{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:41:53Z","timestamp":1758588113060,"version":"3.44.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.transproceed.2019.05.012","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T17:20:00Z","timestamp":1565112000000},"page":"2081-2098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["ASP1126, a Novel Sphingosine-1-Phosphate\u2013Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia"],"prefix":"10.1016","volume":"51","author":[{"given":"Akira","family":"Okimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Shimatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadatsura","family":"Koshika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuaki","family":"Morokata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2019.05.012_bib1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2165\/00003495-200363150-00002","article-title":"Calcineurin inhibitors in renal transplantation: what is the best option?","volume":"63","author":"Tanabe","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.transproceed.2019.05.012_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1517\/14656566.2013.751374","article-title":"Tacrolimus in transplant rejection","volume":"14","author":"Rath","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.transproceed.2019.05.012_bib3","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1517\/14740338.2015.1083974","article-title":"The safety of calcineurin inhibitors for kidney-transplant patients","volume":"14","author":"Malvezzi","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.transproceed.2019.05.012_bib4","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1097\/00007890-199911270-00016","article-title":"Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: a phase II trial. Rapamune Study Group","volume":"68","author":"Kahan","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.5414\/CNP73333","article-title":"Novel immunosuppressive agents in kidney transplantation","volume":"73","author":"Cooper","year":"2010","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/tri.12553","article-title":"The need for minimization strategies: current problems of immunosuppression","volume":"28","author":"Bamoulid","year":"2015","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2019.05.012_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/00041552-199511000-00002","article-title":"Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin","volume":"4","author":"Cardenas","year":"1995","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.transproceed.2019.05.012_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0162-3109(00)00188-0","article-title":"Mycophenolate mofetil and its mechanisms of action","volume":"47","author":"Allison","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.transproceed.2019.05.012_bib9","first-page":"375","article-title":"Profile of belatacept and its potential role in prevention of graft rejection following renal transplantation","volume":"4","author":"Gupta","year":"2010","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.transproceed.2019.05.012_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.1070238","article-title":"Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists","volume":"296","author":"Mandala","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.transproceed.2019.05.012_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.transproceed.2019.05.012_bib12","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ni1545","article-title":"Finding a way out: lymphocyte egress from lymphoid organs","volume":"8","author":"Schwab","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib13","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/S0041-1345(98)00593-4","article-title":"FTY720: a new immunosuppressive agent with novel mechanism(s) of action","volume":"30","author":"Kahan","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.05.012_bib14","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1097\/01.TP.0000121761.02129.A6","article-title":"FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation","volume":"79","author":"Tedesco-Silva","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib15","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1111\/j.1600-6143.2006.01552.x","article-title":"FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia","volume":"6","author":"Salvadori","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2019.05.012_bib16","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/01.tp.0000251718.95622.b3","article-title":"Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation","volume":"82","author":"Tedesco-Silva","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.trim.2006.02.002","article-title":"FTY720 treatment of kidney transplant patients: a differential effect on B cells, naive T cells, memory T cells and NK cells","volume":"15","author":"Vaessen","year":"2006","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib18","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.transproceed.2019.05.012_bib19","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1074\/jbc.M311743200","article-title":"Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate","volume":"279","author":"Sanna","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.transproceed.2019.05.012_bib20","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.yexcr.2006.01.022","article-title":"Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3\/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells","volume":"312","author":"Fieber","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.transproceed.2019.05.012_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1165\/rcmb.2006-0327OC","article-title":"Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation","volume":"37","author":"Singleton","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib22","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/jnnp-2013-307282","article-title":"Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial","volume":"85","author":"Olsson","year":"2014","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.transproceed.2019.05.012_bib23","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S1474-4422(13)70102-9","article-title":"Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study","volume":"12","author":"Selmaj","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1474-4422(16)00018-1","article-title":"Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, phase 