{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:13Z","timestamp":1792831033420,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Oncology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.tranon.2026.103076","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:09Z","timestamp":1792098549000},"page":"103076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Network pharmacology and single-cell sequencing analysis of gastrodin in anticancer effects against colorectal cancer by regulating key target genes and the tumor immune microenvironment"],"prefix":"10.1016","volume":"74","author":[{"given":"Zou","family":"Minjun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8702-5260","authenticated-orcid":false,"given":"Xiaojun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yuting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zhishang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tranon.2026.103076_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]","volume":"71","author":"Bray","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.tranon.2026.103076_bib0002","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery[J]","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.tranon.2026.103076_bib0003","series-title":"2024 5th International Conference on Data Intelligence and Cognitive Informatics (ICDICI)","first-page":"787","article-title":"Development of cancer drug targets and potential anti-cancer agents using deep learning and screening processes[C]","author":"Balamurugan","year":"2024"},{"key":"10.1016\/j.tranon.2026.103076_bib0004","doi-asserted-by":"crossref","unstructured":"Balamurugan KS, Navaneethakrishnan SR, et al. Development of precision medicine for hepatic cancer evolving molecular profiling techniques through artificial intelligence[C]. IET Conference Proceedings, 8th IET Smart Cities Symposium (SCS 2024). Bahrain, 2025, 2024:666\u2013672. doi:10.1049\/icp.2025.0869.","DOI":"10.1049\/icp.2025.0869"},{"key":"10.1016\/j.tranon.2026.103076_bib0005","series-title":"2024 IEEE 9th International Conference on Engineering Technologies and Applied Sciences (ICETAS)","first-page":"1","article-title":"Comprehensive in Vivo and in Vitro platform for evaluating drug efficacy against cancer cells in patient treatment[C]","author":"Shanmugam","year":"2024"},{"key":"10.1016\/j.tranon.2026.103076_bib0006","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-70117-y","article-title":"An efficient colorectal cancer detection network using atrous convolution with coordinate attention transformer and histopathological images[J]","volume":"14","author":"Khalid","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2026.103076_bib0007","series-title":"2025 6th International Conference on Electronics and Sustainable Communication Systems (ICESC)","first-page":"902","article-title":"Graph enhanced transformers for predicting drug using drug synergies and antagonistic interactions[C]","author":"Sherine","year":"2025"},{"key":"10.1016\/j.tranon.2026.103076_bib0008","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-23813-2","article-title":"An intelligent brain tumor detection model using lightweight hybrid twin attentive pyramid convolutional network[J]","volume":"15","author":"Jemina","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.tranon.2026.103076_bib0009","article-title":"Quantum leap in medical mentorship: exploring ChatGPT's transition from textbooks to terabytes[J]","volume":"12","author":"Chokkakula","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"issue":"1","key":"10.1016\/j.tranon.2026.103076_bib0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository[J]","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.tranon.2026.103076_bib0011","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The cancer genome atlas pan-cancer analysis project[J]","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat. Genet."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103076_bib0012","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces[J]","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.tranon.2026.103076_bib0013","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1021\/ci1002747","article-title":"PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach[J]","volume":"50","author":"Wang","year":"2010","journal-title":"J. Chem. Inf. Model."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103076_bib0014","first-page":"D774","article-title":"GeneCards 2019: enhancing genome data annotation and integration with disease and drug information[J]","volume":"47","author":"Stelzer","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.tranon.2026.103076_bib0015","first-page":"D1100","article-title":"HERB 2.0: an integrative platform for traditional Chinese medicine herbal genomics, chemistry and pharmacology[J]","volume":"49","author":"Zhang","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.tranon.2026.103076_bib0016","first-page":"4973","article-title":"SwissTargetPrediction: a web server for target prediction of bioactive small molecules[J]","volume":"57","author":"Daina","year":"2014","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.tranon.2026.103076_bib0017","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies[J]","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.tranon.2026.103076_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data[J]","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinform."},{"issue":"1","key":"10.1016\/j.tranon.2026.103076_bib0019","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis[J]","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"issue":"5","key":"10.1016\/j.tranon.2026.103076_bib0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"Clusterprofiler: an R package for comparing biological themes among gene clusters[J]","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS: J. Integr. Biol."