olivier","family":"Le Bacquer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-7874","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Talvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-0277","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Capel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2025.102596_bib0001","series-title":"Cachexia. StatPearls","author":"Baker Rogers","year":"2024"},{"key":"10.1016\/j.tranon.2025.102596_bib0002","article-title":"The diagnosis of surgical cancer \/by John Zacharias Laurence","volume":"1858","author":"Laurence","year":"2023","journal-title":"Wellcome Collection"},{"key":"10.1016\/j.tranon.2025.102596_bib0003","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tranon.2025.102596_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.tranon.2025.102596_bib0005","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.trecan.2018.10.001","article-title":"Cancer cachexia: more than skeletal muscle wasting","volume":"4","author":"Schmidt","year":"2018","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.tranon.2025.102596_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40170-024-00332-8","article-title":"Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia","volume":"12","author":"Ruan","year":"2024","journal-title":"Cancer Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0007","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1136\/bmjspcare-2019-002176","article-title":"Cachexia is associated with depression, anxiety and quality of life in cancer patients","volume":"13","author":"Sun","year":"2023","journal-title":"BMJ Support. Palliat. Care"},{"key":"10.1016\/j.tranon.2025.102596_bib0008","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1002\/jcsm.13263","article-title":"Association of muscle wasting with mortality risk among adults: a systematic review and meta-analysis of prospective studies","volume":"14","author":"Zhou","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0009","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/fcp.12931","article-title":"Deliberation on debilitating condition of cancer cachexia: skeletal muscle wasting","volume":"37","author":"Dave","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.tranon.2025.102596_bib0010","article-title":"Malnutrition in cancer patients: causes, consequences and treatment options","author":"Arends","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.tranon.2025.102596_bib0011","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jcsm.12528","article-title":"Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia","volume":"11","author":"Peixoto da","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0012","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4103\/apjon.apjon_20_18","article-title":"Impact of cancer cachexia on hospitalization-associated physical inactivity in elderly patients with advanced non-small-cell lung cancer","volume":"5","author":"Morikawa","year":"2018","journal-title":"Asia Pac. J. Oncol. Nurs."},{"key":"10.1016\/j.tranon.2025.102596_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188359","article-title":"Advances in cancer cachexia: intersection between affected organs, mediators, and pharmacological interventions","volume":"1873","author":"Siddiqui","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.tranon.2025.102596_bib0014","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1158\/1541-7786.MCR-13-0189","article-title":"The role of inflammatory pathways in cancer-associated cachexia and radiation resistance","volume":"11","author":"Laine","year":"2013","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0015","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.clnu.2016.12.003","article-title":"Association between cachexia, chemotherapy and outcomes in older cancer patients: a systematic review","volume":"36","author":"Caillet","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0016","article-title":"Desensitizing effect of cancer cachexia on immune checkpoint inhibitors in patients with advanced NSCLC","volume":"1","author":"Miyawaki","year":"2020","journal-title":"JTo Clin. Res. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0017","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcsm.12402","article-title":"Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review","volume":"10","author":"Anker","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0018","doi-asserted-by":"crossref","first-page":"32","DOI":"10.12703\/r\/11-32","article-title":"The role of mTORC1 in the regulation of skeletal muscle mass","volume":"11","author":"Bodine","year":"2022","journal-title":"Fac. Rev."},{"key":"10.1016\/j.tranon.2025.102596_bib0019","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/jcb.29682","article-title":"Akt activation by insulin treatment attenuates cachexia in Walker-256 tumor-bearing rats","volume":"121","author":"de Fatima Silva","year":"2020","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.tranon.2025.102596_bib0020","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1038\/onc.2013.266","article-title":"PDK1 controls upstream PI3K expression and PIP3 generation","volume":"33","author":"Dieterle","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.tranon.2025.102596_bib0021","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1158\/2159-8290.CD-15-0460","article-title":"PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex","volume":"5","author":"Liu","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2025.102596_bib0022","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.biocel.2013.05.039","article-title":"Regulation of muscle protein synthesis and the effects of catabolic states","volume":"45","author":"Gordon","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0023","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/acs.biochem.7b00957","article-title":"eIF2B