{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:53:53Z","timestamp":1776768833498,"version":"3.51.2"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["trasci.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.transci.2024.104022","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:37:06Z","timestamp":1729643826000},"page":"104022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advancement of blood donor factors in RBC and blood component therapy using modern practices and methodologies: How to make multifactorial clinical decisions amid growing complexity"],"prefix":"10.1016","volume":"63","author":[{"given":"Nishaka","family":"William","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Acker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerard","family":"Seghatchian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transci.2024.104022_bib1","first-page":"1132","article-title":"Ueber Agglutinationser-scheinungen normalen menschlichen Blutes","volume":"14","author":"Landsteiner","year":"1901","journal-title":"Wien Clin Wschr"},{"key":"10.1016\/j.transci.2024.104022_bib2","series-title":"Global status report on blood safety and availability 2021","author":"Organization","year":"2022"},{"key":"10.1016\/j.transci.2024.104022_bib3","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1111\/trf.17360","article-title":"Continued stabilization of blood collections and transfusions in the United States: findings from the 2021 National Blood Collection and Utilization Survey","volume":"63","author":"Free","year":"2023","journal-title":"Transfusion"},{"issue":"20","key":"10.1016\/j.transci.2024.104022_bib4","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1182\/bloodadvances.2021005361","article-title":"Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018","volume":"5","author":"Goel","year":"2021","journal-title":"Blood Adv"},{"issue":"5","key":"10.1016\/j.transci.2024.104022_bib5","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/trf.17296","article-title":"Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium","volume":"63","author":"Custer","year":"2023","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.transci.2024.104022_bib6","first-page":"955","article-title":"Studies on the preservation of human blood. I. Variability in erythrocyte storage characteristics among healthy donors","volume":"67","author":"Dern","year":"1966","journal-title":"J Lab Clin Med"},{"issue":"6","key":"10.1016\/j.transci.2024.104022_bib7","first-page":"968","article-title":"Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability","volume":"69","author":"Dern","year":"1967","journal-title":"J Lab Clin Med"},{"issue":"2","key":"10.1016\/j.transci.2024.104022_bib8","first-page":"254","article-title":"Studies on the preservation of human blood. III. The posttransfusion survival of stored and damaged erythrocytes in healthy donors and patients with severe trauma","volume":"71","author":"Dern","year":"1968","journal-title":"J Lab Clin Med"},{"issue":"10","key":"10.1016\/j.transci.2024.104022_bib9","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1046\/j.1537-2995.1999.39101104.x","article-title":"Efficacy of donor screening for HTLV\u2010I and the natural history of transfusion\u2010transmitted infection","volume":"39","author":"Inaba","year":"1999","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.transci.2024.104022_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000237687","article-title":"Immunologic consequences of blood transfusion and their clinical manifestations","volume":"114","author":"Petr\u00e1nyi","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"issue":"6","key":"10.1016\/j.transci.2024.104022_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00062752-200211000-00010","article-title":"Leukoreduction of blood components","volume":"9","author":"Dzik","year":"2002","journal-title":"Curr Opin Hematol"},{"issue":"5","key":"10.1016\/j.transci.2024.104022_bib12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/trf.16362","article-title":"Transfusion-related adverse reactions: data from the National Healthcare Safety Network Hemovigilance Module - United States, 2013-2018","volume":"61","author":"Kracalik","year":"2021","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.transci.2024.104022_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/trf.12804","article-title":"An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies","volume":"55","author":"D'Alessandro","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2024.104022_bib14","article-title":"Sex-and gender-related factors in blood product transfusions","volume":"4","author":"Zimmerman","year":"2020","journal-title":"Gend Genome"},{"issue":"2","key":"10.1016\/j.transci.2024.104022_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tmrv.2018.02.002","article-title":"Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis","volume":"32","author":"McQuilten","year":"2018","journal-title":"Transfus Med Rev"},{"issue":"3","key":"10.1016\/j.transci.2024.104022_bib16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/vox.12495","article-title":"Mortality outcomes in patients transfused with fresher versus older red blood cells: a meta\u2010analysis","volume":"112","author":"Chai\u2010Adisaksopha","year":"2017","journal-title":"Vox Sang"},{"issue":"4","key":"10.1016\/j.transci.2024.104022_bib17","first-page":"400","article-title":"Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis","volume":"127","author":"Alexander","year":"2016","journal-title":"Blood, J Am Soc Hematol"},{"issue":"2","key":"10.1016\/j.transci.2024.104022_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmrv.2016.01.002","article-title":"Effect of blood donor characteristics on transfusion outcomes: a systematic review and meta-analysis","volume":"30","author":"Chass\u00e9","year":"2016","journal-title":"Transfus Med Rev"},{"issue":"5","key":"10.1016\/j.transci.2024.104022_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/vox.12783","article-title":"Sex\u2010mismatched red blood cell transfusions and mortality: a systematic review and meta\u2010analysis","volume":"114","author":"Zeller","year":"2019","journal-title":"Vox Sang"},{"issue":"3","key":"10.1016\/j.transci.2024.104022_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tmrv.2011.03.001","article-title":"The