{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:46:56Z","timestamp":1791704816355,"version":"4.3.4"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tranon.2026.103002","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:17:20Z","timestamp":1789485440000},"page":"103002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gap junctions and hemichannels in cancer: A \u201cWired versus Broadcast\u201d framework for tumor microenvironment routing of cGAMP\u2013STING signals and therapy response"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5349-4997","authenticated-orcid":false,"given":"Soroush","family":"Akbari-Ardabili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-2805","authenticated-orcid":false,"given":"Safiyeh","family":"Aghazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-7754","authenticated-orcid":false,"given":"Ali","family":"Shalizar-Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-3805","authenticated-orcid":false,"given":"Faezeh","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.tranon.2026.103002_bib0001","article-title":"Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application","volume":"26","author":"Wu","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0002","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.3390\/cancers16244191","article-title":"Connexin-43 in cancer: above and beyond gap junctions!","volume":"16","author":"Paunikar","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tranon.2026.103002_bib0003","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3390\/biomedicines10092237","article-title":"Connexins and pannexins: important players in neurodevelopment, neurological diseases, and potential therapeutics","volume":"10","author":"Baracaldo-Santamar\u00eda","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.tranon.2026.103002_bib0004","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/dneu.22447","article-title":"A structural and functional comparison of gap junction channels composed of connexins and innexins","volume":"77","author":"Skerrett","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.tranon.2026.103002_bib0005","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1091\/mbc.e05-11-1059","article-title":"Heteromerization of innexin gap junction proteins regulates epithelial tissue organization in Drosophila","volume":"17","author":"Lehmann","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tranon.2026.103002_bib0006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12964-022-01009-9","article-title":"The roles of connexins and gap junctions in the progression of cancer","volume":"21","author":"Zhou","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.tranon.2026.103002_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1647765","article-title":"Pannexin channels in inflammation and tumorigenesis","volume":"13","author":"Jiang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.tranon.2026.103002_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1080131","article-title":"Role of connexin 43 phosphorylation on serine-368 by PKC in cardiac function and disease","volume":"9","author":"Pun","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.tranon.2026.103002_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612851","article-title":"Endocytosis and endocytic motifs across the Connexin Gene Family","volume":"24","author":"Fisher","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0010","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1091\/mbc.E14-06-1105","article-title":"Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization","volume":"26","author":"Nimlamool","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tranon.2026.103002_bib0011","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1242\/jcs.03149","article-title":"Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process","volume":"119","author":"Leykauf","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0012","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/jcs.202408","article-title":"The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions","volume":"130","author":"Totland","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0013","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","article-title":"The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C","volume":"266","author":"Toullec","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tranon.2026.103002_bib0014","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/cn500288n","article-title":"U0126 Protects cells against oxidative stress independent of its function as a MEK inhibitor","volume":"6","author":"Ong","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.tranon.2026.103002_bib0015","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1091\/mbc.e05-08-0737","article-title":"Zonula Occludens-1 alters Connexin43 gap junction size and organization by influencing channel accretion","volume":"16","author":"Hunter","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tranon.2026.103002_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021527","article-title":"Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and Connexin43 revealed by MD simulations","volume":"6","author":"Xiao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.tranon.2026.103002_bib0017","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1091\/mbc.e07-06-0596","article-title":"Caveolin-1 and -2 interact with Connexin43 and regulate gap junctional intercellular communication in keratinocytes","volume":"19","author":"Langlois","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.tranon.2026.103002_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00063","article-title":"The role of pannexin hemichannels in inflammation and regeneration","volume":"5","author":"Makarenkova","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.tranon.2026.103002_bib0019","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1074\/jbc.M111.323378","article-title":"Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region","volume":"287","author":"Sandilos","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tranon.2026.103002_bib0020","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ncb3194","article-title":"Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival","volume":"17","author":"Furlow","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.tranon.2026.103002_bib0021","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1111\/febs.70060","article-title":"A metastasis-associated pannexin-1 mutant (Panx11-89) forms a minimalist ATP release channel","volume":"292","author":"Wang","year":"2025","journal-title":"FEBS. J."},{"key":"10.1016\/j.tranon.2026.103002_bib0022","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2217\/fon-2023-0871","article-title":"Regulatory role of CD39 and CD73 in tumor immunity","volume":"20","author":"Kaplinsky","year":"2024","journal-title":"Future Oncol."