{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:46:12Z","timestamp":1792086372857,"version":"4.4.0"},"reference-count":116,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.transci.2012.01.007","type":"journal-article","created":{"date-parts":[[2012,2,18]],"date-time":"2012-02-18T22:46:27Z","timestamp":1329605187000},"page":"137-147","source":"Crossref","is-referenced-by-count":103,"title":["Hydroxyethylstarch in cryopreservation \u2013 Mechanisms, benefits and problems"],"prefix":"10.1016","volume":"46","author":[{"given":"A.","family":"Stolzing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Naaldijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2012.01.007_b0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1196\/annals.1363.010","article-title":"Cryo-injury and biopreservation","volume":"1066","author":"Fowler","year":"2005","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0010","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1095\/biolreprod.107.064253","article-title":"Characterization of sperm plasma membrane properties after cholesterol modification: consequences for cryopreservation of rainbow trout spermatozoa","volume":"78","author":"Muller","year":"2008","journal-title":"Biol Reprod"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0015","first-page":"69","article-title":"Cryosurgery \u2013 a review of recent advances and current issues","volume":"23","author":"Gage","year":"2002","journal-title":"Cryo Lett"},{"issue":"934","key":"10.1016\/j.transci.2012.01.007_b0020","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.168.3934.939","article-title":"Cryobiology: the freezing of biological systems","volume":"168","author":"Mazur","year":"1970","journal-title":"Science"},{"issue":"6907","key":"10.1016\/j.transci.2012.01.007_b0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature01106","article-title":"Propagation of the polyamorphic transition of ice and the liquid-liquid critical point","volume":"419","author":"Mishima","year":"2002","journal-title":"Nature"},{"issue":"Pt 2","key":"10.1016\/j.transci.2012.01.007_b0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2818.1987.tb01342.x","article-title":"Computer automated cell size and shape analysis in cryomicroscopy","volume":"146","author":"Diller","year":"1987","journal-title":"J Microsc"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0011-2240(83)90057-3","article-title":"The effect of ice formation on the function of smooth muscle tissue stored at \u221221 or \u221260\u00b0C","volume":"20","author":"Taylor","year":"1983","journal-title":"Cryobiology"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0040","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/S0006-3495(02)75536-7","article-title":"Kinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct","volume":"82","author":"Irimia","year":"2002","journal-title":"Biophys J"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0142-9612(96)85562-1","article-title":"Long-term storage of tissues by cryopreservation: critical issues","volume":"17","author":"Karlsson","year":"1996","journal-title":"Biomaterials"},{"issue":"2 Pt 1","key":"10.1016\/j.transci.2012.01.007_b0050","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0006-3495(94)80806-9","article-title":"The osmotic rupture hypothesis of intracellular freezing injury","volume":"66","author":"Muldrew","year":"1994","journal-title":"Biophys J"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1290\/1071-2690(2000)036<0262:CVIFIO>2.0.CO;2","article-title":"Cell viability improves following inhibition of cryopreservation-induced apoptosis","volume":"36","author":"Baust","year":"2000","journal-title":"In Vitro Cell Dev Biol Anim"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cryobiol.2008.12.004","article-title":"Effect of alpha-tocopherol supplementation during boar semen cryopreservation on sperm characteristics and expression of apoptosis related genes","volume":"58","author":"Jeong","year":"2009","journal-title":"Cryobiology"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0065","first-page":"145","article-title":"Human sperm cryopreservation and reactive oxygen species (ROS) production","volume":"26","author":"Mazzilli","year":"1995","journal-title":"Acta Eur Fertil"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0070","first-page":"69","article-title":"Extracellular presence of reactive oxygen species (ROS) in fresh and frozen-thawed canine semen and their effects on some semen parameters","volume":"107","author":"Tselkas","year":"2000","journal-title":"Dtsch Tierarztl Wochenschr"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0075","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1016-8478(23)15033-3","article-title":"Amelioration of mitochondrial dysfunction and apoptosis of two-cell mouse embryos after freezing and thawing by the high frequency liquid nitrogen infusion","volume":"13","author":"Sohn","year":"2002","journal-title":"Mol