Mechanisms of action and regulation: a thermodynamic view","volume":"57","author":"Bogorad","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.tranon.2025.102596_bib0024","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbadis.2014.12.006","article-title":"Muscle-specific GSK-3\u03b2 ablation accelerates regeneration of disuse-atrophied skeletal muscle","volume":"1852","author":"Pansters","year":"2015","journal-title":"Biochim. et Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.tranon.2025.102596_bib0025","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3892\/mmr.2020.11105","article-title":"Phosphorylated GSK-3\u03b2 protects stress-induced apoptosis of myoblasts via the PI3K\/Akt signaling pathway","volume":"22","author":"Liu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0026","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1242\/jeb.062869","article-title":"Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle","volume":"215","author":"MacLea","year":"2012","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0027","doi-asserted-by":"crossref","DOI":"10.21037\/pcm.2018.07.02","article-title":"The structure of mTOR complexes at a glance","volume":"1","author":"Yang","year":"2018","journal-title":"Precis. Cancer Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0028","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.celrep.2016.09.020","article-title":"S6K1 Is required for increasing skeletal muscle force during hypertrophy","volume":"17","author":"Marabita","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0029","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1172\/JCI77361","article-title":"Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity","volume":"125","author":"Tsai","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2025.102596_bib0030","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1038\/s41598-018-27429-7","article-title":"Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury","volume":"8","author":"Paolini","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.101041","article-title":"Role of autophagy in muscle disease","volume":"82","author":"Franco-Romero","year":"2021","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0032","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ajpath.2012.12.023","article-title":"Autophagic degradation contributes to muscle wasting in cancer cachexia","volume":"182","author":"Penna","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tranon.2025.102596_bib0033","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1016\/j.jmb.2019.05.032","article-title":"Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function","volume":"431","author":"Penna","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.638983","article-title":"The role of autophagy in skeletal muscle diseases","volume":"12","author":"Xia","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0035","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nature09076","article-title":"Termination of autophagy and reformation of lysosomes regulated by mTOR","volume":"465","author":"Yu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2025.102596_bib0036","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrendo.2014.35","article-title":"Autophagy\u2013a key player in cellular and body metabolism","volume":"10","author":"Kim","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.tranon.2025.102596_bib0037","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30977-7","article-title":"AMPK contributes to autophagosome maturation and lysosomal fusion","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0038","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0039","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1038\/ncomms7670","article-title":"Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy","volume":"6","author":"Milan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2025.102596_bib0040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.15698\/cst2018.11.163","article-title":"p38\u03b2 MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice","volume":"2","author":"Liu","year":"2018","journal-title":"Cell Stress."},{"key":"10.1016\/j.tranon.2025.102596_bib0041","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12576-020-00768-9","article-title":"The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders","volume":"70","author":"Kitajima","year":"2020","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.tranon.2025.102596_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105248","article-title":"The ubiquitin-proteasome system and its crosstalk with mitochondria as therapeutic targets in medicine","volume":"163","author":"Kodro\u0144","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0043","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0044","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqab029","article-title":"Identification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics","author":"Baehr","year":"2021","journal-title":"Function"},{"key":"10.1016\/j.tranon.2025.102596_bib0045","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1074\/jbc.M411346200","article-title":"Degradation of MyoD mediated by the SCF (MAFbx) Ubiquitin Ligase *","volume":"280","author":"Tintignac","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tranon.2025.102596_bib0046","doi-asserted-by":"crossref","first-page":"E495","DOI":"10.1152\/ajpendo.00389.2016","article-title":"Forkhead box O3 plays a role in skeletal muscle atrophy through expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in Cushing\u2019s