},{"key":"10.1016\/j.tranon.2026.103002_bib0023","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1158\/2159-8290.CD-20-0387","article-title":"Metastasis and immune evasion from extracellular cGAMP hydrolysis","volume":"11","author":"Li","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2026.103002_bib0024","article-title":"The ectonucleotidases CD39 and CD73 on T cells: the new pillar of hematological malignancy","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0025","article-title":"Adenosine-A2A receptor pathway in cancer immunotherapy","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0026","doi-asserted-by":"crossref","first-page":"13132","DOI":"10.1073\/pnas.0605251103","article-title":"A2A adenosine receptor protects tumors from antitumor T cells","volume":"103","author":"Ohta","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0027","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2313693120","article-title":"ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tranon.2026.103002_bib0028","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s43018-020-0028-4","article-title":"Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity","volume":"1","author":"Carozza","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.tranon.2026.103002_bib0029","article-title":"Significance of the cGAS-STING pathway in health and disease","volume":"24","author":"Zhou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0030","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-101721-032910","article-title":"Regulation of the cGAS-STING pathway","volume":"43","author":"Zhang","year":"2025","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0031","article-title":"The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases","volume":"16","author":"Deng","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0032","doi-asserted-by":"crossref","first-page":"143","DOI":"10.15430\/JCP.2023.28.4.143","article-title":"Cyclic GMP-AMP synthase in cancer prevention","volume":"28","author":"Chen","year":"2023","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.tranon.2026.103002_bib0033","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-\u03bab that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tranon.2026.103002_bib0034","article-title":"The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0035","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2409556122","article-title":"Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell\u2013generated cGAMP","volume":"122","author":"Cryer","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tranon.2026.103002_bib0036","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1073\/pnas.0603154104","article-title":"Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC","volume":"104","author":"Bao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tranon.2026.103002_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvr.2024.200296","article-title":"Modulation of connexin 43 in viral infections","volume":"18","author":"Scott","year":"2024","journal-title":"Tumour Virus Res."},{"key":"10.1016\/j.tranon.2026.103002_bib0038","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1074\/jbc.RA119.012170","article-title":"Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples","volume":"295","author":"Mardjuki","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tranon.2026.103002_bib0039","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.3390\/molecules28134914","article-title":"Connexin 43 phosphorylation: implications in multiple diseases","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.tranon.2026.103002_bib0040","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70211","article-title":"Connexin 43 deficiency confers resistance to immunotherapy in lung cancer via inhibition of the cyclic GMP-AMP synthase\u2013Stimulator of interferon genes pathway","volume":"28","author":"Zhang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.tranon.2026.103002_bib0041","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3390\/cells14211744","article-title":"Gap junctional communication required for the establishment of long-term robust Ca2+ oscillations across Human neuronal spheroids and extended 2D cultures","volume":"14","author":"Kormann","year":"2025","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.tranon.2026.103002_bib0042","article-title":"Connexin 43 confers chemoresistance through activating PI3K","volume":"11","author":"Pridham","year":"2022","journal-title":"Oncogenesis"},{"key":"10.1016\/j.tranon.2026.103002_bib0043","first-page":"1565","article-title":"Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1","volume":"126","author":"Rodgers","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0044","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/hh0302.104471","article-title":"Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions","volume":"90","author":"Barker","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.tranon.2026.103002_bib0045","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/cancers17091491","article-title":"The role of the extracellular matrix in cancer prevention","volume":"17","author":"Baker","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.tranon.2026.103002_bib0046","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40957-1","article-title":"Intercellular cross-talk through lineage-specific gap junction of cancer-associated fibroblasts related to stromal fibrosis and prognosis","volume":"13","author":"Cho","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2026.103002_bib0047","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119189119","article-title":"ENPP1\u2019s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling","volume":"119","author":"Carozza","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.tranon.2026.103002_bib0048","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1186\/s12967-025-07275-8","article-title":"JUN\u2013ENPP1\u2013cGAS\u2013STING axis mediates immune evasion and tumor progression in bladder cancer","volume":"23","author":"You","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.tranon.2026.103002_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergen.2025.03.001","article-title":"ENPP1 promotes immune suppression, drug resistance, and adverse outcomes in bladder cancer: potential for targeted therapy","volume":"294-295","author":"You","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.tranon.2026.103002_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1150705","article-title":"cGAMP the travelling messenger","volume":"14","author":"Blest","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0051","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1038\/s41467-025-58378-1","article-title":"Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103002_bib0052","first-page":"204","article-title":"The multifaceted role of connexins in tumor microenvironment initiation and maintenance","volume":"12","author":"Kutova","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.tranon.2026.103002_bib0053","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1038\/s41388-019-0741-6","article-title":"Connexins in cancer: bridging the gap to the clinic","volume":"38","author":"Aasen","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.tranon.2026.103002_bib0054","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma\u2013astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2026.103002_bib0055","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-025-02773-7","article-title":"Cx43 mediates cross-talk of tumor cells and macrophage via cGAS-STING signaling","volume":"42","author":"Gao","year":"2025","journal-title":"Med. Oncol."},{"key":"10.1016\/j.tranon.2026.103002_bib0056","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.15252\/embr.201540891","article-title":"Expanding the ubiquitin code through post-translational modification","volume":"16","author":"Herhaus","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.tranon.2026.103002_bib0057","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10930-024-10223-y","article-title":"Protein S-nitrosylation: a chemical modification with ubiquitous biological activities","volume":"43","author":"Aboalroub","year":"2024","journal-title":"Protein J."