{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:10:05Z","timestamp":1749154205346,"version":"3.41.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018718","name":"Ko\u00e7 University Research Center for Translational Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","trasci.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion and Apheresis Science"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.transci.2025.104117","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:42:27Z","timestamp":1744188147000},"page":"104117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["T cell subgroup analysis and T cell exhaustion after autologous stem cell transplantation in lymphoma patients"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-4653","authenticated-orcid":false,"given":"Kayra","family":"Somay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Burak","family":"K\u0131z\u0131l\u0131rmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Akan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit Barbaros","family":"\u00dcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Meltem","family":"Akay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burhan","family":"Ferhano\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Birta\u015f","family":"Ate\u015fo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.transci.2025.104117_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1158\/2326-6066.CIR-15-0055","article-title":"T-cell exhaustion in multiple myeloma relapse after autotransplant: optimal timing of immunotherapy","volume":"4","author":"Chung","year":"2016","journal-title":"Cancer Immunol Res"},{"issue":"1","key":"10.1016\/j.transci.2025.104117_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bbmt.2019.08.009","article-title":"T cell transcriptional profiling and immunophenotyping uncover LAG3 as a potential significant target of immune modulation in multiple myeloma","volume":"26","author":"Lucas","year":"2020","journal-title":"Biol Blood Marrow Transpl"},{"issue":"7","key":"10.1016\/j.transci.2025.104117_bib3","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1182\/bloodadvances.2020003857","article-title":"Microenvironment immune reconstitution patterns correlate with outcomes after autologous transplant in multiple myeloma","volume":"5","author":"Parmar","year":"2021","journal-title":"Blood Adv"},{"issue":"ement_1","key":"10.1016\/j.transci.2025.104117_bib4","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1182\/blood-2019-126682","article-title":"Frequency of marrow infiltrating PD-1 expressing CD4 effectors following autologous stem cell transplant (ASCT) for multiple myeloma is prognostic for clinical outcome","volume":"134","author":"Alrasheed","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.transci.2025.104117_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.715234","article-title":"CD8+ T cell exhaustion in cancer","volume":"12","author":"Dolina","year":"2021","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41577-020-00454-2","article-title":"Rethinking peripheral T cell tolerance: checkpoints across a T cell\u2019s journey","volume":"21","author":"ElTanbouly","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1172\/JCI59806","article-title":"IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma","volume":"122","author":"Yang","year":"2012","journal-title":"J Clin Investig"},{"issue":"9","key":"10.1016\/j.transci.2025.104117_bib8","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.3109\/10428194.2015.1011640","article-title":"T-cell-mediated antitumor immunity in B-cell non-Hodgkin lymphoma: activation, suppression and exhaustion","volume":"56","author":"Yang","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"9","key":"10.1016\/j.transci.2025.104117_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41408-019-0234-4","article-title":"Mass cytometry dissects T cell heterogeneity in the immune tumor microenvironment of common dysproteinemias at diagnosis and after first line therapies","volume":"9","author":"Kourelis","year":"2019","journal-title":"Blood Cancer J"},{"issue":"11","key":"10.1016\/j.transci.2025.104117_bib10","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1172\/JCI31184","article-title":"LAG-3 regulates CD8+\u2009T cell accumulation and effector function in murine self- and tumor-tolerance systems","volume":"117","author":"Grosso","year":"2007","journal-title":"J Clin Investig"},{"issue":"5","key":"10.1016\/j.transci.2025.104117_bib11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","article-title":"Lag-3, Tim-3, and TIGIT: Co-inhibitory receptors with specialized functions in immune regulation","volume":"44","author":"Anderson","year":"2016","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.clml.2020.11.009","article-title":"Expression of the immune checkpoint regulators LAG-3 and TIM-3 in classical Hodgkin lymphoma","volume":"21","author":"El