{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:21:42Z","timestamp":1783657302688,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tranon.2026.102776","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:51:10Z","timestamp":1776354670000},"page":"102776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["CD3 and PD-L1 tissue expression have synergistic value in head and neck squamous cell carcinoma prognosis"],"prefix":"10.1016","volume":"68","author":[{"given":"Adrian v.","family":"Witzleben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Remark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Idel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julika","family":"Ribbat-Idel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Krupar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schr\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-0586","authenticated-orcid":false,"given":"Niklas","family":"Kl\u00fcmper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Doescher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsima Abou","family":"Kors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-7085","authenticated-orcid":false,"given":"Julius M","family":"Vahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9722-8771","authenticated-orcid":false,"given":"Matthias","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sonntag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-5508","authenticated-orcid":false,"given":"Cornelia","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Perner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-9520","authenticated-orcid":false,"given":"Sacha","family":"Gnjatic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Laban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0001","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"Suppl 1","key":"10.1016\/j.tranon.2026.102776_bib0002","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.ypmed.2011.08.001","article-title":"The role of HPV in head and neck cancer and review of the HPV vaccine","volume":"53","author":"D'Souza","year":"2011","journal-title":"Prev. Med."},{"issue":"5","key":"10.1016\/j.tranon.2026.102776_bib0003","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/ijc.26500","article-title":"Characteristics and survival of head and neck cancer by HPV status: a cancer registry-based study","volume":"131","author":"Sethi","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tranon.2026.102776_bib0004","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.32623","article-title":"Patterns of antibody responses to non-viral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status","author":"Gangkofner","year":"2019","journal-title":"Int. J. Cancer J. Int. Du Cancer"},{"key":"10.1016\/j.tranon.2026.102776_bib0005","first-page":"1","article-title":"The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination","author":"M\u00fchlenbruch","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tranon.2026.102776_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/hed.24442","article-title":"Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non-human papillomavirus16 viral subtypes","author":"Varier","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.tranon.2026.102776_bib0007","article-title":"Correlation of HPV16 gene status and gene expression with antibody seropositivity and TIL status in OPSCC","volume":"10","author":"von Witzleben","year":"2020","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2026.102776_bib0008","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1172\/JCI67010","article-title":"HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas","volume":"123","author":"Kostareli","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0009","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/1078-0432.CCR-13-3310","article-title":"Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas","volume":"21","author":"Seiwert","year":"2015","journal-title":"Clin. Cancer Res.: An Official J. Am. Association for Cancer Res."},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0010","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/1078-0432.CCR-17-2140","article-title":"Intratumoral HPV16-specific T cells constitute a type I-oriented tumor microenvironment to improve survival in HPV16-driven oropharyngeal cancer","volume":"24","author":"Welters","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"35","key":"10.1016\/j.tranon.2026.102776_bib0011","doi-asserted-by":"crossref","first-page":"56781","DOI":"10.18632\/oncotarget.10788","article-title":"Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors","volume":"7","author":"Wood","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.tranon.2026.102776_bib0012","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1002\/ijc.29962","article-title":"CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma","volume":"138","author":"Wagner","year":"2016","journal-title":"Int. J. Cancer J. Int. Du Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0013","article-title":"HPV-positive status associated with inflamed immune microenvironment and improved response to anti-PD-1 therapy in head and neck squamous cell carcinoma","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.tranon.2026.102776_bib0014","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/ijc.21565","article-title":"T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx","volume":"118","author":"Hoffmann","year":"2006","journal-title":"Int. J. Cancer J. Int. Du Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40425-019-0497-0","article-title":"Tbet-positive regulatory T cells accumulate in oropharyngeal cancers with ongoing tumor-specific type 1 T cell responses","volume":"7","author":"Santegoets","year":"2019","journal-title":"J. Immunother Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2019.11.014","article-title":"Immune landscape of viral- and carcinogen-driven head and neck cancer","volume":"52","author":"Cillo","year":"2020","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.tranon.2026.102776_bib0017","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.oraloncology.2011.08.007","article-title":"Relationship between the expressions of PD-L1 and tumor-infiltrating lymphocytes in oral squamous cell carcinoma","volume":"47","author":"Cho","year":"2011","journal-title":"Oral Oncol."},{"issue":"18","key":"10.1016\/j.tranon.2026.102776_bib0018","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1158\/1078-0432.CCR-17-1350","article-title":"Novel effector phenotype of tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients","volume":"24","author":"Liu","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.tranon.2026.102776_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142656","article-title":"High PD-L1 expression correlates with metastasis and poor prognosis in oral squamous cell carcinoma","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS. One"},{"issue":"4","key":"10.1016\/j.tranon.2026.102776_bib0020","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/his.13646","article-title":"PD-1 and PD-L1 expression in HNSCC primary cancer and related lymph node metastasis - impact on clinical outcome","volume":"73","author":"Schneider","year":"2018","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.tranon.2026.102776_bib0021","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/hed.27329","article-title":"High PD-L1 expression associates with low T-cadherin expression and poor prognosis in human papillomavirus-negative head and neck squamous cell carcinoma","volume":"45","author":"Wang","year":"2023","journal-title":"Head Neck"},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0022","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/hed.26534","article-title":"Immune checkpoint expression in HNSCC patients before and after definitive chemoradiotherapy","volume":"43","author":"Doescher","year":"2021","journal-title":"Head Neck"},{"issue":"6","key":"10.1016\/j.tranon.2026.102776_bib0023","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/0284186X.2020.1729407","article-title":"Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking","volume":"59","author":"Lilja-Fischer","year":"2020","journal-title":"Acta Oncol."