{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:39:08Z","timestamp":1761561548699},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.transproceed.2010.12.062","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T13:55:48Z","timestamp":1309010148000},"page":"1847-1852","source":"Crossref","is-referenced-by-count":19,"title":["Calcineurin Inhibitor-free Immunosuppression Using Everolimus (Certican) after Heart Transplantation: 2 years' Follow-up from the University Hospital M\u00fcnster"],"prefix":"10.1016","volume":"43","author":[{"given":"J.","family":"Stypmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eckernkemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Amler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gunia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Sindermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rothenburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rukosujew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Drees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Welp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5 Suppl","key":"10.1016\/j.transproceed.2010.12.062_bib1","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1016\/j.healun.2004.03.008","article-title":"Calcineurin inhibitors in heart transplantation","volume":"s23","author":"Keogh","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib3","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1161\/01.CIR.0000150332.42276.69","article-title":"Drug therapy in the heart transplant recipient: part II: immunosuppressive drugs","volume":"110","author":"Lindenfeld","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.transproceed.2010.12.062_bib4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2165\/00003495-200464080-00005","article-title":"Everolimus","volume":"64","author":"Chapman","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.transproceed.2010.12.062_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJMoa022171","article-title":"Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients","volume":"349","author":"Eisen","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transproceed.2010.12.062_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-6143.2008.02456.x","article-title":"Outcomes following de novo CNI-free immunosuppression after heart transplantation: a single-center experience","volume":"9","author":"Leet","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00007890-199808270-00016","article-title":"A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients","volume":"66","author":"Kobashigawa","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2010.12.062_bib8","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.transproceed.2004.10.062","article-title":"Initial experience with sirolimus and mycophenolate mofetil for renal rescue from cyclosporine nephrotoxicity after heart transplantation","volume":"36","author":"Lyster","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2010.12.062_bib9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S1053-2498(03)00212-2","article-title":"Sirolimus and mycophenolate mofetil as calcineurin inhibitor\u2013free immunosuppression in a cardiac transplant patient with chronic renal failure","volume":"23","author":"Groetzner","year":"2004","journal-title":"J Heart Lung Transplant"},{"issue":"4 Suppl","key":"10.1016\/j.transproceed.2010.12.062_bib10","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1016\/j.healun.2005.01.012","article-title":"Prevention of cardiac allograft vasculopathy with Certican (everolimus): the Stanford University experience within the Certican phase III clinical trial","volume":"24","author":"Valantine","year":"2005","journal-title":"J Heart Lung Transplant"},{"issue":"4 Suppl","key":"10.1016\/j.transproceed.2010.12.062_bib11","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1016\/j.healun.2005.01.011","article-title":"Clinical experience with Certican (everolimus) in de novo heart transplant patients at the Deutsches Herzzentrum Berlin","volume":"24","author":"Lehmkuhl","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.healun.2007.11.565","article-title":"Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients","volume":"27","author":"Ross","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"4 Suppl","key":"10.1016\/j.transproceed.2010.12.062_bib13","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1016\/j.healun.2005.01.021","article-title":"Clinical experience with Certican (everolimus) in maintenance heart transplant patients at the Medical University of Vienna","volume":"24","author":"Zuckermann","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib14","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1016\/j.healun.2005.11.369","article-title":"Calcineurin inhibitor\u2013free immunosuppression using everolimus in long term heart transplant recipients\u2014procedures of switching protocols and side effects","volume":"25","author":"Rothenburger","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.healun.2007.01.017","article-title":"Calcineurin inhibitor\u2013free immunosuppression using everolimus (Certican) in maintenance heart transplant recipients: 6 months' follow-up","volume":"26","author":"Rothenburger","year":"2007","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib16","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/rcm.323","article-title":"High-throughput semi-automated 96-well liquid\/liquid extraction and liquid chromatography\/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood","volume":"15","author":"Brignol","year":"2001","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.transproceed.2010.12.062_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.transproceed.2010.12.062_bib18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1600-6143.2009.02615.x","article-title":"Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: CONCEPT study","volume":"9","author":"Lebranchu","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib19","first-page":"200","article-title":"Mycophenolate mofetil\/sirolimus maintenance therapy after calcineurin inhibitor withdrawal in renal transplant recipients: 2-year outcomes of the Spare-the-Nephron (STN) trial","volume":"9","author":"Weir","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib20","first-page":"259","article-title":"Analysis of renal function in everolimus\/enteric-coated mycophenolate sodium treated de novo renal transplant recipients after calcineurin inhibitor withdrawal: the Zeus Study","volume":"9","author":"Budde","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib21","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/j.1600-6143.2006.01527.x","article-title":"Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy","volume":"6","author":"Gleissner","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/TP.0b013e3181927a41","article-title":"Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial","volume":"87","author":"Schena","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2010.12.062_bib23","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.transproceed.2007.06.048","article-title":"mTOR inhibitors and their secondary effects in cardiac transplant recipients: a descriptive study","volume":"39","author":"Moro","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2010.12.062_bib24","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1111\/j.1600-6143.2005.01063.x","article-title":"Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients","volume":"5","author":"Vitko","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib25","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1016\/j.transproceed.2008.05.011","article-title":"Metabolic changes following conversion from an anticalcineurin-based therapy to an everolimus-based one: a single-center experience","volume":"40","author":"Ayala","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2010.12.062_bib26","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1399-0012.2007.00686.x","article-title":"Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients","volume":"21","author":"Tenderich","year":"2007","journal-title":"Clin Transplant"},{"key":"10.1016\/j.transproceed.2010.12.062_bib27","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.transproceed.2008.09.049","article-title":"Tolerance profile of the proliferation signal inhibitors everolimus and sirolimus in heart transplantation","volume":"40","author":"Moro","year":"2008","journal-title":"Transplant Proc"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134511002740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134511002740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:23:00Z","timestamp":1543710180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134511002740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0041134511002740"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2010.12.062","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}