{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:30Z","timestamp":1792525590415,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tranon.2026.103069","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:42:00Z","timestamp":1792424520000},"page":"103069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hypoxia-induced SATB homeobox 2 increases hypoxia-inducible factor-1-dependent tumorigenesis and drives bevacizumab resistance in lung adenocarcinoma"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-1955","authenticated-orcid":false,"given":"Suhong","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengteng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangda","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tranon.2026.103069_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.tranon.2026.103069_bib0002","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S2213-2600(24)00428-4","article-title":"Estimated worldwide variation and trends in incidence of lung cancer by histological subtype in 2022 and over time: a population-based study","volume":"13","author":"Luo","year":"2025","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.tranon.2026.103069_bib0003","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1200\/JCO.21.01589","article-title":"Preoperative and Postoperative Systemic Therapy for Operable Non\u2013Small-Cell Lung Cancer","volume":"40","author":"Chaft","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.tranon.2026.103069_bib0004","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.annonc.2022.12.013","article-title":"Non-oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Hendriks","year":"2023","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.tranon.2026.103069_bib0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.annonc.2022.12.009","article-title":"Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Hendriks","year":"2023","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.tranon.2026.103069_bib0006","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1056\/NEJMoa2105281","article-title":"Acquired Resistance to KRASG12C Inhibition in Cancer","volume":"384","author":"Awad","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tranon.2026.103069_bib0007","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2204619","article-title":"Adagrasib in Non\u2013Small-Cell Lung Cancer Harboring a KRASG12C Mutation","volume":"387","author":"J\u00e4nne","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tranon.2026.103069_bib0008","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/med4.38","article-title":"Proteomic characteristics of lung adenocarcinoma tumors that are small but highly invasive","volume":"1","author":"Qiu","year":"2023","journal-title":"Med. Adv."},{"key":"10.1016\/j.tranon.2026.103069_bib0009","article-title":"Epigenetic regulation in lung cancer","volume":"4","author":"Ramazi","year":"2023","journal-title":"MedComm. (2020)"},{"key":"10.1016\/j.tranon.2026.103069_bib0010","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1158\/2159-8290.CD-24-0296","article-title":"The Epigenetic Hallmarks of Cancer","volume":"14","author":"Esteller","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2026.103069_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2021.08.034","article-title":"NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis","volume":"81","author":"Sengupta","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tranon.2026.103069_bib0012","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1158\/2159-8290.CD-20-1863","article-title":"Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation","volume":"11","author":"Quintanal-Villalonga","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.tranon.2026.103069_bib0013","article-title":"m6 A-Dependent Modulation via IGF2BP3\/MCM5\/Notch Axis Promotes Partial EMT and LUAD Metastasis","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.tranon.2026.103069_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.06.006","article-title":"Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma","volume":"38","author":"LaFave","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.tranon.2026.103069_bib0015","doi-asserted-by":"crossref","first-page":"11064","DOI":"10.1111\/jcmm.15755","article-title":"SATB2 is a novel biomarker and therapeutic target for cancer","volume":"24","author":"Roy","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.tranon.2026.103069_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2021.09.004","article-title":"SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling","volume":"29","author":"Gu","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.tranon.2026.103069_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2023.12.024","article-title":"SATB2 organizes the 3D genome architecture of cognition in cortical neurons","volume":"84","author":"Wahl","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tranon.2026.103069_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2023.100491","article-title":"LncRNA SATB2-AS1 promotes tumor growth and metastasis and affects the tumor immune microenvironment in osteosarcoma by regulating SATB2","volume":"41","author":"Wang","year":"2023","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.tranon.2026.103069_bib0019","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1038\/onc.2014.289","article-title":"SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization","volume":"34","author":"Seong","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.tranon.2026.103069_bib0020","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1158\/0008-5472.CAN-18-2900","article-title":"SATB2-AS1 Suppresses Colorectal Carcinoma Aggressiveness by Inhibiting SATB2-Dependent Snail Transcription and Epithelial\u2013Mesenchymal Transition","volume":"79","author":"Wang","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2026.103069_bib0021","article-title":"Multi-omics analysis of epigenetic dysregulation reveals clinical heterogeneity and evaluates the immunotherapeutic potential of lung adenocarcinoma","volume":"12","author":"Ren","year":"2025","journal-title":"Genes. Dis."