},{"key":"10.1016\/j.tranon.2026.103002_bib0058","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3390\/ijms23063281","article-title":"Insights in post-translational modifications: ubiquitin and SUMO","volume":"23","author":"Salas-Lloret","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0059","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41586-025-08758-w","article-title":"STING agonist-based ER-targeting molecules boost antigen cross-presentation","volume":"641","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.tranon.2026.103002_bib0060","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abn6173","article-title":"PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance","volume":"8","author":"van Gulijk","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0061","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41698-024-00522-z","article-title":"Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance","volume":"8","author":"Wang","year":"2024","journal-title":"NPJ Precis. Oncol."},{"key":"10.1016\/j.tranon.2026.103002_bib0062","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax8933","article-title":"Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation","volume":"14","author":"Lorusso","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.tranon.2026.103002_bib0063","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3390\/ijms23031523","article-title":"Mechanisms of Pannexin 1 (PANX1) channel mechanosensitivity and its pathological roles","volume":"23","author":"Yang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0064","article-title":"Immunogenic cell death as a target for combination therapies in solid tumors: a systematic review toward a new paradigm in immuno-oncology","volume":"17","author":"Barjij","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.tranon.2026.103002_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinsp.2024.100390","article-title":"Foxp3+CD39+CD73+ regulatory T-cells are decreased in the peripheral blood of women with deep infiltrating endometriosis","volume":"79","author":"Riccio","year":"2024","journal-title":"Clinics"},{"key":"10.1016\/j.tranon.2026.103002_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.914799","article-title":"The multifaceted actions of CD73 during development and suppressive actions of regulatory T cells","volume":"13","author":"Da","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0067","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1621353","article-title":"Pannexin-1 hemichannels promote experimental colitis inflammation in a CD4+ T cell-specific manner","volume":"16","author":"Mina","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0068","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adn1630","article-title":"Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A\/C volume-regulated anion channels","volume":"10","author":"Cao","year":"2025","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0069","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1158\/2159-8290.CD-20-0387","article-title":"Metastasis and immune evasion from extracellular cgamp hydrolysis","volume":"11","author":"Li","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2026.103002_bib0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.790113","article-title":"Immunological classification of tumor types and advances in Precision combination immunotherapy","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0071","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1344272","article-title":"Overcoming cold tumors: a combination strategy of immune checkpoint inhibitors","volume":"15","author":"Ouyang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0072","article-title":"CD8+ T cell-associated gene signature correlates with prognosis risk and immunotherapy response in patients with lung adenocarcinoma","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.tranon.2026.103002_bib0073","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.191595","article-title":"Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia","volume":"10","author":"Lyman","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.tranon.2026.103002_bib0074","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.gendis.2019.06.006","article-title":"Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies","volume":"6","author":"Shen","year":"2019","journal-title":"Genes Dis."},{"key":"10.1016\/j.tranon.2026.103002_bib0075","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41416-020-0942-3","article-title":"Radiation-induced bystander and abscopal effects: important lessons from preclinical models","volume":"123","author":"Daguenet","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.tranon.2026.103002_bib0076","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/imm.13592","article-title":"The paradoxical role of radiation-induced cGAS\u2013STING signalling network in tumour immunity","volume":"168","author":"Zhang","year":"2023","journal-title":"Immunology"},{"key":"10.1016\/j.tranon.2026.103002_bib0077","article-title":"Trial watch: STING agonists in cancer therapy","volume":"9","author":"Le Naour","year":"2020","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.tranon.2026.103002_bib0078","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2147\/IJN.S503780","article-title":"Novel modifications and delivery modes of cyclic dinucleotides for STING activation in cancer treatment","volume":"Volume 20","author":"Lu","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.tranon.2026.103002_bib0079","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202500296","article-title":"STING agonists and how to reach their full potential in cancer immunotherapy","volume":"12","author":"Gehrcken","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.tranon.2026.103002_bib0080","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/neuonc\/noab092","article-title":"Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma","volume":"23","author":"Schneider","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.tranon.2026.103002_bib0081","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300552","article-title":"Integrating and optimizing tonabersat in standard glioblastoma therapy: a preclinical study","volume":"19","author":"Zoteva","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.tranon.2026.103002_bib0082","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/cancers16020423","article-title":"Mapping the anti-cancer activity of \u03b1-connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer","volume":"16","author":"Baker","year":"2024","journal-title":"Cancers (Basel)"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326003384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326003384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:29:14Z","timestamp":1791703754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326003384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":82,"alternative-id":["S1936523326003384"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103002","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gap junctions and hemichannels in cancer: A \u201cWired versus Broadcast\u201d framework for tumor microenvironment routing of cGAMP\u2013STING signals and therapy response","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103002"}}