{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:19:33Z","timestamp":1789993173608,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Health Labour Science Research Grant","award":["H25-iyaku-shitei-001"],"award-info":[{"award-number":["H25-iyaku-shitei-001"]}]}],"content-domain":{"domain":["trasci.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.transci.2014.11.001","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T20:48:30Z","timestamp":1415738910000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of universal vs bedside leukoreductions on the alloimmunization to platelets and the platelet transfusion refractoriness"],"prefix":"10.1016","volume":"52","author":[{"given":"Yuko","family":"Mishima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-6500","authenticated-orcid":false,"given":"Nelson H.","family":"Tsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Matsuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuichi","family":"Yoshizato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Watanabe-Okochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nagura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Sone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2014.11.001_bib0010","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/j.1537-2995.2008.01799.x","article-title":"The clinical impact of platelet refractoriness: correlation with bleeding and survival","volume":"48","author":"Kerkhoffs","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/1096-8652(200008)64:4<251::AID-AJH3>3.0.CO;2-N","article-title":"Platelet transfusions: utilization and associated costs in a tertiary care hospital","volume":"64","author":"Meehan","year":"2000","journal-title":"Am J Hematol"},{"key":"10.1016\/j.transci.2014.11.001_bib0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1423-0410.1994.tb00310.x","article-title":"Relative importance of immune and non-immune causes of platelet refractoriness","volume":"66","author":"Doughty","year":"1994","journal-title":"Vox Sang"},{"key":"10.1016\/j.transci.2014.11.001_bib0025","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1182\/blood-2003-08-2724","article-title":"Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients","volume":"105","author":"Slichter","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0030","doi-asserted-by":"crossref","first-page":"202","DOI":"10.5581\/1516-8484.20120050","article-title":"Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions","volume":"34","author":"Bianchi","year":"2012","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.transci.2014.11.001_bib0035","first-page":"134","article-title":"Platelet alloimmunization in multitransfused patients with haemato-oncological disorders","volume":"18","author":"Bajpai","year":"2005","journal-title":"Natl Med J India"},{"key":"10.1016\/j.transci.2014.11.001_bib0040","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1046\/j.1537-2995.1978.18478251250.x","article-title":"The natural history of alloimmunization to platelets","volume":"18","author":"Howard","year":"1978","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0045","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1056\/NEJM196911272812202","article-title":"Platelet transfusion the selection of compatible platelet donors for refractory patients by lymphocyte HL-A typing","volume":"281","author":"Yankee","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transci.2014.11.001_bib0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1182\/blood.V77.1.201.201","article-title":"Use of leukocyte-depleted platelet concentrates for the prevention of refractoriness and primary HLA alloimmunization: a prospective, randomized trial","volume":"77","author":"van Marwijk Kooy","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0055","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1182\/blood.V57.3.395.bloodjournal573395","article-title":"Alloimmunization following platelet transfusion: the absence of a dose-response relationship","volume":"57","author":"Dutcher","year":"1981","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0060","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1182\/blood-2012-12-472779","article-title":"Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants","volume":"121","author":"Jackman","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0065","first-page":"247","article-title":"A mini-review on platelet refractoriness","volume":"90","author":"Rebulla","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.transci.2014.11.001_bib0070","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1046\/j.1537-2995.2001.41060766.x","article-title":"Platelet alloantibodies in transfused patients","volume":"41","author":"Kiefel","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1046\/j.1537-2995.2001.41060762.x","article-title":"Platelet-specific antibodies in HLA-immunized patients receiving chronic platelet support","volume":"41","author":"Sanz","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0080","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1537-2995.2001.41060771.x","article-title":"Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments: a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity test","volume":"41","author":"Kurz","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0085","first-page":"77","article-title":"Prevention of platelet refractoriness due to HLA antibodies by administration of leukocyte-poor blood components","volume":"9","author":"Eernisse","year":"1981","journal-title":"Exp Hematol"},{"key":"10.1016\/j.transci.2014.11.001_bib0090","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1182\/blood.V83.10.3028.3028","article-title":"Bedside filtration of blood products in the prevention of HLA alloimmunization\u2013a prospective randomized study. Alloimmunisation Study Group","volume":"83","author":"Williamson","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0095","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1056\/NEJM199712253372601","article-title":"Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. The Trial to Reduce Alloimmunization to Platelets Study Group","volume":"337","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transci.2014.11.001_bib0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00062752-200211000-00010","article-title":"Leukoreduction of blood components","volume":"9","author":"Dzik","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.transci.2014.11.001_bib0105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00062752-200011000-00013","article-title":"Universal leukocyte reduction","volume":"7","author":"Kopko","year":"2000","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.transci.2014.11.001_bib0110","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood-2003-03-0940","article-title":"Universal prestorage leukoreduction in Canada decreases platelet alloimmunization and refractoriness","volume":"103","author":"Seftel","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0115","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1423-0410.1993.tb02168.x","article-title":"Systematic use of leukocyte-free blood components to prevent alloimmunization and platelet refractoriness in multitransfused children with