},{"issue":"1","key":"10.1016\/j.tranon.2026.103076_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent[J]","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.tranon.2026.103076_bib0022","series-title":"e1071: Misc Functions of the Department of Statistics, Probability Theory Group (Formerly: E1071), TU Wien[R]","author":"Meyer","year":"2023"},{"issue":"3","key":"10.1016\/j.tranon.2026.103076_bib0023","first-page":"18","article-title":"Classification and regression by randomForest[J]","volume":"2","author":"Liaw","year":"2002","journal-title":"R. News"},{"issue":"1","key":"10.1016\/j.tranon.2026.103076_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v077.i01","article-title":"Ranger: a fast implementation of random forests for high dimensional data in C++ and R[J]","volume":"77","author":"Wright","year":"2017","journal-title":"J. Stat. Softw."},{"issue":"7","key":"10.1016\/j.tranon.2026.103076_bib0025","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data[J]","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.tranon.2026.103076_bib0026","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony[J]","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"D1","key":"10.1016\/j.tranon.2026.103076_bib0027","first-page":"D1244","article-title":"ImmPort, toward repurposing immunological data for the informatics community[J]","volume":"42","author":"Bhattacharya","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.tranon.2026.103076_bib0028","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles[J]","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.tranon.2026.103076_bib0029","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking[J]","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.tranon.2026.103076_bib0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading[J]","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"9","key":"10.1016\/j.tranon.2026.103076_bib0031","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/dna.2021.0095","article-title":"Downregulation of Hotair or LSD1 impaired heart regeneration in the neonatal mouse[J]","volume":"40","author":"Fei","year":"2021","journal-title":"DNA Cell. Biol."},{"issue":"11","key":"10.1016\/j.tranon.2026.103076_bib0032","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2174\/0118715206286233240328045215","article-title":"Gastrodin attenuates colitis and prevents tumorigenesis in mice by interrupting TLR4\/MD2\/NF-\u03bab signaling transduction[J]","volume":"24","author":"Yu","year":"2024","journal-title":"Anticancer. Agents Med. Chem."},{"issue":"7693","key":"10.1016\/j.tranon.2026.103076_bib0033","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature25501","article-title":"TGF\u03b2 attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells[J]","volume":"554","author":"Mariathasan","year":"2018","journal-title":"Nature"},{"issue":"50","key":"10.1016\/j.tranon.2026.103076_bib0034","doi-asserted-by":"crossref","first-page":"20212","DOI":"10.1073\/pnas.1320318110","article-title":"Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer[J]","volume":"110","author":"Feig","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.tranon.2026.103076_bib0035","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13045-019-0770-1","article-title":"Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy[J]","volume":"12","author":"Liu","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.tranon.2026.103076_bib0036","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/JLB.5RU0222-082R","article-title":"Direct and indirect regulation of the tumor immune microenvironment by VEGF[J]","volume":"111","author":"Zhang","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tranon.2026.103076_bib0037","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66485-2","article-title":"Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer[J]","volume":"16","author":"Iwane","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.tranon.2026.103076_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102793","article-title":"Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination[J]","volume":"95","author":"Zhang","year":"2025","journal-title":"Tissue Cell."},{"issue":"6378","key":"10.1016\/j.tranon.2026.103076_bib0039","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.aao2774","article-title":"Patient-derived organoids model treatment response of metastatic gastrointestinal cancers[J]","volume":"359","author":"Vlachogiannis","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.tranon.2026.103076_bib0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s43856-025-00852-4","article-title":"Clinical utility and future perspectives of liquid biopsy in colorectal cancer[J]","volume":"5","author":"Patelli","year":"2025","journal-title":"Commun. Med."},{"key":"10.1016\/j.tranon.2026.103076_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119686","article-title":"Precision medicine in colorectal cancer: leveraging multi-omics, spatial omics, and artificial intelligence[J]","volume":"559","author":"Xu","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.tranon.2026.103076_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2026.1737113","article-title":"The post-marketing safety of venlafaxine: a real-world two-decade pharmacovigilance study using the FAERS database[J]","volume":"17","author":"Chokkakula","year":"2026","journal-title":"Front. Pharmacol."}],"container-title":["Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1936523326004122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:56:53Z","timestamp":1792828613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1936523326004122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":42,"alternative-id":["S1936523326004122"],"URL":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103076","relation":{},"ISSN":["1936-5233"],"issn-type":[{"value":"1936-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network pharmacology and single-cell sequencing analysis of gastrodin in anticancer effects against colorectal cancer by regulating key target genes and the tumor immune microenvironment","name":"articletitle","label":"Article Title"},{"value":"Translational Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tranon.2026.103076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103076"}}