{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:23:38Z","timestamp":1787228618126,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca PLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tranon.2026.102896","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:06:11Z","timestamp":1782907571000},"page":"102896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Baseline value and longitudinal kinetics of circulating nucleosomes during neo-adjuvant chemotherapy in newly diagnosed ovarian cancer: Results from a GINECO\/GINEGEPS study of the randomized phase II CHIVA trial"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-2562","authenticated-orcid":false,"given":"Pauline","family":"Corbaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-3470","authenticated-orcid":false,"given":"Olivier","family":"Colomban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5946-9474","authenticated-orcid":false,"given":"Gaelle","family":"Lescuyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ray-Coquard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"De Rauglaudre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Abdeddaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Combe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyriac","family":"Blonz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bataillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Alexandre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Berton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Kaminsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Bello Roufai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Venat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Dohollou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Louvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coriolan","family":"Lebreton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Abadie-Lacourtoisie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Favier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Fabbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5892-3842","authenticated-orcid":false,"given":"Nathalie","family":"Bonichon-Lamichhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Emmanuel","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Follana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pujade-Lauraine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Payen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-8857","authenticated-orcid":false,"given":"Benoit","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.tranon.2026.102896_bib0001","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.3390\/cancers12102792","article-title":"Regulating methylation at H3K27: a trick or treat for cancer cell plasticity","volume":"12","author":"Das","year":"2020","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.tranon.2026.102896_bib0002","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/cancers9010005","article-title":"Circulating nucleosomes and nucleosome modifications as biomarkers in cancer","volume":"9","author":"McAnena","year":"2017","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.tranon.2026.102896_bib0003","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1021\/cr500373h","article-title":"Nucleosome structure and function","volume":"115","author":"McGinty","year":"2015","journal-title":"Chem. Rev."},{"issue":"42","key":"10.1016\/j.tranon.2026.102896_bib0004","doi-asserted-by":"crossref","first-page":"16266","DOI":"10.1073\/pnas.0808319105","article-title":"Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood","volume":"105","author":"Fan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.tranon.2026.102896_bib0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/07357907.2011.636117","article-title":"Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer","volume":"30","author":"Ellinger","year":"2012","journal-title":"Cancer Invest."},{"key":"10.1016\/j.tranon.2026.102896_bib0006","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ceb.2015.10.003","article-title":"PRC2 mediated H3K27 methylations in cellular identity and cancer","volume":"37","author":"Conway","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102896_bib0007","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1038\/s41598-021-86630-3","article-title":"A novel proteomics approach to epigenetic profiling of circulating nucleosomes","volume":"11","author":"Van den Ackerveken","year":"2021","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.tranon.2026.102896_bib0008","doi-asserted-by":"crossref","first-page":"8062","DOI":"10.3390\/ijms21218062","article-title":"Putative origins of cell-free DNA in humans: a review of active and passive nucleic acid release mechanisms","volume":"21","author":"Grabuschnig","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.102896_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.bdq.2019.100087","article-title":"The emerging role of cell-free DNA as a molecular marker for cancer management","volume":"17","author":"Bronkhorst","year":"2019","journal-title":"Biomol. Detect. Quantif."},{"issue":"1","key":"10.1016\/j.tranon.2026.102896_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000355467","article-title":"Alterations of global histone H3K9 and H3K27 methylation levels in bladder cancer","volume":"93","author":"Ellinger","year":"2014","journal-title":"Urol. Int."