{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:01Z","timestamp":1761630481259},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.transproceed.2008.01.027","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T14:04:18Z","timestamp":1206626658000},"page":"424-426","source":"Crossref","is-referenced-by-count":17,"title":["Regulatory Challenges in Manufacturing of Pancreatic Islets"],"prefix":"10.1016","volume":"40","author":[{"given":"E.","family":"Linetsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ricordi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2008.01.027_bib1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1097\/00007890-200212270-00034","article-title":"Selected Food and Drug Administration review issues for regulation of allogeneic islets of Langerhans as somatic cell therapy","volume":"74","author":"Weber","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2008.01.027_bib2","first-page":"600","article-title":"Update on regulatory issues in pancreatic islet transplantation","volume":"12","author":"Wonnacott","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2008.01.027_bib3","series-title":"Points to Consider in Human Somatic Cell Therapy and Gene Therapy","year":"1991"},{"key":"10.1016\/j.transproceed.2008.01.027_bib4","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1600-6143.2005.00913.x","article-title":"A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations","volume":"5","author":"Ichii","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2008.01.027_bib5","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S0041-1345(00)02651-8","article-title":"Challenges towards standardization of islet isolation technology","volume":"33","author":"Ricordi","year":"2001","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2008.01.027_bib6","first-page":"356","article-title":"Human islet cell transplantation: new perspectives for an old challenge","volume":"4","author":"Ricordi","year":"1996","journal-title":"Diabetes Reviews"},{"key":"10.1016\/j.transproceed.2008.01.027_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transproceed.2008.01.027_bib8","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2337\/diabetes.46.7.1120","article-title":"Improved human islet isolation using a new enzyme blend, Liberase","volume":"46","author":"Linetsky","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.transproceed.2008.01.027_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.TP.0000147344.73915.C8","article-title":"Assessment of a novel two-component enzyme preparation for human islet isolation and transplantation","volume":"79","author":"Bucher","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2008.01.027_bib10","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1111\/j.1600-6143.2005.00957.x","article-title":"Islet transplantation in type 1 diabetes mellitus using cultured islet and steroid-free immunosuppression: Miami experience","volume":"5","author":"Froud","year":"2005","journal-title":"Am J Transplant"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134508000286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134508000286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T18:51:41Z","timestamp":1546195901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134508000286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0041134508000286"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2008.01.027","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}