{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:43:57Z","timestamp":1782441837851,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PID2020-117265GB-I00"],"award-info":[{"award-number":["PID2020-117265GB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2017-85489-P"],"award-info":[{"award-number":["SAF2017-85489-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PA-20-PF-BP19-014"],"award-info":[{"award-number":["PA-20-PF-BP19-014"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["RYC-2013-12587"],"award-info":[{"award-number":["RYC-2013-12587"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","trasci.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.transci.2022.103413","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T08:01:01Z","timestamp":1646985661000},"page":"103413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Platelet number and function alterations in preclinical models of sterile inflammation and sepsis patients: implications in the pathophysiology and treatment of inflammation"],"prefix":"10.1016","volume":"61","author":[{"given":"Mar\u00eda","family":"Villa-Fajardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Cecilia Y\u00e1\u00f1ez","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Acebes-Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mart\u00ednez-Bot\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Meinders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn A.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina Benavente","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Eble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Gonz\u00e1lez","family":"del Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Mart\u00edn-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2022.103413_bib0005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: from megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J Cell Biol"},{"key":"10.1016\/j.transci.2022.103413_bib0010","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1046\/j.1538-7836.2003.00267.x","article-title":"Signaling events underlying thrombus formation","volume":"1","author":"Jackson","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.transci.2022.103413_bib0015","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1538-7836.2006.01861.x","article-title":"Fibrin structure and wound healing","volume":"4","author":"Laurens","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.transci.2022.103413_bib0020","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1126\/science.328.5978.562","article-title":"Cell biology. Beyond clotting: the powers of platelets","volume":"328","author":"Leslie","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.transci.2022.103413_bib0025","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1182\/blood-2010-08-304808","article-title":"A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing","volume":"117","author":"Feng","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.transci.2022.103413_bib0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrc3004","article-title":"Contribution of platelets to tumour metastasis","volume":"11","author":"Gay","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.transci.2022.103413_bib0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/ijlh.12084","article-title":"Bridging hemostasis, inflammation, and immunity","volume":"35","author":"Jenne","year":"2013","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.transci.2022.103413_bib0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.transci.2022.103413_bib0045","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1160\/TH13-01-0060","article-title":"The physiological and pathophysiological roles of platelet CLEC-2","volume":"109","author":"Navarro-Nunez","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.transci.2022.103413_bib0050","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2009-04-216069","article-title":"Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation","volume":"115","author":"Uhrin","year":"2010","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.transci.2022.103413_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/stem.5530140717","article-title":"Physiologic role of TPO in thrombopoiesis","volume":"14","author":"Miyazaki","year":"1996","journal-title":"Stem Cells"},{"key":"10.1016\/j.transci.2022.103413_bib0060","article-title":"On the quest for in vitro platelet production by Re-Tailoring the concepts of megakaryocyte differentiation","volume":"56","author":"Martinez-Botia","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.transci.2022.103413_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2020.102864","article-title":"In vitro platelet production for transfusion purposes: Where are we now?","volume":"59","author":"Martinez-Botia","year":"2020","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.transci.2022.103413_bib0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1084\/jem.183.2.651","article-title":"Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin","volume":"183","author":"de Sauvage","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.transci.2022.103413_bib0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/pbc.22927","article-title":"Congenital amegakaryocytic thrombocytopenia","volume":"57","author":"Geddis","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.transci.2022.103413_bib0080","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.8073287","article-title":"Thrombocytopenia in c-mpl-deficient mice","volume":"265","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.transci.2022.103413_bib0085","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/blood-2010-04-278135","article-title":"Transfusion-related acute lung injury: from bedside to bench and back","volume":"117","author":"Shaz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.transci.2022.103413_bib0090","first-page":"267","article-title":"The relation between aged blood products and onset of transfusion-related acute lung injury. A review of pre-clinical data","volume":"57","author":"Vlaar","year":"2011","journal-title":"Clin