{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:59:47Z","timestamp":1761469187869,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","trasci.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.transci.2021.103313","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T10:42:40Z","timestamp":1636022560000},"page":"103313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of thrombotic microangiopathy after hematopoietic cell transplantation: A position statement of ThREG (Turkish Hematology Research and Education Group)"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-9658","authenticated-orcid":false,"given":"Ali Hakan","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Tekgunduz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2021.103313_bib0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.bmt.1705758","article-title":"Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting?","volume":"40","author":"Batts","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0010","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1053\/j.ajkd.2010.06.006","article-title":"The role of endothelial cell injury in thrombotic microangiopathy","volume":"6","author":"Goldberg","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.transci.2021.103313_bib0015","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/bmt.2008.350","article-title":"Nitric oxide in transplantation-related thrombotic microangiopathy","volume":"43","author":"Thachil","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.seminhematol.2018.04.003","article-title":"Complement in pathophysiology and treatment of transplant-associated thrombotic microangiopathies","volume":"55","author":"Jodele","year":"2018","journal-title":"Semin Hematol"},{"key":"10.1016\/j.transci.2021.103313_bib0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/CCO.0b013e3280148a2f","article-title":"Thrombotic microangiopathy following allogeneic hematopoietic stem cell transplantation","volume":"19","author":"Kojouri","year":"2007","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.transci.2021.103313_bib0030","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1537-2995.2004.00700.x","article-title":"Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation: a diagnostic dilemma","volume":"44","author":"George","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2021.103313_bib0035","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hon.2310","article-title":"Risk and prognostic factors of transplantation-associated thrombotic microangiopathy in allogeneic haematopoietic stem cell transplantation: a nested case control study","volume":"35","author":"Ye","year":"2017","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.transci.2021.103313_bib0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood-2014-03-564997","article-title":"Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults","volume":"124","author":"Jodele","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.transci.2021.103313_bib0045","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13371","article-title":"Transplant-associated thrombotic microangiopathy: incidence, prognostic factors, morbidity, and mortality in allogeneic hematopoietic cell transplantation","volume":"32","author":"Gavriilaki","year":"2018","journal-title":"Clin Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0050","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/bjh.16457","article-title":"Incidence, risk factors for and outcomes of transplant-associated thrombotic microangiopathy","volume":"189","author":"Epperla","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.transci.2021.103313_bib0055","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2011-02-321315","article-title":"Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"118","author":"Laskin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.transci.2021.103313_bib0060","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00467-017-3803-4","article-title":"Thrombotic microangiopathy following haematopoietic stem cell transplant","volume":"33","author":"Seaby","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.transci.2021.103313_bib0065","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1111\/trf.14263","article-title":"Impact of treatment and outcomes for patients with posttransplant drug-associated thrombotic microangiopathy","volume":"57","author":"Epperla","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2021.103313_bib0070","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41409-021-01283-0","article-title":"Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis","volume":"56","author":"Young","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/jca.21352","article-title":"Outcomes of plasma exchange in patients with transplant-associated thrombotic microangiopathy based on time of presentation since transplant","volume":"30","author":"Mulay","year":"2015","journal-title":"J Clin Apher"},{"key":"10.1016\/j.transci.2021.103313_bib0080","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2215\/CJN.02070508","article-title":"Renal thrombotic microangiopathy after hematopoietic cell transplant: role of GVHD in pathogenesis","volume":"4","author":"Changsirikulchai","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.transci.2021.103313_bib0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/TP.0b013e31829807aa","article-title":"Renal arteriolar C4d deposition: a novel characteristic of hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"96","author":"Laskin","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.transci.2021.103313_bib0090","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbmt.2019.08.025","article-title":"Distribution of transplantation-associated thrombotic microangiopathy (TA-TMA) and comparison between renal TA-TMA and intestinal TA-TMA: autopsy study","volume":"26","author":"Yamada","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0095","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.bmt.1705976","article-title":"Clinical impact of thrombotic microangiopathy on the outcome of patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation","volume":"41","author":"Cho","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.transci.2007.03.004","article-title":"ABO-incompatible allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning: close association with transplant-associated microangiopathy","volume":"36","author":"Worel","year":"2007","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2021.103313_bib0105","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.tp.0000230373.82376.46","article-title":"Risk factors and severe outcome in thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation","volume":"82","author":"Uderzo","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.transci.2021.103313_bib0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1473-0502(02)00020-4","article-title":"Transplantation-associated thrombotic microangiopathy is associated with transplantation from unrelated donors, acute graft-versus-host disease and venoocclusive disease of the liver","volume":"27","author":"Daly","year":"2002","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2021.103313_bib0115","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1182\/blood-2019-125343","article-title":"Plasmic and plasic \u03b1re \u03b5xcellent predictors of severe ADAMTS13 deficiency in thrombotic microangiopathy patients without secondary causes","volume":"134","author":"Gavriilaki","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.transci.2021.103313_bib0120","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1038\/nrdp.2017.20","article-title":"Thrombotic thrombocytopenic