},{"issue":"9","key":"10.1016\/j.tranon.2026.102776_bib0024","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/jop.13055","article-title":"The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma","volume":"49","author":"Gurin","year":"2020","journal-title":"J. Oral Pathol. Med."},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0025","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ijc.30770","article-title":"The PD-1\/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: a multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)","volume":"141","author":"Balermpas","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tranon.2026.102776_bib0026","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejca.2019.08.028","article-title":"Immune gene expression in head and neck squamous cell carcinoma patients","volume":"121","author":"Lecerf","year":"2019","journal-title":"Eur. J. Cancer"},{"issue":"8","key":"10.1016\/j.tranon.2026.102776_bib0028","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11912-020-00938-3","article-title":"The immune microenvironment in head and neck squamous cell carcinoma: on subsets and subsites","volume":"22","author":"Wondergem","year":"2020","journal-title":"Curr. Oncol. Rep."},{"issue":"9","key":"10.1016\/j.tranon.2026.102776_bib0029","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.18632\/oncotarget.14830","article-title":"MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy","volume":"8","author":"Laban","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2026.102776_bib0030","first-page":"497","article-title":"Multiplexed immunohistochemical consecutive staining on single slide (MICSSS): multiplexed chromogenic IHC assay for high-dimensional tissue analysis","volume":"2055","author":"Akturk","year":"2020","journal-title":"Methods Molecular Bio."},{"issue":"9","key":"10.1016\/j.tranon.2026.102776_bib0031","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.18632\/oncotarget.14830","article-title":"MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy","volume":"8","author":"Laban","year":"2017","journal-title":"Oncotarget"},{"issue":"10212","key":"10.1016\/j.tranon.2026.102776_bib0032","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.tranon.2026.102776_bib0033","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2415434","article-title":"Neoadjuvant and Adjuvant pembrolizumab in locally advanced head and neck cancer","author":"Uppaluri","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.tranon.2026.102776_bib0034","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201605","article-title":"Tissue-resident memory T cells in tumor immunity and immunotherapy","volume":"218","author":"Ok\u0142a","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tranon.2026.102776_bib0035","article-title":"Tumor infiltrating CD103+ tissue residentmemory T cells and CD103-CD8+ T cells in HNSCC are linked to outcome in primary but not metastatic disease","author":"von Witzleben","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.tranon.2026.102776_bib0036","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/cas.14272","article-title":"Infiltration of tumor-associated macrophages is involved in tumor programmed death-ligand 1 expression in early lung adenocarcinoma","volume":"111","author":"Shima","year":"2020","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0037","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s40001-024-01897-2","article-title":"M2-type tumor-associated macrophages upregulated PD-L1 expression in cervical cancer via the PI3K\/AKT pathway","volume":"29","author":"Guo","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"4","key":"10.1016\/j.tranon.2026.102776_bib0038","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00262-017-1955-5","article-title":"Regulation of PD-L1 expression on murine tumor-associated monocytes and macrophages by locally produced TNF-\u03b1","volume":"66","author":"Hartley","year":"2017","journal-title":"Cancer Immunol. Immunther."},{"key":"10.1016\/j.tranon.2026.102776_bib0039","article-title":"Distinct CD8+T cell dynamics associate with response to neoadjuvant cancer immunotherapies","author":"Li","year":"2025","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.tranon.2026.102776_bib0040","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1158\/1078-0432.CCR-21-2051","article-title":"Multiplex tissue imaging harmonization: a multicenter experience from CIMAC-CIDC immuno-oncology biomarkers Network","volume":"27","author":"Akturk","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.tranon.2026.102776_bib0041","doi-asserted-by":"crossref","first-page":"78","DOI":"10.21037\/atm-23-1928","article-title":"Multiplexed immunohistochemical analysis of the immune microenvironment of biliary tract cancers pre- & post-neoadjuvant chemotherapy: case series","volume":"12","author":"Dharmapuri","year":"2024","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"10.1016\/j.tranon.2026.102776_bib0042","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1158\/2326-6066.CIR-24-0649","article-title":"Different PD-L1 assays reveal distinct immunobiology and clinical outcomes in urothelial cancer","volume":"13","author":"Galsky","year":"2025","journal-title":"Cancer Immunol. Res."},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0043","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/path.6238","article-title":"Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer","volume":"262","author":"Jahangir","year":"2024","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.tranon.2026.102776_bib0044","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1158\/1078-0432.CCR-24-2469","article-title":"The Society for Immunotherapy of Cancer perspective on tissue-based technologies for Immuno-oncology biomarker discovery and application","volume":"31","author":"Monette","year":"2025","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.tranon.2026.102776_bib0045","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/path.6165","article-title":"Spatial analyses of immune cell infiltration in cancer: current methods and future directions: a report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer","volume":"260","author":"Page","year":"2023","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0046","doi-asserted-by":"crossref","first-page":"aaf6925","DOI":"10.1126\/sciimmunol.aaf6925","article-title":"In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide","volume":"1","author":"Remark","year":"2016","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0047","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000155","article-title":"The Society for immunotherapy of cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation","volume":"8","author":"Taube","year":"2020","journal-title":"J. Immunother Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.102776_bib0048","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-008875","article-title":"Society for immunotherapy of cancer: updates and best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) image analysis and data sharing","volume":"13","author":"Taube","year":"2025","journal-title":"J. Immunother Cancer"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326001130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326001130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:22:41Z","timestamp":1778923361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326001130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"alternative-id":["S1936523326001130"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102776","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD3 and PD-L1 tissue expression have synergistic value in head and neck squamous cell carcinoma prognosis","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102776"}}