Cell"},{"issue":"9","key":"10.1016\/j.transci.2012.01.007_b0080","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/humrep\/dep214","article-title":"Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis","volume":"24","author":"Thomson","year":"2009","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/j.1939-4640.1992.tb00306.x","article-title":"Evidence for increased lipid peroxidative damage and loss of superoxide dismutase activity as a mode of sublethal cryodamage to human sperm during cryopreservation","volume":"13","author":"Alvarez","year":"1992","journal-title":"J Androl"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0090","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1006\/cryo.1997.2011","article-title":"The efficacy of antioxidants administered during low temperature storage of warm ischemic kidney tissue slices","volume":"34","author":"McAnulty","year":"1997","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0095","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.tiv.2006.11.005","article-title":"Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures","volume":"21","author":"Stevenson","year":"2007","journal-title":"Toxicol In Vitro"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0100","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/(SICI)1098-2795(200003)55:3<282::AID-MRD6>3.0.CO;2-7","article-title":"Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing","volume":"55","author":"Bilodeau","year":"2000","journal-title":"Mol Reprod Dev"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.2001.4585","article-title":"Induction of telomere shortening and replicative senescence by cryopreservation","volume":"282","author":"Honda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cryobiol.2004.12.003","article-title":"Evaluation of DNA damage in rainbow trout (Oncorhynchus mykiss) and gilthead sea bream (Sparus aurata) cryopreserved sperm","volume":"50","author":"Cabrita","year":"2005","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/mutage\/17.3.211","article-title":"Cryopreserved versus freshly isolated lymphocytes in human biomonitoring: endogenous and induced DNA damage, antioxidant status and repair capability","volume":"17","author":"Duthie","year":"2002","journal-title":"Mutagenesis"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cryobiol.2008.06.005","article-title":"Autophosphorylation of H2AX in a cell-specific frozen dependent way","volume":"57","author":"Peng","year":"2008","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0125","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.fertnstert.2007.06.105","article-title":"Effects of cryoprotectants and cryopreservation on germinal vesicle-stage cumulus-oocyte complexes of rhesus monkeys","volume":"90","author":"Vandevoort","year":"2008","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0130","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0011-2240(78)90056-1","article-title":"Differing actions of penetrating and nonpenetrating cryoprotective agents","volume":"15","author":"McGann","year":"1978","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0135","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cryobiol.2004.12.006","article-title":"Cryopreservation of human endothelial cells for vascular tissue engineering","volume":"50","author":"Lehle","year":"2005","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0006-3495(88)82983-7","article-title":"Mechanism of cryoprotection by extracellular polymeric solutes","volume":"54","author":"Takahashi","year":"1988","journal-title":"Biophys J"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0145","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/cryo.2000.2247","article-title":"Effects of high-molecular-weight cryoprotectants on platelets and the coagulation system","volume":"40","author":"Bakaltcheva","year":"2000","journal-title":"Cryobiology"},{"issue":"Pt 9","key":"10.1016\/j.transci.2012.01.007_b0150","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1242\/jeb.199.9.2071","article-title":"Effects of antifreeze proteins on red blood cell survival during cryopreservation","volume":"199","author":"Chao","year":"1996","journal-title":"J Exp Biol"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0155","first-page":"965","article-title":"Intravascular persistence, tissue storage, and excretion of hydroxyethyl starch","volume":"131","author":"Thompson","year":"1970","journal-title":"Surg Gynecol Obstet"},{"issue":"1\u20132","key":"10.1016\/j.transci.2012.01.007_b0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00370817","article-title":"Hydroxyethylstarch deposits in human skin \u2013 a model for pruritus?","volume":"285","author":"Jurecka","year":"1993","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0168-8278(86)80030-7","article-title":"Accumulation of hydroxyethyl starch (HES) in the liver of patients with renal failure and portal hypertension","volume":"3","author":"Dienes","year":"1986","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0170","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s004410000324","article-title":"Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term