purpura","volume":"3","author":"Kremer Hovinga","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.transci.2021.103313_bib0125","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/bloodadvances.2018020321","article-title":"Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD","volume":"2","author":"Wall","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.transci.2021.103313_bib0130","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bbmt.2005.06.001","article-title":"Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation","volume":"11","author":"Ho","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3324\/haematol.10699","article-title":"Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group","volume":"92","author":"Ruutu","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.transci.2021.103313_bib0140","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/TP.0b013e3181f24e8d","article-title":"Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation","volume":"90","author":"Cho","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.transci.2021.103313_bib0145","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbmt.2012.10.006","article-title":"Thrombotic microangiopathy associated with sirolimus level after allogeneic hematopoietic cell transplantation with tacrolimus\/sirolimus-based graft-versus-host disease prophylaxis","volume":"19","author":"Shayani","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0150","first-page":"152","article-title":"Transplant-associated thrombotic microangiopathy (TA-TMA) and consensus based diagnostic and therapeutic recommendations: which TA-TMA patients to treat and when?","volume":"02","author":"Uderzo","year":"2014","journal-title":"J Bone Marrow Res"},{"key":"10.1016\/j.transci.2021.103313_bib0155","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1046\/j.1365-2141.2002.03721.x","article-title":"Thrombotic thrombocytopenic purpura after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT)","volume":"118","author":"Ruutu","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.transci.2021.103313_bib0160","first-page":"1049","article-title":"Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab","volume":"135","author":"Jodele","year":"2020","journal-title":"Blood"},{"issue":"174","key":"10.1016\/j.transci.2021.103313_bib0165","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.7326\/M21-0834","article-title":"Management of blood pressure in patients with chronic kidney disease not receiving Dialysis: synopsis of the 2021 KDIGO clinical practice guideline","author":"Tomson","year":"2021","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.transci.2021.103313_bib0170","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/j.ajkd.2013.02.349","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury","volume":"61","author":"Palevsky","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.transci.2021.103313_bib0175","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/trf.12859","article-title":"Hematopoietic stem cell transplant-associated thrombotic microangiopathy: review of pharmacologic treatment options","volume":"55","author":"Kim","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2021.103313_bib0180","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jca.21705","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the eighth special issue","volume":"34","author":"Padmanabhan","year":"2019","journal-title":"J Clin Apher"},{"key":"10.1016\/j.transci.2021.103313_bib0185","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbmt.2016.12.192","article-title":"Early results of phase II study using OMS721 in patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HCT-TMA)","volume":"23","author":"Khaled","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0190","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2125.2009.03491.x","article-title":"Eculizumab","volume":"68","author":"Dubois","year":"2009","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.transci.2021.103313_bib0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/ejh.13127","article-title":"Eculizumab for transplant-associated thrombotic microangiopathy in adult allogeneic stem cell transplant recipients","volume":"101","author":"Rudoni","year":"2018","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.transci.2021.103313_bib0200","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.bbmt.2017.08.019","article-title":"Thrombotic microangiopathy after allogeneic stem cell transplantation: a comparison of eculizumab therapy and conventional therapy","volume":"23","author":"Bohl","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0205","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/TP.0000000000000601","article-title":"Use of eculizumab in patients with allogeneic stem cell transplant-associated thrombotic microangiopathy: a study from the SFGM-TC","volume":"99","author":"de Fontbrune","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.transci.2021.103313_bib0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.564647","article-title":"Efficacy and safety of eculizumab in the treatment of transplant-associated thrombotic microangiopathy: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.transci.2021.103313_bib0215","first-page":"72","article-title":"Successful treatment of transplant-associated microangiopathy with rituximab","volume":"122","author":"Marr","year":"2009","journal-title":"N Z Med J"},{"key":"10.1016\/j.transci.2021.103313_bib0220","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2141.2007.06588.x","article-title":"Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab","volume":"137","author":"Au","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.transci.2021.103313_bib0225","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41409-019-0474-8","article-title":"Systematic review of defibrotide studies in the treatment of veno-occlusive disease\/sinusoidal obstruction syndrome (VOD\/SOS)","volume":"54","author":"Richardson","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0230","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/bmt.2016.130","article-title":"Revised diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation","volume":"51","author":"Mohty","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0235","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41409-018-0256-8","article-title":"Use of defibrotide to treat adult patients with transplant-associated thrombotic microangiopathy","volume":"54","author":"Mart\u00ednez-Mu\u00f1oz","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2021.103313_bib0240","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.bmt.1703414","article-title":"Defibrotide as a promising treatment for thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation","volume":"29","author":"Corti","year":"2002","journal-title":"Bone Marrow Transplant"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147305022100313X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147305022100313X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:52:52Z","timestamp":1761468772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147305022100313X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S147305022100313X"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2021.103313","relation":{},"ISSN":["1473-0502"],"issn-type":[{"type":"print","value":"1473-0502"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of thrombotic microangiopathy after hematopoietic cell transplantation: A position statement of ThREG (Turkish Hematology Research and Education Group)","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2021.103313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103313"}}