2 trial","volume":"15","author":"Cohen","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1399-0012.2006.00596.x","article-title":"FTY720 (fingolimod) in renal transplantation","volume":"20","author":"Budde","year":"2006","journal-title":"Clin Transplant"},{"year":"2011","series-title":"Guide for the Care and Use of Laboratory Animals","key":"10.1016\/j.transproceed.2019.05.012_bib26"},{"key":"10.1016\/j.transproceed.2019.05.012_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-5223(19)42744-X","article-title":"Improved technique of heart transplantation in rats","volume":"57","author":"Ono","year":"1969","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.transproceed.2019.05.012_bib28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1254\/jphs.08142FP","article-title":"Efficacy of oral treatment with tacrolimus in the renal transplant model in cynomolgus monkeys","volume":"108","author":"Kinugasa","year":"2008","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.transproceed.2019.05.012_bib29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0192623311425056","article-title":"Determination of absolute counts of circulating regulatory T cells in cynomolgus macaques using an optimized flow cytometric method","volume":"40","author":"Clark","year":"2012","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fncel.2014.00283","article-title":"Fingolimod for the treatment of neurological diseases\u2014state of play and future perspectives","volume":"8","author":"Brunkhorst","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.transproceed.2019.05.012_bib31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0026-895X(24)23174-6","article-title":"Transduction of intracellular calcium signals through G protein mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors","volume":"55","author":"An","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110819","article-title":"ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile","volume":"9","author":"Yamamoto","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2019.05.012_bib33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/01.CIR.0000152101.41037.AB","article-title":"KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts","volume":"111","author":"Shimizu","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib34","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.chembiol.2006.09.017","article-title":"A\u00a0monoselective sphingosine-1- phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model","volume":"13","author":"Pan","year":"2006","journal-title":"Chem Biol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.intimp.2015.03.004","article-title":"Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice","volume":"26","author":"Ni","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.intimp.2015.06.016","article-title":"Effect of novel PKCtheta selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation","volume":"27","author":"Fukahori","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib37","first-page":"471","article-title":"Calcineurin inhibitor-sparing strategies in renal transplantation: where are we? A comprehensive review of the current evidence","volume":"14","author":"Camilleri","year":"2016","journal-title":"Exp Clin Transplant"},{"key":"10.1016\/j.transproceed.2019.05.012_bib38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0006-2952(94)90136-8","article-title":"Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes","volume":"47","author":"Shiraga","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib39","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/FTD.0b013e3181aa36cd","article-title":"New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and mycophenolic acid: possible consequences for therapeutic drug monitoring in solid organ transplantation","volume":"31","author":"de Jonge","year":"2009","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.transproceed.2019.05.012_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0009-9236(03)00168-1","article-title":"Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus","volume":"74","author":"Hesselink","year":"2003","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.transproceed.2019.05.012_bib41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/hep.1840200207","article-title":"Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients","volume":"20","author":"Cakaloglu","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.transproceed.2019.05.012_bib42","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1002\/phar.1752","article-title":"Cobicistat significantly increases tacrolimus serum concentrations in a renal transplant recipient with human immunodeficiency virus infection","volume":"36","author":"Han","year":"2016","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.transproceed.2019.05.012_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.trim.2017.01.002","article-title":"ASP0028 in combination with suboptimal dose of tacrolimus in cynomolgus monkey renal transplantation model","volume":"40","author":"Dun","year":"2017","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib44","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jcph.513","article-title":"Effect of ceralifimod (ONO-4641) on lymphocytes and cardiac function: Randomized, double-blind, placebo-controlled trial with an open-label fingolimod arm","volume":"55","author":"Krosser","year":"2015","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib45","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/jpet.110.176487","article-title":"The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation","volume":"337","author":"Piali","year":"2011","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.transproceed.2019.05.012_bib46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/cei.12304","article-title":"Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice","volume":"177","author":"Dong","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJMoa0909494","article-title":"A\u00a0placebo