{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:33:19Z","timestamp":1776331999024,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","transplantation-proceedings.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.transproceed.2015.12.068","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T15:11:08Z","timestamp":1461942668000},"page":"499-506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum"],"prefix":"10.1016","volume":"48","author":[{"given":"J.","family":"Reiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-J.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Straarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bodammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sch\u00e4ffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Graepler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"St\u00fcker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Linnebacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nadalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2015.12.068_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cgh.2005.10.002","article-title":"Short bowel syndrome and intestinal failure: consensus definitions and overview","volume":"4","author":"O'Keefe","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1056\/NEJMra0804605","article-title":"Intestinal transplantation","volume":"361","author":"Fishbein","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.transproceed.2015.12.068_bib3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00007890-200202270-00013","article-title":"Zoom endoscopic evaluation of rejection in living-related small bowel transplantation","volume":"73","author":"Sasaki","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2015.12.068_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/TP.0b013e31817613f8","article-title":"Chronic kidney disease\u2013a common and serious complication after intestinal transplantation","volume":"86","author":"Herlenius","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2015.12.068_bib5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/0148607193017005438","article-title":"Serious renal impairment is associated with long-term parenteral nutrition","volume":"17","author":"Buchman","year":"1993","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.transproceed.2015.12.068_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/0148607100024004234","article-title":"Renal function and urinary excretion of electrolytes in patients receiving cyclic parenteral nutrition","volume":"24","author":"Boncompain-Gerard","year":"2000","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.transproceed.2015.12.068_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMoa021744","article-title":"Chronic renal failure after transplantation of a nonrenal organ","volume":"349","author":"Ojo","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.transproceed.2015.12.068_bib8","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.nut.2014.02.001","article-title":"Renal function in patients on long-term home parenteral nutrition and in intestinal transplant recipients","volume":"30","author":"Pironi","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.transproceed.2015.12.068_bib9","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.transproceed.2014.08.004","article-title":"Effect of age on native kidney function after adult intestinal transplants on long-term follow-up","volume":"46","author":"Lauro","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2015.12.068_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-physiol-012110-142244","article-title":"Regulation of electroneutral NaCl absorption by the small intestine","volume":"73","author":"Kato","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 Na+\/H+ exchanger","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.transproceed.2015.12.068_bib12","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1053\/j.gastro.2008.07.083","article-title":"Down-regulated in adenoma Cl\/HCO3 exchanger couples with Na\/H exchanger 3 for NaCl absorption in murine small intestine","volume":"135","author":"Walker","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.transproceed.2015.12.068_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng1196-316","article-title":"Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea","volume":"14","author":"Hoglund","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.transproceed.2015.12.068_bib14","doi-asserted-by":"crossref","first-page":"C1224","DOI":"10.1152\/ajpcell.2001.280.5.C1224","article-title":"IFN-gamma downregulates expression of Na(+)\/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2\/bbe cells","volume":"280","author":"Rocha","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib15","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI29218","article-title":"Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in\u00a0vivo","volume":"116","author":"Clayburgh","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.transproceed.2015.12.068_bib16","first-page":"G1445","article-title":"Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea","volume":"275","author":"Yang","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI116966","article-title":"Localization of cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization","volume":"93","author":"Strong","year":"1994","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.transproceed.2015.12.068_bib18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.physiol.62.1.535","article-title":"Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects","volume":"62","author":"Barrett","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib19","first-page":"1202","article-title":"Monitoring and treatment of intestinal allograft rejection in humans","volume":"25","author":"Abu-Elmagd","year":"1993","journal-title":"Transplant Proc"},{"issue":"2 Suppl 1","key":"10.1016\/j.transproceed.2015.12.068_bib20","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1053\/j.gastro.2005.11.050","article-title":"Optimal