Lab"},{"key":"10.1016\/j.transci.2022.103413_bib0095","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.2174\/1381612811209023260","article-title":"Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury","volume":"18","author":"Caudrillier","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.transci.2022.103413_bib0100","first-page":"3450","article-title":"Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury","volume":"119","author":"Looney","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.transci.2022.103413_bib0105","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1182\/blood-2010-10-315218","article-title":"Chronic IFN-gamma production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1\/PU.1 axis","volume":"118","author":"Libregts","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.transci.2022.103413_bib0110","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(01)00236-9","article-title":"Constitutive CD27\/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion","volume":"15","author":"Arens","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.transci.2022.103413_bib0115","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1182\/blood-2012-06-437723","article-title":"A novel flow cytometry-based platelet aggregation assay","volume":"121","author":"De Cuyper","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.transci.2022.103413_bib0120","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3389\/fimmu.2019.01687","article-title":"Platelets in sepsis: an update on experimental models and clinical data","volume":"10","author":"Assinger","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.transci.2022.103413_bib0125","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/j.1538-7836.2004.01009.x","article-title":"Platelet function in sepsis","volume":"2","author":"Yaguchi","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.transci.2022.103413_bib0130","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11239-010-0486-0","article-title":"Platelet aggregation in severe sepsis","volume":"31","author":"Woth","year":"2011","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.transci.2022.103413_bib0135","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"Suppl 1","key":"10.1016\/j.transci.2022.103413_bib0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10245330512331390177","article-title":"Platelets in sepsis","volume":"10","author":"Levi","year":"2005","journal-title":"Hematology"},{"issue":"357","key":"10.1016\/j.transci.2022.103413_bib0145","article-title":"Platelet mitochondrial function in sepsis","volume":"40","author":"Sjovall","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.transci.2022.103413_bib0150","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.1097\/00003246-200205001-00022","article-title":"Platelet function in sepsis","volume":"30","author":"Vincent","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.transci.2022.103413_bib0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102200","article-title":"Platelets and multi-organ failure in sepsis","volume":"18","author":"Greco","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.transci.2022.103413_bib0160","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood.2020008958","article-title":"Platelet MHC class I mediates CD8+ T-cell suppression during sepsis","volume":"138","author":"Guo","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.transci.2022.103413_bib0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/09537109876735","article-title":"Impaired platelet function correlates with multi-organ dysfunction. A study of patients with sepsis","volume":"9","author":"Lundahl","year":"1998","journal-title":"Platelets"},{"key":"10.1016\/j.transci.2022.103413_bib0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"Rayes","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.transci.2022.103413_bib0175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.thromres.2019.05.008","article-title":"Modulation of megakaryopoiesis and platelet production during inflammation","volume":"179","author":"Couldwell","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.transci.2022.103413_bib0180","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1164\/rccm.200807-1085OC","article-title":"Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity","volume":"179","author":"Freishtat","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.transci.2022.103413_bib0185","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1182\/bloodadvances.2020001758","article-title":"Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation","volume":"4","author":"French","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.transci.2022.103413_bib0190","first-page":"1","article-title":"Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5","author":"Schwertz","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.transci.2022.103413_bib0195","first-page":"L181","article-title":"A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia","volume":"268","author":"McElroy","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.transci.2022.103413_bib0200","first-page":"10","article-title":"Clinical management of hypertension, inflammation and thrombosis in hospitalized COVID-19 patients: impact on survival and concerns","author":"Martinez-Botia","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.transci.2022.103413_bib0205","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12525","article-title":"Comparison of the coagulopathies associated with COVID-19 and sepsis","volume":"5","author":"Campbell","year":"2021","journal-title":"Res Pract Thromb Haemost."},{"key":"10.1016\/j.transci.2022.103413_bib0210","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/eci.12101","article-title":"Platelets and autoimmunity","volume":"43","author":"Habets","year":"2013","journal-title":"Eur J Clin Invest"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050222000751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050222000751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T08:55:33Z","timestamp":1761468933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050222000751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1473050222000751"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2022.103413","relation":{},"ISSN":["1473-0502"],"issn-type":[{"value":"1473-0502","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet number and function alterations in preclinical models of sterile inflammation and sepsis patients: implications in the pathophysiology and treatment of inflammation","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2022.103413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103413"}}