study","volume":"304","author":"Stander","year":"2001","journal-title":"Cell Tissue Res"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0175","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000064005","article-title":"Endothelial accumulation of hydroxyethyl starch and functional consequences on leukocyte-endothelial interactions","volume":"34","author":"Nohe","year":"2002","journal-title":"Eur Surg Res"},{"issue":"7","key":"10.1016\/j.transci.2012.01.007_b0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tplants.2010.04.004","article-title":"Trehalose and plant stress responses: friend or foe?","volume":"15","author":"Fernandez","year":"2010","journal-title":"Trends Plant Sci"},{"issue":"3 Pt 2","key":"10.1016\/j.transci.2012.01.007_b0185","first-page":"R559","article-title":"Life in a frozen state: adaptive strategies for natural freeze tolerance in amphibians and reptiles","volume":"258","author":"Storey","year":"1990","journal-title":"Am J Physiol"},{"issue":"4637","key":"10.1016\/j.transci.2012.01.007_b0190","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.223.4637.701","article-title":"Preservation of membranes in anhydrobiotic organisms: the role of trehalose","volume":"223","author":"Crowe","year":"1984","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0195","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1213\/ane.0b013e31819e9e6c","article-title":"Modern rapidly degradable hydroxyethyl starches: current concepts","volume":"108","author":"Boldt","year":"2009","journal-title":"Anesth Analg"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0200","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/00000542-200509000-00031","article-title":"Effects of hydroxyethyl starch solutions on hemostasis","volume":"103","author":"Kozek-Langenecker","year":"2005","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0205","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s001340050833","article-title":"An international view of hydroxyethyl starches","volume":"25","author":"Treib","year":"1999","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0210","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1055\/s-0038-1657671","article-title":"Coagulation disorders caused by hydroxyethyl starch","volume":"78","author":"Treib","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.transci.2012.01.007_b0215","unstructured":"Sputtek A. HES \u2013 A Nightmare? Society for Low Temperature Biology (SLTB) Newsletter February. 2001 Available from: www.sputtek.de\/info\/HES.pdf."},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0220","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0011-2240(80)90008-5","article-title":"The cryoprotective properties of hydroxyethyl starch investigated by means of differential thermal analysis","volume":"17","author":"Korber","year":"1980","journal-title":"Cryobiology"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0225","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0011-2240(73)80002-1","article-title":"Cryoprotection of mammalian cells in tissue culture with polymers; possible mechanisms","volume":"10","author":"Connor","year":"1973","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0230","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0955-3886(96)00009-4","article-title":"A method for the cryopreservation of red blood cells using hydroxyethyl starch as a cryoprotectant","volume":"17","author":"Thomas","year":"1996","journal-title":"Transfus Sci"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/153303460700600206","article-title":"Issues critical to the successful application of cryosurgical ablation of the prostate","volume":"6","author":"Baust","year":"2007","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.transci.2012.01.007_b0240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1515\/bchm2.1934.229.4-6.213","article-title":"Action of amylascs on hydroxyethyl starch","volume":"229","author":"Ziese","year":"1934","journal-title":"Z Physiol Chem"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0245","first-page":"118","article-title":"Synthetic macromolecular compounds and their use in medical therapy","volume":"3","author":"Wiedersheim","year":"1957","journal-title":"S Afr J Lab Clin Med"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0250","first-page":"197","article-title":"A method for separation of granulocytes from normal human blood using hydroxyethyl starch","volume":"1","author":"Roy","year":"1971","journal-title":"Prep Biochem"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0255","first-page":"33","article-title":"The effect of hydroxyethyl starch upon survival of dogs subjected to hemorrhagic shock","volume":"122","author":"Ballinger","year":"1966","journal-title":"Surg Gynecol Obstet"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0260","first-page":"725","article-title":"Use of hydroxyethyl starch solution in extensive surgical operations","volume":"128","author":"Gollub","year":"1969","journal-title":"Surg Gynecol Obstet"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0265","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00005373-196709000-00013","article-title":"Hydroxyethyl