{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:01:26Z","timestamp":1790740886269,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015285","name":"Hebei Province Medical Science Research Key Project","doi-asserted-by":"publisher","award":["20240930"],"award-info":[{"award-number":["20240930"]}],"id":[{"id":"10.13039\/501100015285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tranon.2026.102931","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:00:46Z","timestamp":1785891646000},"page":"102931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer"],"prefix":"10.1016","volume":"72","author":[{"given":"Zhisheng","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tranon.2026.102931_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.tranon.2026.102931_bib0002","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1089\/thy.2012.0302","article-title":"American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer","volume":"22","author":"Smallridge","year":"2012","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.tranon.2026.102931_bib0003","first-page":"24","article-title":"Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer","volume":"9","author":"Zhang","year":"2025","journal-title":"NPJ Precis. Oncol."},{"key":"10.1016\/j.tranon.2026.102931_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2026.102795","article-title":"Prognostic value and therapeutic potential of the cuproptosis-related gene LOXL2 in thyroid cancer","volume":"69","author":"Liu","year":"2026","journal-title":"Transl. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2026.102931_bib0005","article-title":"A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer","volume":"9","author":"Chen","year":"2024","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.tranon.2026.102931_bib0006","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1158\/0008-5472.CAN-18-2797","article-title":"Citrullination in cancer","volume":"79","author":"Yuzhalin","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2026.102931_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/895343","article-title":"Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis","volume":"2012","author":"Mohanan","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.tranon.2026.102931_bib0008","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev-cellbio-020520-111016","article-title":"Cellular mechanisms of NETosis","volume":"36","author":"Thiam","year":"2020","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.tranon.2026.102931_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2026.101298","article-title":"ESM1 drives cancer angiogenesis and bevacizumab resistance via trioleate synthesis","volume":"75","author":"Chen","year":"2026","journal-title":"Neoplasia"},{"issue":"4","key":"10.1016\/j.tranon.2026.102931_bib0010","first-page":"1517","article-title":"PADI4-mediated epithelial-mesenchymal transition in lung cancer cells","volume":"42","author":"Li","year":"2019","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.tranon.2026.102931_bib0011","first-page":"45","article-title":"PADI4 promotes epithelial-mesenchymal transition in gastric cancer via the upregulation of interleukin 8","volume":"22","author":"Chang","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tranon.2026.102931_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102501","article-title":"Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma","volume":"61","author":"Huang","year":"2025","journal-title":"Transl. Oncol."},{"issue":"3","key":"10.1016\/j.tranon.2026.102931_bib0013","first-page":"642","article-title":"The nutrient environment of tumors","volume":"175","author":"Muir","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.tranon.2026.102931_bib0014","first-page":"4829","article-title":"Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.tranon.2026.102931_bib0015","doi-asserted-by":"crossref","first-page":"700","DOI":"10.2174\/1389450116666150202160954","article-title":"Protein arginine deiminases and associated citrullination: physiological functions and diseases associated with dysregulation","volume":"16","author":"Witalison","year":"2015","journal-title":"Curr. Drug Targets"},{"issue":"13","key":"10.1016\/j.tranon.2026.102931_bib0016","first-page":"3725","article-title":"Dynamic matrisomal proteome changes in tumor progression identified by near-infrared optical imaging","volume":"78","author":"Yuzhalin","year":"2018","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0017","article-title":"PADI2 citrullinates histone H3 at H3R8 and H3R26 and regulates gene expression in triple-negative breast cancer cells","volume":"298","author":"McGovern","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"40","key":"10.1016\/j.tranon.2026.102931_bib0018","first-page":"5934","article-title":"PADI4 regulates alternative splicing and promotes lung adenocarcinoma progression","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0019","first-page":"825","article-title":"PADI2 expression in human thyroid cancer and its association with clinicopathological features","volume":"35","author":"Cantarino","year":"2020","journal-title":"Histol. Histopathol."},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0020","first-page":"1357","article-title":"Autophagy-dependent cancer cells exhibit elevated PADI4 expression and citrullination of vimentin","volume":"19","author":"Slack","year":"2021","journal-title":"Mol. Cancer Res."