syndrome","volume":"312","author":"Kang","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0047","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cmet.2011.01.001","article-title":"Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle","volume":"13","author":"Shimizu","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0048","doi-asserted-by":"crossref","first-page":"C1316","DOI":"10.1152\/ajpcell.00114.2011","article-title":"Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins","volume":"301","author":"Lokireddy","year":"2011","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0049","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1083\/jcb.201211134","article-title":"The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass","volume":"203","author":"Winbanks","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"IKKbeta\/NF-kappaB activation causes severe muscle wasting in mice","volume":"119","author":"Cai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2025.102596_bib0051","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41467-022-35524-7","article-title":"Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury","volume":"14","author":"Sastourn\u00e9-Arrey","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2025.102596_bib0052","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/j.2040-4603.2015.tb00646.x","article-title":"Satellite cells and skeletal muscle regeneration","volume":"5","author":"Dumont","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0053","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00018-019-03093-6","article-title":"von Eyss B, von Maltzahn J. Adult stem cells at work: regenerating skeletal muscle","volume":"76","author":"Schmidt","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tranon.2025.102596_bib0054","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20220284","article-title":"Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies","volume":"43","author":"Deprez","year":"2023","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0055","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210110","article-title":"Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases","volume":"11","author":"Molina","year":"2021","journal-title":"Open. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0056","article-title":"What role do inflammatory cytokines play in cancer cachexia?","volume":"14","author":"Malla","year":"2022","journal-title":"Cureus."},{"key":"10.1016\/j.tranon.2025.102596_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106700","article-title":"Mechanisms of immune escape in the cancer immune cycle","volume":"86","author":"Tang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tranon.2025.102596_bib0058","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3390\/antiox11091686","article-title":"Inflammation: roles in skeletal muscle atrophy","volume":"11","author":"Ji","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.tranon.2025.102596_bib0059","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41577-021-00624-w","article-title":"The interplay of immunology and cachexia in infection and cancer","volume":"22","author":"Baazim","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tranon.2025.102596_bib0060","doi-asserted-by":"crossref","first-page":"eaay9592","DOI":"10.1126\/scitranslmed.aay9592","article-title":"Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia","volume":"13","author":"Sartori","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0061","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biocel.2013.12.003","article-title":"Myostatin signaling regulates Akt activity via the regulation of miR-486 expression","volume":"47","author":"Hitachi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0062","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1210\/me.2013-1194","article-title":"Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo","volume":"27","author":"Goodman","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tranon.2025.102596_bib0063","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/molecules23020285","article-title":"PTEN inhibition in Human disease therapy","volume":"23","author":"Pulido","year":"2018","journal-title":"Molecules."},{"key":"10.1016\/j.tranon.2025.102596_bib0064","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","article-title":"The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression","volume":"95","author":"Vaupel","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0065","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.3390\/cancers12113244","article-title":"Lactate in the tumor microenvironment: an essential molecule in cancer progression and treatment","volume":"12","author":"P\u00e9rez-Tom\u00e1s","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.tranon.2025.102596_bib0066","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/cbf.3652","article-title":"Distinct glycolytic pathway regulation in liver, tumour and skeletal muscle of mice with cancer cachexia","volume":"39","author":"Visavadiya","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.tranon.2025.102596_bib0067","first-page":"1","article-title":"Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison","volume":"73","author":"Masi","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0068","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jcsm.13073","article-title":"Molecular mechanisms of cancer cachexia-related loss of skeletal muscle mass: data analysis from preclinical and clinical studies","volume":"14","author":"Martin","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0069","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.3390\/ijms22179469","article-title":"IGF-1 and IGFBP-3 in inflammatory cachexia","volume":"22","author":"Mart\u00edn","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102596_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.597675","article-title":"Inflammation and skeletal muscle wasting during Cachexia","volume":"11","author":"Webster","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0071","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cmet.2016.10.010","article-title":"Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity","volume":"24","author":"Flint","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0072","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.cmet.2023.05.008","article-title":"Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia","volume":"35","author":"Ferrer","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0073","doi-asserted-by":"crossref","unstructured":"Gicquel T., Marchiano F., Reyes-Castellanos G., Audebert S., Camoin L., Habermann B.H., et al. Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model. eLife.;13:RP93312. https:\/\/doi.org\/10.7554\/eLife.93312.","DOI":"10.7554\/eLife.93312"},{"key":"10.1016\/j.tranon.2025.102596_bib0074","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3292087","article-title":"Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation","author":"VanderVeen","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tranon.2025.102596_bib0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbcan.2018.07.008","article-title":"Mitochondrial dynamics in cancer-induced cachexia","volume":"1870","author":"van der Ende","year":"2018","journal-title":"Biochim. et Biophys. Acta (BBA) - Rev. Can."},{"key":"10.1016\/j.tranon.2025.102596_bib0076","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3390\/cells10113150","article-title":"Mitochondrial dysfunction in cancer cachexia: impact on muscle health and regeneration","volume":"10","author":"Beltr\u00e0","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tranon.2025.102596_bib0077","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1186\/s12885-025-14630-x","article-title":"Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females","volume":"25","author":"Morena","year":"2025","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.tranon.2025.102596_bib0078","doi-asserted-by":"crossref","first-page":"C1514","DOI":"10.1152\/ajpcell.00647.2024","article-title":"Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex","volume":"327","author":"Morena","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0079","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/cancers15051407","article-title":"Unveiling the role of the proton gateway, uncoupling proteins (UCPs), in cancer cachexia","volume":"15","author":"Joshi","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.tranon.2025.102596_bib0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3164\/jcbn.23-1","article-title":"Mitophagy-mediated inflammation and oxidative stress contribute to muscle wasting in cancer cachexia","volume":"73","author":"Zhang","year":"2023","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0081","doi-asserted-by":"crossref","DOI":"10.3724\/abbs.2023151","article-title":"Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia","author":"Qiu","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.tranon.2025.102596_bib0082","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3390\/cancers11121929","article-title":"ER stress and unfolded protein response in cancer cachexia","volume":"11","author":"Roy","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.tranon.2025.102596_bib0083","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2063179","article-title":"Role of oxidative stress as key regulator of muscle wasting during Cachexia","volume":"2018","author":"\u00c1brigo","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tranon.2025.102596_bib0084","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.656604","article-title":"Amino acid trafficking and skeletal muscle protein synthesis: a case of supply and demand","volume":"9","author":"White","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/BST20130244","article-title":"AMPK \u2013 a cellular energy sensor primarily regulated by AMP","volume":"42","author":"Gowans","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tranon.2025.102596_bib0086","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1096\/fj.201700442R","article-title":"AMPK in skeletal muscle function and metabolism","volume":"32","author":"Kj\u00f8bsted","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.tranon.2025.102596_bib0087","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/jcsm.12232","article-title":"Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice","volume":"8","author":"Brown","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0088","first-page":"275","article-title":"AMP-activated protein kinase mediates mitochondrial fission in response to energy stress","volume":"351","author":"Toyama","year":"2016","journal-title":"Science 1979"},{"key":"10.1016\/j.tranon.2025.102596_bib0089","doi-asserted-by":"crossref","first-page":"E1042","DOI":"10.1152\/ajpendo.00410.2012","article-title":"Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK","volume":"304","author":"White","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0090","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.3390\/ijms22052567","article-title":"Confounding roles of ER stress and the unfolded protein response in skeletal muscle atrophy","volume":"22","author":"Gallot","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2025.102596_bib0091","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.878755","article-title":"Hidden agenda - the involvement of endoplasmic reticulum stress and unfolded protein response in inflammation-induced muscle wasting","volume":"13","author":"Kny","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2025.102596_bib0092","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/febs.14358","article-title":"ER stress in skeletal muscle remodeling and myopathies","volume":"286","author":"Afroze","year":"2019","journal-title":"FEBS. J."