starch (HES) and bleeding. An experimental investigation of its effect on hemostasis","volume":"7","author":"Garzon","year":"1967","journal-title":"J Trauma"},{"issue":"794","key":"10.1016\/j.transci.2012.01.007_b0270","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.157.3794.1312","article-title":"Hydroxyethyl starch: extracellular cryophylactic agent for erythrocytes","volume":"157","author":"Knorpp","year":"1967","journal-title":"Science"},{"issue":"4672","key":"10.1016\/j.transci.2012.01.007_b0275","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/1831394a0","article-title":"Prevention of freezing damage to living cells by dimethyl sulphoxide","volume":"183","author":"Lovelock","year":"1959","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0280","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0011-2240(71)90013-7","article-title":"Hydroxyethyl starch as a cryopreservative for nucleated mammalian cells","volume":"8","author":"Persidsky","year":"1971","journal-title":"Cryobiology"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0285","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0011-2240(72)90161-7","article-title":"Low-temperature preservation of mammalian cells in tissue culture with polyvinylpyrrolidone (PVP), dextrans, and hydroxyethyl starch (HES)","volume":"9","author":"Ashwood-Smith","year":"1972","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0290","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0011-2240(75)80002-2","article-title":"Cryopreservation of human red cells in liquid nitrogen with hydroxyethyl starch","volume":"12","author":"Lionetti","year":"1975","journal-title":"Cryobiology"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0295","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1046\/j.1537-2995.1978.18679077950.x","article-title":"In vitro studies of cryopreserved baboon granulocytes","volume":"18","author":"Lionetti","year":"1978","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0300","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0011-2240(83)90054-8","article-title":"Unfractionated human marrow cell cryopreservation using dimethylsulfoxide and hydroxyethyl starch","volume":"20","author":"Stiff","year":"1983","journal-title":"Cryobiology"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0305","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1182\/blood.V70.4.974.974","article-title":"Autologous bone marrow transplantation using unfractionated cells cryopreserved in dimethylsulfoxide and hydroxyethyl starch without controlled-rate freezing","volume":"70","author":"Stiff","year":"1987","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.transci.2012.01.007_b0310","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1292\/jvms.66.1543","article-title":"A comparative study of the effects of glycerol and hydroxyethyl starch in canine red blood cell cryopreservation","volume":"66","author":"Kim","year":"2004","journal-title":"J Vet Med Sci"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0315","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0011-2240(75)90016-4","article-title":"Cryopreservation of human granulocytes","volume":"12","author":"Lionetti","year":"1975","journal-title":"Cryobiology"},{"issue":"1\u20132","key":"10.1016\/j.transci.2012.01.007_b0320","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3727\/000000008783907026","article-title":"Cryopreservation of human pancreatic islets from non-heart-beating donors using hydroxyethyl starch and dimethyl sulfoxide as cryoprotectants","volume":"17","author":"Kenmochi","year":"2008","journal-title":"Cell Transplant"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0325","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.transproceed.2004.04.016","article-title":"Simplified method for cryopreservation of islets using hydroxyethyl starch and dimethyl sulfoxide as cryoprotectants","volume":"36","author":"Maruyama","year":"2004","journal-title":"Transplant Proc"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0330","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/cryo.1994.1042","article-title":"Effect of dimethylsulfoxide and hydroxyethyl starch in the preservation of fractionated human marrow cells","volume":"31","author":"Luo","year":"1994","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0335","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.bbrc.2005.03.059","article-title":"The anti-cell death FNK protein protects cells from death induced by freezing and thawing","volume":"330","author":"Sudo","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0340","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hep.510250331","article-title":"Deletion of hydroxyethylstarch from University of Wisconsin solution induces cell shrinkage and proteolysis during and after cold storage of rat liver","volume":"25","author":"Neveux","year":"1997","journal-title":"Hepatology"},{"issue":"1\u20132","key":"10.1016\/j.transci.2012.01.007_b0345","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0041-1345(00)02166-7","article-title":"Mechanical