{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:10:11Z","timestamp":1788768611849,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.tranon.2026.102897","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:45:00Z","timestamp":1783752300000},"page":"102897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integration of inflammatory and nutritional biomarkers with machine learning enhances prediction of progesterone response in fertility-preserving endometrial carcinoma management"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-8057","authenticated-orcid":false,"given":"Yue","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuman","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2026.102897_bib0001","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tranon.2026.102897_bib35","article-title":"The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma","volume":"4","author":"Liu","year":"2024","journal-title":"Gynecol. Obstetr. Clin. Med."},{"key":"10.1016\/j.tranon.2026.102897_bib0002","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41572-021-00324-8","article-title":"Endometrial cancer","volume":"7","author":"Makker","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.tranon.2026.102897_bib0003","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/AOG.0000000000005297","article-title":"ACOG Clinical Consensus No. 5","volume":"142","year":"2023","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.tranon.2026.102897_bib0004","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000027961","article-title":"Fertility-preserving treatment in patients with early-stage endometrial cancer: a protocol for systematic review and meta-analysis","volume":"100","author":"Zhao","year":"2021","journal-title":"Medicine"},{"issue":"6","key":"10.1016\/j.tranon.2026.102897_bib36","article-title":"Lipid-driven OLR1\/FOXM1\/FGF19 axis orchestrates crosstalk in an epithelial-fibroblast positive feedback promoting progesterone resistance in endometrial cancer","volume":"13","author":"Li","year":"2026","journal-title":"Adv. Sci. (Weinh)."},{"key":"10.1016\/j.tranon.2026.102897_bib0005","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1016\/S1470-2045(14)70263-3","article-title":"Cancer-related inflammation and treatment effectiveness","volume":"15","author":"Diakos","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tranon.2026.102897_bib0006","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2026.102897_bib0007","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1186\/s12885-023-11752-y","article-title":"Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma","volume":"23","author":"Zhou","year":"2023","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.tranon.2026.102897_bib0008","doi-asserted-by":"crossref","first-page":"75381","DOI":"10.18632\/oncotarget.18856","article-title":"Prognostic role of systemic immune-inflammation index in solid tumors: a systematic review and meta-analysis","volume":"8","author":"Zhong","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2026.102897_bib0009","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.clnu.2017.06.017","article-title":"ESPEN expert group recommendations for action against cancer-related malnutrition","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.tranon.2026.102897_bib0010","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/SLA.0000000000002985","article-title":"Prognostic nutritional index, tumor-infiltrating lymphocytes, and prognosis in patients with esophageal cancer","volume":"271","author":"Okadome","year":"2020","journal-title":"Ann. Surg."},{"key":"10.1016\/j.tranon.2026.102897_bib0011","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/sj.bjc.6605578","article-title":"Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres","volume":"102","author":"Pressoir","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tranon.2026.102897_bib0012","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.nut.2009.04.013","article-title":"Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea","volume":"26","author":"Wie","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.tranon.2026.102897_bib0013","first-page":"429","article-title":"Researchers P.R., prevalence of hospital malnutrition in cancer patients: a sub-analysis of the PREDyCES(R) study","volume":"24","author":"Planas","year":"2016","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.tranon.2026.102897_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.707705","article-title":"Evaluation and validation of the prognostic value of serum albumin to globulin ratio in patients with cancer cachexia: results from a large multicenter collaboration","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tranon.2026.102897_bib0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2147\/CMAR.S234688","article-title":"The value of geriatric nutritional risk index in evaluating postoperative complication risk and long-term prognosis in elderly colorectal cancer patients","volume":"Volume 12","author":"Tang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.tranon.2026.102897_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-048324","article-title":"Inflammation and nutrition-based biomarkers in the prognosis of oesophageal cancer: a systematic review and meta-analysis","volume":"11","author":"Jiang","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.tranon.2026.102897_bib0017","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10100","article-title":"The advanced lung cancer inflammation index predicts short and long-term outcomes in patients with colorectal cancer following surgical resection: a retrospective study","volume":"8","author":"Xie","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.tranon.2026.102897_bib0018","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jtcvs.2020.06.030","article-title":"Comparison of three nutritional scoring systems for outcomes after complete resection of non-small cell lung cancer","volume":"162","author":"Takahashi","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.tranon.2026.102897_bib0019","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10388-020-00795-w","article-title":"Modified geriatric nutrition risk index as a prognostic predictor of esophageal cancer","volume":"18","author":"Kouzu","year":"2021","journal-title":"Esophagus"},{"key":"10.1016\/j.tranon.2026.102897_bib0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12885-022-09628-8","article-title":"Prognostic value of CD4+ T lymphopenia in non-small cell lung cancer","volume":"22","author":"Eberst","year":"2022","journal-title":"BMC. Cancer"},{"key":"10.1016\/j.tranon.2026.102897_bib0021","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41467-022-28492-5","article-title":"Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications","volume":"13","author":"Xia","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.102897_bib0022","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3390\/cancers13061308","article-title":"Neutrophil-to-lymphocyte ratio predicts development of immune-related adverse events and outcomes from immune checkpoint blockade: a case-control study","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.tranon.2026.102897_bib0023","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.semcancer.2013.02.005","article-title":"Modulation of neutrophil granulocytes in the tumor microenvironment: mechanisms and consequences for tumor progression","volume":"23","author":"Dumitru","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.tranon.2026.102897_bib0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12307-014-0147-5","article-title":"The multifaceted roles neutrophils play in the tumor microenvironment","volume":"8","author":"Sionov","year":"2015","journal-title":"Cancer Microenviron."},{"key":"10.1016\/j.tranon.2026.102897_bib0025","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.3390\/ijms23073636","article-title":"Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases","volume":"23","author":"Buonacera","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.102897_bib0026","article-title":"Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.102897_bib0027","article-title":"The clinical value of nutritional and inflammatory indicators in predicting pneumonia among patients with intracerebral hemorrhage","volume":"14","author":"Zhao","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2026.102897_bib0028","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00404-019-05278-7","article-title":"Pre-operative hypoalbuminemia is associated with complication rate and overall survival in patients with vulvar cancer undergoing surgery","volume":"300","author":"Bekos","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.tranon.2026.102897_bib0029","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00384-017-2884-7","article-title":"Preoperative hypoalbuminemia is an independent risk factor for increased high-grade morbidity after elective rectal cancer resection","volume":"32","author":"Hardt","year":"2017","journal-title":"Int. J. Colorectal. Dis."},{"key":"10.1016\/j.tranon.2026.102897_bib0030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41392-022-01149-x","article-title":"Signaling pathways in obesity: mechanisms and therapeutic interventions","volume":"7","author":"Wen","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tranon.2026.102897_bib0031","first-page":"340","article-title":"The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression","volume":"4","author":"Ando","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tranon.2026.102897_bib0032","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/MOU.0000000000001041","article-title":"Metabolic syndrome, obesity and cancer risk","volume":"32","author":"Belladelli","year":"2022","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.tranon.2026.102897_bib0033","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12876-024-03583-3","article-title":"Immune-nutritional indicators predict short-term mortality in older patients after emergency gastrointestinal surgery: a retrospective study","volume":"25","author":"Jin","year":"2025","journal-title":"BMC. Gastroenterol."},{"key":"10.1016\/j.tranon.2026.102897_bib0034","first-page":"742","article-title":"Fertility-preserving treatment outcomes in endometrial cancer and atypical hyperplasia patients with different molecular profiles","volume":"58","author":"Shao","year":"2023","journal-title":"Zhonghua Fu Chan Ke Za Zhi"}],"updated-by":[{"DOI":"10.1016\/j.tranon.2026.103007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000}},{"DOI":"10.1016\/j.tranon.2026.103007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000}}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:30:19Z","timestamp":1787225419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326002342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S1936523326002342"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102897","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of inflammatory and nutritional biomarkers with machine learning enhances prediction of progesterone response in fertility-preserving endometrial carcinoma management","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102897"}}