{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:33:22Z","timestamp":1789824802084,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University of Arizona State Health Library"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.transproceed.2018.02.091","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T09:33:27Z","timestamp":1540546407000},"page":"3756-3762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resistant Cytomegalovirus Infection in Solid-organ Transplantation: Single-center Experience, Literature Review of Risk Factors, and Proposed Preventive Strategies"],"prefix":"10.1016","volume":"50","author":[{"given":"A.","family":"Majeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Latif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sohail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Florita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Georgescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zangeneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2018.02.091_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11908-012-0292-2","article-title":"Cytomegalovirus in solid organ transplantation: epidemiology, prevention, and treatment","volume":"14","author":"Beam","year":"2012","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.transproceed.2018.02.091_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eimc.2009.07.008","article-title":"Direct and indirect effects of cytomegalovirus: can we prevent them?","volume":"28","author":"Razonable","year":"2010","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.transproceed.2018.02.091_bib3","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/j.1600-6143.2010.03114.x","article-title":"Effects of the intensity of immunosuppressive therapy on outcome of treatment for CMV disease in organ transplant recipients","volume":"10","author":"Asberg","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1600-6143.2004.00382.x","article-title":"Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients","volume":"4","author":"Paya","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib5","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(97)05535-9","article-title":"Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. The Oral Ganciclovir International Transplantation Study Group [corrected]","volume":"350","author":"Gane","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.transproceed.2018.02.091_bib6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/AAC.49.3.873-883.2005","article-title":"Human cytomegalovirus resistance to antiviral drugs","volume":"49","author":"Gilbert","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.transproceed.2018.02.091_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/cid\/cix259","article-title":"Risk factors and outcomes of ganciclovir resistant cytomegalovirus infection in solid organ transplant recipients","volume":"65","author":"Fisher","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1399-0012.2007.00761.x","article-title":"Emergence of drug-resistant cytomegalovirus in the era of valganciclovir prophylaxis: therapeutic implications and outcomes","volume":"22","author":"Eid","year":"2008","journal-title":"Clin Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/519941","article-title":"Incidence and clinical features of ganciclovir-resistant cytomegalovirus disease in heart transplant recipients","volume":"45","author":"Li","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib10","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S1053-2498(02)00463-1","article-title":"Emergence of ganciclovir-resistant cytomegalovirus in lung transplant recipients","volume":"21","author":"Bhorade","year":"2002","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1086\/650463","article-title":"Cytomegalovirus resistance testing: pitfalls and problems for the clinician","volume":"50","author":"Drew","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib12","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1016\/j.transproceed.2005.09.141","article-title":"Preemptive therapy with intravenous ganciclovir for the prevention of cytomegalovirus disease in lung transplant recipients","volume":"37","author":"Monforte","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2018.02.091_bib13","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.transproceed.2016.06.062","article-title":"Effect of cytomegalovirus infection on survival of older kidney transplant patients (D+\/R+): impact of valganciclovir prophylaxis versus preemptive therapy","volume":"48","author":"Luna","year":"2016","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2018.02.091_bib14","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/jac\/dkq368","article-title":"Drug-resistant cytomegalovirus in transplant recipients: a French cohort study","volume":"65","author":"Hantz","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.transproceed.2018.02.091_bib15","first-page":"897","article-title":"Six months anti-viral prophylaxis significantly decreased cytomegalovirus disease compared with no anti-viral prophylaxis following renal transplantation","volume":"23","author":"Leone","year":"2010","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2018.02.091_bib16","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/TP.0b013e3181ff1493","article-title":"Extended valganciclovir prophylaxis in D+\/R- kidney transplant recipients is associated with long-term reduction in cytomegalovirus disease: two-year results of the IMPACT study","volume":"90","author":"Humar","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2018.02.091_bib17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jcv.2011.12.019","article-title":"Incidence of cytomegalovirus UL97 and UL54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis","volume":"53","author":"Boivin","year":"2012","journal-title":"J\u00a0Clin Virol"},{"issue":"suppl","key":"10.1016\/j.transproceed.2018.02.091_bib18","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/j.healun.2009.11.199","article-title":"Subtherapeutic ganciclovir levels result in resistant CMV in lung transplantation patients","volume":"29","author":"Gagermeier","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/tid.12317","article-title":"Subtherapeutic