and histological characteristics of human trachea before and after cryopreservation: an opportunity for tracheal tissue banking","volume":"33","author":"Mabrut","year":"2001","journal-title":"Transplant Proc"},{"issue":"Suppl 2","key":"10.1016\/j.transci.2012.01.007_b0350","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1055\/s-2001-18177","article-title":"Cryopreservation of red blood cells using hydroxyethyl starch (HES) \u2013 from laboratory investigations to clinical application","volume":"36","author":"Sputtek","year":"2001","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0355","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0011-2240(78)90055-X","article-title":"Post-thaw suspension of red cells cryopreserved with hydroxyethyl starch","volume":"15","author":"Allen","year":"1978","journal-title":"Cryobiology"},{"issue":"7","key":"10.1016\/j.transci.2012.01.007_b0360","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1021\/bi00459a037","article-title":"Why preferential hydration does not always stabilize the native structure of globular proteins","volume":"29","author":"Arakawa","year":"1990","journal-title":"Biochemistry"},{"issue":"35","key":"10.1016\/j.transci.2012.01.007_b0365","doi-asserted-by":"crossref","first-page":"10453","DOI":"10.1021\/jp073113e","article-title":"Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide","volume":"111","author":"Gurtovenko","year":"2007","journal-title":"J Phys Chem B"},{"issue":"6B","key":"10.1016\/j.transci.2012.01.007_b0370","first-page":"4705","article-title":"Clinical toxicity of cryopreserved circulating progenitor cells infusion","volume":"18","author":"Zambelli","year":"1998","journal-title":"Anticancer Res"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0375","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.bmt.1702120","article-title":"Evaluation of acute toxicities associated with autologous peripheral blood progenitor cell reinfusion in patients undergoing high-dose chemotherapy","volume":"25","author":"Ferrucci","year":"2000","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0380","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1537-2995.1991.31291142944.x","article-title":"Comparison of the effectiveness of potential marrow donors recruited from apheresis donors or whole blood donors and through appeals to the general public","volume":"31","author":"Stroncek","year":"1991","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0385","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/0032472031000141303","article-title":"Post-thaw removal of DMSO does not completely abrogate infusional toxicity or the need for pre-infusion histamine blockade","volume":"1","author":"Rowley","year":"1999","journal-title":"Cytotherapy"},{"issue":"11","key":"10.1016\/j.transci.2012.01.007_b0390","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1212\/01.wnl.0000256716.04218.5b","article-title":"Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation","volume":"68","author":"Chen-Plotkin","year":"2007","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0395","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/sj.bmt.1704631","article-title":"Adoption of long-term cultures to evaluate the cryoprotective potential of trehalose for freezing hematopoietic stem cells","volume":"34","author":"Scheinkonig","year":"2004","journal-title":"Bone Marrow Transplant"},{"issue":"8","key":"10.1016\/j.transci.2012.01.007_b0400","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.bmt.1704650","article-title":"Infusion of unwashed umbilical cord blood stem cells after thawing for allogeneic transplantation","volume":"34","author":"Antonenas","year":"2004","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0405","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1537-2995.2004.03389.x","article-title":"A new automated cell washer device for thawed cord blood units","volume":"44","author":"Perotti","year":"2004","journal-title":"Transfusion"},{"issue":"8","key":"10.1016\/j.transci.2012.01.007_b0410","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1182\/blood.V96.8.2717","article-title":"Cell dose and speed of engraftment in placental\/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell quantity","volume":"96","author":"Migliaccio","year":"2000","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0415","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1468-0734.2001.00034.x","article-title":"Results of unrelated umbilical cord blood hematopoietic stem cell transplantation","volume":"5","author":"Gluckman","year":"2001","journal-title":"Rev Clin Exp Hematol"},{"issue":"7","key":"10.1016\/j.transci.2012.01.007_b0420","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sj.bmt.1705100","article-title":"Variation in dimethyl sulfoxide use in stem cell transplantation: a survey of EBMT centres","volume":"36","author":"Windrum","year":"2005","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0425","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1098-1101(1997)12:3<146::AID-JCA8>3.0.CO;2-A","article-title":"Alternatives