{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T22:10:12Z","timestamp":1758579012282,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.transproceed.2022.08.035","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:28:50Z","timestamp":1666096130000},"page":"2381-2387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vascular Neonatal Thymus Transplantation in Rabbits"],"prefix":"10.1016","volume":"54","author":[{"given":"Luis Fernando","family":"Tintinago-Londo\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-732X","authenticated-orcid":false,"given":"Daniel Francisco","family":"Isaza-Pierotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Gonzalo","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Rico-Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Osorio-Cardona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estephania","family":"Candelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2022.08.035_bib0001","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1056\/NEJMra1911109","article-title":"Tolerance in the age of immunotherapy","volume":"383","author":"Bluestone","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0002","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10875-021-01059-7","article-title":"Congenital athymia: genetic etiologies, clinical manifestations, diagnosis, and treatment","volume":"41","author":"Collins","year":"2021","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0003","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","article-title":"Hallmarks of T cell aging","volume":"22","author":"Mittelbrunn","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0004","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ncb3023","article-title":"An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts","volume":"16","author":"Bredenkamp","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0005","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1084\/jem.20131289","article-title":"Sex steroid blockade enhances thymopoiesis by modulating Notch signaling","volume":"211","author":"Velardi","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0006","article-title":"Foxn1 is dynamically regulated in thymic epithelial cells during embryogenesis and at the onset of thymic involution","volume":"11","author":"O'Neill","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0007","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.celrep.2016.02.080","article-title":"Identification of a bipotent epithelial progenitor population in the adult thymus","volume":"14","author":"Ulyanchenko","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0008","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1084\/jem.20161564","article-title":"Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches","volume":"214","author":"Mart\u00edn-Gayo","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0009","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cryobiol.2017.06.010","article-title":"Effect of cryopreservation on viability and growth efficiency of stromal-epithelial cells derived from neonatal human thymus","volume":"78","author":"Shichkin","year":"2017","journal-title":"Cryobiology"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0010","first-page":"1","article-title":"Optimization of quality parameters for human thymic cell samples stored in liquid nitrogen","volume":"10","author":"Shichkin","year":"2018","journal-title":"Trends Transplant"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0011","article-title":"Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development","volume":"145","author":"Garc\u00eda-Le\u00f3n","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0012","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1038\/s41467-020-20082-7","article-title":"Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds","volume":"11","author":"Campinoti","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0013","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/109454503322733063","article-title":"Apparent induction of partial thymic regeneration in a normal human subject: a case report","volume":"6","author":"Fahy","year":"2003","journal-title":"J Anti Aging Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0014","doi-asserted-by":"crossref","first-page":"e13028","DOI":"10.1111\/acel.13028","article-title":"Reversal of epigenetic aging and immunosenescent trends in humans","volume":"18","author":"Fahy","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2214\/ajr.103.1.32","article-title":"Congenital absence of the thymus","volume":"103","author":"Kirkpatrick","year":"1968","journal-title":"Am j Roentgenol Radium Ther Nucl Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0016","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0022-3476(79)80207-3","article-title":"The spectrum of the DiGeorge syndrome","volume":"94","author":"Conley","year":"1979","journal-title":"J Pediatr"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajmg.1320280508","article-title":"Embryologic and other developmental considerations of thirty-eight possible variants of the DiGeorge anomaly","volume":"3","author":"Thomas","year":"1987","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0018","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/18997","article-title":"Exposing the human nude phenotype","volume":"398","author":"Frank","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0019","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<167::AID-AJMG17>3.0.CO;2-O","article-title":"Congenital alopecia and nail dystrophy associated with severe functional T-cell immunodeficiency in two sibs","volume":"65","author":"Pignata","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0020","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1056\/NEJM199910143411603","article-title":"Transplantation of thymus tissue in complete DiGeorge syndrome","volume":"341","author":"Markert","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0021","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jpedsurg.2004.07.020","article-title":"Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations","volume":"39","author":"Rice","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0022","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1182\/blood-2010-06-292490","article-title":"First use of thymus transplantation therapy for FOXN1 deficiency (nude\/SCID): a report of 2 cases","volume":"117","author":"Markert","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0023","doi-asserted-by":"crossref","first-page":"e37042","DOI":"10.1371\/journal.pone.0037042","article-title":"Human FOXN1-deficiency is associated with \u03b1\u03b2 double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation","volume":"7","author":"Albuquerque","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0024","series-title":"Stiehm's immune deficiencies","first-page":"1059","article-title":"Thymus transplantation","author":"Markert","year":"2015"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0025","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jaci.2017.03.020","article-title":"Thymus transplantation for complete DiGeorge syndrome: European experience","volume":"140","author":"Davies","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0026","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jaci.2021.06.028","article-title":"Experience with cultured thymus tissue in 105 children","volume":"149","author":"Markert","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0027","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00007890-199010000-00028","article-title":"Vascular thymus transplantation in rats. Technique, morphology, and function","volume":"50","author":"Kampinga","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0028","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/(SICI)1098-2752(1999)19:2<56::AID-MICR3>3.0.CO;2-F","article-title":"Surgical technique for vascularized thymus transplantation in mice","volume":"19","author":"Jiang","year":"1999","journal-title":"Microsurgery"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0029","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0041-1345(00)02053-4","article-title":"A model of vascular thymus transplantation in athymic rats","volume":"33","author":"Ortak","year":"2001","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0030","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/00007890-200203150-00032","article-title":"Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesis","volume":"73","author":"LaMattina","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0031","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.trim.2010.03.007","article-title":"Vascularized whole thymus transplantation in Rowett nude rats: effect of thymus allograft volume on tolerance induction","volume":"23","author":"Zhao","year":"2010","journal-title":"Transplant Immunol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0032","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.transproceed.2011.10.055","article-title":"A model of isolated, vascular whole thymus transplantation in nude rats","volume":"44","author":"Zhao","year":"2012","journal-title":"Transplant Proc"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0033","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/bjc.1960.8","article-title":"Graft-versus-host reactions in the rabbit","volume":"14","author":"Porter","year":"1960","journal-title":"Br J Cancer"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0034","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00281-001-0098-z","article-title":"Age-associated changes in thymopoiesis","volume":"24","author":"Aspinall","year":"2002","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0035","series-title":"The EBMT handbook: hematopoietic stem cell transplantation and cellular therapies","article-title":"Acute graft-versus-host disease","author":"Holler","year":"2019"},{"key":"10.1016\/j.transproceed.2022.08.035_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7271097","article-title":"Role of regulatory T cells in tumor-bearing mice treated with allo-hematopoietic stem cell transplantation plus thymus transplantation","volume":"2018","author":"Hosaka","year":"2018","journal-title":"J Immunol Res"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134522005930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134522005930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:44:15Z","timestamp":1758577455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134522005930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0041134522005930"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2022.08.035","relation":{},"ISSN":["0041-1345"],"issn-type":[{"type":"print","value":"0041-1345"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular Neonatal Thymus Transplantation in Rabbits","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2022.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}