ganciclovir (GCV) levels and GCV-resistant cytomegalovirus in lung transplant recipients","volume":"16","author":"Gagermeier","year":"2014","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/tid.12537","article-title":"Ganciclovir-resistant cytomegalovirus infection in solid organ transplant recipients: a single-center retrospective cohort study","volume":"18","author":"Young","year":"2016","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/tid.12507","article-title":"Resistant cytomegalovirus in intestinal and multivisceral transplant recipients","volume":"18","author":"Timpone","year":"2016","journal-title":"Transpl Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib22","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.healun.2007.09.012","article-title":"A\u00a0single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome","volume":"26","author":"Reddy","year":"2007","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib23","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.transproceed.2014.09.012","article-title":"Cytomegaloviral infection in solid organ transplant recipients: preliminary report of one transplant center experience","volume":"46","author":"Hryniewiecka","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2018.02.091_bib24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1600-6143.2009.02617.x","article-title":"Long-term outcomes of CMV disease treatment with valganciclovir versus IV ganciclovir in solid organ transplant recipients","volume":"9","author":"\u00c5sberg","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib25","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.healun.2010.04.022","article-title":"Cytomegalovirus disease among donor-positive\/recipient-negative lung transplant recipients in the era of valganciclovir prophylaxis","volume":"29","author":"Mitsani","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib26","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/cid\/cis1035","article-title":"Clinical aspects of cytomegalovirus antiviral resistance in solid organ transplant recipients","volume":"56","author":"Le Page","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1086\/514041","article-title":"High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes","volume":"176","author":"Smith","year":"1997","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.idc.2013.02.005","article-title":"Management strategies for cytomegalovirus infection and disease in solid organ transplant recipients","volume":"27","author":"Razonable","year":"2013","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.transproceed.2018.02.091_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/AAC.00561-13","article-title":"Ganciclovir-resistant cytomegalovirus infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens","volume":"58","author":"Minces","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.transproceed.2018.02.091_bib30","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00007890-200103270-00013","article-title":"Cytomegalovirus infection and graft rejection in renal transplantation","volume":"71","author":"Dickenmann","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2018.02.091_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1600-6143.2011.03766.x","article-title":"High incidence of anticytomegalovirus drug resistance among D+R- kidney transplant recipients receiving preemptive therapy","volume":"12","author":"Couzi","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib32","first-page":"700","article-title":"Molecular analysis of ganciclovir-resistant cytomegalovirus in renal transplant recipients with high viral load","volume":"19","author":"Sohrabi","year":"2016","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.transproceed.2018.02.091_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/TP.0b013e31821fad25","article-title":"Incidence and outcomes of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients","volume":"92","author":"Myhre","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2018.02.091_bib34","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/cid\/cis818","article-title":"State-of-the-art monitoring of cytomegalovirus-specific cell-mediated immunity after organ transplant: a primer for the clinician","volume":"55","author":"Egli","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.transproceed.2018.02.091_bib35","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/j.1600-6143.2009.02672.x","article-title":"Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy","volume":"9","author":"Brestrich","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2018.02.091_bib36","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1038\/cti.2015.5","article-title":"Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation","volume":"4","author":"Holmes-Liew","year":"2015","journal-title":"Clin Transpl Immunol"},{"issue":"suppl","key":"10.1016\/j.transproceed.2018.02.091_bib37","first-page":"S111","article-title":"Cytomegalovirus viraemia and rates of antiviral resistance following intestinal and multivisceral transplantation","volume":"99","author":"Ambrose","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2018.02.091_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/ajt.13023","article-title":"Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient","volume":"15","author":"Macesic","year":"2015","journal-title":"Am J Transplant"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518302628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518302628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:30:42Z","timestamp":1758576642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134518302628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0041134518302628"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2018.02.091","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resistant Cytomegalovirus Infection in Solid-organ Transplantation: Single-center Experience, Literature Review of Risk Factors, and Proposed Preventive Strategies","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2018.02.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}