},{"key":"10.1016\/j.tranon.2025.102596_bib0093","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding and unmasking of golgi localization signals","volume":"3","author":"Shen","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.tranon.2025.102596_bib0094","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41594-019-0324-9","article-title":"UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor","volume":"26","author":"Kopp","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0095","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1101\/gad.964702","article-title":"IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response","volume":"16","author":"Lee","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.tranon.2025.102596_bib0096","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.molcel.2007.06.011","article-title":"XBP1 Controls diverse cell type- and condition-specific transcriptional regulatory networks","volume":"27","author":"Acosta-Alvear","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tranon.2025.102596_bib0097","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nsb0402-239","article-title":"How calpain is activated by calcium","volume":"9","author":"Khorchid","year":"2002","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0098","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118788","article-title":"Role of calpains in promoting desmin filaments depolymerization and muscle atrophy","volume":"1867","author":"Cohen","year":"2020","journal-title":"Biochim. et Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0099","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1093\/hmg\/ddv116","article-title":"CAPN3-mediated processing of C-terminal titin replaced by pathological cleavage in titinopathy","volume":"24","author":"Charton","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tranon.2025.102596_bib0100","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/antiox9090852","article-title":"Oxidative stress: concept and some practical aspects","volume":"9","author":"Sies","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.tranon.2025.102596_bib0101","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2016.02.021","article-title":"Redox control of skeletal muscle atrophy","volume":"98","author":"Powers","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0102","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/flgastro-2019-101324","article-title":"Patient ownership of primary biliary cholangitis long-term management","volume":"12","author":"Leighton","year":"2021","journal-title":"Frontline Gastroenterol."},{"key":"10.1016\/j.tranon.2025.102596_bib0103","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1172\/JCI68523","article-title":"NF-\u03bab-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia","volume":"123","author":"He","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2025.102596_bib0104","article-title":"Decreased insulin-like growth factor-1 expression in response to mechanical loading is associated with skeletal muscle anabolic resistance in cancer cachexia","volume":"69\u201370","author":"Miyazaki","year":"2023","journal-title":"Growth Horm. IGF. Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0105","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.3390\/jcm9072029","article-title":"Mathematical model of muscle wasting in cancer cachexia","volume":"9","author":"Farhang-Sardroodi","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0106","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13045-023-01454-0","article-title":"Cancer cachexia: molecular mechanisms and treatment strategies","volume":"16","author":"Setiawan","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tranon.2025.102596_bib0107","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer cachexia: ASCO guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2025.102596_bib0108","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100092","article-title":"Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines\u2606","volume":"6","author":"Arends","year":"2021","journal-title":"ESMo Open."},{"key":"10.1016\/j.tranon.2025.102596_bib0109","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","article-title":"ESPEN practical guideline: clinical Nutrition in cancer","volume":"40","author":"Muscaritoli","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0110","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.3390\/nu12123717","article-title":"Essential amino acids and protein synthesis: insights into maximizing the muscle and whole-body response to feeding","volume":"12","author":"Church","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.tranon.2025.102596_bib0111","first-page":"nuae055","article-title":"The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and meta-analysis","author":"Therdyothin","year":"2024","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.tranon.2025.102596_bib0112","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00421-019-04104-x","article-title":"Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state","volume":"119","author":"Dzik","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0113","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.3390\/nu14173613","article-title":"The evolution of ketosis: potential impact on clinical conditions","volume":"14","author":"Dilliraj","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.tranon.2025.102596_bib0114","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/1028415X.2019.1627769","article-title":"Ketogenic diet: overview, types, and possible anti-seizure mechanisms","volume":"24","author":"Barzegar","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.tranon.2025.102596_bib0115","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/nu12030788","article-title":"Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states","volume":"12","author":"D\u0105bek","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.tranon.2025.102596_bib0116","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0117","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/s42255-023-00935-3","article-title":"Metabolic messengers: ketone bodies","volume":"5","author":"Nelson","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0118","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0119","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.3390\/biom13091330","article-title":"Exploring the therapeutic potential of ethyl 3-hydroxybutyrate in alleviating skeletal muscle wasting in cancer cachexia","volume":"13","author":"Zhou","year":"2023","journal-title":"Biomolecules."