},{"issue":"3","key":"10.1016\/j.tranon.2026.102896_bib0011","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1464-410X.2011.10278.x","article-title":"Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma","volume":"109","author":"Rogenhofer","year":"2012","journal-title":"BJu Int."},{"issue":"9","key":"10.1016\/j.tranon.2026.102896_bib0012","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/cancers12092587","article-title":"Plasma nucleosomes in primary breast cancer","volume":"12","author":"Mego","year":"2020","journal-title":"Cancers"},{"issue":"21","key":"10.1016\/j.tranon.2026.102896_bib0013","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.3390\/cells11213376","article-title":"H3K27me3 in diffuse midline glioma and epithelial ovarian cancer: opposing epigenetic changes leading to the same poor outcomes","volume":"11","author":"Day","year":"2022","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.tranon.2026.102896_bib0014","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/biom13081255","article-title":"Circulating H3K27 methylated nucleosome plasma concentration: synergistic information with Circulating tumor DNA molecular profiling","volume":"13","author":"Grolleau","year":"2023","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.tranon.2026.102896_bib0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.annonc.2022.05.520","article-title":"ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group","volume":"33","author":"Pascual","year":"2022","journal-title":"Ann. Oncol. J. Eur. Soc. Med. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.tranon.2026.102896_bib0016","first-page":"21","article-title":"Roles of the EZH2 histone methyltransferase in cancer epigenetics","volume":"647","author":"Simon","year":"2008","journal-title":"Mutat. Res."},{"issue":"3","key":"10.1016\/j.tranon.2026.102896_bib0017","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1158\/1535-7163.MCT-17-0437","article-title":"Histone methyltransferase EZH2: a therapeutic target for ovarian cancer","volume":"17","author":"Jones","year":"2018","journal-title":"Mol. Cancer Ther."},{"issue":"11","key":"10.1016\/j.tranon.2026.102896_bib0018","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.7150\/jca.38391","article-title":"Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers","volume":"11","author":"Chen","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.tranon.2026.102896_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1204463","article-title":"SETD2-H3K36ME3: an important bridge between the environment and tumors","volume":"14","author":"He","year":"2023","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.tranon.2026.102896_bib0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.annonc.2023.11.015","article-title":"ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease","volume":"35","author":"Ledermann","year":"2024","journal-title":"Ann. Oncol. J. Eur. Soc. Med. Oncol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102896_bib0021","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/annonc\/mdt382","article-title":"A critical review of the analytical approaches for circulating tumor biomarker kinetics during treatment","volume":"25","author":"Almufti","year":"2014","journal-title":"Ann. Oncol. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.tranon.2026.102896_bib0022","article-title":"Survival and modelled cancer antigen\u201325 ELIMination rate constant K score in ovarian cancer patients in first-line before poly(ADP-ribose) polymerase inhibitor era: a Gynaecologic Cancer Intergroup meta-analysis","volume":"191","author":"Corbaux","year":"2023","journal-title":"Eur. J. Cancer Oxf. Engl."},{"key":"10.1016\/j.tranon.2026.102896_bib0023","unstructured":"A. Lauby, O. Colomban, P. Corbaux, et al. The increasing prognostic and predictive roles of the tumor primary chemosensitivity assessed by CA\u201325 elimination rate constant K (KELIM) In ovarian cancer: a narrative review."},{"key":"10.1016\/j.tranon.2026.102896_bib0024","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-20-0054","article-title":"CA\u201325 ELIMination rate constant K (KELIM) is A marker of chemosensitivity In patients with ovarian cancer: results from the Phase II CHIVA trial","author":"You","year":"2020","journal-title":"Clin. Cancer Res. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.tranon.2026.102896_bib0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ygyno.2023.01.008","article-title":"Neoadjuvant chemotherapy with or without nintedanib for advanced epithelial ovarian cancer: lessons from the GINECO double-blind randomized phase II CHIVA trial","volume":"170","author":"Ferron","year":"2023","journal-title":"Gynecol. Oncol."},{"issue":"2","key":"10.1016\/j.tranon.2026.102896_bib0026","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng.3757","article-title":"Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas","volume":"49","author":"Papillon-Cavanagh","year":"2017","journal-title":"Nat. Genet."},{"issue":"17","key":"10.1016\/j.tranon.2026.102896_bib0027","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1158\/1078-0432.CCR-18-3335","article-title":"Early modeled longitudinal CA\u201325 kinetics and survival of ovarian cancer patients: a GINECO AGO MRC CTU study","volume":"25","author":"Colomban","year":"2019","journal-title":"Clin. Cancer Res. J. Am. Assoc. Cancer Res."