{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:46:56Z","timestamp":1791704816456,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303032"],"award-info":[{"award-number":["82303032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172564"],"award-info":[{"award-number":["82172564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573338"],"award-info":[{"award-number":["82573338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.tranon.2026.103049","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:16:50Z","timestamp":1789762610000},"page":"103049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15\u2013ATP4B axis in renal cell carcinoma"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-042X","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoliang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhankui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2026.103049_bib0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.critrevonc.2018.02.017","article-title":"Treatment of spinal metastases in renal cell carcinoma: A critical review","volume":"125","author":"Teyssonneau","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0002","doi-asserted-by":"crossref","DOI":"10.1186\/s40164-026-00775-3","article-title":"Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities","volume":"15","author":"Wang","year":"2026","journal-title":"Exp. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.tranon.2026.103049_bib0003","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s12276-023-01020-1","article-title":"Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential","volume":"55","author":"Xu","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.tranon.2026.103049_bib0004","article-title":"Tumor microenvironment heterogeneity and immunotherapy resistance: multidimensional modulation strategies for precision breakthroughs","author":"Wei","year":"2026","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.tranon.2026.103049_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1805039","article-title":"Efficacy and safety of immune checkpoint inhibitors combined with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma: a risk-stratified systematic review and meta-analysis","volume":"17","author":"Rao","year":"2026","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.tranon.2026.103049_bib0006","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.trecan.2025.11.001","article-title":"Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics","volume":"12","author":"Gok Yavuz","year":"2026","journal-title":"Trends Cancer"},{"key":"10.1016\/j.tranon.2026.103049_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/abp.2025.13922","article-title":"Advancements in single-cell RNA sequencing and spatial transcriptomics: transforming biomedical research","volume":"72","author":"Molla Desta","year":"2025","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.tranon.2026.103049_bib0008","article-title":"Integrating multi-omics data: Methods and applications in human complex diseases","volume":"48","author":"Sibilio","year":"2025","journal-title":"Biotechnol. Rep."},{"key":"10.1016\/j.tranon.2026.103049_bib0009","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fonc.2019.00490","article-title":"Targeting the Tumor Microenvironment in Renal Cell Cancer Biology and Therapy","volume":"9","author":"Heidegger","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.tranon.2026.103049_bib0010","doi-asserted-by":"crossref","unstructured":"Wen H, Zheng S, Zhu X, Wang L, Chen D: Characteristics of the tumor microenvironment and potential immunotherapy strategies in renal cell carcinoma. 2025, Volume 16 - 2025.","DOI":"10.3389\/fimmu.2025.1643533"},{"issue":"4","key":"10.1016\/j.tranon.2026.103049_bib0011","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human Transcription Factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.tranon.2026.103049_bib0012","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00467-016-3462-x","article-title":"Spectrum of LMX1B mutations: from nail-patella syndrome to isolated nephropathy","volume":"32","author":"Harita","year":"2017","journal-title":"Pediatr. Nephrol."},{"issue":"5935","key":"10.1016\/j.tranon.2026.103049_bib0013","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.1162327","article-title":"Diversity and complexity in DNA recognition by transcription factors","volume":"324","author":"Badis","year":"2009","journal-title":"Science"},{"issue":"24 PartA","key":"10.1016\/j.tranon.2026.103049_bib0014","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1016\/j.febslet.2015.10.020","article-title":"Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b","volume":"589","author":"Doucet-Beaupr\u00e9","year":"2015","journal-title":"Febs Lett."},{"key":"10.1016\/j.tranon.2026.103049_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7375879","article-title":"LMX1B activated circular RNA GFRA1 Modulates the tumorigenic properties and immune escape of prostate cancer","volume":"2022","author":"Meng","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.tranon.2026.103049_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109358","article-title":"LMX1B involved in the radioresistance, proliferation and migration of esophageal cancer cells","volume":"118","author":"Zang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.tranon.2026.103049_bib0017","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/kjm2.12411","article-title":"Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression","volume":"37","author":"Guo","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0018","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00125-018-4751-7","article-title":"Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmo diet and cancer-cardiovascular cohort","volume":"62","author":"Bao","year":"2019","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.tranon.2026.103049_bib0019","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cytogfr.2013.05.003","article-title":"The multiple facets of the TGF-beta family cytokine growth\/differentiation factor-15\/macrophage inhibitory cytokine-1","volume":"24","author":"Unsicker","year":"2013","journal-title":"Cytokine Growth Factor. Rev."