},{"key":"10.1016\/j.tranon.2026.103069_bib0022","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.tranon.2026.103069_bib0023","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41588-018-0318-2","article-title":"Molecular landmarks of tumor hypoxia across cancer types","volume":"51","author":"Bhandari","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tranon.2026.103069_bib0024","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/onc.2017.338","article-title":"The HIF and other quandaries in VHL disease","volume":"37","author":"Tarade","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.tranon.2026.103069_bib0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","volume":"21","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.tranon.2026.103069_bib0026","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.gendis.2023.02.039","article-title":"HIF-1\u03b1 signaling: Essential roles in tumorigenesis and implications in targeted therapies","volume":"11","author":"Zhao","year":"2024","journal-title":"Genes. Dis."},{"key":"10.1016\/j.tranon.2026.103069_bib0027","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.3390\/ijms22073765","article-title":"Anti-Angiogenic Therapy: Current Challenges and Future Perspectives","volume":"22","author":"Lopes-Coelho","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.tranon.2026.103069_bib0028","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3390\/cells12050798","article-title":"Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators","volume":"12","author":"Yfantis","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.tranon.2026.103069_bib0029","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41467-021-27944-8","article-title":"HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia","volume":"13","author":"Yang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103069_bib0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54671-7","article-title":"Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development","volume":"15","author":"Takano","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103069_bib0031","doi-asserted-by":"crossref","DOI":"10.31083\/FBL46692","article-title":"Hypoxia-Activated PERK Promotes Epithelial-Mesenchymal Transition in Gliomas: A Single-Cell and Spatial Transcriptomic Study With Therapeutic Implications","volume":"30","author":"Gu","year":"2025","journal-title":"Front. Biosci.-Landmark"},{"key":"10.1016\/j.tranon.2026.103069_bib0032","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41576-021-00370-8","article-title":"Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics","volume":"22","author":"Longo","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tranon.2026.103069_bib0033","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13644","article-title":"K63-polyubiquitinated HAUSP deubiquitinates HIF-1\u03b1 and dictates H3K56 acetylation promoting hypoxia-induced tumour progression","volume":"7","author":"Wu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103069_bib0034","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/febs.16694","article-title":"Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia","volume":"290","author":"Karagiota","year":"2023","journal-title":"FEBS. J."},{"key":"10.1016\/j.tranon.2026.103069_bib0035","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cell.2011.03.054","article-title":"Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1","volume":"145","author":"Luo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.tranon.2026.103069_bib0036","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1158\/0008-5472.CAN-20-1049","article-title":"CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors","volume":"80","author":"Wang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.tranon.2026.103069_bib0037","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1172\/JCI95089","article-title":"ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis","volume":"128","author":"Chen","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tranon.2026.103069_bib0038","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103069_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70084","article-title":"A comprehensive benchmarking for spatially resolved transcriptomics clustering methods across variable technologies, organs, and replicates","volume":"4","author":"Chen","year":"2025","journal-title":"Imeta"},{"key":"10.1016\/j.tranon.2026.103069_bib0040","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41592-024-02215-8","article-title":"Benchmarking spatial clustering methods with spatially resolved transcriptomics data","volume":"21","author":"Yuan","year":"2024","journal-title":"Nat. Methods"}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:37:10Z","timestamp":1792525030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326004055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S1936523326004055"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103069","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia-induced SATB homeobox 2 increases hypoxia-inducible factor-1-dependent tumorigenesis and drives bevacizumab resistance in lung adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103069"}}