controlled trial of oral fingolimod in relapsing multiple sclerosis","volume":"362","author":"Kappos","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.transproceed.2019.05.012_bib48","doi-asserted-by":"crossref","first-page":"13423","DOI":"10.1038\/srep13423","article-title":"Sphingosine 1-phosphate receptor 2 and 3 mediate bone marrow-derived monocyte\/macrophage motility in cholestatic liver injury in mice","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.transproceed.2019.05.012_bib49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000369291","article-title":"The effect of sphingosine 1- phosphate\/sphingosine 1-phosphate receptor on neutrophil function and the relevant signaling pathway","volume":"134","author":"Wang","year":"2015","journal-title":"Acta Haematol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib50","doi-asserted-by":"crossref","first-page":"e95566","DOI":"10.1371\/journal.pone.0095566","article-title":"Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor kappaB in BEAS-2B cells","volume":"9","author":"O'Sullivan","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2019.05.012_bib51","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1124\/jpet.301.2.519","article-title":"Heining P, Jusko WJ. Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1.3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses","volume":"301","author":"Li","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.transproceed.2019.05.012_bib52","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/00007890-200205150-00001","article-title":"Multiple pathways to allograft rejection","volume":"73","author":"Le Moine","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1600-065X.2003.00090.x","article-title":"Effector mechanisms in transplant rejection","volume":"196","author":"Rocha","year":"2003","journal-title":"Immunol Rev"},{"key":"10.1016\/j.transproceed.2019.05.012_bib54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.iy.11.040193.002125","article-title":"The molecular basis of allorecognition","volume":"11","author":"Sherman","year":"1993","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib55","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00007890-200210150-00009","article-title":"Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD","volume":"74","author":"Schuurman","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib56","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1097\/01.tp.0000232687.78242.cd","article-title":"Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation","volume":"82","author":"Fujishiro","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1067\/msy.2000.100884","article-title":"Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantation","volume":"127","author":"Tamura","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.transproceed.2019.05.012_bib58","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00007890-199601270-00006","article-title":"A\u00a0novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation","volume":"61","author":"Suzuki","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib59","first-page":"1062","article-title":"FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A","volume":"28","author":"Kawaguchi","year":"1996","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2019.05.012_bib60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ddmod.2008.06.002","article-title":"Non-human primate models in allo-transplantation research: a short review","volume":"5","author":"Haanstra","year":"2008","journal-title":"Drug Discov Today Dis Models"},{"key":"10.1016\/j.transproceed.2019.05.012_bib61","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/00007691-200412000-00001","article-title":"Overview of FTY720 clinical pharmacokinetics and pharmacology","volume":"26","author":"Kovarik","year":"2004","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.transproceed.2019.05.012_bib62","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1111\/j.1600-6143.2009.02742.x","article-title":"Contribution of naive and memory T-cell populations to the human alloimmune response","volume":"9","author":"Macedo","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2019.05.012_bib63","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1365-3083.2010.02493.x","article-title":"The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells","volume":"73","author":"Wang","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib64","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1600-6143.2007.01786.x","article-title":"Repeat organ transplantation in the United States, 1996-2005","volume":"7","author":"Magee","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.transproceed.2019.05.012_bib65","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib66","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1172\/JCI77837","article-title":"CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?","volume":"124","author":"Mackay","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.transproceed.2019.05.012_bib67","doi-asserted-by":"crossref","first-page":"e80601","DOI":"10.1371\/journal.pone.0080601","article-title":"Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients","volume":"8","author":"San Segundo","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2019.05.012_bib68","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1097\/01.tp.0000241077.83511.be","article-title":"Controlling the generation and function of human CD8+ memory T cells in\u00a0vitro with immunosuppressants","volume":"82","author":"Jones","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2019.05.012_bib69","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/imm.12603","article-title":"Different in\u00a0vitro proliferation and cytokine-production inhibition of memory T-cell subsets after calcineurin and mammalian target of rapamycin inhibitors