},{"issue":"2","key":"10.1016\/j.tranon.2026.102896_bib0028","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ygyno.2013.05.013","article-title":"The strong prognostic value of KELIM, a model-based parameter from CA 125 kinetics in ovarian cancer: data from CALYPSO trial (a GINECO-GCIG study)","volume":"130","author":"You","year":"2013","journal-title":"Gynecol. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2026.102896_bib0029","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/bjc.2014.75","article-title":"Prediction of tumour response induced by chemotherapy using modelling of CA\u201325 kinetics in recurrent ovarian cancer patients","volume":"110","author":"Wilbaux","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.tranon.2026.102896_bib0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-2125.2007.02975.x","article-title":"Overview of model-building strategies in population PK\/PD analyses: 2002\u20132004 literature survey","volume":"64","author":"Dartois","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.tranon.2026.102896_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/psp4.12422","article-title":"NONMEM tutorial Part II: estimation methods and advanced examples","author":"Bauer","year":"2019","journal-title":"CPT Pharmacomet. Syst. Pharmacol."},{"issue":"2","key":"10.1016\/j.tranon.2026.102896_bib0032","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/tri.13081","article-title":"An unjustified benefit: immortal time bias in the analysis of time-dependent events","volume":"31","author":"Gleiss","year":"2018","journal-title":"Transpl. Int."},{"issue":"2","key":"10.1016\/j.tranon.2026.102896_bib0033","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.trecan.2023.08.010","article-title":"Circulating cell-free DNA-based multi-cancer early detection","volume":"10","author":"Zhang","year":"2024","journal-title":"Trends. Cancer"},{"issue":"16","key":"10.1016\/j.tranon.2026.102896_bib0034","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1158\/1078-0432.CCR-24-0507","article-title":"Intraperitoneal nivolumab after debulking surgery and hyperthermic Intraperitoneal chemotherapy in advanced ovarian cancer: a phase I study with expansion cohort","volume":"30","author":"Corbaux","year":"2024","journal-title":"Clin. Cancer Res. J. Am. Assoc. Cancer Res."},{"issue":"8","key":"10.1016\/j.tranon.2026.102896_bib0035","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/1878-0261.12729","article-title":"The effect of surgical trauma on circulating free DNA levels in cancer patients-implications for studies of circulating tumor DNA","volume":"14","author":"Henriksen","year":"2020","journal-title":"Mol. Oncol."},{"issue":"7","key":"10.1016\/j.tranon.2026.102896_bib0036","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0959-8049(05)80203-5","article-title":"CA 125 serum levels in the early post-operative period do not reflect tumour reduction obtained by cytoreductive surgery","volume":"29A","author":"Yedema","year":"1993","journal-title":"Eur. J. Cancer Oxf. Engl."},{"issue":"10","key":"10.1016\/j.tranon.2026.102896_bib0037","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.humpath.2014.07.002","article-title":"Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc\/Bcl2 coexpression","volume":"45","author":"Oh","year":"2014","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.tranon.2026.102896_bib0038","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3816\/CLC.2010.n.006","article-title":"Plasma nucleosome levels might predict response to therapy in patients with advanced non-small-cell lung cancer","volume":"11","author":"Kumar","year":"2010","journal-title":"Clin. Lung Cancer"},{"issue":"5","key":"10.1016\/j.tranon.2026.102896_bib0039","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2022.33.e83","article-title":"Peritoneal dissemination of high-grade serous ovarian cancer: pivotal roles of chromosomal instability and epigenetic dynamics","volume":"33","author":"Konishi","year":"2022","journal-title":"J. Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.tranon.2026.102896_bib0040","doi-asserted-by":"crossref","first-page":"S229","DOI":"10.1016\/S1556-0864(25)00587-8","article-title":"395P: h3K27Me3-nucleosome is a strong prognostic biomarker in non-small cell lung cancer (NSCLC): interim results from the analysis of up to 1050 samples at baseline","volume":"20","author":"Piecyk","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.tranon.2026.102896_bib0041","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13048-019-0503-7","article-title":"Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review","volume":"12","author":"Dochez","year":"2019","journal-title":"J. Ovarian. Res."},{"issue":"6","key":"10.1016\/j.tranon.2026.102896_bib0042","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s13277-011-0204-3","article-title":"HE4 a novel tumour marker for ovarian cancer: comparison with CA 125 and ROMA algorithm in patients with gynaecological diseases","volume":"32","author":"Molina","year":"2011","journal-title":"Tumour. Biol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:24:53Z","timestamp":1787225093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326002330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S1936523326002330"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102896","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline value and longitudinal kinetics of circulating nucleosomes during neo-adjuvant chemotherapy in newly diagnosed ovarian cancer: Results from a GINECO\/GINEGEPS study of the randomized phase II CHIVA trial","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102896"}}