Halabi","year":"2021","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"13","key":"10.1016\/j.transci.2025.104117_bib13","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1158\/1078-0432.CCR-19-3548","article-title":"FS118, a bispecific antibody targeting LAG-3 and PD-L1, enhances T-cell activation resulting in potent antitumor activity","volume":"26","author":"Kraman","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.transci.2025.104117_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108093","article-title":"Highly proliferative and functional PD-1(+) and TIM-3(+) T cells are transiently increased in multiple myeloma following autologous hematopoietic stem cell transplantation","volume":"100","author":"Batorov","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"10.1016\/j.transci.2025.104117_bib15","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/s41409-021-01320-y","article-title":"Pre-existing immune checkpoints activation predicts relapse after allogeneic stem cell transplantation in lymphoma","volume":"56","author":"Derenzini","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.transci.2025.104117_bib16","article-title":"Increased immune-regulatory receptor expression on effector T cells as early indicators of relapse following autologous stem cell transplantation for multiple myeloma","volume":"12","author":"Lee","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.transci.2025.104117_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.634435","article-title":"The role of immune checkpoint molecules for relapse after allogeneic hematopoietic cell transplantation","volume":"12","author":"K\u00f6hler","year":"2021","journal-title":"Front Immunol"},{"issue":"608","key":"10.1016\/j.transci.2025.104117_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf5107","article-title":"LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade","volume":"13","author":"Shen","year":"2021","journal-title":"Sci Transl Med"},{"issue":"ement 1","key":"10.1016\/j.transci.2025.104117_bib19","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1182\/blood-2018-99-119577","article-title":"Exploring LAG-3 expression in multiple myeloma patients following autologous stem cell transplant","volume":"132","author":"Fabienne","year":"2018","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.transci.2025.104117_bib20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41590-019-0312-6","article-title":"Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade","volume":"20","author":"Miller","year":"2019","journal-title":"Nat Immunol"},{"issue":"8","key":"10.1016\/j.transci.2025.104117_bib21","first-page":"665","article-title":"Rewriting history: epigenetic reprogramming of CD8(+) T cell differentiation to enhance immunotherapy. trends immunol","volume":"41","author":"Zebley","year":"2020"},{"issue":"8","key":"10.1016\/j.transci.2025.104117_bib22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.transci.2025.104117_bib23","doi-asserted-by":"crossref","DOI":"10.4110\/in.2020.20.e2","article-title":"Re-defining T-cell exhaustion: subset, function, and regulation","volume":"20","author":"Im","year":"2020","journal-title":"Immune Netw"},{"issue":"8","key":"10.1016\/j.transci.2025.104117_bib24","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1158\/1078-0432.CCR-15-1849","article-title":"Reversing T-cell dysfunction and exhaustion in cancer","volume":"22","author":"Zarour","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib25","doi-asserted-by":"crossref","first-page":"184.e1","DOI":"10.1016\/j.jtct.2022.01.016","article-title":"High Proliferating regulatory T cells post-transplantation are associated with poor survival in lymphoma patients treated with autologous hematopoietic stem cell transplantation","volume":"28","author":"Sumransub","year":"2022","journal-title":"Transpl Cell Ther"},{"issue":"6","key":"10.1016\/j.transci.2025.104117_bib26","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1080\/10428190310001641260","article-title":"Immune reconstitution following stem cell transplantation","volume":"45","author":"Peggs","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.transci.2025.104117_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.beha.2008.06.003","article-title":"Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation","volume":"21","author":"Williams","year":"2008","journal-title":"Best Pr Res Clin Haematol"},{"issue":"5","key":"10.1016\/j.transci.2025.104117_bib28","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1182\/blood.V92.5.1471","article-title":"Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation","volume":"92","author":"Guillaume","year":"1998","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0025-6196(11)62388-4","article-title":"Immune reconstitution after autologous hematopoietic stem cell transplantation","volume":"76","author":"Porrata","year":"2001","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.transci.2025.104117_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ebiom.2016.08.029","article-title":"Chemotherapy