{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:47:37Z","timestamp":1792453657292,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","trasci.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.transci.2021.103316","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T21:30:32Z","timestamp":1636407032000},"page":"103316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transregional autologous serum eye drop provision by a large German Red Cross Blood Donation Service"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-7467","authenticated-orcid":false,"given":"Garnet","family":"Suck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Antonio Noriega","family":"Urena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Grolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Kischnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Deitenbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zeiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2021.103316_bib0005","article-title":"High-throughput centralized manufacturing of blood components in the German Red Cross Blood Donation Service West","author":"Suck","year":"2019","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.transci.2021.103316_bib0010","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"Suppl 1","key":"10.1016\/j.transci.2021.103316_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/01.icu.0000512373.81749.b7","article-title":"Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment","volume":"27","author":"Milner","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jtos.2016.11.003","article-title":"Visual acuity and quality of life in dry eye disease: proceedings of the OCEAN group meeting","volume":"15","author":"Benitez-Del-Castillo","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.transci.2021.103316_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/396410","article-title":"Human serum eye drops in eye alterations: an insight and a critical analysis","volume":"2015","author":"De Pascale","year":"2015","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fmed.2018.00033","article-title":"Reflections on dry eye syndrome treatment: therapeutic role of blood products","volume":"5","author":"Drew","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.transci.2021.103316_bib0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000505630","article-title":"Autologous serum eye drops versus artificial tear drops for dry eye disease: a systematic review and meta-analysis of randomized controlled trials","volume":"63","author":"Wang","year":"2020","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.transci.2021.103316_bib0040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/bjophthalmol-2015-306842","article-title":"Blood-derived topical therapy for ocular surface diseases","volume":"100","author":"Soni","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0045","first-page":"322","article-title":"Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study","volume":"101","author":"Tahmaz","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0050","doi-asserted-by":"crossref","DOI":"10.1111\/aos.14788","article-title":"Allogeneic and autologous serum eye drops: a pilot double-blind randomized crossover trial","author":"van der Meer","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0055","first-page":"45","article-title":"Autologous serum eye drops improve tear production, both lachrymal flow and stability tests and conjunctival impression cytology with transfer in dry eye disease","volume":"19","author":"Valencia Castillo","year":"2021","journal-title":"Blood Transfus"},{"key":"10.1016\/j.transci.2021.103316_bib0060","first-page":"22","article-title":"Autologe Serumaugentropfen. Eine ungew\u00f6hnliche Form der H\u00e4motherapie","volume":"25","author":"Deitenbeck","year":"2015","journal-title":"H\u00e4motherapie"},{"key":"10.1016\/j.transci.2021.103316_bib0065","article-title":"Manufacture of autologous serum eye drops for out-patient therapy\u202f: cooperation between ophthalmic clinic and transfusion medicine department","volume":"105","author":"Dietrich","year":"2008","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.transci.2021.103316_bib0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-0033-1357976","article-title":"Besonderheiten der Herstellung von autologen Serum-Augentropfen. Characteristics in Manufacturing Autologous Serum Eye Drops","volume":"4","author":"Petresczu","year":"2014","journal-title":"Transfusionsmedizin"},{"key":"10.1016\/j.transci.2021.103316_bib0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1055\/s-0034-1397552","article-title":"Rechtsrahmen f\u00fcr autologe Serum-Augentropfen","volume":"5","author":"Pannenbecker","year":"2015","journal-title":"Transfusionsmedizin"},{"key":"10.1016\/j.transci.2021.103316_bib0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.transci.2015.05.015","article-title":"Serum eye drop preparation in Australia: current manufacturing practice","volume":"53","author":"Marks","year":"2015","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2021.103316_bib0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/02713683.2013.855237","article-title":"Comparison of application systems for autologous serum eye drops","volume":"39","author":"Spaniol","year":"2014","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.transci.2021.103316_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2019.06.032","article-title":"Serum growth factor stability in different eye drop packaging systems during storage","volume":"59","author":"Tan","year":"2020","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2021.103316_bib0095","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0042-123226","article-title":"SOP Autologe Serumaugentropfen - Indikation, Herstellung, Anwendung","volume":"7","author":"Tahmaz","year":"2017","journal-title":"Augenheilkunde up2date"},{"key":"10.1016\/j.transci.2021.103316_bib0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.sjopt.2013.06.007","article-title":"Ocular manifestations of graft-versus-host disease","volume":"27","author":"Nassar","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0105","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.rdc.2018.03.002","article-title":"Update on sjogren syndrome and other causes of Sicca in older adults","volume":"44","author":"Baer","year":"2018","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.transci.2021.103316_bib0110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/vox.12502","article-title":"Biomedical Excellence for Safer Transfusion C. Serum eye drops: a survey of international production methods","volume":"112","author":"Marks","year":"2017","journal-title":"Vox Sang"},{"key":"10.1016\/j.transci.2021.103316_bib0115","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.transci.2021.103316_bib0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/IIO.0000000000000170","article-title":"Effects of aging in dry eye","volume":"57","author":"de Paiva","year":"2017","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.transci.2021.103316_bib0125","first-page":"540","article-title":"Applications and sterility of autologous serum eye drops","volume":"13","author":"Reed-Kane","year":"2009","journal-title":"Int J Pharm Compd"},{"key":"10.1016\/j.transci.2021.103316_bib0130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/ICO.0b013e3182542085","article-title":"Stability of serum eye drops after storage of 6 months","volume":"31","author":"Fischer","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.transci.2021.103316_bib0135","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091478","article-title":"Blood-based treatments for severe dry eye disease: the need of a consensus","volume":"8","author":"Bernabei","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.transci.2021.103316_bib0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/aos.12386","article-title":"Ready-made allogeneic ABO-specific serum eye drops: production from regular male blood donors, clinical routine, safety and efficacy","volume":"92","author":"Harritshoj","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.transci.2021.103316_bib0145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.transci.2016.01.022","article-title":"Quality standards, safety and efficacy of blood-derived serum eye drops: a review","volume":"54","author":"van der Meer","year":"2016","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2021.103316_bib0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ophtha.2019.08.018","article-title":"Autologous serum-based eye drops for treatment of ocular surface disease: a report by the american academy of ophthalmology","volume":"127","author":"Shtein","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.transci.2021.103316_bib0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00417-020-04865-8","article-title":"Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease","volume":"259","author":"Tahmaz","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050221003165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050221003165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:54:18Z","timestamp":1761468858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050221003165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1473050221003165"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2021.103316","relation":{},"ISSN":["1473-0502"],"issn-type":[{"value":"1473-0502","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transregional autologous serum eye drop provision by a large German Red Cross Blood Donation Service","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2021.103316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103316"}}