Age of Blood Evaluation (ABLE) randomized controlled trial: study design","volume":"25","author":"Lacroix","year":"2011","journal-title":"Transfus Med Rev"},{"issue":"1","key":"10.1016\/j.transci.2024.104022_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.transci.2010.05.014","article-title":"Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS)(Section 7)","volume":"43","author":"Steiner","year":"2010","journal-title":"Transfus Apher Sci"},{"issue":"2","key":"10.1016\/j.transci.2024.104022_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-049598","article-title":"Pragmatic, double-blind, randomised trial evaluating the impact of red blood cell donor sex on recipient mortality in an academic hospital population: the innovative Trial Assessing Donor Sex (iTADS) protocol","volume":"11","author":"Fergusson","year":"2021","journal-title":"BMJ Open"},{"issue":"15","key":"10.1016\/j.transci.2024.104022_bib23","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1056\/NEJMoa2211523","article-title":"Effect of donor sex on recipient mortality in transfusion","volume":"388","author":"Chass\u00e9","year":"2023","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.transci.2024.104022_bib24","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1111\/trf.14640","article-title":"Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial","volume":"58","author":"Green","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.transci.2024.104022_bib25","doi-asserted-by":"crossref","unstructured":"Mazzeffi M.A., Faraoni D., Tanaka K.A. Reassessing RECESS: in pursuit of the Golden Ratio of hemostatic components to red blood cells. Vol 124: LWW; 2017:1760\u20131761.","DOI":"10.1213\/ANE.0000000000002123"},{"issue":"4","key":"10.1016\/j.transci.2024.104022_bib26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/trf.13460","article-title":"Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes","volume":"56","author":"Bordbar","year":"2016","journal-title":"Transfusion"},{"issue":"13","key":"10.1016\/j.transci.2024.104022_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146077","article-title":"Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage","volume":"131","author":"Page","year":"2021","journal-title":"J Clin Investig"},{"key":"10.1016\/j.transci.2024.104022_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.06.007","article-title":"Biological and genetic determinants of glycolysis: phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes","author":"Nemkov","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.transci.2024.104022_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmrv.2023.150750","article-title":"Red blood cell storage: from genome to exposome towards personalized transfusion medicine","author":"D'Alessandro","year":"2023","journal-title":"Transfus Med Rev"},{"issue":"3","key":"10.1016\/j.transci.2024.104022_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146175","article-title":"Blood donor exposome and impact of common drugs on red blood cell metabolism","volume":"6","author":"Nemkov","year":"2021","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.transci.2024.104022_bib31","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000605","article-title":"Screening out the exposome to improve transfusion quality","volume":"5","author":"DeSimone","year":"2021","journal-title":"HemaSphere"},{"issue":"11","key":"10.1016\/j.transci.2024.104022_bib32","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1111\/trf.16017","article-title":"Donor\u2010dependent aging of young and old red blood cell subpopulations: metabolic and functional heterogeneity","volume":"60","author":"Mykhailova","year":"2020","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.transci.2024.104022_bib33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ajh.23344","article-title":"Changes in the properties of normal human red blood cells during in vivo aging","volume":"88","author":"Franco","year":"2013","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.transci.2024.104022_bib34","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/ijms17091555","article-title":"Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations","volume":"17","author":"Tebani","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.transci.2024.104022_bib35","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1111\/trf.13745","article-title":"Testosterone\u2010dependent sex differences in red blood cell hemolysis in storage, stress, and disease","volume":"56","author":"Kanias","year":"2016","journal-title":"Transfusion"},{"issue":"7","key":"10.1016\/j.transci.2024.104022_bib36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbagen.2008.09.010","article-title":"Iron overload following red blood cell transfusion and its impact on disease severity","volume":"1790","author":"Ozment","year":"2009","journal-title":"Biochim Et Biophys Acta (BBA)-Gen Subj"},{"issue":"1","key":"10.1016\/j.transci.2024.104022_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s42003-021-01793-z","article-title":"Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform","volume":"4","author":"Chng","year":"2021","journal-title":"Commun Biol"},{"issue":"33","key":"10.1016\/j.transci.2024.104022_bib38","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1039\/D2AY00931E","article-title":"A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells","volume":"14","author":"Hayter","year":"2022","journal-title":"Anal Methods"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050224002039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050224002039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T02:52:39Z","timestamp":1732675959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050224002039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1473050224002039"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2024.104022","relation":{},"ISSN":["1473-0502"],"issn-type":[{"value":"1473-0502","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancement of blood donor factors in RBC and blood component therapy using modern practices and methodologies: How to make multifactorial clinical decisions amid growing complexity","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2024.104022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104022"}}