management of the post-intestinal transplant patient","volume":"130","author":"Horslen","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.transproceed.2015.12.068_bib21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A\u00a0more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.transproceed.2015.12.068_bib22","doi-asserted-by":"crossref","first-page":"e52485","DOI":"10.1371\/journal.pone.0052485","article-title":"Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas","volume":"7","author":"Maletzki","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.transproceed.2015.12.068_bib23","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1572-0241.2006.00710.x","article-title":"Candidates for intestinal transplantation: a multicenter survey in Europe","volume":"101","author":"Pironi","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib24","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1097\/00007890-200205270-00004","article-title":"Intestinal transplantation before and after the introduction of sirolimus","volume":"73","author":"Fishbein","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2015.12.068_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-3046.2012.01767.x","article-title":"Renal function and histology in children after small bowel transplantation","volume":"17","author":"Boyer","year":"2013","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.transproceed.2015.12.068_bib26","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.transproceed.2006.05.066","article-title":"Renal dysfunction following adult intestinal transplant under tacrolimus-based immunosuppression","volume":"38","author":"Ueno","year":"2006","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2015.12.068_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clnu.2005.09.010","article-title":"Chronic dehydration may impair renal function in patients with chronic intestinal failure on long-term parenteral nutrition","volume":"25","author":"Lauverjat","year":"2006","journal-title":"Clin Nutr"},{"key":"10.1016\/j.transproceed.2015.12.068_bib28","doi-asserted-by":"crossref","first-page":"E351","DOI":"10.1111\/j.1399-0012.2012.01672.x","article-title":"Risk factors for native kidney dysfunction in patients with abdominal multivisceral\/small bowel transplantation","volume":"26","author":"Suzuki","year":"2012","journal-title":"Clin Transplant"},{"key":"10.1016\/j.transproceed.2015.12.068_bib29","doi-asserted-by":"crossref","first-page":"G907","DOI":"10.1152\/ajpgi.00191.2010","article-title":"Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts","volume":"299","author":"Lissner","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1749-6632.2009.04044.x","article-title":"Regulation of the intestinal anion exchanger DRA (downregulated in adenoma)","volume":"1165","author":"Lamprecht","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.transproceed.2015.12.068_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/BJ20102062","article-title":"Transcriptional regulation of the intestinal luminal Na(+) and Cl(\u2212) transporters","volume":"435","author":"Malakooti","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.transproceed.2015.12.068_bib32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1399-3046.2010.01363.x","article-title":"The use of sirolimus as a rescue therapy in pediatric intestinal transplant recipients","volume":"14","author":"Andres","year":"2010","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.transproceed.2015.12.068_bib33","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1432-2277.2010.01167.x","article-title":"Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function","volume":"24","author":"Malinowski","year":"2011","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2015.12.068_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0016-5085(98)70366-X","article-title":"The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans","volume":"115","author":"Gabe","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.transproceed.2015.12.068_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1053\/j.gastro.2015.03.046","article-title":"Rapamycin inhibition of mTOR reduces levels of the Na+\/H+ exchanger 3 in intestines of mice and humans, leading to diarrhea","volume":"149","author":"Yang","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.transproceed.2015.12.068_bib36","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4161\/auto.25381","article-title":"FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice","volume":"9","author":"Nakagaki","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.transproceed.2015.12.068_bib37","doi-asserted-by":"crossref","first-page":"7044","DOI":"10.1073\/pnas.1303510110","article-title":"Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents","volume":"110","author":"Karapetyan","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2015.12.068_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1432-2277.2008.00785.x","article-title":"Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance","volume":"22","author":"Abu-Elmagd","year":"2009","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2015.12.068_bib39","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.transproceed.2015.12.068_bib40","doi-asserted-by":"crossref","first-page":"G157","DOI":"10.1152\/ajpgi.00227.2003","article-title":"Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in\u00a0vivo","volume":"286","author":"Bertelsen","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134516001573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134516001573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T04:28:52Z","timestamp":1567830532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134516001573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0041134516001573"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2015.12.068","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2015.12.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}