{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:35:03Z","timestamp":1781274903142,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.transproceed.2019.04.051","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T17:18:57Z","timestamp":1565111937000},"page":"1699-1705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Noninvasive and Donor-independent Method Simultaneously Monitors Rejection and Infection in Patients With Organ Transplant"],"prefix":"10.1016","volume":"51","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongda","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longkai","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2019.04.051_bib1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJM199904083401406","article-title":"Lung transplantation","volume":"340","author":"Arcasoy","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib2","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1073\/pnas.1517494112","article-title":"Noninvasive monitoring of infection and rejection after lung transplantation","volume":"112","author":"De Vlaminck","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2019.04.051_bib3","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jmoldx.2016.07.003","article-title":"Validation of a clinical-grade assay to measure donor-derived cell-free DNA in solid organ transplant recipients","volume":"18","author":"Grskovic","year":"2016","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.transproceed.2019.04.051_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1164\/rccm.201204-0693OC","article-title":"Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota after lung transplant","volume":"186","author":"Charlson","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib5","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0002-9149(96)00202-0","article-title":"Biopsy-induced flail tricuspid leaflet and tricuspid regurgitation following orthotopic cardiac transplantation","volume":"77","author":"Williams","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.transproceed.2019.04.051_bib6","doi-asserted-by":"crossref","first-page":"20458","DOI":"10.1073\/pnas.0810641105","article-title":"Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma","volume":"105","author":"Chiu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2019.04.051_bib7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nm.1789","article-title":"Circulating mutant DNA to assess tumor dynamics","volume":"14","author":"Diehl","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib8","doi-asserted-by":"crossref","first-page":"16266","DOI":"10.1073\/pnas.0808319105","article-title":"Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood","volume":"105","author":"Fan","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2019.04.051_bib9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3519","article-title":"An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage","volume":"20","author":"Newman","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib10","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1111\/ajt.13387","article-title":"Cell-free DNA: an upcoming biomarker in transplantation","volume":"15","author":"Gielis","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2019.04.051_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/tri.13341","article-title":"Dynamics of early post-operative plasma ddcfDNA levels in kidney transplantation: a single-center pilot study","volume":"32","author":"Shen","year":"2019","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2019.04.051_bib12","first-page":"520","article-title":"Noninvasive detection of infection and rejection in renal transplant patients","volume":"18","author":"Zhou","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2019.04.051_bib13","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1373\/clinchem.2009.129072","article-title":"Cell-free DNA as a noninvasive acute rejection marker in renal transplantation","volume":"55","author":"Garcia Moreira","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.transproceed.2019.04.051_bib14","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1073\/pnas.1013924108","article-title":"Universal noninvasive detection of solid organ transplant rejection","volume":"108","author":"Snyder","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2019.04.051_bib15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1515\/cclm-2015-0622","article-title":"A\u00a0fast and simple method for detecting and quantifying donor-derived cell-free DNA in sera of solid organ transplant recipients as a biomarker for graft function","volume":"54","author":"Adamek","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5808\/GI.2017.15.1.2","article-title":"Evaluation of digital PCR as a technique for monitoring acute rejection in kidney transplantation","volume":"15","author":"Lee","year":"2017","journal-title":"Genomics Inform"},{"key":"10.1016\/j.transproceed.2019.04.051_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/TP.0b013e318295ee5a","article-title":"A\u00a0rapid noninvasive assay for the detection of renal transplant injury","volume":"96","author":"Sigdel","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.04.051_bib18","doi-asserted-by":"crossref","first-page":"e113987","DOI":"10.1371\/journal.pone.0113987","article-title":"Monitoring of transplanted liver health by quantification of organ-specific genomic marker in circulating DNA from receptor","volume":"9","author":"Macher","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.transproceed.2019.04.051_bib19","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(05)79055-3","article-title":"Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients","volume":"351","author":"Lo","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.transproceed.2019.04.051_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jim.2018.09.011","article-title":"Characteristics, properties, and potential applications of circulating cell-free dna in clinical diagnostics: a focus on transplantation","volume":"463","author":"Sherwood","year":"2018","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.transproceed.2019.04.051_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/302205","article-title":"Rapid clearance of fetal DNA from maternal plasma","volume":"64","author":"Lo","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.transproceed.2019.04.051_bib22","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.transproceed.2015.08.035","article-title":"Donor-derived cell-free DNA is a novel universal biomarker for allograft rejection in solid organ transplantation","volume":"47","author":"Beck","year":"2015","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.04.051_bib23","first-page":"47","article-title":"Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?","volume":"3","author":"Daly","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib24","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1373\/clinchem.2013.210328","article-title":"Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury","volume":"59","author":"Beck","year":"2013","journal-title":"Clin Chem"},{"key":"10.1016\/j.transproceed.2019.04.051_bib25","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1681\/ASN.2016091034","article-title":"Cell-free DNA and active rejection in kidney allografts","volume":"28","author":"Bloom","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.transproceed.2019.04.051_bib26","doi-asserted-by":"crossref","first-page":"e1002286","DOI":"10.1371\/journal.pmed.1002286","article-title":"Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: a prospective, observational, multicenter cohort study","volume":"14","author":"Schutz","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.transproceed.2019.04.051_bib27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.humimm.2017.03.002","article-title":"Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch","volume":"78","author":"Zou","year":"2017","journal-title":"Hum Immunol"},{"key":"10.1016\/j.transproceed.2019.04.051_bib28","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jacc.2013.09.029","article-title":"Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid","volume":"63","author":"Hidestrand","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.transproceed.2019.04.051_bib29","doi-asserted-by":"crossref","first-page":"820621","DOI":"10.1100\/2012\/820621","article-title":"Viral infection in renal transplant recipients","volume":"2012","author":"Cukuranovic","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.transproceed.2019.04.051_bib30","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.transproceed.2016.07.011","article-title":"Bacterial infections after kidney transplantation: a single-center experience","volume":"48","author":"Illesy","year":"2016","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.04.051_bib31","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.transproceed.2014.09.115","article-title":"Bacterial and fungal infections in the early post-transplant period after kidney transplantation: etiological agents and their susceptibility","volume":"46","author":"Kawecki","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.04.051_bib32","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.transproceed.2017.02.051","article-title":"Results of real-time multiplex polymerase chain reaction assay in renal transplant recipients with sterile pyuria","volume":"49","author":"Sarier","year":"2017","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.04.051_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fcimb.2014.00025","article-title":"The diagnosis of infectious diseases by whole genome next generation sequencing: a new era is opening","volume":"4","author":"Lecuit","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.transproceed.2019.04.051_bib34","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa1401268","article-title":"Actionable diagnosis of neuroleptospirosis by next-generation sequencing","volume":"370","author":"Wilson","year":"2014","journal-title":"N\u00a0Engl J Med"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518318049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134518318049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:30:07Z","timestamp":1758576607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134518318049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0041134518318049"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.04.051","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Noninvasive and Donor-independent Method Simultaneously Monitors Rejection and Infection in Patients With Organ Transplant","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.04.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}