{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:41:18Z","timestamp":1792406478946,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372883"],"award-info":[{"award-number":["82372883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82605618"],"award-info":[{"award-number":["82605618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874093"],"award-info":[{"award-number":["81874093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474506"],"award-info":[{"award-number":["82474506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tranon.2026.103064","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:23:13Z","timestamp":1791688993000},"page":"103064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts"],"prefix":"10.1016","volume":"74","author":[{"given":"Hao","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8863-528X","authenticated-orcid":false,"given":"Chencan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-1832","authenticated-orcid":false,"given":"Linhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0001","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0002","first-page":"47","article-title":"He J: cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"3","key":"10.1016\/j.tranon.2026.103064_bib0003","first-page":"263","article-title":"DCS, a novel classifier system based on disulfidptosis reveals tumor microenvironment heterogeneity and guides frontline therapy for clear cell renal carcinoma","volume":"4","author":"Jiang","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"4","key":"10.1016\/j.tranon.2026.103064_bib0004","first-page":"382","article-title":"TDERS, an exosome RNA-derived signature predicts prognosis and immunotherapeutic response in clear cell renal cell cancer: a multicohort study","volume":"4","author":"Jiang","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0005","article-title":"Kidney cancer: from tumor biology to innovative therapeutics","volume":"1880","author":"Rinaldi","year":"2025","journal-title":"Biochim. Biophys. Acta (BBA) - Rev. Cancer"},{"issue":"7","key":"10.1016\/j.tranon.2026.103064_bib0006","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1097\/JS9.0000000000001377","article-title":"Urological surgical robot in China: state of the art and future prospect","volume":"110","author":"Jiang","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.tranon.2026.103064_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2022.102377","article-title":"New first-line immunotherapy-based combinations for metastatic renal cell carcinoma: a systematic review and network meta-analysis","volume":"106","author":"Lombardi","year":"2022","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12943-025-02377-9","article-title":"Single-cell multi-omics reveals that FABP1\u202f+\u202frenal cell carcinoma drive tumor angiogenesis through the PLG-PLAT axis under fatty acid reprogramming","volume":"24","author":"Wang","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0009","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40364-025-00811-0","article-title":"Single-cell sequencing technology in renal cancer: insights into tumor biology and clinical application","volume":"13","author":"Zhang","year":"2025","journal-title":"Biomark Res."},{"key":"10.1016\/j.tranon.2026.103064_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101388","article-title":"Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling","author":"Zhang","year":"2026","journal-title":"Drug Resist. Updates"},{"issue":"7","key":"10.1016\/j.tranon.2026.103064_bib0011","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","article-title":"Cancer-associated fibroblasts: from basic science to anticancer therapy","volume":"55","author":"Yang","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cmp.2025.06.003","article-title":"Large language models in drug development: current progress and future directions","volume":"18","author":"Lin","year":"2025","journal-title":"Curr. Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.tranon.2026.103064_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.curpro.2025.100052","article-title":"Emerging role of tumor associated macrophages in pan-tumor progression: biological mechanisms to clinical application","volume":"22","author":"Zhang","year":"2025","journal-title":"Curr Proteom."},{"issue":"2","key":"10.1016\/j.tranon.2026.103064_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/imo2.70014","article-title":"Linking preclinical models to clinical realities: VEGF\/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy","volume":"2","author":"Jiang","year":"2025","journal-title":"iMetaOmics"},{"issue":"10","key":"10.1016\/j.tranon.2026.103064_bib0015","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-012991","article-title":"Spatial transcriptomic profiling of metastatic renal cell carcinoma identifies chemokine-driven macrophage and CD8+ T-cell interactions predictive of immunotherapy response","volume":"13","author":"Kalogirou","year":"2025","journal-title":"J. ImmunOther Cancer"},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0016","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41467-020-15816-6","article-title":"Accurate estimation of cell composition in bulk expression through robust integration of single-cell information","volume":"11","author":"Jew","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.tranon.2026.103064_bib0017","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1507","article-title":"TCGAbiolinks: an R\/bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.tranon.2026.103064_bib0018","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.tranon.2026.103064_bib0019","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"He Q-Y: clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics: J. Integr. Biol."