},{"issue":"11","key":"10.1016\/j.tranon.2026.102931_bib0021","article-title":"The role of protein arginine deiminases in the regulation of cellular signaling pathways","volume":"1868","author":"Ciesielski","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0022","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/bip.22835","article-title":"Review: the HSP90 molecular chaperone\u2013An enigmatic ATPase","volume":"105","author":"Pearl","year":"2016","journal-title":"Biopolymers"},{"issue":"6","key":"10.1016\/j.tranon.2026.102931_bib0023","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm.2017.20","article-title":"The HSP90 chaperone machinery","volume":"18","author":"Schopf","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.tranon.2026.102931_bib0024","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrc2420","article-title":"Targeting the oncogene and kinome chaperone CDC37","volume":"8","author":"Gray","year":"2008","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"10.1016\/j.tranon.2026.102931_bib0025","first-page":"762","article-title":"The regulatory roles of CDC37 in cancer","volume":"10","author":"Stebbing","year":"2019","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.tranon.2026.102931_bib0026","first-page":"4412","article-title":"Ganetespib, an HSP90 inhibitor, exhibits potent anti-cancer effects in thyroid cancer cells","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.tranon.2026.102931_bib0027","first-page":"1385","article-title":"HSP90 inhibitors in thyroid cancer: a systematic review","volume":"11","author":"Marzullo","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.tranon.2026.102931_bib0028","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.tranon.2026.102931_bib0029","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2026.102931_bib0030","first-page":"52","article-title":"Autophagy in antigen-presenting cells: antigen processing and presentation","volume":"46","author":"Ireland","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.tranon.2026.102931_bib0031","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3389\/fimmu.2019.03030","article-title":"Phagocytosis of necrotic debris at sites of injury and inflammation","volume":"10","author":"Westman","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.tranon.2026.102931_bib0032","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0034-1370765","article-title":"NETosis: a new factor in tumor progression and cancer-associated thrombosis","volume":"40","author":"Demers","year":"2014","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.tranon.2026.102931_bib0033","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcancer.2021.07.011","article-title":"Neutrophil extracellular traps in cancer","volume":"79","author":"Cristinziano","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"7","key":"10.1016\/j.tranon.2026.102931_bib0034","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.tranon.2026.102931_bib0035","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41568-022-00547-1","article-title":"A timeline of tumour-associated macrophage biology","volume":"23","author":"Cassetta","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tranon.2026.102931_bib0036","series-title":"Proceedings of the Association of American Physicians","first-page":"1","article-title":"Interaction between CD44 and osteopontin as a potential basis for metastasis formation","volume":"109","author":"Weber","year":"1997"},{"issue":"1","key":"10.1016\/j.tranon.2026.102931_bib0037","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10555-007-9104-9","article-title":"Osteopontin: regulation in tumor metastasis","volume":"27","author":"Wai","year":"2008","journal-title":"Cancer Metastasis Rev."},{"issue":"6","key":"10.1016\/j.tranon.2026.102931_bib0038","first-page":"2777","article-title":"Osteopontin expression is associated with the progression and prognosis of papillary thyroid cancer","volume":"31","author":"Zhang","year":"2014","journal-title":"Oncol. Rep."},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0039","first-page":"1523","article-title":"Osteopontin expression is increased in aggressive thyroid tumors","volume":"45","author":"Castellone","year":"2022","journal-title":"J. Endocrinol. Investig."},{"issue":"1","key":"10.1016\/j.tranon.2026.102931_bib0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.tranon.2026.102931_bib0041","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcell.2017.00018","article-title":"CD44: a multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cells","volume":"5","author":"Senbanjo","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.tranon.2026.102931_bib0042","first-page":"2458","article-title":"Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface","volume":"11","author":"Hunter","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2026.102931_bib0043","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-230X(08)00404-1","article-title":"Adhesion proteins meet receptors: a common theme?","volume":"101","author":"Orian-Rousseau","year":"2008","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.tranon.2026.102931_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2087204","article-title":"The importance of CD44 as a stem cell marker and therapeutic target in cancer","author":"Thapa","year":"2016","journal-title":"Stem Cells Int."},{"issue":"4","key":"10.1016\/j.tranon.2026.102931_bib0045","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2018.09.006","article-title":"A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade","volume":"175","author":"Jerby-Arnon","year":"2018","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.tranon.2026.102931_bib0046","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/s41588-022-01141-9","article-title":"Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment","volume":"54","author":"Barkley","year":"2022","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.tranon.2026.102931_bib0047","first-page":"2335","article-title":"Inhibition of tumor growth and metastasis by targeting CD44","volume":"126","author":"Matzke-Ogi","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.tranon.2026.102931_bib0048","article-title":"Regulation of CD44 expression in tumor cells and its therapeutic potential","volume":"13","author":"Prochazka","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326002676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:57Z","timestamp":1790739597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326002676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"alternative-id":["S1936523326002676"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102931","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.102931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102931"}}