to albumin: starch replacement for plasma exchange","volume":"12","author":"Brecher","year":"1997","journal-title":"J Clin Apher"},{"issue":"11","key":"10.1016\/j.transci.2012.01.007_b0430","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.bmt.1704030","article-title":"A randomized phase III clinical trial of autologous blood stem cell transplantation comparing cryopreservation using dimethylsulfoxide vs dimethylsulfoxide with hydroxyethylstarch","volume":"31","author":"Rowley","year":"2003","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0435","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1213\/01.ANE.0000149326.45137.9A","article-title":"The influence of two different hydroxyethyl starch solutions (6% HES 130\/0.4 and 200\/0.5) on blood viscosity","volume":"100","author":"Neff","year":"2005","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0440","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/ALN.0b013e3181a7ec82","article-title":"Hydroxyethyl starches: different products \u2013 different effects","volume":"111","author":"Westphal","year":"2009","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0445","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1177\/106002808301700503","article-title":"Hetastarch: an overview of the colloid and its metabolism","volume":"17","author":"Hulse","year":"1983","journal-title":"Drug Intell Clin Pharm"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0450","first-page":"61","article-title":"The effects of 500ml 10% hydroxyethyl starch 200\/0.5 and 10% dextran 40 on blood volume, colloid osmotic pressure and renal function in human volunteers (author\u2019s transl)","volume":"31","author":"Kohler","year":"1982","journal-title":"Der Anaesthesist"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0455","first-page":"18","article-title":"Increased haemorrhagic risk after repeated infusion of highly substituted medium molecular weight hydroxyethyl starch","volume":"47","author":"Treib","year":"1997","journal-title":"Arzneimittel-Forschung"},{"issue":"8865","key":"10.1016\/j.transci.2012.01.007_b0460","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0140-6736(93)92345-T","article-title":"Hydroxyethylstarch and osmotic-nephrosis-like lesions in kidney transplantation","volume":"342","author":"Legendre","year":"1993","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0465","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007594.pub2","article-title":"Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function","author":"Dart","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0470","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/bja\/82.4.510","article-title":"Tissue deposits of hydroxyethyl starch (HES): dose-dependent and time-related","volume":"82","author":"Sirtl","year":"1999","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0475","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/BF01112917","article-title":"Human monocytes and keratinocytes in culture ingest hydroxyethylstarch","volume":"285","author":"Szepfalusi","year":"1993","journal-title":"Arch Dermatol Res"},{"issue":"6313","key":"10.1016\/j.transci.2012.01.007_b0480","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/bmj.284.6313.385-a","article-title":"Pruritus after administration of hetastarch","volume":"284","author":"Parker","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0485","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0750-7658(94)80038-3","article-title":"Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study","volume":"13","author":"Laxenaire","year":"1994","journal-title":"Ann Fr Anesth Reanim"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0490","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1399-6576.1994.tb03924.x","article-title":"Influence of volume replacement with different HES-solutions on microcirculatory blood flow in cardiac surgery","volume":"38","author":"Boldt","year":"1994","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.transci.2012.01.007_b0495","first-page":"44","article-title":"Cryopreservation of erythrocytes using hydroxyethyl starch: in vivo results of an autologous retransfusion model in humans","volume":"32","author":"Sputtek","year":"1994","journal-title":"Beitr Infusionsther Transfusionsmed"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.54680\/fr23110110112","article-title":"Application of phosphoenolpyruvate into canine red blood cell cryopreservation with hydroxyethyl starch","volume":"26","author":"Kim","year":"2005","journal-title":"Cryo Lett"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0505","first-page":"479","article-title":"Cryopreservation of vascular mixed cell for tissue engineering in cardiovascular surgery","volume":"54","author":"Hibino","year":"2001","journal-title":"Kyobu Geka"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0510","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/cryo.2000.2270","article-title":"Variation of the HES concentration for the