},{"key":"10.1016\/j.tranon.2026.103064_bib0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"21","key":"10.1016\/j.tranon.2026.103064_bib0021","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2026.103064_bib0022","article-title":"Quantiseq: quantifying immune contexture of human tumors","author":"Finotello","year":"2017","journal-title":"BioRxiv"},{"issue":"7","key":"10.1016\/j.tranon.2026.103064_bib0023","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/bioinformatics\/btx744","article-title":"GDSCTools for mining pharmacogenomic interactions in cancer","volume":"34","author":"Cokelaer","year":"2018","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.tranon.2026.103064_bib0024","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41592-023-01938-4","article-title":"SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks","volume":"20","author":"Bravo Gonz\u00e1lez-Blas","year":"2023","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Nie Q: inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0026","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103064_bib0027","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103064_bib0028","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab1011","article-title":"HIT 2.0: an enhanced platform for Herbal Ingredients' Targets","volume":"50","author":"Yan","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.tranon.2026.103064_bib0029","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.apsb.2021.03.024","article-title":"A comprehensive review of integrative pharmacology-based investigation: a paradigm shift in traditional Chinese medicine","volume":"11","author":"Xu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0030","first-page":"136","article-title":"Systematic investigation of tumor microenvironment and antitumor immunity with IOBR","volume":"1","author":"Fang","year":"2025","journal-title":"Med Res."},{"key":"10.1016\/j.tranon.2026.103064_bib0031","article-title":"DrugSurvPlot: a novel web-based platform harnessing drug sensitivity scores as molecular biomarkers for pan-cancer survival prognosis","author":"Shi","year":"2025","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.tranon.2026.103064_bib0032","article-title":"Cloud-based GWAS platform: an innovative solution for efficient acquisition and analysis of genomic data","author":"Ke","year":"2025","journal-title":"Med Res."},{"issue":"2","key":"10.1016\/j.tranon.2026.103064_bib0033","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clgc.2024.01.005","article-title":"SPCS, a novel classifier system based on senescence axis regulators reveals tumor microenvironment heterogeneity and guides frontline therapy for clear cell renal carcinoma","volume":"22","author":"Jiang","year":"2024","journal-title":"Clin. Genitourin. Cancer"},{"key":"10.1016\/j.tranon.2026.103064_bib0034","article-title":"Towards green urology: application prospects and challenges of sustainable biodegradable hydrogels","volume":"4","author":"Guo","year":"2026","journal-title":"Green Technol. Sustain."},{"key":"10.1016\/j.tranon.2026.103064_bib0035","article-title":"Heterogeneity of intratumoral microbiota within the tumor microenvironment and relationship to tumor development","author":"Gao","year":"2025","journal-title":"Med Res."},{"key":"10.1016\/j.tranon.2026.103064_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102650","article-title":"Single-cell profiling of bone metastasis ecosystems reveals pivotal role of INSR+AEC in clear cell renal cell carcinoma","volume":"64","author":"Zhang","year":"2026","journal-title":"Transl. Oncol."},{"issue":"8","key":"10.1016\/j.tranon.2026.103064_bib0037","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.676","article-title":"Renal cancer: signaling pathways and advances in targeted therapies","volume":"5","author":"Jiang","year":"2024","journal-title":"MedComm"},{"issue":"11","key":"10.1016\/j.tranon.2026.103064_bib0038","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41585-024-00876-w","article-title":"Von Hippel\u2013Lindau protein signalling in clear cell renal cell carcinoma","volume":"21","author":"Liao","year":"2024","journal-title":"Nat. Rev. Urol."},{"issue":"34","key":"10.1016\/j.tranon.2026.103064_bib0039","doi-asserted-by":"crossref","first-page":"12779","DOI":"10.1074\/jbc.RA119.007834","article-title":"CD44 inhibits \u03b1-SMA gene expression via a novel G-actin\/MRTF-mediated pathway that intersects with TGF\u03b2R\/p38MAPK signaling in murine skin fibroblasts","volume":"294","author":"Wang","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.tranon.2026.103064_bib0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/s12957-022-02824-7","article-title":"Does intraoperative cyst rupture of malignant cystic renal masses really have no negative impact on oncologic outcomes?","volume":"20","author":"Xu","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.tranon.2026.103064_bib0041","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00428-024-03930-5","article-title":"Localized cystic disease of the kidney: study of 14 cases and review of the literature","volume":"487","author":"Tannous","year":"2024","journal-title":"Virchows Arch."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:19Z","timestamp":1792403419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326004006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":41,"alternative-id":["S1936523326004006"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103064","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103064"}}