and stem cell transplantation increase p16(INK4a) expression, a biomarker of T-cell Aging","volume":"11","author":"Wood","year":"2016","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.transci.2025.104117_bib31","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41409-018-0162-0","article-title":"Homeostatic proliferation leads to telomere attrition and increased PD-1 expression after autologous hematopoietic SCT for systemic sclerosis","volume":"53","author":"Arruda","year":"2018","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"10.1016\/j.transci.2025.104117_bib32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.bmt.1702144","article-title":"Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation","volume":"25","author":"Akiyama","year":"2000","journal-title":"Bone Marrow Transpl"},{"issue":"10","key":"10.1016\/j.transci.2025.104117_bib33","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3390\/cancers12102828","article-title":"Senescent Tumor CD8+\u2009T Cells: mechanisms of Induction and Challenges to Immunotherapy","volume":"12","author":"Liu","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.transci.2025.104117_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103409","article-title":"Senescent T cells: a potential biomarker and target for cancer therapy","volume":"68","author":"Zhang","year":"2021","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.transci.2025.104117_bib35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/14728222.2021.1937123","article-title":"Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations","volume":"25","author":"Tabana","year":"2021","journal-title":"Expert Opin Ther Targets"},{"issue":"5","key":"10.1016\/j.transci.2025.104117_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051152","article-title":"PD-1 and LAG-3 checkpoint blockade: potential avenues for therapy in B-cell lymphoma","volume":"10","author":"Tobin","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.transci.2025.104117_bib37","doi-asserted-by":"crossref","first-page":"32.e1","DOI":"10.1016\/j.jtct.2021.10.010","article-title":"Immune reconstitution following high-dose chemotherapy and autologous stem cell transplantation with or without pembrolizumab maintenance therapy in patients with lymphoma","volume":"28","author":"Merryman","year":"2022","journal-title":"Transpl Cell Ther"},{"key":"10.1016\/j.transci.2025.104117_bib38","doi-asserted-by":"crossref","first-page":"S1387","DOI":"10.1016\/j.annonc.2021.10.051","article-title":"35P PD-1+\u2009and TIM-3+\u2009T-cells differ in the expression of common & # x3b3;-chain cytokine receptors after AHSCT in multiple myeloma patients","volume":"32","author":"Batorov","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.transci.2025.104117_bib39","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3389\/fimmu.2019.01034","article-title":"Dynamics of expression of programmed cell death protein-1 (PD-1) on T cells after allogeneic hematopoietic stem cell transplantation","volume":"10","author":"Simonetta","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.transci.2025.104117_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-016-0345-3","article-title":"T cells in multiple myeloma display features of exhaustion and senescence at the tumor site","volume":"9","author":"Zelle-Rieser","year":"2016","journal-title":"J Hematol Oncol"},{"issue":"7","key":"10.1016\/j.transci.2025.104117_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040146","article-title":"Tim-3 negatively regulates cytotoxicity in exhausted CD8+\u2009T cells in HIV infection","volume":"7","author":"Sakhdari","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.transci.2025.104117_bib42","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1007\/s10875-021-01109-0","article-title":"CD8\u2009+\u2009T cells exhibit an exhausted phenotype in hemophagocytic lymphohistiocytosis","volume":"41","author":"Kelkar","year":"2021","journal-title":"J Clin Immunol"}],"container-title":["Transfusion and Apheresis Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050225000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1473050225000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T19:35:36Z","timestamp":1749152136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1473050225000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1473050225000515"],"URL":"https:\/\/doi.org\/10.1016\/j.transci.2025.104117","relation":{},"ISSN":["1473-0502"],"issn-type":[{"type":"print","value":"1473-0502"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T cell subgroup analysis and T cell exhaustion after autologous stem cell transplantation in lymphoma patients","name":"articletitle","label":"Article Title"},{"value":"Transfusion and Apheresis Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transci.2025.104117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104117"}}