{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:36:46Z","timestamp":1770507406976,"version":"3.49.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.transproceed.2013.03.040","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T22:48:08Z","timestamp":1376434088000},"page":"2347-2350","source":"Crossref","is-referenced-by-count":9,"title":["Inhaled Iloprost Plus Oral Sildenafil in Patients With Severe Pulmonary Arterial Hypertension Delays the Need for Lung Transplantation"],"prefix":"10.1016","volume":"45","author":[{"given":"M.","family":"Lopez-Meseguer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Berastegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Monforte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.transproceed.2013.03.040_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1513\/pats.200803-032SK","article-title":"Patients with pulmonary arterial hypertension in clinical trials: who are they?","volume":"5","author":"Hill","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"5","key":"10.1016\/j.transproceed.2013.03.040_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJM199602013340504","article-title":"A\u00a0comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group","volume":"334","author":"Barst","year":"1996","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.transproceed.2013.03.040_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-132-6-200003210-00002","article-title":"Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial","volume":"132","author":"Badesch","year":"2000","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.transproceed.2013.03.040_bib4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa020204","article-title":"Inhaled iloprost for severe pulmonary hypertension","volume":"347","author":"Olschewski","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.transproceed.2013.03.040_bib5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0735-1097(03)00463-7","article-title":"Beraprost therapy for pulmonary arterial hypertension","volume":"41","author":"Barst","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.transproceed.2013.03.040_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1164\/rccm.200307-957OC","article-title":"Sitaxsentan therapy for pulmonary arterial hypertension","volume":"169","author":"Barst","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.transproceed.2013.03.040_bib7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/eurheartj\/ehp022","article-title":"A\u00a0meta-analysis of randomized controlled trials in pulmonary arterial hypertension","volume":"30","author":"Galie","year":"2009","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.transproceed.2013.03.040_bib8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1183\/09031936.00139009","article-title":"Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"34","author":"Galie","year":"2009","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.transproceed.2013.03.040_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0735-1097(03)00555-2","article-title":"Oral sildenafil as\u00a0long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension","volume":"42","author":"Ghofrani","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.transproceed.2013.03.040_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4684-6015-5_15","article-title":"Ca\/CaM-stimulated and cGMP-specific phosphodiesterases in vascular and non-vascular tissues","volume":"308","author":"Ahn","year":"1991","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10.1016\/j.transproceed.2013.03.040_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.7326\/0003-4819-136-7-200204020-00008","article-title":"Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension","volume":"136","author":"Ghofrani","year":"2002","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.transproceed.2013.03.040_bib12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.109.898122","article-title":"Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)","volume":"122","author":"Benza","year":"2010","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.transproceed.2013.03.040_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era","volume":"122","author":"Humbert","year":"2010","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.transproceed.2013.03.040_bib14","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.transproceed.2013.03.040_bib15","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0735-1097(02)02012-0","article-title":"Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival","volume":"40","author":"Sitbon","year":"2002","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.transproceed.2013.03.040_bib16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.ahj.2007.02.037","article-title":"A\u00a0meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology","volume":"153","author":"Macchia","year":"2007","journal-title":"Am Heart J"},{"issue":"11","key":"10.1016\/j.transproceed.2013.03.040_bib17","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/hc3601.096826","article-title":"Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension","volume":"104","author":"Wilkens","year":"2001","journal-title":"Circulation"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134513005174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134513005174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T20:29:53Z","timestamp":1539462593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134513005174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0041134513005174"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2013.03.040","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}