},{"key":"10.1016\/j.tranon.2025.102596_bib0120","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13578-022-00826-2","article-title":"Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate","volume":"12","author":"Chen","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.tranon.2025.102596_bib0121","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"A signaling metabolite","volume":"37","author":"Newman","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0122","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1172\/JCI113570","article-title":"Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans","volume":"82","author":"Nair","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2025.102596_bib0123","article-title":"Short term isocaloric ketogenic diet modulates NLRP3 inflammasome via B-hydroxybutyrate and fibroblast Growth factor 21","volume":"13","author":"Kim","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2025.102596_bib0124","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/ajcn\/nqy170","article-title":"Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies","volume":"108","author":"Thomsen","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0125","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fphys.2017.00310","article-title":"Intake of a Ketone Ester drink during recovery from exercise promotes mTORC1 signaling but not glycogen resynthesis in Human muscle","volume":"8","author":"Vandoorne","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0126","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12263-018-0598-2","article-title":"Effect of \u03b2-hydroxy-\u03b2-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide","volume":"13","author":"Chodkowska","year":"2018","journal-title":"Genes. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0127","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1177\/0148607115595980","article-title":"Functional roles of fatty acids and their effects on Human health","volume":"39","author":"Calder","year":"2015","journal-title":"JPEN. J. Parenter. Enteral. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0128","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cmet.2021.05.016","article-title":"Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects","volume":"33","author":"Dierge","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0129","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pharmthera.2018.12.001","article-title":"New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids","volume":"196","author":"Gorjao","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.tranon.2025.102596_bib0130","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.145207","article-title":"Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade","volume":"6","author":"Ferrere","year":"2021","journal-title":"JCI. Insight."},{"key":"10.1016\/j.tranon.2025.102596_bib0131","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/life12060880","article-title":"Cancer cachexia and antitumor immunity: common mediators and potential targets for new therapies","volume":"12","author":"Rounis","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.tranon.2025.102596_bib0132","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2025.102596_bib0133","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2025.102596_bib0134","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tranon.2025.102596_bib0135","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3390\/nu12092597","article-title":"Docosahexaenoic acid, a potential treatment for sarcopenia, modulates the ubiquitin-proteasome and the autophagy-lysosome systems","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients."},{"key":"10.1016\/j.tranon.2025.102596_bib0136","article-title":"Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia","volume":"2007","author":"Dewey","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.tranon.2025.102596_bib0137","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/nu8060329","article-title":"Insulin-sensitizing effects of omega-3 fatty acids: lost in translation?","volume":"8","author":"Lalia","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.tranon.2025.102596_bib0138","article-title":"Omega-3 fatty acid supplementation and its impact on systemic inflammation and body weight in patients with cancer cachexia-A systematic review and meta-analysis","volume":"8","author":"de Castro","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0139","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.canlet.2021.11.023","article-title":"Multi-targeted therapy of cancer by omega-3 fatty acids-an update","volume":"526","author":"Wei","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tranon.2025.102596_bib0140","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1139\/apnm-2013-0423","article-title":"Role of n-3 fatty acids in muscle loss and myosteatosis","volume":"39","author":"Ewaschuk","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0141","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.682091","article-title":"Regulation of skeletal muscle satellite cell differentiation by omega-3 polyunsaturated fatty acids: a critical review","volume":"12","author":"Isesele","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0142","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fnut.2018.00015","article-title":"Effect of eicosapentaenoic acid and docosahexaenoic acid on myogenesis and mitochondrial biosynthesis during murine skeletal muscle cell differentiation","volume":"5","author":"Hsueh","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0143","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10522-016-9667-3","article-title":"Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation","volume":"18","author":"Saini","year":"2017","journal-title":"Biogerontology."