cryopreservation of keratinocytes in suspensions and in monolayers","volume":"41","author":"Pasch","year":"2000","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.transci.2012.01.007_b0515","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/cryo.1997.2072","article-title":"Altered membrane skeleton of hydroxyethylstarch-cryopreserved human erythrocytes","volume":"36","author":"Singbartl","year":"1998","journal-title":"Cryobiology"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0520","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0006-355X(97)00005-X","article-title":"Flash freezing of erythrocyte suspensions","volume":"34","author":"Mantzavinos","year":"1997","journal-title":"Biorheology"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0525","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1182\/blood.V99.3.850","article-title":"Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait","volume":"99","author":"Kang","year":"2002","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.transci.2012.01.007_b0530","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/j.1537-2995.2010.02684.x","article-title":"5% Dimethyl sulfoxide (DMSO) and pentastarch improves cryopreservation of cord blood cells over 10% DMSO","volume":"50","author":"Hayakawa","year":"2010","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0535","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1537-2995.2009.02482.x","article-title":"Long-term storage of peripheral blood stem cells frozen and stored with a conventional liquid nitrogen technique compared with cells frozen and stored in a mechanical freezer","volume":"50","author":"McCullough","year":"2010","journal-title":"Transfusion"},{"issue":"11","key":"10.1016\/j.transci.2012.01.007_b0540","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1292\/jvms.70.1211","article-title":"Investigation of various methods for the cryopreservation of canine bone marrow-derived CD34(+) cells","volume":"70","author":"Ide","year":"2008","journal-title":"J Vet Med Sci"},{"issue":"5","key":"10.1016\/j.transci.2012.01.007_b0545","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1537-2995.2001.41050667.x","article-title":"Uncontrolled-rate freezing and storage at \u221280\u00b0C, with only 3.5-percent DMSO in cryoprotective solution for 109 autologous peripheral blood progenitor cell transplantations","volume":"41","author":"Halle","year":"2001","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0550","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/scd.1.1998.7.385","article-title":"Effects of long-term storage at \u221290\u00b0C of bone marrow and PBPC on cell recovery, viability, and clonogenic potential","volume":"7","author":"Ayello","year":"1998","journal-title":"J Hematother"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0555","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/sj.bmt.1700644","article-title":"The effects of a simplified method for cryopreservation and thawing procedures on peripheral blood stem cells","volume":"19","author":"Katayama","year":"1997","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0560","first-page":"725","article-title":"Optimal cryopreservation of human umbilical cord blood","volume":"18","author":"Donaldson","year":"1996","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"10.1016\/j.transci.2012.01.007_b0565","first-page":"801","article-title":"Comparative-analysis of engraftment after cryopreservation of peripheral-blood stem-cell autografts by controlled-rate versus uncontrolled-rate methods","volume":"13","author":"Takaue","year":"1994","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.transci.2012.01.007_b0570","first-page":"E97","article-title":"Cryopreservation with hydroxyethylstarch (HES) + dimethylsulfoxide (DMSO) gives better results than DMSO alone","volume":"91","author":"Clapisson","year":"2004","journal-title":"Bull Cancer"},{"issue":"3","key":"10.1016\/j.transci.2012.01.007_b0575","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000313419","article-title":"Slow cooling cryopreservation of cell-microcarrier constructs","volume":"192","author":"Lippens","year":"2010","journal-title":"Cells Tissues Organs"},{"issue":"1","key":"10.1016\/j.transci.2012.01.007_b0580","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.archoralbio.2003.07.002","article-title":"Periodontal regeneration of transplanted rat molars after cryopreservation","volume":"49","author":"Kawasaki","year":"2004","journal-title":"Arch Oral Biol"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050212000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050212000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T21:19:05Z","timestamp":1713561545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050212000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":116,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1473050212000080"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2012.01.007","relation":{},"ISSN":["1473-0502"],"issn-type":[{"value":"1473-0502","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}