treatment","volume":"148","author":"Merino","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.transproceed.2019.05.012_bib70","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1073\/pnas.1516485113","article-title":"T\u00a0cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection","volume":"113","author":"Benechet","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.transproceed.2019.05.012_bib71","doi-asserted-by":"crossref","first-page":"e1006960","DOI":"10.1371\/journal.ppat.1006960","article-title":"Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection","volume":"14","author":"Opata","year":"2018","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.transproceed.2019.05.012_bib72","first-page":"85","article-title":"T\u00a0cell memory","volume":"311","author":"Tan","year":"2006","journal-title":"Current topics in microbiology and immunology"},{"key":"10.1016\/j.transproceed.2019.05.012_bib73","doi-asserted-by":"crossref","first-page":"e1006191","DOI":"10.1371\/journal.ppat.1006191","article-title":"Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance","volume":"13","author":"Abdel-Hakeem","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.transproceed.2019.05.012_bib74","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.imbio.2010.04.008","article-title":"Characterization and IL-15 dependence of NK cells in humanized mice","volume":"216","author":"Pek","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.transproceed.2019.05.012_bib75","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1084\/jem.20082013","article-title":"IL-15 trans-presentation promotes human NK cell development and differentiation in\u00a0vivo","volume":"206","author":"Huntington","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.transproceed.2019.05.012_bib76","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.4049\/jimmunol.0903729","article-title":"NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells","volume":"184","author":"Zecher","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib77","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.trsl.2008.12.001","article-title":"Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells","volume":"153","author":"Xia","year":"2009","journal-title":"Transl Res"},{"key":"10.1016\/j.transproceed.2019.05.012_bib78","doi-asserted-by":"crossref","first-page":"e7840","DOI":"10.1371\/journal.pone.0007840","article-title":"Induction of Foxp3-expressing regulatory T-cells by donor blood transfusion is required for tolerance to rat liver allografts","volume":"4","author":"Abe","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2019.05.012_bib79","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1600-6143.2003.00293.x","article-title":"CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential","volume":"4","author":"Fu","year":"2004","journal-title":"Am J Transpl"},{"key":"10.1016\/j.transproceed.2019.05.012_bib80","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/ni.1743","article-title":"The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR","volume":"10","author":"Liu","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib81","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ni.1939","article-title":"The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells","volume":"11","author":"Liu","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaut.2018.08.002","article-title":"Fingolimod modulates T cell phenotype and regulatory T cell plasticity in\u00a0vivo","volume":"96","author":"Dominguez-Villar","year":"2019","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.transproceed.2019.05.012_bib83","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000362992","article-title":"Sphingosine 1-phosphate in blood: function, metabolism, and fate","volume":"34","author":"Thuy","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.transproceed.2019.05.012_bib84","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1172\/JCI12450","article-title":"Sphingosine 1- phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement","volume":"108","author":"Garcia","year":"2001","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.transproceed.2019.05.012_bib85","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nchembio804","article-title":"Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in\u00a0vivo","volume":"2","author":"Sanna","year":"2006","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib86","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1165\/rcmb.2009-0345OC","article-title":"Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury","volume":"43","author":"Shea","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib87","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.coph.2006.09.008","article-title":"Sphingosine-1-phosphate signaling in the cardiovascular system","volume":"7","author":"Peters","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.transproceed.2019.05.012_bib88","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/cvr\/cvp086","article-title":"Sphingosine-1-phosphate receptor signalling in the heart","volume":"82","author":"Means","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.transproceed.2019.05.012_bib89","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1124\/jpet.103.062828","article-title":"Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes","volume":"309","author":"Forrest","year":"2004","journal-title":"J\u00a0Pharmacol Exp Ther"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134519306591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134519306591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:34:31Z","timestamp":1758576871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134519306591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0041134519306591"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.05.012","relation":{},"ISSN":["0041-1345"],"issn-type":[{"type":"print","value":"0041-1345"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ASP1126, a Novel Sphingosine-1-Phosphate\u2013Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2019.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}