},{"key":"10.1016\/j.tranon.2025.102596_bib0144","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1038\/emm.2016.133","article-title":"Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro","volume":"49","author":"Shin","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0145","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3390\/cimb43020042","article-title":"Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities","volume":"43","author":"Talib","year":"2021","journal-title":"Curr. Issues. Mol. Biol."},{"key":"10.1016\/j.tranon.2025.102596_bib0146","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1001\/jama.1925.02660520007003","article-title":"The ketogenic diet in Epilepsy","volume":"84","author":"PETERMAN","year":"1925","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.tranon.2025.102596_bib0147","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A ketogenic diet extends longevity and healthspan in adult mice","volume":"26","author":"Roberts","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0148","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0149","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.molmet.2019.06.026","article-title":"Ketogenic diet in the treatment of cancer - where do we stand?","volume":"33","author":"Weber","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0150","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-018-0343-4","article-title":"Suppression of insulin feedback enhances the efficacy of PI3K inhibitors","volume":"560","author":"Hopkins","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2025.102596_bib0151","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00066-022-01941-2","article-title":"Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients","volume":"198","author":"Klement","year":"2022","journal-title":"Strahlenther. Onkol."},{"key":"10.1016\/j.tranon.2025.102596_bib0152","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/07315724.1995.10718495","article-title":"Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports","volume":"14","author":"Nebeling","year":"1995","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0153","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/jn\/nxy119","article-title":"A ketogenic diet reduces Central obesity and serum insulin in women with ovarian or endometrial cancer","volume":"148","author":"Cohen","year":"2018","journal-title":"J. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0154","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/01635581.2019.1650942","article-title":"Feasibility, safety, and beneficial effects of MCT-based ketogenic diet for breast cancer treatment: a randomized controlled trial study","volume":"72","author":"Khodabakhshi","year":"2020","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.tranon.2025.102596_bib0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nutres.2022.09.009","article-title":"Omega-3 polyunsaterated fatty acids improve quality of life and survival, but not body weight in cancer cachexia: a systematic review and meta-analysis of controlled trials","volume":"107","author":"Jin","year":"2022","journal-title":"Nutr. Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0156","doi-asserted-by":"crossref","DOI":"10.1177\/15347354241275052","article-title":"Omega-3 fatty acids increase weight and Quality of life scores in patients with advanced non-small cell lung cancer and cancer cachexia: a meta-analysis","volume":"23","author":"Chua","year":"2024","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.tranon.2025.102596_bib0157","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/j.cmet.2023.11.003","article-title":"GDF15 is a major determinant of ketogenic diet-induced weight loss","volume":"35","author":"Lu","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0158","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41591-020-0945-x","article-title":"Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice","volume":"26","author":"Suriben","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0159","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jcsm.12033","article-title":"Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients","volume":"6","author":"Lerner","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0160","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2049-3002-2-18","article-title":"Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia","volume":"2","author":"Shukla","year":"2014","journal-title":"Cancer Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0161","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56166-8","article-title":"Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice","volume":"9","author":"Nakao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0162","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.3390\/nu14183842","article-title":"Effects of ketogenic diet on muscle metabolism in health and disease","volume":"14","author":"Yakupova","year":"2022","journal-title":"Nutrients."