cancer","volume":"65","author":"Saarinen","year":"1993","journal-title":"Vox Sang"},{"key":"10.1016\/j.transci.2014.11.001_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1423-0410.1999.7610027.x","article-title":"Benefit of prestorage leukocyte depletion of single-donor platelet concentrates","volume":"76","author":"Chalandon","year":"1999","journal-title":"Vox Sang"},{"key":"10.1016\/j.transci.2014.11.001_bib0125","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1182\/blood.V93.5.1770","article-title":"Soluble HLA class I, HLA class II, and Fas ligand in blood components: a possible key to explain the immunomodulatory effects of allogeneic blood transfusions","volume":"93","author":"Ghio","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.transci.2014.11.001_bib0130","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1111\/j.1537-2995.2010.02602.x","article-title":"Posttransfusion platelet count increments after ABO-compatible versus ABO-incompatible platelet transfusions in noncancer patients: an observational study","volume":"50","author":"Pavenski","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0135","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.0041-1132.2004.00608.x","article-title":"Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction","volume":"44","author":"Paglino","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0140","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.0041-1132.2003.00518.x","article-title":"The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC","volume":"44","author":"Yazer","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.0041-1132.2004.00609.x","article-title":"Universal leukoreduction decreases the incidence of febrile nonhemolytic transfusion reactions to RBCs","volume":"44","author":"King","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0041-1132.2004.00657.x","article-title":"Universal leukoreduction and acute transfusion reactions: putting the puzzle together","volume":"44","author":"Heddle","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0155","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1097\/01.ta.0000199537.09201.7b","article-title":"The clinical benefits of the leukoreduction of blood products","volume":"60","author":"Blajchman","year":"2006","journal-title":"J Trauma"},{"key":"10.1016\/j.transci.2014.11.001_bib0160","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0887-7963(98)80002-3","article-title":"Meta-analysis of randomized controlled trials of the efficacy of white cell reduction in preventing HLA-alloimmunization and refractoriness to random-donor platelet transfusions","volume":"12","author":"Vamvakas","year":"1998","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.transci.2014.11.001_bib0165","first-page":"604","article-title":"Effective prevetion against the development of platelet allo-antibodies using filtered blood products","volume":"43","author":"Shimoyama","year":"1992","journal-title":"J Nara Med Ass"},{"key":"10.1016\/j.transci.2014.11.001_bib0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-3148.2000.00232.x","article-title":"Transfusion of platelet concentrates from pooled buffy-coats: comparison of bedside vs. prestorage leukofiltration","volume":"10","author":"Muller-Steinhardt","year":"2000","journal-title":"Transfus Med"},{"key":"10.1016\/j.transci.2014.11.001_bib0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1399-0039.2012.01852.x","article-title":"HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management","volume":"79","author":"Pavenski","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.transci.2014.11.001_bib0180","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-3148.2004.00535.x","article-title":"The natural history of maternal immunization against foetal platelet alloantigens","volume":"14","author":"Ohto","year":"2004","journal-title":"Transfus Med"},{"key":"10.1016\/j.transci.2014.11.001_bib0185","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmi008","article-title":"Sex hormones and the immune response in humans","volume":"11","author":"Bouman","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.transci.2014.11.001_bib0190","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.autrev.2006.10.001","article-title":"Gender and autoimmunity","volume":"6","author":"Zandman-Goddard","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.transci.2014.11.001_bib0195","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.autrev.2010.02.008","article-title":"Genetic and hormonal factors in female-biased autoimmunity","volume":"9","author":"Rubtsov","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.transci.2014.11.001_bib0200","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tmrv.2011.12.001","article-title":"Is female sex a risk factor for red blood cell alloimmunization after transfusion? A systematic review","volume":"26","author":"Verduin","year":"2012","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.transci.2014.11.001_bib0205","first-page":"69","article-title":"Mechanism of transfusion-associated graft-versus-host disease","volume":"39","author":"Yasuda","year":"1993","journal-title":"Fukushima J Med Sci"},{"key":"10.1016\/j.transci.2014.11.001_bib0210","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1537-2995.2003.00390.x","article-title":"HLA and RBC immunization after filtered and buffy coat-depleted blood transfusion in cardiac surgery: a randomized controlled trial","volume":"43","author":"van de Watering","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0215","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.transci.2014.11.001_bib0220","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1537-2995.2006.00946.x","article-title":"Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells","volume":"46","author":"Hendrickson","year":"2006","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2014.11.001_bib0225","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ajh.20837","article-title":"Variable adhesion of different red blood cell products to activated vascular endothelium under flow conditions","volume":"82","author":"Anniss","year":"2007","journal-title":"Am J Hematol"},{"key":"10.1016\/j.transci.2014.11.001_bib0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1537-2995.2001.41020243.x","article-title":"Platelet storage lesion of WBC-reduced, pooled, buffy coat-derived platelet concentrates prepared in three in-process filter\/storage bag combinations","volume":"41","author":"Krailadsiri","year":"2001","journal-title":"Transfusion"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050214002043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050214002043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T17:59:50Z","timestamp":1598464790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050214002043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1473050214002043"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2014.11.001","relation":{},"ISSN":["1473-0502"],"issn-type":[{"value":"1473-0502","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of universal vs bedside leukoreductions on the alloimmunization to platelets and the platelet transfusion refractoriness","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2014.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}