},{"key":"10.1016\/j.tranon.2026.103049_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113964","article-title":"Qizhen capsule inhibits colorectal cancer by inducing NAG-1\/GDF15 expression that mediated via MAPK\/ERK activation","volume":"273","author":"Guo","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0021","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41420-021-00462-8","article-title":"NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15","volume":"7","author":"Guo","year":"2021","journal-title":"Cell. Death Discov."},{"issue":"2","key":"10.1016\/j.tranon.2026.103049_bib0022","doi-asserted-by":"crossref","first-page":"452","DOI":"10.62347\/KYIY8286","article-title":"GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts","volume":"15","author":"Guo","year":"2025","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.tranon.2026.103049_bib0023","article-title":"ESRRG, ATP4A, and ATP4B as diagnostic biomarkers for gastric cancer: a bioinformatic analysis based on machine learning","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.tranon.2026.103049_bib0024","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s10120-020-01128-7","article-title":"Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation","volume":"24","author":"Pan","year":"2021","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.tranon.2026.103049_bib0025","doi-asserted-by":"crossref","unstructured":"Zhang L, Liu M, Zhang Z, Chen D, Chen G, Liu MJM: Machine learning based identification of hub genes in renal clear cell carcinoma using multi-omics data. 2022, 207:110-117.","DOI":"10.1016\/j.ymeth.2022.09.008"},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0026","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103049_bib0027","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses","volume":"19","author":"Shimoga Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.tranon.2026.103049_bib0028","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"issue":"D1","key":"10.1016\/j.tranon.2026.103049_bib0029","first-page":"D87","article-title":"JASPAR 2020: update of the open-access database of transcription factor binding profiles","volume":"48","author":"Fornes","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103049_bib0030","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0031","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13059-022-02663-5","article-title":"Explainable multiview framework for dissecting spatial relationships from highly multiplexed data","volume":"23","author":"Tanevski","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.tranon.2026.103049_bib0032","doi-asserted-by":"crossref","unstructured":"Shi W, Zhang Z, Xu X, Tian Y, Feng L, Huang X, Du Y, Li Z: Single-cell and spatial transcriptomics integration: new frontiers in tumor microenvironment and cellular communication. 2025, Volume 16 - 2025.","DOI":"10.3389\/fimmu.2025.1649468"},{"issue":"1","key":"10.1016\/j.tranon.2026.103049_bib0033","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.tranon.2026.103049_bib0034","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell. Rep. Methods"},{"issue":"8","key":"10.1016\/j.tranon.2026.103049_bib0035","article-title":"Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells","volume":"11","author":"Florido","year":"2022","journal-title":"Antioxid. (basel)"},{"issue":"9","key":"10.1016\/j.tranon.2026.103049_bib0036","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.18632\/oncotarget.7457","article-title":"GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.tranon.2026.103049_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2026.103049_bib0038","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.tranon.2026.103049_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-022-02512-6","article-title":"Cystathionine \u03b3-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.tranon.2026.103049_bib0040","article-title":"Schisandrin B antagonizes cardiotoxicity induced by pirarubicin by inhibiting mitochondrial permeability transition pore (mPTP) opening and decreasing cardiomyocyte apoptosis","volume":"12","author":"Shi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.tranon.2026.103049_bib0041","doi-asserted-by":"crossref","unstructured":"Mignozzi S, Santucci C, Briganti A, Montorsi F, La Vecchia C, Corso G, Negri E, Gandaglia GJEjocptojotECPO: the global burden of kidney cancer: trends in mortality and incidence with predictions to 2025. 2025.","DOI":"10.1097\/CEJ.0000000000001000"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326003852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326003852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:29:44Z","timestamp":1791703784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326003852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S1936523326003852"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103049","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15\u2013ATP4B axis in renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103049"}}