},{"key":"10.1016\/j.tranon.2025.102596_bib0163","doi-asserted-by":"crossref","first-page":"eado1463","DOI":"10.1126\/sciadv.ado1463","article-title":"Ketogenic diet induces p53-dependent cellular senescence in multiple organs","volume":"10","author":"Wei","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.tranon.2025.102596_bib0164","doi-asserted-by":"crossref","unstructured":"Gallop M.R., Vieira R.F.L., Mower P.D., Matsuzaki E.T., Liou W., Smart F.E., et al. A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice. Sci. Adv.;11:eadx2752. https:\/\/doi.org\/10.1126\/sciadv.adx2752.","DOI":"10.1126\/sciadv.adx2752"},{"key":"10.1016\/j.tranon.2025.102596_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101675","article-title":"A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice","volume":"69","author":"Long","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0166","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pediatrneurol.2017.01.007","article-title":"Complications during ketogenic diet initiation: prevalence, treatment, and influence on seizure outcomes","volume":"68","author":"Lin","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.tranon.2025.102596_bib0167","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116026","article-title":"Divergent sex-specific effects on a ketogenic diet: male, but not female, mice exhibit oxidative stress and cellular senescence","volume":"44","author":"Wei","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.tranon.2025.102596_bib0168","doi-asserted-by":"crossref","first-page":"63","DOI":"10.33549\/physiolres.930770","article-title":"The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women","volume":"55","author":"Kunesov\u00e1","year":"2006","journal-title":"Physiol. Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0169","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/jcsm.12554","article-title":"Ketone bodies attenuate wasting in models of atrophy","volume":"11","author":"Koutnik","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0170","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jacc.2020.12.065","article-title":"Therapeutic potential of ketone bodies for patients with cardiovascular disease: JACC State-of-the-art review","volume":"77","author":"Yurista","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.tranon.2025.102596_bib0171","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5596125","article-title":"The value of ketone bodies in the evaluation of kidney function in patients with type 2 diabetes mellitus","volume":"2021","author":"Li","year":"2021","journal-title":"J. Diabetes. Res."},{"key":"10.1016\/j.tranon.2025.102596_bib0172","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/jcm9020321","article-title":"Ketone bodies are mildly elevated in subjects with type 2 diabetes mellitus and are inversely associated with insulin resistance as measured by the lipoprotein insulin resistance index","volume":"9","author":"Garcia","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.tranon.2025.102596_bib0173","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cmet.2017.08.015","article-title":"Distinct circadian signatures in liver and gut clocks revealed by ketogenic diet","volume":"26","author":"Tognini","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.tranon.2025.102596_bib0174","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4253651","article-title":"Alternate-day ketogenic diet feeding protects against heart failure through preservation of ketogenesis in the liver","volume":"2022","author":"Guo","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.tranon.2025.102596_bib0175","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.3390\/cancers14102512","article-title":"Exercise counteracts the deleterious effects of cancer cachexia","volume":"14","author":"Tsitkanou","year":"2022","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.tranon.2025.102596_bib0176","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcsm.12900","article-title":"Physical exercise at the crossroad between muscle wasting and the immune system: implications for lung cancer cachexia","volume":"13","author":"Cortiula","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.tranon.2025.102596_bib0177","article-title":"Muscle-to-tumor crosstalk: the effect of exercise-induced myokine on cancer progression","volume":"1877","author":"Huang","year":"2022","journal-title":"Biochim. et Biophys. Acta (BBA) - Rev. Cancer"},{"key":"10.1016\/j.tranon.2025.102596_bib0178","article-title":"Gut microbiota in muscular atrophy development, progression, and treatment: new therapeutic targets and opportunities","volume":"4","author":"Chen","year":"2023","journal-title":"Innovation"},{"key":"10.1016\/j.tranon.2025.102596_bib0179","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1285516","article-title":"Diet-driven microbiome changes and physical activity in cancer patients","volume":"10","author":"Ciernikova","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.tranon.2025.102596_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2022.100800","article-title":"Diet-microbiome interactions in cancer treatment: opportunities and challenges for precision nutrition in cancer","volume":"29","author":"Greathouse","year":"2022","journal-title":"Neoplasia"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325003274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523325003274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:11:37Z","timestamp":1766157097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523325003274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":180,"alternative-id":["S1936523325003274"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102596","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutritional strategies against skeletal muscle wasting in cancer-associated cachexia: the role of \u03b2-hydroxybutyrate and polyunsaturated fatty acids","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2025.102596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102596"}}