{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:04:47Z","timestamp":1781665487494,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671525"],"award-info":[{"award-number":["81671525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070478"],"award-info":[{"award-number":["81070478"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004509","name":"Department of Health of Guangdong Province","doi-asserted-by":"publisher","award":["B2013276"],"award-info":[{"award-number":["B2013276"]}],"id":[{"id":"10.13039\/501100004509","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science and Technology Research Foundation of Guangdong Province","award":["A2015247"],"award-info":[{"award-number":["A2015247"]}]},{"name":"Science and Technology Program Project of Shantou","award":["2012165"],"award-info":[{"award-number":["2012165"]}]},{"name":"Science and Technology Program Project of Shantou","award":["2013"],"award-info":[{"award-number":["2013"]}]},{"name":"Basic and Clinical Scientific Research Foundation of Shantou University Medical College","award":["201410"],"award-info":[{"award-number":["201410"]}]},{"name":"Science and Technology Program of Shenzhen","award":["JCYJ20150402092905162"],"award-info":[{"award-number":["JCYJ20150402092905162"]}]},{"name":"Research Project of Health and Family Planning Commission of Shenzhen Municipality","award":["201501053"],"award-info":[{"award-number":["201501053"]}]},{"name":"Medical Science and Technology Research Foundation of Guangdong Province","award":["A2017187"],"award-info":[{"award-number":["A2017187"]}]},{"name":"The Medical and Health Technology Plan Project of Shantou","award":["2018-121"],"award-info":[{"award-number":["2018-121"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.transproceed.2019.01.080","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T23:09:23Z","timestamp":1548889763000},"page":"936-941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Human Umbilical Cord Mesenchymal Stem Cells Alleviate Myocardial\u00a0Endothelial-Mesenchymal Transition in a Rat Dilated Cardiomyopathy Model"],"prefix":"10.1016","volume":"51","author":[{"given":"C.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2019.01.080_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.transproceed.2019.01.080_bib2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.transproceed.2019.01.080_bib3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.transproceed.2019.01.080_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40824-016-0060-8","article-title":"Antifibrotic therapies to control cardiac fibrosis","volume":"20","author":"Fan","year":"2016","journal-title":"Biomater Res"},{"key":"10.1016\/j.transproceed.2019.01.080_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/01.bor.0000139310.77347.9c","article-title":"Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis","volume":"16","author":"Postlethwaite","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.exphem.2010.03.004","article-title":"Fibrocytes in health and disease","volume":"38","author":"Herzog","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.116.305629","article-title":"Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition","volume":"116","author":"Xu","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.transproceed.2019.01.080_bib9","doi-asserted-by":"crossref","first-page":"C216","DOI":"10.1152\/ajpcell.00328.2012","article-title":"Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis","volume":"304","author":"Zeisberg","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","article-title":"Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders","volume":"179","author":"Piera-Velazquez","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib11","doi-asserted-by":"crossref","first-page":"175979","DOI":"10.1155\/2012\/175979","article-title":"Mesenchymal stem cells and cardiovascular disease: a bench to bedside roadmap","volume":"2012","author":"Mazo","year":"2012","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.transproceed.2019.01.080_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-9-12","article-title":"Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC","volume":"9","author":"Hass","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.transproceed.2019.01.080_bib13","doi-asserted-by":"crossref","first-page":"761643","DOI":"10.1155\/2015\/761643","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury","volume":"2015","author":"Zhao","year":"2015","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.transproceed.2019.01.080_bib14","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.3892\/mmr.2015.3999","article-title":"Characteristics of human umbilical cord mesenchymal stem cells during ex\u00a0vivo expansion","volume":"12","author":"Li","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.transproceed.2019.01.080_bib15","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1634\/stemcells.2007-1028","article-title":"Immune properties of human umbilical cord Wharton's jelly-derived cells","volume":"26","author":"Weiss","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.transproceed.2019.01.080_bib16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1177\/1477153513497176","article-title":"Human umbilical cord mesenchymal stem cells attenuate cisplatin-induced acute and chronic renal injury","volume":"238","author":"Peng","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.transproceed.2019.01.080_bib17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/lt.21715","article-title":"The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis","volume":"15","author":"Tsai","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.transproceed.2019.01.080_bib18","first-page":"71","article-title":"Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNFalpha and TGFbeta1\/ERK1\/2 signaling pathways","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.transproceed.2019.01.080_bib19","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.2147\/DDDT.S85399","article-title":"Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway","volume":"9","author":"Zhou","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.transproceed.2019.01.080_bib20","first-page":"1534","article-title":"Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into insulin-producing cells in\u00a0vitro","volume":"124","author":"Wang","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.transproceed.2019.01.080_bib21","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.transproceed.2019.01.080_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/CIRCRESAHA.112.266882","article-title":"Membrane-associated matrix proteolysis and heart failure","volume":"112","author":"Spinale","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.transproceed.2019.01.080_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib24","doi-asserted-by":"crossref","first-page":"e0155730","DOI":"10.1371\/journal.pone.0155730","article-title":"Losartan attenuates myocardial endothelial-to-mesenchymal transition in spontaneous hypertensive rats via inhibiting TGF-beta\/Smad signaling","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.transproceed.2019.01.080_bib25","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.111.040352","article-title":"Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease","volume":"125","author":"Kovacic","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.transproceed.2019.01.080_bib26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.transproceed.2019.01.080_bib27","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1161\/CIRCULATIONAHA.110.938217","article-title":"Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition","volume":"121","author":"Widyantoro","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.transproceed.2019.01.080_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tcm.2009.01.001","article-title":"Transforming growth factor beta-induced endothelial-to-mesenchymal transition: a switch to cardiac fibrosis?","volume":"18","author":"Goumans","year":"2008","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.transproceed.2019.01.080_bib29","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.ijcard.2013.03.126","article-title":"Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction","volume":"168","author":"Zhang","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.transproceed.2019.01.080_bib30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1055\/s-0042-124044","article-title":"Evodiamine prevents isoproterenol-induced cardiac fibrosis by regulating endothelial-to-mesenchymal transition","volume":"83","author":"Jiang","year":"2017","journal-title":"Planta Med"},{"key":"10.1016\/j.transproceed.2019.01.080_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.fitote.2014.12.009","article-title":"Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPAR\u03b3)","volume":"101","author":"Rebhun","year":"2015","journal-title":"Fitoterapia"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518308327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518308327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:38:17Z","timestamp":1565203097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134518308327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0041134518308327"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.01.080","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Umbilical Cord Mesenchymal Stem Cells Alleviate Myocardial\u00a0Endothelial-Mesenchymal Transition in a Rat Dilated Cardiomyopathy Model","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.01.080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}